Caspase and calpain substrates: Roles in synaptic plasticity and cell death

Journal of Neuroscience Research

Volumn 58, Issue 1, 1999, Pages 167-190

  Chan, Sic L ^b   Mattson, Mark P ^a,b  

^a 211 Sanders Brown Building ^*  (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Actin; Apoptosis; Calcium; Excitatory amino acid; Kinases; Long term potentiation

Indexed keywords

ACTIN; AMYLOID PRECURSOR PROTEIN; CALCIUM; CALPAIN; CASPASE; EXCITATORY AMINO ACID; MEMBRANE RECEPTOR; PHOSPHATASE; PHOSPHOTRANSFERASE; PRESENILIN 1; PROTEIN BCL 2; STEROID RECEPTOR;

APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; ENZYME ACTIVATION; ENZYME SUBSTRATE COMPLEX; LONG TERM POTENTIATION; NERVE CELL EXCITABILITY; NERVE CELL PLASTICITY; NERVE DEGENERATION; NEUROTOXICITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION;

ANIMALS; APOPTOSIS; CALPAIN; CASPASES; CELL DEATH; HUMANS; MODELS, NEUROLOGICAL; NEURODEGENERATIVE DISEASES; NEURONAL PLASTICITY; NEURONS; SIGNAL TRANSDUCTION; SYNAPSES;

EID: 0033213973     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19991001)58:1<167::AID-JNR16>3.0.CO;2-K     Document Type: Article

References (339)

1. Adachi E, Mukaiyama T, Sasai K, Hayashi T, Kawashima S, Kasai Y, Hayashi M, Hashimoto PH. 1990. Immunohistochemical evidence of the extracellular localization of calcium-activated neutral protease (CANP) in rabbit skeletal muscle, lung and aorta. Arch Histol Cytol 53:413-422.
2. Ahmad M, Srinivasula SM, Hegde R, Mukattash R, Fernandes-Alnemri T, Alnemri ES. 1998. Identification and characterization of murine caspase-14, a new member of the caspase family. Cancer Res 58:5201-5205.
3. Alnemri ES, Fernandes-Alnemri T, Litwack G. 1995. Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities. J Biol Chem 270:4312-4317.
4. Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thomberry NA, Wong WW, Yuan J. 1996. Human ICE/CED-3 protease nomenclature. Cell 87:71.
5. An B, Jin JR, Lin P, Dou QP. 1996. Failure to activate interleukin 1beta-converting enzyme-like proteases and to cleave retinoblastoma protein in drug-resistant cells. FEBS Lett 399:158-162.
6. Armstrong RC, Aja T, Xiang J, Gaur S, Krebs JF, Hoang K, Bai X, Korsmeyer SJ, Karanewsky DS, Fritz LC, Tomaselli KJ. 1996. Fas-induced activation of the cell death-related protease CPP32 is inhibited by Bcl-2 and by ICE family protease inhibitors. J Biol Chem 271:16850-16855.
7. Asahi M, Hoshimaru M, Uemura Y, Tokime T, Kojima M, Ohtsuka T, Matsuura N, Aoki T, Shibahara K, Kikuchi H. 1997. Expression of interleukin-1 beta converting enzyme gene family and bcl-2 gene family in the rat brain following permanent occlusion of the middle cerebral artery. J Cereb Blood Flow Metab 17:11-18.
8. Bamji SX, Majdan M, Pozniak CD, Belliveau DJ, Aloyz R, Kohn J, Causing CG, Miller FD. 1998. The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death. J Cell Biol 140:911-923.
9. Banno Y, Nakashima S, Hachiya T, Nozawa Y. 1995. Endogenous cleavage of phospholipase C-beta 3 by agonist-induced activation of calpain in human platelets. J Biol Chem 270:4318-4324.
10. 2+ accumulation. Proc Natl Acad Sci USA 92:9328-9332.
11. Barger SW, Mattson MP. 1996. Induction of neuroprotective kappa B-dependent transcription by secreted forms of the Alzheimer's beta-amyloid precursor. Brain Res Mol Brain Res 40:116-126.
12. Barkett M, Xue D, Horvitz HR, Gilmore TD. 1997. Phosphorylation of IkappaB-alpha inhibits its cleavage by caspase CPP32 in vitro. J Biol Chem 272:29419-28422.
13. Barnes NY, Li L, Yoshikawa K, Schwartz LM, Oppenheim RW, Milligan CE. 1998. Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons. J Neurosci 18:5869-5880.
14. Bartus RT, Dean RL, Cavanaugh K, Eveleth D, Carriero DL, Lynch G. 1995a. Time-related neuronal changes following middle cerebral artery occlusion: implications for therapeutic intervention and the role of calpain. J Cereb Blood Flow Metab 15:969-979.
15. Bartus RT, Elliott PJ, Hayward NJ, Dean RL, Harbeson S, Straub JA, Li Z, Powers JC. 1995b. Calpain as a novel target for treating acute neurodegenerative disorders. Neurol Res 17:249-258.
16. Basu A, Akkaraju GR. 1999. Regulation of caspase activation and cis-Diamminedichloro-platinum(II)-induced cell death by protein kinase C. Biochemistry 38:4245-4251
17. Bergeron L, Perez GI, Macdonald G, Shi L, Sun Y, Jurisicova A, Varmuza S, Latham KE, Flaws JA, Salter JC, Hara H, Moskowitz MA, Li E, Greenberg A, Tilly JL, Yuan J. 1998. Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev 12:1304-1314.
18. Beyaert R, Kidd VJ, Cornelis S, Van de Craen M, Denecker G, Lahti JM, Gururajan R, Vandenabeele P, Fiers W. 1997. Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor. J Biol Chem 272:11694-11697.
19. Bi X, Tocco G, Baudry M. 1994. Calpain-mediated regulation of AMPA receptors in adult rat brain. NeuroReport 6:61-64.
20. Bi X, Chang V, Molnar E, McIlhinney RA, Baudry M. 1996. The C-terminal domain of glutamate receptor subunit 1 is a target for calpain-mediated proteolysis. Neuroscience 73:903-906.
21. Bi X, Rong Y, Chen J, Dang S, Wang Z, Baudry M. 1998. Calpain-mediated regulation of NMDA receptor structure and function. Brain Res 790:245-253.
22. Billger M, Wallin M, Karlsson JO. 1988. Proteolysis of tubulin and microtubule-associated proteins 1 and 2 by calpain I and II. Difference in sensitivity of assembled and disassembled microtubules. Cell Calcium 9:33-44.
23. Blanchard H, Grochulski P, Li Y, Arthur JS, Davies PL, Elce JS, Cygler M. 1997. Structure of a calpain Ca(2+)-binding domain reveals a novel EF-hand and Ca(2+)-induced conformational changes. Nat Struct Biol 4:532-538.
24. Boldin MP, Goncharov TM, Goltsev YV, Wallach D. 1996. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1-and TNF receptor-induced cell death. Cell 85:803-815.
25. Brancolini C, Benedetti M, Schneider C. 1995. Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases. EMBO J 14:5179-5190.
26. Brancolini C, Lazarevic D, Rodriguez J, Schneider C. 1997. Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin. J Cell Biol 139:759-771.
27. Brancolini C, Sgorbissa A, Schneider C. 1998. Proteolytic processing of the adherens junctions components beta-catenin and gamma-catenin/plakoglobin during apoptosis. Cell Death Differ 5: 1042-1050.
28. Brown SB, Bailey K, Savill J. 1997. Actin is cleaved during constitutive apoptosis. Biochem J 323:233-237.
29. Brace AJ, Boling W, Kindy MS, Peschon J, Kraemer PJ, Carpenter MK, Holtsberg FW, Mattson MP. 1996. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med 2:788-794.
30. Bump NJ, Hackett M, Hugunin M, Seshagiri S, Brady K, Chen P, Ferenz C, Franklin S, Ghayur T, Li P. 1995. Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35. Science 269:1885-1888.
31. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC. 1998. Regulation of cell death protease caspase-9 by phosphorylation. Science 282:1318-1321.
32. Carillo S, Pariat M, Steff AM, Roux P, Etienne-Julan M, Lorca T, Piechaczyk M. 1994. Differential sensitivity of FOS and JUN family members to calpains. Oncogene 9:1679-1689.
33. Casciola-Rosen LA, Miller DK, Anhalt GJ, Rosen A. 1994. Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death. J Biol Chem 269:30757-30760.
34. Casciola-Rosen LA, Anhalt GJ, Rosen A. 1995. DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. J Exp Med 182:1625-1634.
35. Casiano CA, Martin SJ, Green DR, Tan EM. 1996. Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis. J Exp Med 184:765-770.
36. Chan SL, Griffin WST, Mattson MP. 1999a. Evidence for caspase-mediated cleavage of AMPA receptor subunits in neuronal apoptosis and in Alzheimer's disease. J Neurosci Res. 57:315-323.
37. Chan SL, Tammariello SP, Estus S, Mattson MP. 1999b. Par-4 mediates trophic factor withdrawal-induced apoptosis of hippocampal neurons: actions prior to mitochondrial dysfunction and caspase activation. J Neurochem. In press.
38. Chen L, Marechal V, Moreau J, Levine AJ, Chen J. 1997a. Proteolytic cleavage of the mdm2 oncoprotein during apoptosis. J Biol Chem 272:22966-22973.
39. Chen WD, Otterson GA, Lipkowitz S, Khleif SN, Coxon AB, Kaye FJ. 1997b. Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding. Oncogene 14:1243-1248.
40. Cheng B, Christakos S, Mattson MP. 1994. Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis. Neuron 12:139-153.
41. Cheng EH, Kirsch DG, Clem RJ, Ravi R, Kastan MB, Bedi A, Ueno K, Hardwick JM. 1997 Conversion of Bcl-2 to a Bax-like death effector by caspases. Science 278:1966-1968.
42. Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM. 1995. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81:505-512.
43. Choi YH, Lee SJ, Nguyen P, Jang JS, Lee J, Wu ML, Takano E, Maki M, Henkart PA, Trepel JB. 1997. Regulation of cyclin D1 by calpain protease. J Biol Chem 272:28479-28484.
44. Clem RJ, Cheng EH, Karp CL, Kirsch DG, Ueno K, Takahashi A, Kastan MB, Griffin DE, Earnshaw WC, Veliuona MA, Hardwick JM. 1998. Modulation of cell death by Bcl-XL through caspase interaction. Proc Natl Acad Sci USA 95:554-559.
45. Cooray P, Yuan Y, Schoenwaelder SM, Mitchell CA, Salem HH, Jackson SP. 1996. Focal adhesion kinase (pp125FAK) cleavage and regulation by calpain. Biochem J 318:41-47.
46. Cosulich SC, Horiuchi H, Zerial M, Clarke PR, Woodman PG. 1997. Cleavage of rabaptin-5 blocks endosome fusion during apoptosis. EMBO J 16:6182-6191.
47. Croall DE, DeMartino GN. 1991. Calcium-activated neutral protease (calpain) system: structure, function, and regulation. Physiol Rev 71:813-847.
48. Cryns VL, Bergeron L, Zhu H, Li H, Yuan J. 1996. Specific cleavage of alpha-fodrin during Fas-and tumor necrosis factor-induced apoptosis is mediated by an interleukin-1 beta-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease. J Biol Chem 271:31277-41282.
49. Cryns VL, Byun Y, Rana A, Mellor H, Lustig KD, Ghanem L, Parker PJ, Kirschner MW, Yuan J. 1997. Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy. J Biol Chem 272:29449-29453.
50. Datta R, Kojima H, Yoshida K, Kufe D. 1997. Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis. J Biol Chem 272:20317-20320.
51. Dayton WR, Schollmeyer JV, Lepley RA, Cortes LR. 1981. A calcium-activated protease possibly involved in myofibrillar protein turnover. Isolation of a low-calcium-requiring form of the protease. Biochim Biophys Acta 659:48-61.
52. Deiss LP, Galinka H, Berissi H, Cohen O, Kimchi A. 1996. Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha. EMBO J 15:3861-3870.
53. De Jongh KS, Colvin AA, Wang KK, Catterall WA. 1994. Differential proteolysis of the full-length form of the L-type calcium channel alpha 1 subunit by calpain. J Neurochem 63:1558-1564.
54. del Cerro S, Larson J, Oliver MW, Lynch G. 1990. Development of hippocampal long-term potentiation is reduced by recently introduced calpain inhibitors. Brain Res 530:91-95.
55. Denny JB, Polan-Curtain J, Ghuman A, Wayner MJ, Armstrong DL. 1990. Calpain inhibitors block long-term potentiation. Brain Res 534:317-320.
56. Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC. 1998. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J 17:2215-2223.
57. Diaz F, Bourguignon LYW. 1998. IP3 receptors subtypes are cellular targets for TNFα-induced caspases during apoptosis of human T-lymphoblasts. Mol Biol Cell 9:250a.
58. Dimmeler S, Haendeler J, Nehls M, Zeiher AM. 1997. Suppression of apoptosis by nitric oxide via inhibition of interleukin-1 beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases. J Exp Med 185:601-607.
59. Dimmeler S, Zeiher AM. 1997. Nitric oxide and apoptosis: another paradigm for the double-edged role of nitric oxide. Nitric Oxide 1:275-281.
60. D'Mello SR, Galli C, Ciotti T, Calissano P. 1993. Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc Natl Acad Sci USA 90:10989-10993.
61. Dosemeci A, Reese TS. 1995. Effect of calpain on the composition and structure of postsynaptic densities. Synapse 20:91-97.
62. Droin N, Dubrez L, Eymin B, Renvoize C, Breard J, Dimanche-Boitrel MT, Solary E. 1998. Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis. Oncogene 16:2885-2894.
63. Duan H, Chinnaiyan AM, Hudson PL, Wing JP, He WW, Dixit VM. 1996. ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas-and tumor necrosis factor-induced apoptosis. J Biol Chem 271:1621-1625.
64. Duan W, Rangnekar V, Mattson MP. 1999. Par-4 production in synaptic compartments following apoptotic and excitotoxic insults: evidence for a pivotal role in mitochondrial dysfunction and neuronal degeneration. J Neurochem 72:2312-2322.
65. Dwyer LD, Miller AC, Parks AL, Jaken S, Malkinson AM. 1994. Calpain-induced downregulation of activated protein kinase C-alpha affects lung epithelial cell morphology. Am J Physiol 266:L569-L576.
66. Ellerby LM, Hackam AS, Propp SS, Ellerby HM, Rabizadeh S, Cashman NR, Trifiro MA, Pinsky L, Wellington CL, Salvesen GS, Hayden MR, Bredesen DE. 1999. Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity. J Neurochem 72:185-195.
67. Elvira M, Diez JA, Wang KK, Villalobo A. 1993. Phosphorylation of connexin-32 by protein kinase C prevents its proteolysis by mu-calpain and m-calpain. J Biol Chem 268:14294-14300.
68. Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S. 1998. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391:43-50.
69. Faucheu C, Diu A, Chan AW, Blanchet AM, Miossec C, Herve F, Collard-Dutilleul V, Gu Y, Aldape RA, Lippke JA, et al. 1997. A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells. EMBO J 14:1914-1922.
70. Fernandes-Alnemri T, Litwack G, Alnemri ES. 1995a. Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. Cancer Res 55:2737-2742.
71. Fernandes-Alnemri T, Takahashi A, Armstrong R, Krebs J, Fritz L, Tomaselli KJ, Wang L, Yu Z, Croce CM, Salveson G, et al. 1995b. Mch3, a novel human apoptotic cysteine protease highly related to CPP32. Cancer Res 55:6045-6052.
72. Fernandes-Alnemri T, Armstrong RC, Krebs J. 1996. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci USA 93:7464-7469.
73. Flygare J, Armstrong RC, Wennborg A, Orsan S, Hellgren D. 1998. Proteolytic cleavage of HsRad51 during apoptosis. FEBS Lett 427:247-251.
74. Friedlander RM, Gagliardini V, Hara H, Fink KB, Li W, MacDonald G, Fishman MC, Greenberg AH, Moskowitz MA, Yuan J. 1997. Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury. J Exp Med 185:933-940.
75. Fukuda K. 1999. Apoptosis-associated cleavage of beta-catenin in human colon cancer and rat hepatoma cells. Int J Biochem Cell Biol 31:519-529.
76. Fukuda S, Harada K, Kunimatsu M, Sakabe T, Yoshida K. 1998. Postischemic reperfusion induces alpha-fodrin proteolysis by m-calpain in the synaptosome and nucleus in rat brain. J Neurochem 70:2526-2532.
77. Fukuda T, Adachi E, Kawashima S, Yoshiya I, Hashimoto PH. 1990. Immunohistochemical distribution of calcium-activated neutral proteinases and endogenous CANP inhibitor in the rabbit hippocampus. J Comp Neurol 302:100-109.
78. Furukawa K, Mattson MP. 1995a. Cytochalasins protect hippocampal neurons against amyloid beta-peptide toxicity: evidence that actin depolymerization suppresses Ca2+ influx. J Neurochem 65:1061-1068.
79. Furukawa K, Smith-Swintosky VL, Mattson MP. 1995b. Evidence that actin depolymerization protects hippocampal neurons against excitotoxicity by stabilizing [Ca2+]i. Exp Neurol 133:153-163.
80. + channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein. Nature 379:74-78.
81. Furukawa K, Fu W, Li Y, Witke W, Kwiatkowski DJ, Mattson MP. 1997. The actin-severing protein gelsolin modulates calcium channel and NMDA receptor activities and vulnerability to excitotoxicity in hippocampal neurons. J Neurosci 17:8178-8186.
82. Gagliardini V, Fernandez PA, Lee RK, Drexler HC, Rotello RJ, Fishman MC, Yuan J. 1994. Prevention of vertebrate neuronal death by the crmA gene. Science 263:826-828.
83. Gao WD, Atar D, Liu Y, Perez NG, Murphy AM, Marban E. 1997. Role of troponin 1 proteolysis in the pathogenesis of stunned myocardium. Circ Res 80:393-399.
84. Gary DS, Bruce-Keller AJ, Kindy MS, Mattson MP. 1998. Ischemic and excitotoxic brain injury is enhanced in mice lacking the p55 tumor necrosis factor receptor. J Cereb Blood Flow Metab 18:1283-1267.
85. Gates RE, King LE Jr. 1983. Proteolysis of the epidermal growth factor receptor by endogenous calcium-activated neutral protease from rat liver. Biochem Biophys Res Commun 113:255-261.
86. Gervais FG, Thornberry NA, Ruffolo SC, Nicholson DW, Roy S. 1998a. Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide. J Biol Chem 273:17102-17108.
87. Gervais JL, Seth P, Zhang H. 1998b, Cleavage of CDK inhibitor p21(Cipl/Waf1) by caspases is an early event during DNA damage-induced apoptosis. J Biol Chem 273:19207-19212.
88. Gervais FG, Xu D, Robertson GS, Vaillancourt JP, Zhu Y, Huang J, LeBlanc A, Smith D, Rigby M, Shearman MS, Clarke EE, Zheng H, Van Der Ploeg LH, Ruffolo SC, Thornberry NA, Xanthoudakis S, Zamboni RJ, Roy S, Nicholson DW. 1999. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Cell 97:395-406.
89. Ghayur T, Hugunin M, Talanian RV, Ratnofsky S, Quinlan C, Emoto Y, Pandey P, Datta R, Huang Y, Kharbanda S, Allen H, Kamen R, Wong W, Kufe D. 1996. Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis. J Exp Med 184:2399-2404.
90. Ghayur T, Banerjee S, Hugunin M, Butler D, Herzog L, Carter A, Quintal L, Sekut L, Talanian R, Paskind M, Wong W, Kamen R, Tracey D, Allen H. 1997. Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Nature 386:619-623.
91. Gilchrist JS, Wang KK, Katz S, Belcastro AN. 1992. Calcium-activated neutral protease effects upon skeletal muscle sarcoplasmic reticulum protein structure and calcium release. J Biol Chem 267:20857-20865.
92. Gillardon F, Bottiger B, Schmitz B, Zimmermann M, Hossmann KA. 1997. Activation of CPP-32 protease in hippocampal neurons following ischemia and epilepsy. Mol Brain Res 50:16-22.
93. Goldberg YP, Nicholson DW, Rasper DM, Kalchman MA, Koide HB, Graham RK, Bromm M, Kazemi-Esfarjani P, Thornberry NA, Vaillancourt JP, Hayden MR. 1996. Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. Nat Genet 13:442-449.
94. Goll DE, Thompson VF, Taylor RG, Zalewska T. 1992. Is calpain activity regulated by membranes and autolysis or by calcium and calpastatin? Bioessays 14:549-556.
95. Greenwood AF, Jope RS. 1994. Brain G-protein proteolysis by calpain: enhancement by lithium. Brain Res 636:320-326.
96. Gregoriou M, Willis AC, Pearson MA, Crawford C. 1994. The calpain cleavage sites in the epidermal growth factor receptor kinase domain. Eur J Biochem 223:455-464.
97. Gross A, Yin XM, Wang K, Wei MC, Jockel J, Milliman C, Erdjument-Bromage H, Tempst P, Korsmeyer SJ. 1999. Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem 274:1156-1163.
98. Gu C, Casaccia-Bonnefil P, Srinivasan A, Chao MV. 1999. Oligodendrocyte apoptosis mediated by caspase activation. J Neurosci 19:3043-3049.
99. Gu Y, Wu J, Faucheu C, Lalanne JL, Diu A, Livingston DJ, Su MS. 1995. Interleukin-1 beta converting enzyme requires oligomerization for activity of processed forms in vivo. EMBO J 14:1923-1931.
100. Gu Y, Kuida K, Tsutsui H, Ku G, Hsiao K, Fleming MA, Hayashi N, Higashino K, Okamura H, Nakanishi K, Kurimoto M, Tanimoto T, Flavell RA, Sato V, Harding MW, Livingston DJ, Su MS. 1997. Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Science 275:206-209.
101. Quo Q, Furukawa K, Sopher BL, Pham DG, Xie J, Robinson N, Martin GM, Mattson MP. 1996. Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide. NeuroReport 8:379-383.
102. Guo Q, Sopher BL, Furukawa K, Pham DG, Robinson N, Martin GM, Mattson MP. 1997. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid β-peptide: involvement of calcium and oxyradicals. J Neurosci 17:4212-4222.
103. Guo Q, Fu W, Xie J, Luo H, Sells SF, Geddes JW, Bondada V, Rangnekar VM, Mattson MP. 1998. Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease. Nat Med 4:957-962.
104. Guo Q, Fu W, Sopher BL, Miller MW, Ware CB, Martin GM, Mattson MP. 1999a. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nat Med 5:101-106.
105. Guo Q, Sebastian L, Sopher BL, Miller MW, Ware CB, Martin GM, Mattson MP. 1999b. Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation. J Neurochem 72:1019-1029.
106. Hamakubo T, Kannagi R, Murachi T, Matus A. 1986. Distribution of calpains I and II in rat brain. J Neurosci 6:3103-3111.
107. Man Y, Weinman S, Boldogh I, Walker RK, Brasier AR. 1999. Tumor necrosis factor-alpha-inducible IkappaBalpha proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappab activation. J Biol Chem 274:787-794.
108. Han Z, Malik N, Carter T, Reeves WH, Wyche JH, Hendrickson EA. 1996. DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease. J Biol Chem 271:25035-25040.
109. Harvey KF, Harvey NL, Michael JM, Parasivam G, Waterhouse N, Alnemri ES, Watters D, Kumar S. 1998. Caspase-mediated cleavage of the ubiquitin-protein ligase Nedd4 during apoptosis. J Biol Chem 273:13524-13530.
110. Hashimoto M, Inoue S, Ogawa S, Conrad C, Muramatsu M, Shackelford D, Masliah E. 1998. Rapid fragmentation of vimentin in human skin fibroblasts exposed to tamoxifen: a possible involvement of caspase-3. Biochem Biophys Res Commun 247:401-406.
111. Hell JW, Westenbroek RE, Breeze LJ, Wang KK, Chavkin C, Catterall WA. 1996. N-methyl-D-aspartate receptor-induced proteolytic conversion of postsynaptic class C L-type calcium channels in hippocampal neurons. Proc Natl Acad Sci USA 93:3362-3367.
112. Herren B, Levkau B, Raines EW, Ross R. 1998. Cleavage of beta-catenin and plakoglobin and shedding of VE-cadherin during endothelial apoptosis: evidence for a role for caspases and metalloproteinases. Mol Biol Cell 9:1589-1601.
113. Hirai S, Kawasaki H, Yaniv M, Suzuki K. 1995. Degradation of transcription factors, c-Jun and c-Fos, by calpain. FEBS Lett 287:57-61.
114. Hirao T, Hara K, Takahashi K. 1983. Degradation of neuropeptides by calcium-activated neutral protease. J Biochem (Tokyo) 94:2071-2074.
115. Hirao T, Takahashi K. 1984. Purification and characterization of a calcium-activated neutral protease from monkey brain and its action on neuropeptides. J Biochem (Tokyo) 96:775-784.
116. Hirsch T, Marchetti P, Susin SA, Dallaporta B, Zamzami N, Marzo I, Geuskens M, Kroemer G. 1997. The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death. Oncogene 15:1573-1581.
117. Hortelano S, Dallaporta B, Zamzami N, Hirsch T, Susin SA, Marzo I, Bosca L, Kroemer G. 1997. Nitric oxide induces apoptosis via triggering mitochondrial permeability transition. FEBS Lett 410:373-377.
118. Huang C, Tandon NN, Greco NJ, Ni Y, Wang T, Zhan X. 1997a. Proteolysis of platelet cortactin by calpain. J Biol Chem 272:19248-19252
119. Huang S, Jiang Y, Li Z, Nishida E, Mathias P, Lin S, Ulevitch RJ, Nemerow GR, Han J. 1997b. Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b. Immunity 6:739-749.
120. Humke EW, Ni J, Dixit VM. 1998. ERICE, a novel FLICE-activalable caspase. J Biol Chem 273:15702-15707.
121. Inohara N, Koseki T, Hu Y, Chen S, Nunez G. 1997. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis. Proc Natl Acad Sci USA 94:10717-10722.
122. Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J. 1997. Inhibition of death receptor signals by cellular FLIP. Nature 388:190-195.
123. Ishida A, Furukawa K, Keller JN, Mattson MP. 1997. Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices. NeuroReport 8:2133-2137.
124. Jang JS, Lee SJ, Choi YH, Nguyen PM, Lee J, Hwang SG, Wu ML, Takano E, Maki M, Henkart PA, Trepel JB. 1999. Posttranslational regulation of the retinoblastoma gene family member p107 by calpain protease. Oncogene 18:1789-1796.
125. Janicke RU, Walker PA, Lin XY, Porter AG. 1996. Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis. EMBO J 15:6969-6978.
126. Jiang ZH, Zhang WJ, Rao Y, Wu JY. 1998. Regulation of Ich-1 pre-mRNA alternative splicing and apoptosis by mammalian splicing factors. Proc Natl Acad Sci USA 95:9155-9160.
127. Johnson GV, Jope RS, Binder LI. 1989. Proteolysis of tau by calpain. Biochem Biophys Res Commun 163:1505-1511.
128. Juin P, Pelletier M, Oliver L, Tremblais K, Gregoire M, Meflah K, Valletta FM. 1998. Induction of a caspase-3-like activity by calcium in normal cytosolic extracts triggers nuclear apoptosis in a cell-free system. J Biol Chem 273:17559-17564.
129. Kamens J, Paskind M, Hugunin M, Talanian RV, Allen H, Banach D, Bump N, Hackett M, Johnston CG, Li P. 1995. Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases. J Biol Chem 270:15250-15256.
130. Kanzaki M, Morris PL. 1998. Identification and regulation of testicular interferon-gamma (IFNgamma) receptor subunits: IFNgamma enhances interferon regulatory factor-1 and interleukin-1beta converting enzyme expression. Endocrinology 139:2636-2644.
131. Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE, Poirier GG. 1993. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res 53:3976-3985.
132. Kayalar C, Ord T, Testa MP, Zhong LT, Bredesen DE. 1996.Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition. Proc Natl Acad Sci USA 93:2234-2238.
133. Kim TW, Pettingell WH, Jung YK, Kovacs DM, Tanzi RE. 1997a. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 277:373-376.
134. Kim YM, Talanian RV, Billiar TR. 1997b. Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. J Biol Chem 272:31138-31148.
135. King P, Goodbourn S. 1998. STAT1 is inactivated by a caspase. J Biol Chem 273:8699-8704.
136. Kinoshita M, Tomimoto H, Kinoshita A, Kumar S, Noda M. 1997. Up-regulation of the Nedd2 gene encoding an ICE/Ced-3-like cysteine protease in the gerbil brain after transient global ischemia. J Cereb Blood Flow Metab 17:507-514.
137. Kishimoto A, Mikawa K, Hashimoto K, Yasuda I, Tanaka S, Tominaga M, Kuroda T, Nishizuka Y. 1989. Limited proteolysis of protein kinase C subspecies by calcium-dependent neutral protease (calpain). J Biol Chem 264:4088-4092.
138. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. 1997. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275:1132-1136.
139. Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, Chu K, McGarry TJ, Kirschner MW, Koths K, Kwiatkowski DJ, Williams LT. 1997. Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science 278:294-298.
140. Krebs JF, Armstrong RC, Srinivasan A, Aja T, Wong AM, Aboy A, Sayers R, Pham B, Vu T, Hoang K, Karanewsky DS, Leist C, Schmitz A, Wu JC, Tomaselli KJ, Fritz LC. 1999. Activation of membrane-associated procaspase-3 is regulated by Bcl-2. J Cell Biol 144:915-926.
141. Kruman I, Bruce-Keller AJ, Bredesen D, Waeg G, Mattson MP. 1997. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J Neurosci 17:5089-5100.
142. Kubbutat MH, Vousden KH. 1997. Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability. Mol Cell Biol 17:460-468.
143. Kuida K, Lippke JA, Ku G, Harding MW, Livingston DJ, Su MS, Flavell RA. 1995. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 267:2000-2003.
144. Kuida K, Zheng TS, Na S, Kuan C, Yang D, Karasuyama H, Rakic P, Flavell RA. 1996. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384:368-372.
145. Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H, Su MS, Rakic P, Flavell RA. 1998. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94:325-337.
146. Kumar S. 1995. Inhibition of apoptosis by the expression of antisense Nedd2. FEBS Lett 368:69-72.
147. Kumar S, Kinoshita M, Noda M, Copeland NG, Jenkins NA. 1994. Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. Genes Dev 8:1613-1626.
148. Kuo WN, Ganesan U, Walbey DL, Davis DL, Allen K, McCall LK. 1993. Modulation of the activity of calpain II by phosphorylation - changes in the proteolysis of cyclic AMP-dependent protein kinase (peak II, DEAE). Appl Theor Electrophor 13:317-320.
149. Kuwana T, Smith JJ, Muzio M, Dixit V, Newmeyer DD, Kornbluth S. 1998. Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c. J Biol Chem 273:16589-16594.
150. Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG, Earnshaw WC. 1994. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371:346-347.
151. Lee N, MacDonald H, Reinhard C, Halenbeck R, Roulston A, Shi T, Williams LT. 1997. Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis. Proc Natl Acad Sci USA 94:13642-13647.
152. Leist M, Volbracht C, Kuhnle S, Fava E, Ferrando-May E, Nicotera P. 1997. Caspase-mediated apoptosis in neuronal excitotoxicity triggered by nitric oxide. Mol Med 3:750-764.
153. Levkau B, Herren B, Koyama H, Ross R, Raines EW. 1998a. Caspase-mediated cleavage of focal adhesion kinase pp 125FAK and disassembly of focal adhesions in human endothelial cell apoptosis. J Exp Med 187:579-586.
154. Levkau B, Koyama H, Raines EW, Clurman BE, Herren B, Orth K, Roberts JM, Ross R. 1998b. Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade. Mol Cell 1:553-563.
155. Li H, Zhu H, Xu CJ, Yuan J. 1998a. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94:491-501.
156. Li J, Billiar TR, Talanian RV, Kim YM. 1997a. Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation. Biochem Biophys Res Commun 240:419-424.
157. Li J, Nixon R, Messer A, Berman S, Bursztajn S. 1998b. Altered gene expression for calpain/calpastatin system in motor neuron degeneration (Mnd) mutant mouse brain and spinal cord. Brain Res Mol Brain Res 53:174-186.
158. Li P, Allen H, Banerjee S, Franklin S, Herzog L, Johnston C, McDowell J, Paskind M, Rodman L, Salfeld J. 1995a. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 80:401-411.
159. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X. 1997b. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479-489.
160. Li QX, Evin G, Small DH, Multhaup G, Beyreuther K, Masters CL. 1995b.
161. Lin YC, Brown K, Siebenlist U. 1995. Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B. Proc Natl Acad Sci USA 92:552-556.
162. Liu X, Zou H, Slaughter C, Wang X. 1997. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89:175-184.
163. Loetscher H, Deuschle U, Brockhaus M, Reinhardt D, Nelboeck P, Mous J, Grunberg J, Haass C, Jacobsen H. 1997. Presenilins are processed by caspase-type proteases. J Biol Chem 272:20655-20659.
164. Lopes UG, Erhardt P, Yao R, Cooper GM. 1997. p53-Dependent induction of apoptosis by proteasome inhibitors. J Biol Chem 272:12893-12896.
165. Lynch G, Baudry M. 1987. Brain spectrin, calpain and long-term changes in synaptic efficacy. Brain Res Bull 18:809-815.
166. MacFarlane M, Cain K, Sun XM, Alnemri ES, Cohen GM. 1997. Processing/activation of at least four interleukin-1beta converting enzyme-like proteases occurs during the execution phase of apoptosis in human monocytic tumor cells. J Cell Biol 137:469-479.
167. Makowski GS, Ramsby ML. 1998. Degradation of cytokeratin intermediate filaments by calcium-activated proteases (calpains) in vitro: implications for formation of Mallory bodies. Res Commun Mol Pathol Pharmacol 101:211-223.
168. Mancini M, Nicholson DW, Roy S, Thomberry NA, Peterson EP, Casciola-Rosen LA, Rosen A. 1998. The caspase-3 precursor has a cytosolic and mitochondrial distribution: implications for apoptotic signaling. J Cell Biol 140:1485-1495.
169. Mao PL, Jiang Y, Wee BY, Porter AG. 1998. Activation of caspase-1 in the nucleus requires nuclear translocation of pro-caspase-1 mediated by its prodomain. J Biol Chem 273:23621-23624.
170. Margolin N, Raybuck SA, Wilson KP, Chen W, Fox T, Gu Y, Livingston DJ. 1997. Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases. J Biol Chem 272:7223-7228.
171. Martin SJ, O'Brien GA, Nishioka WK, McGahon AJ, Mahboubi A, Saido TC, Green DR. 1995. Proteolysis of fodrin (non-erythroid spectrin) during apoptosis. J Biol Chem 270:6425-6428.
172. Martin SJ, Amarante-Mendes GP, Shi L, Chuang TH, Casiano CA, O'Brien GA, Fitzgerald P, Tan EM, Bokoch GM, Greenberg AH, Green DR. 1996. The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism. EMBO J 15:2407-2416.
173. Martinou I, Fernandez PA, Missotten M, White E, Allet B, Sadoul R, Martinou JC. 1995. Viral proteins E1B19K and p35 protect sympathetic neurons from cell death induced by NGF deprivation. J Cell Biol 128:201-208.
174. Martins LM, Kottke T, Mesner PW, Basi GS, Sinha S, Frigon N Jr, Tatar E, Tung JS, Bryant K, Takahashi A, Svingen PA, Madden BJ, McCormick DJ, Earnshaw WC, Kaufmann SH. 1997. Activation of multiple interleukin-1beta converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis. J Biol Chem 272:7421-7430.
175. Mashima T, Naito M, Noguchi K, Miller DK, Nicholson DW, Tsuruo T. 1997. Actin cleavage by CPP-32/apopain during the development of apoptosis. Oncogene 14:1007-1012.
176. Mattson MP. 1996. Calcium and free radicals: mediators of neurotrophic factor and excitatory transmitter-regulated developmental plasticity and cell death. Perspect Dev Neurobiol 3:79-91.
177. Mattson MP. 1997. Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol Rev 77:1081-1132.
178. Mattson MP. 1998. Free radicals, calcium, and the synaptic plasticity-cell death continuum: emerging roles of the transcription factor NF-κB. Int Rev Neurobiol 42:103-168.
179. 2+ homeostasis in Alzheimer's disease. Trends Neurosci 16:409-414.
180. Mattson MP, Keller JN, Begley JG. 1998a. Evidence for synaptic apoptosis. Exp Neurol 153:35-48.
181. Mattson MP, Partin J, Begley JG. 1998b. Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites. Brain Res 807:167-176.
182. Mattson MP, Guo Q. 1999. The presenilins. Neuroscientist 5:112-124.
183. Matzel LD, Talk AC, Muzzio IA, Rogers RF. 1998. Ubiquitous molecular substrates for associative learning and activity-dependent neuronal facilitation. Rev Neurosci 9:129-167.
184. McDermott JR, Mantle D, Biggins JA, Kidd AM, Davison K, Lauffart B, Pennington RJ. 1985. Specificity of neuropeptide degradation by two calcium-activated neutral proteases from human skeletal muscle. Life Sci 37:725-730.
185. McGinnis KM, Whitton MM, Gnegy ME, Wang KK. 1998. Calcium/ calmodulin-dependent protein kinase IV is cleaved by caspase-3 and calpain in SH-SY5Y human neuroblastoma cells undergoing apoptosis. J Biol Chem 273:19993-20000.
186. Mellgren RL. 1987. Calcium-dependent proteases: an enzyme system active at cellular membranes? FASEB J 1:110-115.
187. Mendel DB, Holbrook NJ, Bodwell JE. 1985. Degradation without apparent change in size of molybdate-stabilized nonactivated glucocorticoid-receptor complexes in rat thymus cytosol. J Biol Chem 260:8736-8740.
188. Meredith J Jr, Mu Z, Saido T, Du X. 1998. Cleavage of the cytoplasmic domain of the integrin beta3 subunit during endothelial cell apoptosis. J Biol Chem 273:19525-19531.
189. Merry DE, Korsmeyer SJ. 1997. Bcl-2 gene family in the nervous system. Annu Rev Neurosci 20:245-267.
190. Miossec C, Dutilleul V, Fassy F, Diu-Hercend A. 1997. Evidence for CPP32 activation in the absence of apoptosis during T lymphocyte stimulation. J Biol Chem 272:13459-13462.
191. Mittl PR, Di Marco S, Krebs JF, Bai X, Karanewsky DS, Priestle JP, Tomaselli KJ, Grutter MG. 1997. Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone. J Biol Chem 272:6539-6547.
192. Miura M, Zhu H, Rotello R, Hartwieg EA, Yuan J. 1993. Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75:653-660.
193. Miyashita T, Okamura-Oho Y, Mito Y, Nagafuchi S, Yamada M. 1997. Dentatorubral pallidoluysian atrophy (DRPLA) protein is cleaved by caspase-3 during apoptosis. J Biol Chem 272:29238-29242.
194. Miyashita T, Matsui J, Ohtsuka Y. 1999. Expression of extended polyglutamine sequentially activates initiator and effector caspases. Biochem Biophys Res Commun 257:724-730.
195. Mohr S, Zech B, Lapetina EG, Brune B. 1997. Inhibition of caspase-3 by S-nitrosation and oxidation caused by nitric oxide. Biochem Biophys Res Commun 238:387-391.
196. Molinari M, Anagli J, Carafoli E. 1995. PEST sequences do not influence substrate susceptibility to calpain proteolysis. J Biol Chem 270:2032-2035.
197. Mouatt-Prigent A, Karlsson JO, Agid Y, Hirsch EC. 1996. Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death? Neuroscience 73:979-987.
198. Murayama A, Fukai F, Murachi T. 1984. Action of calpain on the basic estrogen receptor molecule of porcine uterus. J Biochem (Tokyo) 95:1697-1704.
199. Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM. 1996. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85:817-827.
200. Na S, Chuang TH, Cunningham A, Turi TG, Hanke JH, Bokoch GM, Danley DE. 1996. D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis. J Biol 271:11209-11213.
201. Nakagawara A, Nakamura Y, Ikeda H, Hiwasa T, Kuida K, Su MS, Zhao H, Cnaan A, Sakiyama S. 1997. High levels of expression and nuclear localization of interleukin-1 beta converting enzyme (ICE) and CPP32 in favorable human neuroblastomas. Cancer Res 57:4578-4584.
202. Nath R, Raser KJ, McGinnis K, Nadimpalli R, Stafford D, Wang KK. 1996a. Effects of ICE-like protease and calpain inhibitors on neuronal apoptosis. NeuroReport 8:249-255.
203. Nath R, Raser KJ, Stafford D, Hajimohammadreza I, Posner A, Allen H, Talanian RV, Yuen P, Gilbertsen RB, Wang KK. 1996b. Non-erythroid alpha-spectrin breakdown by calpain and interleukin-1 beta-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis. Biochem J 319:683-690.
204. Neamati N, Fernandez A, Wright S, Kiefer J, McConkey DJ. 1995. Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei. J Immunol 154:3788-3795.
205. Ng PW, Porter AG, Janicke RU. 1999. Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10. J Biol Chem 274:10301-10308.
206. Nguyen FW, Nguyen M, Kwan T, Branton PE, Nicholson DW, Cromlish JA, Shore GC. 1997. p28 Bap31, a Bcl-2/Bcl-XL-and procaspase-8-associated protein in the endoplasmic reticulum. J Cell Biol 139:327-338.
207. Ni B, Wu X, Du Y, Su Y, Hamilton-Byrd E, Rockey PK, Rosteck P Jr., Poirier GG, Paul SM. 1997. Cloning and expression of a rat brain interleukin-1 beta-converting enzyme (ICE)-related protease (IRP) and its possible role in apoptosis of cultured cerebellar granule neurons. J Neurosci 17:1561-1569.
208. Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA. 1995. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376:37-43.
209. Nixon RA. 1986. Fodrin degradation by calcium-activated neutral proteinase (CANP) in retinal ganglion cell neurons and optic glia: preferential localization of CANP activities in neurons. J Neurosci 6:1264-1271.
210. Nixon RA, Saito KI, Grynspan F, Griffin WR, Katayama S, Honda T, Mohan PS, Shea TB, Beermann M. 1994. Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease. Ann N Y Acad Sci 747:77-91.
211. Nobel CS, Burgess DH, Zhivotovsky B, Burkitt MJ, Orrenius S, Slater AF. 1997a. Mechanism of dithiocarbamate inhibition of apoptosis: thiol oxidation by dithiocarbamate disulfides directly inhibits processing of the caspase-3 proenzyme. Chem Res Toxicol 10:636-643.
212. Nobel CS, Kimland M, Nicholson DW, Orrenius S, Slater AF. 1997b. Disulfiram is a potent inhibitor of proteases of the caspase family. Chem Res Toxicol 10:1319-1324.
213. Ohtsu M, Sakai N, Fujita H, Kashiwagi M, Gasa S, Shimizu S, Eguchi Y, Tsujimoto Y, Sakiyama Y, Kobayashi K, Kuzumaki N. 1997. Inhibition of apoptosis by the actin-regulatory protein gelsolin. EMBO J 16:4650-4656.
214. Okuno S, Shimizu S, Ito T, Nomura M, Hamada E, Tsujimoto Y, Matsuda H. 1998. Bcl-2 prevents caspase-independent cell death. J Biol Chem 273:34272-34277.
215. Onizuka K, Kunimatsu M, Ozaki Y, Muramatsu K, Sasaki M, Nishino H. 1995. Distribution of mu-calpain proenzyme in the brain and other neural tissues in the rat. Brain Res 697:179-186.
216. Orrenius S, Nobel CS, van den Dobbelsteen DJ, Burkitt MJ, Slater AF. 1996. Dithiocarbamates and the redox regulation of cell death. Biochem Soc Trans 24:1032-1038.
217. Orth K, Chinnaiyan AM, Garg M, Froelich CJ, Dixit VM. 1996. The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. J Biol Chem 271:16443-16446.
218. Ossina NK, Cannas A, Powers VC, Fitzpatrick PA, Knight JD, Gilbert JR, Shekhtman EM, Tomei LD, Umansky SR, Kiefer MC. 1997. Interferon-gamma modulates a p53-independent apoptotic pathway and apoptosis-related gene expression. J Biol Chem 272:16351-16357.
219. Ou J, Carlos TM, Watkins SC, Saavedra JE, Keefer LK, Kim YM, Harbrecht BG, Billiar TR. 1997. Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia. Nitric Oxide 1:404-416.
220. Pariat M, Carillo S, Molinari M, Salvat C, Debussche L, Bracco L, Milner J, Piechaczyk M. 1997. Proteolysis by calpains: a possible contribution to degradation of p53. Mol Cell Biol 17:2806-2815.
221. Park D, Jhon DY, Lee CW, Ryu SH, Rhee SG. 1993. Removal of the carboxyl-terminal region of phospholipase C-beta 1 by calpain abolishes activation by G alpha q. J Biol Chem 268:3710-3714.
222. Perera LP, Waldmann TA. 1998. Activation of human monocytes induces differential resistance to apoptosis with rapid down regulation of caspase-8/FLICE. Proc Natl Acad Sci USA 95:14308-14313.
223. Piedrafita FJ, Pfahl M. 1997. Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation. Mol Cell Biol 17:6348-6358.
224. Porn-Ares MI, Samali A, Orrenius S. 1998. Cleavage of the calpain inhibitor, calpastatin, during apoptosis. Cell Death Differ 5:1028-1033.
225. Posmantur R, Wang KK, Gilbertsen RB. 1998. Caspase-3-like activity is necessary for IL-2 release in activated Jurkat T-cells. Exp Cell Res 244:302-309.
226. Rabizadeh S, LaCount DJ, Friesen PD, Bredesen DE. 1993. Expression of the baculovirus p35 gene inhibits mammalian neural cell death. J Neurochem 61:2318-2321.
227. Raja S, Avraham S, Avraham H. 1997. Tyrosine phosphorylation of the novel protein-tyrosine kinase RAFTK during an early phase of platelet activation by an integrin glycoprotein IIb-IIIa-independent mechanism. J Biol Chem 272:10941-10970.
228. Rao L, Perez D, White E. 1996. Lamin proteolysis facilitates nuclear events during apoptosis. J Cell Biol 135:1441-1455.
229. Ravi R, Bedi A, Fuchs EJ, Bedi A. 1998. CD95 (Fas)-induced caspase-mediated proteolysis of NF-kappaB. Cancer Res 58:882-886.
230. Ray CA, Black RA, Kronheim SR, Greenstreet TA, Sleath PR, Salvesen GS, Pickup DJ 1992. Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. Cell 69:597-604.
231. Refaeli Y, Van Parijs L, London CA, Tschopp J, Abbas AK. 1998. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 8:615-623.
232. Rheaume E, Cohen LY, Uhlmann F, Lazure C, Alam A, Hurwitz J, Sekaly RP, Denis F. 1997. The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis. EMBO J 16:6346-6354.
233. Rickers A, Peters N, Badock V, Beyaert R, Vandenabeele P, Dorken B, Bommert K. 1999. Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis. Eur J Biochem 261:269-274.
234. Roberts-Lewis JM, Savage MJ, Marcy VR, Pinsker LR, Siman R. 1994. Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain. J Neurosci 14:3934-3944.
235. Rossig L, Fichtischerer B, Breitschopf K, Haendeler J, Zeiher AM, Mulsch A, Dimmeler S. 1999. Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J Biol Chem 274:6823-6826.
236. Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC. 1997. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J 16:6914-6925.
237. Rudel T, Bokoch GM. 1997. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science 276:1571-1574.
238. Saavedra JE, Billiar TR, Williams DL, Kim YM, Watkins SC, Keefer LK. 1997. Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver. J Med Chem 40:1947-1954.
239. Sadoul R, Fernandez PA, Quiquerez AL, Martinou I, Maki M, Schroter M, Becherer JD, Irmler M, Tschopp J, Martinou JC. 1996. Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons. EMBO J 15:3845-3852.
240. Saido TC, Sorimachi H, Suzuki K. 1994. Calpain: new perspectives in molecular diversity and physiological-pathological involvement. FASEB J 8:814-822.
241. Saito K, Elce JS, Hamos JE, Nixon RA. 1993. Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. Proc Natl Acad Sci USA 90:2628-2632.
242. Sakahira H, Enari M, Nagata S. 1998. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 391:96-99.
243. Salamino F, De Tullio R, Michetti M, Mengotti P, Melloni E, Pontremoli S. 1994a. Modulation of calpastatin specificity in rat tissues by reversible phosphorylation and dephosphorylation. Biochem Biophys Res Commun 199:1326-1332.
244. Salamino F, Sparatore B, Melloni E, Michetti M, Viotti PL, Pontremoli S, Carafoli E. 1994b. The plasma membrane calcium pump is the preferred calpain substrate within the erythrocyte. Cell Calcium 15:28-35.
245. Samali A, Nordgren H, Zhivotovsky B, Peterson E, Orrenius S. 1999. A comparative study of apoptosis and necrosis in HepG2 cells: oxidant-induced caspase inactivation leads to necrosis. Biochem Biophys Res Commun 255:6-11.
246. Santoro MF, Annand RR, Robertson MM, Peng YW, Brady MJ, Mankovich JA, Hackett MC, Ghayur T, Walter G, Wong WW, Giegel DA. 1998. Regulation of protein phosphatase 2A activity by caspase-3 during apoptosis J Biol Chem 273:13119-13128.
247. Satoh M, Yokosawa H, Ishii S. 1989. Characterization of cysteine proteases functioning in degradation of dynorphin in neuroblastoma cells: evidence for the presence of a novel enzyme with strict specificity toward paired basic residues. J Neurochem 52:61-68.
248. Scaffidi C, Schmitz I, Krammer PH, Peter ME. 1999. The role of c-FLIP in modulation of CD95-induced apoptosis. J Biol Chem 274:1541-1548.
249. Schlaepfer WW, Lee C, Lee VM, Zimmerman UJ. 1985. An immunoblot study of neurofilament degradation in situ and during calcium-activated proteolysis. J Neurochem 44:502-509.
250. Schmeiser K, Hammond EM, Roberts S, Grand RJ. 1998. Specific cleavage of gamma catenin by caspases during apoptosis. FEBS Lett 433:51-57.
251. Seimiya H, Mashima T, Toho M, Tsuruo T. 1997. c-Jun NH2-terminal kinase-mediated activation of interleukin-1beta converting enzyme/CED-3-like protease during anticancer drug-induced apoptosis. J Biol Chem 272:4631-4636.
252. Sentman CL, Shutter JR, Hockenbery D, Kanagawa O, Korsmeyer SJ. 1991. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67:879-888.
253. Seol DW, Billiar TR. 1999. A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis. J Biol Chem 274:2072-2076.
254. Shea TB, Beermann ML, Griffin WR, Leli U. 1994. Degradation of protein kinase C alpha and its free catalytic subunit, protein kinase M, in intact human neuroblastoma cells and under cell-free conditions. Evidence that PKM is degraded by mM calpain-mediated proteolysis at a faster rate than PKC. FEBS Lett 350:223-229.
255. Sheppard A, Wu J, Rutishauser U, Lynch G. 1991. Proteolytic modification of neural cell adhesion molecule (NCAM) by the intracellular proteinase calpain. Biochim Biophys Acta 1076: 156-160.
256. Shevchenko S, Feng W, Varsanyi M, Shoshan-Barmatz V. 1998. Identification, characterization and partial purification of a thiol-protease which cleaves specifically the skeletal muscle ryanodine receptor/Ca2+ release channel. J Membr Biol 161: 33-43.
257. Shi L, Kraut RP, Aebersold R, Greenberg AH. 1992. A natural killer cell granule protein that induces DNA fragmentation and apoptosis. J Exp Med 75:553-566.
258. Shiba E, Kim S, Fujitani M, Kambayashi JI, Kawamura I, Tsujimoto S, Shimomura K, Tanji Y, Taguchi T, Kimoto Y, Izukura M, Takai SI. 1996. Possible involvement of calpain in the growth of estrogen receptor positive breast cancer cells. Anticancer Res 16:773-777.
259. Shinohara K, Tomioka M, Nakano H, Tone S, Ito H, Kawashima S. 1996. Apoptosis induction resulting from proteasome inhibition. Biochem J 317:385-388.
260. Siegel RM, Martin DA, Zheng L, Ng SY, Bertin J, Cohen J, Lenardo MJ. 1998. Death-effector filaments: novel cytoplasmic structures that recruit caspases and trigger apoptosis. J Cell Biol 141:1243-1253.
261. Siman R, Baudry M, Lynch G. 1983. Purification from synaptosomal plasma membranes of calpain I, a thiol protease activated by micromolar calcium concentrations. J Neurochem 41:950-956.
262. Siman R, Ahdoot M, Lynch G. 1987. Ontogeny, compartmentation, and turnover of spectrin isoforms in rat central neurons. J Neurosci 7:55-64.
263. Siman R, Card JP, Davis LG. 1990. Proteolytic processing of beta-amyloid precursor by calpain I. J Neurosci 10:2400-2411.
264. Singer II, Scott S, Chin J, Bayne EK, Limjuco G, Weidner J, Miller DK, Chapman K, Kostura MJ. 1995. The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy. J Exp Med 82:1447-1459.
265. Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD, Wang HG, Reed JC, Nicholson DW, Alnemri ES, Green DR, Martin SJ. 1999. Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol 144:281-292.
266. Smith-Swimosky VL, Pettigrew LC, Craddock SD, Culwell AR, Rydel RE, Mattson MP. 1994. Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury. J Neurochem 63:781-784.
267. Smith-Swintosky VL, Kraemer PJ, Bruce AJ, McCants N, Maki A, Brown RW, Alcala M, Goodman Y, Slevin JT, Mattson MP. 1996. Bacterial alkaloids mitigate seizure-induced hippocampal damage and memory deficits. Exp Neurol 141:287-296.
268. Song Q, Lees-Miller SP, Kumar S, Zhang Z, Chan DW, Smith GC, Jackson SP, Alnemri ES, Litwack G, Khanna KK, Lavin MF. 1996. DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO J 15:3238-3246.
269. Sorimachi H, Saido TC, Suzuki K. 1994. New era of calpain research. Discovery of tissue-specific calpains. FEBS Lett 343:1-5.
270. Sorimachi H, Ishiura S, Suzuki K. 1997. Structure and physiological function of calpains. Biochem J 328:721-732.
271. Squier MK, Miller AC, Malkinson AM, Cohen JJ. 1994. Calpain activation in apoptosis. J Cell Physiol 159:229-237.
272. Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Litwack G, Alnemri ES. 1996. Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc Natl Acad Sci USA 93:14486-14491.
273. Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Alnemri ES. 1998. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol Cell 1:949-957.
274. Srinivasula SM, Ahmad M, Guo Y, Zhan Y, Lazebnik Y, Fernandes-Alnemri T, Alnemri ES. 1999. Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis. Cancer Res 59:999-1002.
275. Stoscheck CM, Gates RE, King LE Jr. 1988. A search for EGF-elicited degradation products of the EGF receptor. J Cell Biochem 38:51-63.
276. Susin SA, Zamzami N, Castedo M, Hirsch T, Marchetti P, Macho A, Daugas E, Geuskens M, Kroemer G. 1996. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J Exp Med 184:1331-1341.
277. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Brenner C, Larochette N, Prevost MC, Alzari PM, Kroemer G. 1999. Mitochondrial release of caspase-2 and -9 during the apoptotic process. J Exp Med 189:381-394.
278. Suzuki K, Imajoh S, Emori Y, Kawasaki H, Minami Y, Ohno S. 1987. Calcium-activated neutral protease and its endogenous inhibitor. Activation at the cell membrane and biological function. FEBS Lett 220:271-277.
279. Suzuki T, Okumura-Noji K, Ogura A, Tanaka R, Nakamura K, Kudo Y. 1992. Calpain may produce a Ca(2+)-independent form of kinase C in long-term potentiation. Biochem Biophys Res Commun 189:1515-1520.
280. Takahashi A, Musy PY, Martins LM, Poirier GG, Moyer RW, Earnshaw WC. 1996. CrmA/SPI-2 inhibition of an endogenous ICE-related protease responsible for lamin A cleavage and apoptotic nuclear fragmentation. J Biol Chem 271:32487-32490.
281. Takahashi M, Mukai H, Toshimori M, Miyamoto M, Ono Y. 1998. Proteolytic activation of PKN by caspase-3 or related protease during apoptosis. Proc Natl Acad Sci USA 95:11566-11571.
282. Talanian RV, Quinlan C, Trautz S, Hackett MC, Mankovich JA, Banach D, Ghayur T, Brady KD, Wong WW. 1997a. Substrate specificities of caspase family proteases. J Biol Chem 272:9677-9682.
283. Talanian RV, Yang X, Turbov J, Seth P, Ghayur T, Casiano CA, Orth K, Froelich CJ. 1997b. Granule-mediated killing: pathways for granzyme B-initiated apoptosis. J Exp Med 186:1323-1331.
284. Tallant EA, Brumley LM, Wallace RW. 1988. Activation of a calmodulin-dependent phosphatase by a Ca2+-dependent protease. Biochemistry 27:2205-2211.
285. Tamura T, Ueda S, Yoshida M, Matsuzaki M, Mohri H, Okubo T. 1996. Interferon-gamma induces Ice gene expression and enhances cellular susceptibility to apoptosis in the U937 leukemia cell line. Biochem Biophys Res Commun 229:21-26.
286. Tan X, Martin SJ, Green DR, Wang JYJ. 1997. Degradation of retinoblastoma protein in tumor necrosis factor-and CD95-induced cell death. J Biol Chem 272:9613-9616.
287. Tewari M, Dixit VM. 1995. Fas-and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J Biol Chem 270:3255-3260.
288. Thomas A, El Rouby S, Reed JC, Krajewski S, Silber R, Potmesil M, Newcomb EW. 1996. Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance. Oncogene 12:1055-1062.
289. Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineaux SM, Weidner JR, Aunins J. 1992. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 356:768-774.
290. Thornberry NA, Rano TA, Peterson EP, Rasper DM, Timkey. 1997. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J Biol Chem 272:17907-17911.
291. Toyoshima F, Moriguchi T, Nishida E. 1997. Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases. J Cell Biol 139:1005-1015.
292. Traub P, Scherbarth A, Willingale-Theune J, Paulin-Levasseur M, Shoeman R. 1988. Differential sensitivity of vimentin and nuclear lamins from Ehrlich ascites tumor cells toward Ca2+ -activated neutral thiol proteinase. Eur J Cell Biol 46:478-490.
293. Tsushima H, Imaizumi Y, Imanishi D, Fuchigami K, Tomonaga M. 1999. Fas antigen (CD95) in pure erythroid cell line AS-E2 is induced by interferon-gamma and tumor necrosis factor-alpha and potentiates apoptotic death. Exp Hematol 27:433-440.
294. Ubeda M, Habener JF. 1997. The large subunit of the DNA replication complex C (DSEB/RF-C140) cleaved and inactivated by caspase-3 (CPP32/YAMA) during Fas-induced apoptosis. J Biol Chem 272:19562-19568.
295. Vanags DM, Porn-Ares MI, Coppola S, Burgess DH, Orrenius S. 1996. Protease involvement in fodrin cleavage and phosphatidylserine exposure in apoptosis. J Biol Chem 271:31075-31085.
296. Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC, Kollet O, Lapidot T, Soffer D, Sobe T, Avraham KB, Goncharov T, Holtmann H, Lonai P, Wallach D. 1998. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apol, and DR3 and is lethal prenatally. Immunity 9:267-276.
297. Vaux DL, Cory S, Adams JM. 1988. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440-442.
298. Villa PG, Henzel WJ, Sensenbrenner M, Henderson CE, Pettmann B. 1998. Calpain inhibitors, but not caspase inhibitors, prevent actin proteolysis and DNA fragmentation during apoptosis. J Cell Sci 111:713-722.
299. Voehringer DW, McConkey DJ, McDonnell TJ, Brisbay S, Meyn RE. 1998. Bcl-2 expression causes redistribution of glutathione to the nucleus. Proc Natl Acad Sci USA 95:2956-2960.
300. Voelkel-Johnson C, Entingh AJ, Wold WS, Gooding LR, Laster SM. 1995. Activation of intracellular proteases is an early event in TNF-induced apoptosis. J Immunol 154:1707-1716.
301. Walker NP, Talanian RV, Brady KD, Dang LC, Bump NJ, Ferenz CR, Franklin S, Ghayur T, Hackett MC, Hammill LD. 1994. Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer. Cell 78:343-352.
302. Walowitz JL, Bradley ME, Chen S, Lee T. 1998. Proteolytic regulation of the zinc finger transcription factor YY1, a repressor of muscle-restricted gene expression. J Biol Chem 273:6656-6661.
303. Walter J, Schindzielorz A, Grunberg J, Haass C. 1999. Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis. Proc Natl Acad Sci USA 96:1391-1396.
304. Wang KK, Posmantur R, Nadimpalli R, Nath R, Mohan P, Nixon RA, Talanian RV, Keegan M, Herzog L, Allen H. 1998a. Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis. Arch Biochem Biophys 356:187-196.
305. Wang KK, Posmantur R, Nath R, McGinnis K, Whitton M, Talanian RV, Glantz SB, Morrow JS. 1998b. Simultaneous degradation of alphaII-and betaII-spectrin by caspase 3 (CPP32) in apoptotic cells. J Biol Chem 273:22490-22497.
306. Wang KK, Roufogalis BD, Villalobo A. 1988. Further characterization of calpain-mediated proteolysis of the human erythrocyte plasma membrane Ca2+-ATPase. Arch Biochem Biophys 267: 317-327.
307. Wang KK, Roufogalis BD, Villalobo A. 1989. Characterization of the fragmented forms of calcineurin produced by calpain I. Biochem Cell Biol 67:703-711.
308. Wang L, Miura M, Bergeron L, Zhu H, Yuan J. 1994. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78:739-750.
309. Wang S, Miura M, Jung YK, Zhu H, Li E, Yuan J. 1998c. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell 92:501-509.
310. Wang X, Zelenski NG, Yang J, Sakai J, Brown MS, Goldstein JL. 1996. Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. EMBO J 15:1012-1020.
311. Waterhouse N, Kumar S, Song Q, Strike P, Sparrow L, Dreyfuss G, Alnemri ES, Litwack G, Lavin M, Watters D. 1996. Heteronuclear ribonucleoproteins C1 and C2, components of the spliceosome, are specific targets of interleukin 1beta-converting enzyme-like proteases in apoptosis. J Biol Chem 271:29335-29341.
312. Waton PH, Mortimer ST, Wang KK, Croall DE, Hanley DA. 1995. Calcium-activated proteases in the bovine parathyroid gland: potential role in degradation of parathyroid hormone to peptide fragments. J Mol Endocrinol 15:61-71.
313. Webb SJ, Nicholson D, Bubb VJ, Wyllie AH. 1999. Caspase-mediated cleavage of APC results in an ammo-terminal fragment with an intact armadillo repeat domain. FASEB J 13:339-346.
314. Weidemann A, Paliga K, D rrwang U, Reinhard FB, Schuckert O, Evin G, Masters CL. 1999. Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases. J Biol Chem 274:5823-5829.
315. Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR. 1998. Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. J Biol Chem 273:9158-9167.
316. Wen LP, Fahrni JA, Troie S, Guan JL, Orth K, Rosen GD. 1997.Cleavage of focal adhesion kinase by caspases during apoptosis. J Biol Chem 272:26056-26061.
317. Widmann C, Gerwins P, Johnson NL, Jarpe MB, Johnson GL. 1998a. MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis. Mol Cell Biol 18:2416-2429.
318. Widmann C, Gibson S, Johnson GL. 1998b. Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals. J Biol Chem 273:7141-7147.
319. Wissing D, Mouritzen H, Egeblad M, Poirier GG, Jaattela M. 1997. Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor-induced apoptosis. Proc Natl Acad Sci USA 94:5073-5077.
320. Woo M, Hakem R, Soengas MS, Duncan GS, Shahinian A, Kagi D, Hakem A, McCurrach M, Khoo W, Kaufman SA, Senaldi G, Howard T, Lowe SW, Mak TW. 1998. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev 12:806-819.
321. Wood DE, Thomas A, Devi LA, Berman Y, Beavis RC, Reed JC, Newcomb EW. 1998. Bax cleavage is mediated by calpain during drug-induced apoptosis. Oncogene 17:1069-1078.
322. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326-1331.
323. Xie HQ, Johnson GV. 1998. Calcineurin inhibition prevents calpain-mediated proteolysis of tau in differentiated PC 12 cells. J Neurosci Res 53:153-164.
324. Xue D, Horvitz HR. 1995. Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature 377:248-251.
325. Yakovlev AG, Knoblach SM, Fan L, Fox GB, Goodnight R, Faden AI. 1997. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J Neurosci 17:7415-7424.
326. Yan GM, Ni B, Weller M, Wood KA, Paul SM. 1994. Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons. Brain Res 656:43-51.
327. Yanagisawa K, Sato S, Amaya N, Miyatake T. 1983. Degradation of myelin basic protein by calcium-activated neutral protease (CANP) in human brain and inhibition by E-64 analogue. Neurochem Res 8:1285-1293.
328. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP, Wang X. 1997. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 1997 275: 1129-1132.
329. Yoshihara Y, Ueda H, Imajoh S, Takagi H, Satoh M. 1988. Calcium-activated neutral protease (CANP), a putative processing enzyme of the neuropeptide, kyotorphin, in the brain. Biochem Biophys Res Commun 155:546-553.
330. Yu ZF, Zhou D, Bruce-Keller AJ, Kindy MS, Mattson MP. 1999. Involvement of the p50 subunit of NF-κB in resistance of hippocampal neurons to excitotoxic injury. J Neurosci. In press.
331. Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR. 1994. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell 78:739-750.
332. Yuan Y, Dopheide SM, Ivanidis C, Salem HH, Jackson SP. 1997. Calpain regulation of cytoskeletal signaling complexes in von Willebrand factor-stimulated platelets. Distinct roles for glycoprotein Ib-V-IX and glycoprotein IIb-IIIa (integrin alphaIIb-beta3) in von Willebrand factor-induced signal transduction. J Biol Chem 272:21847-21854.
333. Zhang Y, Center DM, Wu DM, Cruikshank WW, Yuan J, Andrews DW, Kornfeld H. 1998. Processing and activation of pro-interleukin-16 by caspase-3. J Biol Chem 273:1144-1149.
334. Zhou BB, Li H, Yuan J, Kirschner MW. 1998a. Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells. Proc Natl Acad Sci USA 95:6785-6790.
335. Zhou Q, Krebs JF, Snipas SJ, Price A, Alnemri ES, Tomaselli KJ, Salvesen GS. 1998b. Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex. Biochemistry 37:10757-10765.
336. Zimmerman UJ, Schlaepfer WW. 1984. Kinase activities associated with calcium-activated neutral proteases. Biochem Biophys Res Commun 120:767-774.
337. Zimmerman UJ, Schlaepfer WW. 1985. Characterization of calcium-activated neutral protease (CANP)-associated protein kinase from bovine brain and its phosphorylation of neurofilaments. Biochem Biophys Res Commun 129:804-811.
338. Zimmerman UJ, Wang M, Nelson JB, Ekwunife FS, Liu L. 1996. Secretagogue-induced proteolysis of cAMP-dependent protein kinase in intact rat alveolar epithelial type II cells. Biochim Biophys Acta 1311:117-123.
339. Zou H, Li Y, Liu X, Wang X. 1999. An APAF-1.Cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J. Biol Chem 274:11549-11556.