Calcium channel blocker D-cis-diltiazem does not slow retinal degeneration in the PDE6B mutant rcd1 canine model of pigmentosa

Molecular Vision

Volumn 7, Issue , 2001, Pages 42-47

  Pearce Kelling, Susan E ^a   Aleman, Tomas S ^b   Nickle, Amanda ^b   Laties, Alan M ^b   Aguirre, Gustavo D ^a   Jacobson, Samuel G ^b   Acland, Gregory M ^a  

^a Department of Obstetrics Gynecology   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; PHOSPHODIESTERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B WAVE; CELL COUNT; CELL SURVIVAL; CONTROLLED STUDY; CRITICAL FLICKER FUSION; DARK ADAPTATION; DISEASE COURSE; DISEASE MODEL; DOG; DRUG WITHDRAWAL; DYSPNEA; ELECTRORETINOGRAPHY; ENUCLEATION; EUTHANASIA; GENE MUTATION; HISTOPATHOLOGY; HYPOTENSION; HYPOTHESIS; LIGHT ADAPTATION; MOUSE STRAIN; NONHUMAN; PHOTORECEPTOR CELL; PHYSICAL DISABILITY; RETINA DEGENERATION; RETINA ROD; RETINITIS PIGMENTOSA; SPECIES DIFFERENCE; TREATMENT FAILURE;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; CALCIUM CHANNEL BLOCKERS; DARK ADAPTATION; DILTIAZEM; DISEASE MODELS, ANIMAL; DOGS; ELECTRORETINOGRAPHY; EYE PROTEINS; FEMALE; MALE; PHOTIC STIMULATION; PHOTORECEPTORS, VERTEBRATE; RETINITIS PIGMENTOSA;

EID: 0346949036     PISSN: 10900535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Frasson M, Sahel JA, Fabre M, Simonutti M, Dreyfus H, Picaud S. Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse. Nat Med 1999; 5:1183-7.
2. Farber DB, Lolley RN. Cyclic guanosine monophosphate: elevation in degenerating photoreceptor cells of the C3H mouse retina. Science 1974; 186:449-51.
3. Farber DB, Lolley RN. Enzymic basis for cyclic GMP accumulation in degenerative photoreceptor cells of mouse retina. J Cyclic Nucleotide Res 1976; 2:139-48.
4. Bowes C, Li T, Danciger M, Baxter LC, Applebury ML, Farber DB. Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase. Nature 1990; 347:677-80.
5. Pittler SJ, Baehr W. Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase beta-subunit gene of the rd mouse. Proc Natl Acad Sci U S A 1991; 88:8322-6.
6. Farber DB. From mice to men: the cyclic GMP phosphodiesterase gene in vision and disease. The Proctor Lecture. Invest Ophthalmol Vis Sci 1995; 36:263-75.
7. Aguirre G, Farber D, Lolley R, Fletcher RT, Chader GJ. Rod-cone dysplasia in Irish setters: a defect in cyclic GMP in visual cells. Science 1978; 201:1133-4.
8. Aguirre G, Farber D, Lolley R, O'Brien P, Alligood J, Fletcher RT, Chader G. Retinal degeneration in the dog. III. Abnormal cyclic nucleotide metabolism in rod-cone dysplasia. Exp Eye Res 1982; 35:625-42.
9. Suber ML, Pittler SJ, Qin N, Wright GC, Holcombe V, Lee RH, Craft CM, Lolley RN, Baehr W, Hurwitz RL. Irish setter dogs affected with rod/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase beta-subunit gene. Proc Natl Acad Sci U S A 1993; 90:3968-72.
10. Ray K, Baldwin, VJ, Acland GM, Blanton SH, Aguirre GD. Cosegregation of codon 807 mutation of the canine rod cGMP phosphodiesterase beta gene and rcd1. Invest Ophthalmol Vis Sci 1994; 35:4291-9.
11. McLaughlin ME, Sandberg MA, Berson EL, Dryja TP. Recessive mutations in the gene encoding the beta-subunit of rod phosphodiesterase in patients with retinitis pigmentosa. Nat Genet 1993; 4:130-4.
12. Danciger M, Blaney J, Gao YQ, Zhao DY, Heckenlively JR, Jacobson SG, Farber DB. Mutations in the PDE6B gene in autosomal recessive retinitis pigmentosa. Genomics 1995; 30:1-7.
13. McLaughlin ME, Ehrhart TL, Berson EL, Dryja TP. Mutation spectrum of the gene encoding the beta subunit of rod phosphodiesterase among patients with autosomal recessive retinitis pigmentosa. Proc Natl Acad Sci U S A 1995; 92:3249-53.
14. Ray K, Tejero MD, Baldwin VJ, Aguirre GD. An improved diagnostic test for rod cone dysplasia 1 (rcd1) using allele-specific polymerase chain reaction. Curr Eye Res 1996; 15:583-7.
15. Schmidt SY, Aguirre GD. Reductions in taurine secondary to photoreceptor loss in Irish setters with rod-cone dysplasia. Invest Ophthalmol Vis Sci 1985; 26:679-83.
16. Piepho RW, Bloedow DC, Lacz JP, Runser DJ, Dimmit DC, Browne RK. Pharmacokinetics of diltiazem in selected animal species and human beings. Am J Cardiol 1982; 49:525-8.
17. Kemp CM, Jacobson SG. Rhodopsin levels in the central retinas of normal miniature poodles and those with progressive rod-cone degeneration. Exp Eye Res 1992; 54:947-56.
18. Acland GM, Aguirre GD. Retinal degenerations in the dog. IV. Early retinal degeneration (erd) in Norwegian elkhounds. Exp Eye Res 1987; 44:491-521.
19. Aguirre G, Andrews L. Nomarski evaluation of rod outer segment renewal in a hereditary retinal degeneration. Comparison with autoradiographic evaluation. Invest Ophthalmol Vis Sci 1987; 28:1049-58.
20. Acland GM, Fletcher RT, Gentleman S, Chader GJ, Aguirre GD. Non-allelism of three genes (rcd1, rcd2 and erd) for early-onset hereditary retinal degeneration. Exp Eye Res 1989; 49:983-98.
21. Narfstrom K, Andersson BE, Andreasson S, Gouras P. Clinical electroretinography in the dog with ganzfeld stimulation: a practical method of examining rod and cone function. Doc Ophthalmol 1995; 90:279-90.
22. Yanase J, Ogawa H, Ohtsuka H. Rod and cone components of the dog electroretinogram during and after dark adaptation. J Vet Med Sci 1995; 57:877-81.
23. Yanase J, Ogawa H, Ohtsuka H. Scotopic threshold response of the electroretinogram of dogs. Am J Vet Res 1996; 57:361-6.
24. Aguirre GD, Rubin LF. Rod-cone dysplasia (progressive retinal atrophy) in Irish setters. J Am Vet Med Assoc 1975; 166:157-64.
25. Farber DB, Danciger JS, Aguirre G. The beta subunit of cyclic GMP phosphodiesterase mRNA is deficient in canine rod-cone dysplasia 1. Neuron 1992; 9:349-56.
26. Lolley RN. The rd gene defect triggers programmed rod cell death. The Proctor Lecture. Invest Ophthalmol Vis Sci 1994; 35:4182-91.
27. Bush RA, Kononen L, Machida S, Sieving PA. The effect of calcium channel blocker diltiazem on photoreceptor degeneration in the rhodopsin Pro23His rat. Invest Ophthalmol Vis Sci 2000; 41:2697-701.
28. Buyukmihci N, Aguirre G, Marshall J. Retinal degenerations in the dog. II. Development of the retina in rod-cone dysplasia. Exp Eye Res 1980; 30:575-91.
29. Semple-Rowland SL, Lee NR, Van Hooser JP, Palczewski K, Baehr W. A null mutation in the photoreceptor guanylate cyclase gene causes the retinal degeneration chicken phenotype. Proc Natl Acad Sci U S A 1998; 95:1271-6.
30. Yang RB, Robinson SW, Xiong WH, Yau KW, Birch DG, Garbers DL. Disruption of a retinal guanylyl cyclase gene leads to cone-specific dystrophy and paradoxical rod behavior. J Neurosci 1999; 19:5889-97.
31. Redmond TM, Yu S, Lee E, Bok D, Hamasaki D, Chen N, Goletz P, Ma JX, Crouch RK, Pfeifer K. Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle. Nat Genet 1998; 20:344-51.
32. Aguirre GD, Baldwin V, Pearce-Kelling S, Narfstrom K, Ray K, Acland GM. Congenital stationary night blindness in the dog: common mutation in the RPE65 gene indicates founder effect. Mol Vis 1998; 4:23 .
33. Veske A, Nilsson SE, Narfstrom K, Gal A. Retinal dystrophy of Swedish briard/briard-beagle dogs is due to a 4-bp deletion in RPE65. Genomics 1999; 57:57-61.
34. Naash MI, Hollyfield JG, al-Ubaidi MR, Baehr W. Simulation of human autosomal dominant retinitis pigmentosa in transgenic mice expressing a mutated murine opsin gene. Proc Natl Acad Sci U S A 1993; 90:5499-503.
35. Petters RM, Alexander CA, Wells KD, Collins EB, Sommer JR, Blanton MR, Rojas G, Hao Y, Flowers WL, Banin E, Cideciyan AV, Jacobson SG, Wong F. Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa. Nat Biotechnol 1997; 15:965-70.
36. LaVail MM, Yasumura D, Matthes MT, Drenser KA, Flannery JG, Lewin AS, Hauswirth WW. Ribozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy. Proc Natl Acad Sci U S A 2000; 97:11488-93.
37. Zeiss CJ, Ray K, Acland GM, Aguirre GD. Mapping of X-linked progressive retinal atrophy (XLPRA), the canine homolog of retinitis pigmentosa 3 (RP3). Hum Mol Genet 2000; 9:531-7.
38. Hong DH, Pawlyk BS, Shang J, Sandberg MA, Berson EL, Li T. A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3). Proc Natl Acad Sci U S A 2000; 97:3649-54.
39. Sahly I, Bar Nachum S, Suss-Toby E, Rom A, Peretz A, Kleiman J, Byk T, Selinger Z, Minke B. Calcium channel blockers inhibit retinal degeneration in the retinal-degeneration-B mutant of Drosophila. Proc Natl Acad Sci U S A 1992; 89:435-9.