Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 8, 2003, Pages 4742-4747

  Radu, Roxana A ^a   Mata, Nathan L ^a   Nusinowitz, Steven ^a   Liu, Xinran ^c   Sieving, Paul A ^d   Travis, Gabriel H ^a,b  

^a JULES STEIN EYE INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d NATIONAL EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETHANOLAMINE DERIVATIVE; ISOTRETINOIN; LIPOFUSCIN; N RETINYLIDENE N RETINYLETHANOLAMINE; RETINAL; RETINOL DEHYDROGENASE; RHODOPSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; LIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN SYNTHESIS; STARGARDT DISEASE; VISUAL IMPAIRMENT;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; DARK ADAPTATION; DISEASE MODELS, ANIMAL; GENES, RECESSIVE; HUMANS; ISOTRETINOIN; LIPOFUSCIN; MACULAR DEGENERATION; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON; MODELS, BIOLOGICAL; PIGMENT EPITHELIUM OF EYE; PYRIDINIUM COMPOUNDS; RETINAL PIGMENTS; RETINOIDS; ROD OUTER SEGMENTS;

ANIMALIA;

EID: 0037447253     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0737855100     Document Type: Article

References (40)

1. Leibowitz, H. M., Krueger, D. E., Maunder, L. R., Milton, R. C., Kini, M. M., Kahn, H. A., Nickerson, R. J., Pool, J., Colton, T. L., Ganley, J. P., et al. (1980) Surv. Ophthalmol. 24, 335-610.
2. Klein, R., Klein, B. E. & Linton, K. L. P. (1992) Ophthalmology 99, 933-943.
3. Lee, B. L. & Heckenlively, J. R. (1999) in Retina - Vitreous-Macula, eds. Guyer, D. R., Yannuzzi, L. A., Chang, S., Shields, J. A. & Green, W. R. (Saunders, Philadelphia), pp. 978-988.
4. Blacharski, P. A. (1988) Fundus flavimaculutus (Raven, New York).
5. Eagle, R. C., Jr., Lucier, A. C., Bernardino, V. B., Jr., & Yanoff, M. (1980) Ophthalmology 87, 1189-1200.
6. Birnbach, C. D., Jarvelainen, M., Possin, D. E. & Milam, A. H. (1994) Ophthalmology 101, 1211-1219.
7. Steinberg, R. H. (1985) Doc. Ophthalmol. 60, 327-346.
8. Allikmets, R., Shroyer, N. F., Singh, N., Seddon, J. M., Lewis, R. A., Bernstein, P. S., Peiffer, A., Zabriskie, N. A., Li, Y., Hutchinson, A., et al. (1997) Science 277, 1805-1807.
9. Illing, M., Molday, L. L. & Molday, R. S. (1997) J. Biol. Chem. 272, 10303-10310.
10. Azarian, S. M. & Travis, G. H. (1997) FEBS Lett. 409, 247-252.
11. Weng, J., Mata, N. L., Azarian, S. M., Tzekov, R. T., Birch, D. G. & Travis, G. H. (1999) Cell 98, 13-23.
12. Mata, N. L., Weng, J. & Travis, G. H. (2000) Proc. Natl. Acad. Sci. USA 97, 7154-7159.
13. Mata, N. L., Tzekov, R. T., Liu, X. R., Weng, J., Birch, D. G. & Travis, G. H. (2001) Invest. Ophthalmol. Visual Sci. 42, 1685-1690.
14. Sun, H., Molday, R. S. & Nathans, J. (1999) J. Biol. Chem. 274, 8269-8281.
15. Ahn, J., Wong, J. T. & Molday, R. S. (2000) J. Biol. Chem. 275, 20399-20405.
16. Sakai, N., Decatur, J., Nakanishi, K. & Eldred, G. E. (1996) J. Am. Chem. Soc. 118, 1559-1560.
17. Reinboth, J. J., Gautschi, K., Munz, K., Eldred, G. E. & Reme, C. E. (1997) Exp. Eye Res. 65, 639-643.
18. Parish, C. A., Hashimoto, M., Nakanishi, K., Dillon, J. & Sparrow, J. (1998) Proc. Natl. Acad. Sci. USA 95, 14609-14613.
19. Schutt, F., Davies, S., Kopitz, J., Holz, F. G. & Boulton, M. E. (2000) Invest. Ophthalmol. Visual Sci. 41, 2203-2208.
20. Suter, M., Reme, C., Grimm, C., Wenzel, A., Jaattela, M., Esser, P., Kociok, N., Leist, M. & Richter, C. (2000) J. Biol. Chem. 275, 39625-39630.
21. Sparrow, J. R., Zhou, J., Ben-Shabat, S., Vollmer, H., Itagaki, Y. & Nakanishi, K. (2002) Invest. Ophthalmol. Visual Sci. 43, 1222-1227.
22. Finnemann, S. C., Leung, L. W. & Rodriguez-Boulan, E. (2002) Proc. Natl. Acad. Sci. USA 99, 3842-3847.
23. Peck, G. L., Olsen, T. G., Yoder, F. W., Strauss, J. S., Downing, D. T., Pandya, M., Butkus, D. & Arnaud-Battandier, J. (1979) N. Engl. J. Med. 300, 329-333.
24. Weleber, R. G., Denman, S. T., Hanifin, J. M. & Cunningham, W. J. (1986) Arch. Ophthalmol. 104, 831-837.
25. Fraunfelder, F. T., Fraunfelder, F. W. & Edwards, R. (2001)Am. J. Ophthalmol. 132, 299-305.
26. Law, W. C. & Rando, R. R. (1989) Biochem. Biophys. Res. Commun. 161, 825-829.
27. Gamble, M. V., Mata, N. L., Tsin, A. T., Mertz, J. R. & Blaner, W. S. (2000) Biochim. Biophys. Acta 1476, 3-8.
28. Sieving, P. A., Chaudhry, P., Kondo, M., Provenzano, M., Wu, D., Carlson, T. J., Bush, R. A. & Thompson, D. A. (2001) Proc. Natl. Acad. Sci. USA 98, 1835-1840.
29. Lynch, H. J., Rivest, R. W. & Wurtman, R. J. (1980) Neuroendocrinology 31, 106-111.
30. Nusinowitz, S., Ridder, W. & Heckenlively, J. (2001) in Systemic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods, eds. Smith, R., John, S. W. M. & Nishina, P. (Kluwer, Dordrecht, The Netherlands), pp. 320-344.
31. Hood, D. C. & Birch, D. G. (1993) Vision Res. 33, 1605-1618.
32. Hood, D. C. & Birch, D. G. (1990) Invest. Ophthalmol. Visual Sci. 31, 2070-2081.
33. Suzuki, T., Fujita, Y., Noda, Y. & Miyata, S. (1986) Vision Res. 26, 425-429.
34. Mata, N. L., Radu, R. A., Clemmons, R. & Travis, G. H. (2002) Neuron 36, 69-80.
35. Saari, J. C. & Bredberg, D. L. (1987) J. Biol. Chem. 262, 7618-7622.
36. Mata, N. L. & Tsin, A. T. (1998) Biochim. Biophys. Acta 1394, 16-22.
37. Driessen, C., Winkens, H. J., Hoffmann, K., Kuhlmann, L. D., Janssen, B. P. M., van Vugt, A. H. M., Van Hooser, J. P., Wieringa, B. E., Deutman, A. F., Palczewski, K., et al. (2000) Mol. Cell. Biol. 20, 4275-4287.
38. Fong, S. L., Liou, G. I., Landers, R. A., Alvarez, R. A. & Bridges, C. D. (1984) J. Biol. Chem. 259, 6534-6542.
39. Palczewski, K., Van Hooser, J. P., Garwin, G. G., Chen, J., Liou, G. I. & Saari, J. C. (1999) Biochemistry 38, 12012-12019.
40. Nau, H. (2001) J. Am. Acad. Dermatol. 45, S183-S187.