Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked

Science

Volumn 275, Issue 5303, 1997, Pages 1129-1132

  Yang, Jie ^a   Liu, Xuesong ^a,b   Bhalla, Kapil ^a   Kim, Caryn Naekyung ^a   Ibrado, Ana Maria ^a   Cai, Jiyang ^a   Peng, Tsung I ^a   Jones, Dean P ^a   Wang, Xiaodong ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C; PROTEIN BCL 2;

ARTICLE; CELL DEATH; CELL PROTECTION; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOSOL; ENZYME RELEASE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL;

APOPROTEINS; APOPTOSIS; CASPASE 3; CASPASES; CYSTEINE ENDOPEPTIDASES; CYTOCHROME C GROUP; CYTOCHROMES C; CYTOSOL; DNA FRAGMENTATION; ENZYME ACTIVATION; ETOPOSIDE; HELA CELLS; HL-60 CELLS; HUMANS; INTRACELLULAR MEMBRANES; MEMBRANE POTENTIALS; MITOCHONDRIA; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; STAUROSPORINE; TRANSFECTION;

EID: 0031036872     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.275.5303.1129     Document Type: Article

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41. We thank R. Jemmerson of University of Minnesota for monoclonal antibody to cytochrome c; S, McKnight, J. L. Goldstein, and M. S, Brown for critically reading the manuscript; and T. Greenamyer for help with confocal microscopy. Supported by the start-up fund from Emory University, an American Cancer Society research grant, and a Junior Faculty award (to X.W.).