Phosphatidylserine Receptor Is Required for Clearance of Apoptotic Cells

Science

Volumn 302, Issue 5650, 2003, Pages 1560-1563

  Li, Ming O ^a   Sarkisian, Matthew R ^a   Mehal, Wajahat Z ^a   Rakic, Pasko ^a   Flavell, Richard A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; DISEASES; NEUROLOGY; RESPIRATORY SYSTEM;

APOPTOSIS; CONGENITAL BRAIN MALFORMATION; HYPERPLASIC BRAIN PHENOTYPES; PHAGOCYTES;

GENES;

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 9; PHOSPHATIDYLSERINE RECEPTOR; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ABNORMALITY; DEVELOPMENTAL BIOLOGY;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN MALFORMATION; BRAIN TISSUE; CELL ADHESION; CONTROLLED STUDY; EMBRYO; KNOCKOUT MOUSE; LETHALITY; LUNG PARENCHYMA; MOUSE; NONHUMAN; ORGANOGENESIS; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; RESPIRATORY DISTRESS SYNDROME;

ANIMALS; APOPTOSIS; BRAIN; CELL DIVISION; CELL NUCLEUS; EPITHELIAL CELLS; EYE; EYE ABNORMALITIES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IN SITU NICK-END LABELING; INFLAMMATION; LUNG; MACROPHAGES; MESODERM; MICE; MICE, KNOCKOUT; NECROSIS; NEURONS; PHAGOCYTOSIS; PHENOTYPE; PHOSPHATIDYLSERINES; PULMONARY SURFACTANTS; RECEPTORS, CELL SURFACE; RESPIRATORY INSUFFICIENCY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

ANIMALIA; MAMMALIA;

EID: 0345374586     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1087621     Document Type: Article

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30. We thank M. Pypaert and C. Marks at the Yale EM facility for technical assistance; L Evangelisti, C. Hughes, and J. Stein for their help in creating the PSR-deficient mice; F. Manzo for preparing the manuscript; and C. Zeiss and C. Iwema for technical assistance. Supported by the Howard Hughes Medical Institute (R.A.F.), National Institute of Neurological Disorders and Stroke (P.R.), and American Heart Association (P.R.).