Glial cell line derived neurotrophic factor delays photoreceptor degeneration in a transgenic rat model of retinitis pigmentosa

Molecular Therapy

Volumn 4, Issue 6, 2001, Pages 622-629

  Sanftner, Laura H McGee ^a   Abel, Hilla ^a   Hauswirth, William W ^b   Flannery, John G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

GDNF; Gene therapy; rAAV vector; Retinal degeneration

Indexed keywords

BETA ACTIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOMEGALOVIRUS; DEGENERATION; ELECTRORETINOGRAPHY; ENHANCER REGION; GENE TRANSFER; GENETICS; IMMUNOHISTOCHEMISTRY; MORPHOMETRICS; NONHUMAN; PHOTORECEPTOR; PHOTORECEPTOR CELL; PIGMENT EPITHELIUM; PROMOTER REGION; RAT; RAT STRAIN; RETINA; RETINITIS PIGMENTOSA; SURVIVAL; THICKNESS; TRANSGENIC ANIMAL; VIRUS RECOMBINANT;

ADENO-ASSOCIATED VIRUS; ANIMALIA; CYTOMEGALOVIRUS; GALLUS GALLUS;

EID: 0035664438     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2001.0498     Document Type: Article

References (39)

1. Changes in the numbers of optic nerve fibers during late prenatal and postnatal development in the albino rat
2. Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor
3. A brief review of retinitis pigmentosa and the identified retinitis pigmentosa genes
4. Activation of caspase-3 in the retina of transgenic rats with the rhodopsin mutation s334ter during photoreceptor degeneration
5. Characterization of rhodopsin mis-sorting and constitutive activation in a transgenic rat model of retinitis pigmentosa
6. Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse
7. Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse
8. Protection of mouse photoreceptors by survival factors in retinal degenerations
9. Retinal degeneration is slowed in transgenic rats by AAV-mediated delivery of FGF-2
10. Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal
11. Mechanisms of cell death in the inherited retinal degenerations
12. Mechanisms of photoreceptor death and survival in mammalian retina
13. Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa
14. Retinal degeneration is rescued in transgenic rd mice by expression of the cGMP phosphodiesterase β subunit
15. Complete rescue of photoreceptor dysplasia and degeneration in transgenic retinal degeneration slow (rds) mice
16. Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy
17. Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat
18. Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light
19. Ocular gene therapy: Quo vadis?
20. Gene therapy restores vision in a canine model of childhood blindness
21. Recombinant AAV-mediated delivery of a tet-inducible reporter gene to the rat retina
22. GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
23. Conditioned medium from aged monkey fibroblasts stably expressing GDNF and BDNF improves survival of embryonic dopamine neurons in vitro
24. Functional recovery in parkinsonian monkeys treated with GDNF
25. Dopaminergic neurons protected from degeneration by GDNF gene therapy
26. Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor for sensory neurons: Comparison with the effects of the neurotrophins
27. Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF
28. GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-α, a novel receptor for GDNF
29. Characterization of a multicomponent receptor for GDNF
30. Ret transforming gene encodes a fusion protein homologous to tyrosine kinases
31. Cellular expression of GDNF mRNA suggests multiple functions inside and outside the nervous system
32. Expression of the c-ret proto-oncogene during mouse embryogenesis
33. Rod outer segment maintenance is enhanced in the presence of bFGF, CNTF and GDNF
34. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
35. Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis
36. Analysis of immune deviation elicited by antigens injected into the subretinal space
37. Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus
38. Production and purification of recombinant adeno-associated virus
39. Genetic regulation of light damage to photoreceptors