Phosphatidylserine, a death knell

Cell Death and Differentiation

Volumn 8, Issue 6, 2001, Pages 551-563

  Schlegel, R A ^a   Williamson, P ^b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b AMHERST COLLEGE   (United States)

Author keywords

Aminophospholipid translocase; Apoptosis; Macrophages; Membrane asymmetry; Phagocytosis; Phosphatidylserine

Indexed keywords

CELL RECEPTOR; LIGAND; PHOSPHATIDYLSERINE; PHOSPHATIDYLSERINE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; AUTOIMMUNE DISEASE; BLOOD CLOTTING; CELL DEATH; CELL DIFFERENTIATION; CELL SURFACE; CELL TYPE; CELLULAR DISTRIBUTION; EMBRYO; ENERGY; ERYTHROCYTE; EVOLUTION; EXPOSURE; HUMAN; HUMAN CELL; INFLAMMATION; LIPID BILAYER; LONG TERM EXPOSURE; MAMMAL; MEMBRANE FUSION; MOLECULAR RECOGNITION; NONHUMAN; PHAGOCYTOSIS; PLASMA CELL; PRIORITY JOURNAL; RANDOMIZATION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL MEMBRANE; HUMANS; PHAGOCYTES; PHAGOCYTOSIS; PHOSPHATIDYLSERINES; RECEPTORS, CELL SURFACE; RETICULOENDOTHELIAL SYSTEM; SIGNAL TRANSDUCTION;

ANIMALIA; MAMMALIA;

EID: 0034961554     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400817     Document Type: Review

References (172)

1. Transmembrane domain-dependent sorting of proteins to the ER and plasma membrane in yeast
2. GPI-anchored proteins are organized in submicron domains at the cell surface
3. Microdomains of GPI-anchored proteins in living cells revealed by crosslinking
4. The differential miscibility of lipids as the basis for the formation of functional membrane rafts
5. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
6. Most thymocytes die in the absence of DNA fragmentation
7. DNA fragmentation is not the primary event in glucocorticoid-induced thymocyte death in vivo
8. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans
9. Phosphatidylserine as a determinant of reticuloendothelial recognition of liposome models of the erythrocyte surface
10. Effects of liposome structure and lipid composition on the activation of the tumoricidal properties of macrophages by liposomes containing muramyl dipeptide
11. Scavenger receptor-mediated uptake and metabolism of lipid vesicles containing acidic phospholipids by mouse peritoneal macrophages
12. Uptake of liposomes by cultured mouse bone marrow macrophages: Influence of liposomes composition and size
13. Recognition of liposomes by cells-in vitro binding and endocytosis mediated by specific lipid headgroups and surface charge density
14. Quantitative analysis of liposome-cell interactions in vitro-rate constants of binding and endocytosis with suspension and adherent J774-cells and human monocytes
15. Phosphatidylserine vesicles inhibit phagocytosis of erythrocytes with a symmetric transbilayer distribution of phospholipids
16. Merocyanine 540 as a flow cytometric probe of membrane lipid organization in leukocytes
17. Back and forth: The regulation and function of transbilayer phospholipid movement in eukaryotic cells
18. Measurement of phosphatidylserine exposure in leukocytes and platelets by whole-blood flow cytometry with annexin V
19. In vivo recognition and clearance of red blood cells containing phosphatidylserine in their plasma membranes
20. Single cell analysis of factors increasing the survival of resealed erythrocytes in the circulation of mice
21. Insertion of fluorescent phosphatidylserine into the plasma membrane of red blood cells. Recognition by autologous macrophages
22. Membrane phospholipid asymmetry as a determinant of erythrocyte recognition by macrophages
23. Phosphatidylserine vesicles inhibit phagocytosis of erythrocytes with a symmetric transbilayer distribution of phospholipids
24. Multiple systems for recognition of apoptotic lymphocytes by macrophages
25. Phosphatidlyserine exposure and red cell viability in red cell aging and in hemolytic anemia
26. Alterations in plasma membrane lipid organization during lymphocyte differentiation
27. Plasma membrane lipid organization and the adherence of differentiating lymphocytes to macrophages
28. Altered lipid packing identifies apoptotic thymocytes
29. Membrane phospholipid organization as a determinant of blood cell-reticuloendothelial cell interactions
30. Asymmetrical lipid bilayer structure for biological membranes
31. ATP-dependent asymmetric distribution of spin-labeled phospholipids in the erythrocyte membrane: Relation to shape changes
32. Control of transmembrane lipid asymmetry in chromaffin granules by an ATP-dependent protein
33. Phospholipid transverse diffusion in synaptosomes: Evidence for the involvement of the aminophospholipid translocase
34. Partial purification and characterization of the human erythrocyte Mg2(+)-ATPase. A candidate aminophospholipid translocase
35. Purification and properties of a vanadate- and N-ethylmaleimide-sensitive ATPase from chromaffin granule membranes
36. Characterization of the P-Type and V-Type ATPases of cholinergic synaptic vesicles and coupling of nucleotide hydrolysis to acetylcholine transport
37. A subfamily of P-Type ATPases with aminophospholipid transporting activity
38. Multiple members of a third subfamily of P-type ATPases identified by genomic sequences and ESTs
39. Differential expression of putative transbilayer amphipath transporters
40. A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis
41. In situ detection of apoptosis during embryogenesis with annexin V: From whole mount to ultrastructure
42. Cell surface exposure of phosphatidylserine during apoptosis is phylogenetically conserved
43. Phospholipid asymmetry in human erythrocyte ghosts
44. Loss of membrane phospholipid asymmetry in platelets and red cells may be associated with calcium-induced shedding of plasma membrane and inhibition of aminophospholipid translocase
45. Ion regulation of phosphatidylserine and phosphatidylethanolamine outside-inside translocation in human erythrocytes
46. Relationship of phospholipid distribution to shape change in Ca(2+)-crenated and recovered human erythrocytes
47. Ca2+ induces transbilayer redistribution of all major phospholipids in human erythrocytes
48. Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid
49. Reconstitution of phospholipid scramblase activity from human blood platelets
50. Molecular cloning of human plasma membrane phospholipid scramblase a protein mediating transbilayer movement of plasma membrane phospholipids
51. Expression of proteins controlling transbilayer movement of plasma membrane phospholipids in the B lymphocytes from a patient with Scott syndrome
52. Assessment of the expression of candidate human plasma membrane phospholipid scramblase in Scott syndrome cells
53. Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes
54. Mechanisms for recognition and phagocytosis of apoptotic lymphocytes by macrophages
55. Altered lipid packing identifies apoptotic thymocytes
56. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexperssion of Bcl-2 and Abl
57. Binding and phagocytosis of apoptotic vascular smooth muscle cells is mediated in part by exposure of phosphatidylserine
58. Apoptotic vascular endothelial cells become procoagulant
59. Recognition of phosphatidylserine on the surface of apoptotic spermatogenic cells and subsequent phagocytosis by sertoli cells of the rat
60. Annexin V labels apoptotic neurons following hypoxiaischemia
61. Apoptotic cell death during normal embryogenesis of the coronal suture: Early detection of apoptosis in mice using annexin V
62. Phosphatidylserine plasma membrane asymmetry in vivo: A pancellular phenomenon which alters during apoptosis
63. Phosphatidylserine is exposed by apoptotic cells in mouse embryos in vivo
64. Annexin V: A new marker for in situ detection of apoptotic cell death at the light microscopical and ultrastructural level during embryogenesis and metamorphosis
65. In situ detection of apoptosis during embryogenesis with Annexin V: From whole mount to ultrastructure
66. Cell surface exposure of phosphatidylserine during apoptosis is phylogenetically conserved
67. Spatiotemporal distribution of dying neurons during early mouse development
68. Appearance of phosphatidylserine on apoptotic cells requires calcium-mediated nonspecific flip-flop and is enhanced by loss of the aminophospholipid translocase
69. Regulation of phosphatidylserine exposure and phagocytosis of apoptotic T lymphocytes
70. Involvement of extracellular calcium in phosphatidylserine exposure during apoptosis
71. Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase C delta
72. Polyamine regulation of plasma membrane phospholipid flip-flop during apoptosis
73. Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity
74. Dissociation of phagocyte recognition of cells undergoing apoptosis from other features of the apoptotic program
75. Are caspases involved in the death of cells with a transcriptionally inactive nucleus? Sperm and chicken erythrocytes
76. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
77. Apaf-1, a human protein homologous to C-elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
78. Heterogeneity in the fluidity of intact erythrocyte membrane and its homogenization upon hemolysis
79. Involvement of spectrin in the maintenance of phase-state asymmetry in the erythrocyte membrane
80. Asymmetric lateral mobility of phospholipids in the human erythrocyte membrane
81. Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells
82. Exposure of phosphatidylserine is a general feature in the phagocytosis of apoptotic lymphocytes by macrophages
83. Role of phospholipid asymmetry in cellular membrane fusion
84. Surface expression of phosphatidylserine on macrophages is required for phagocytosis of apoptotic thymocytes
85. A receptor for phosphatidylserine-specific clearance of apoptotic cells
86. Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
87. Macrophage recognition of ICAM-3 on apoptotic leukocytes
88. Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis
89. SRB1, a class B scavenger receptor, recognizes both negatively charged liposomes and apoptotic cells
90. Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila
91. Structures and functions of multiligand lipoprotein receptors: Macrophage scavenger receptors and LDL receptor-related protein (LRP)
92. CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha(v)beta(3))
93. Apoptotic thymocyte clearance in scavenger receptor class A-deficient mice is apparently normal
94. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
95. Human CD14 mediates recognition and phagocytosis of apoptotic cells
96. Recognition of apoptotic cells by human macrophages: Inhibition by a monocyte/macrophage-specific monoclonal antibody
97. CD14 is a component of multiple recognition systems used by macrophages to phagocytose apoptotic lymphocytes
98. Phosphatidylinositides bind to plasma membrane CD14 and can prevent monocyte activation by bacterial lipopolysaccharide
99. Programmed cell death and Bcl-2 protection in the absence of a nucleus
100. Constitutive expression of the machinery for programmed cell death
101. Loss of phospholipid asymmetry and surface exposure of phosphati ylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts
102. The central role of phosphatidylserine in the phagocytosis of apoptotic thymocytes
103. Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans
104. Immunosuppressive effects of apoptotic cells
105. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF
106. CED-2/Crkll and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
107. Molecular signaling mechanisms of cell migration and invasion
108. The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters
109. ABC transporters: From microorganisms to man
110. Comparative aspects of the function and mechanism of SUR1 and MDR1 proteins
111. Structure and function of the CFTR chloride channel
112. The multidrug resistance protein family
113. The ATP binding cassette transporter ABC1, is required for the engulfment of corpses generated by apoptotic cell death
114. ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine
115. Engulfment of apoptotic cells involves the redistribution of membrane phosphatidylserine on phagocyte and prey
116. Transport of lipids from Golgi to plasma membrane is defective in Tangier disease patients and Abc1-deficient mice
117. Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux
118. The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway
119. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
120. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
121. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
122. Plasma and fibroblasts of Tangier disease patients are disturbed in transferring phospholipids onto apolipoprotein A-l
123. Differences between the clearance of apoptotic cells by professional and non-professional phagocytes
124. Independent mechanisms for macrophage binding and macrophage phagocytosis of damaged erythrocytes-evidence of receptor cooperativity. Arterioscl
125. An assay for the quantitative measurement of in vitro phagocytosis of early apoptotic thymocytes by murine resident peritoneal macrophages
126. Exposure of endogenous phosphatidylserine at the outer surface of stimulated platelets is reserved by restoration of aminophospholipid translocase activity
127. Continuous analysis of the mechanism of activated transbilayer lipid movement in platelets
128. Lipid-protein interactions in blood coagulation
129. Activation of the factor VIIIa-factor IXa enzyme complex of blood coagulation by membranes containing phosphatidyl-L-serine
130. Specific membrane binding of factor VIII is mediated by O-phospho-L-serine, a moiety of phosphatidylserine
131. Assembly of the prothrombinase complex on lipid vesicles depends on the stereochemical configuration of the polar headgroup of phosphatidylserine
132. Prothrombinase complex assembly. Kinetic mechanism of enzyme assembly on phospholipid vesicles
133. Gamma-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase
134. Binding of blood coagulation factor VIII and its light chain to phosphatidylserine/phosphatidylcholine bilayers as measured by ellipsometry
135. Primary structure and tissue distribution of two novel proline-rich gamma-carboxyglutamic acid proteins
136. Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: An isolated defect in platelet procoagulant activity
137. 2+-induced activation of platelets from a patient with Scott syndrome
138. 2+-induced microvesiculation and deficient progression of procoagulant activity in erythrocytes from a patient with a bleeding disorder-A study of the red blood cells of Scott syndrome
139. Production and characterization of transformed B-lymphocytes expressing the membrane defect of Scott syndrome
140. Myoblast aminophospholipid asymmetry differs from that of fibroblasts
141. The structure of bone marrow. Functional interrelationships of vascular and hematopoietic compartments in experimental hemolytic anemia: An electron microscopic study
142. An electron microscopic study of nuclear elimination from the late erythroblast
143. Binding of merocyanine 540 to normal and leukemic erythroid cells
144. Enucleation eliminates a differentiation-specific surface marker from normal and leukemic murine erythroid cells
145. Continuous analysis of the mechanism of activated transbilayer lipid movement in platelets
146. The complex of phosphatidylinositol 4,5-bisphosphate and calcium ions is not responsible for Ca(2+)-induced loss of phospholipid asymmetry in the human erythrocyte: A study in Scott syndrome, a disorder of scrambling
147. Molecular changes in the membranes of mouse erythroid cells accompanying differentiation
148. Release of spectrin-free spicules on reoxygenation of sickled erythrocytes
149. Microvesicles from sickle erythrocytes and their relation to irreversible sickling
150. Alteration of red cell membrane organization in sickle cell anaemia
151. Detection of altered membrane phospholipid asymmetry in subpopulations of human red blood cells using fluorescently labeled annexin V
152. Increased erythrocyte phosphatidylserine exposure in sickle cell disease: Flow-cytometric measurement and clinical associations
153. Antiphospholipid antibodies, proteins C and S, and coagulation changes in sickle cell disease
154. Compartmentalization of sickle-cell calcium in endocytic inside-out vesicles
155. 2+ accumulation and loss by aberrant endocytic vesicles in sickle erythrocytes
156. Blood cell lipid asymmetry and antiphospholipid antibodies
157. Antiphospholipid antibodies-Involvement of protein cofactors
158. Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: Implications for coagulation events and antigenic spread in systemic lupus erythematosus
159. Characterization of phosphatidylserine-dependent beta(2)-glycoprotein I macrophage interactions- implications for apoptotic cell clearance by phagocytes
160. Apoptotic cell clearance in systemic lupus erythematosus II. Role of beta(2)-glycoprotein I
161. A novel beta 1 integrin-dependent mechanism of leukocyte adherence to apoptotic cells
162. Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: Role of membrane phosphatidylserine
163. Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro
164. Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells
165. The clearance of apoptotic cells in the liver is mediated by the asialoglycoprotein receptor
166. Macrophage recognition of cells undergoing programmed cell death (apoptosis)
167. C-elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
168. Complement-dependent clearance of apoptotic cells by human macrophages
169. A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo
170. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
171. Promotion of the uptake of PS liposomes and apoptotic cells by a product of growth arrest-specific gene, gas6