Calcium/calmodulin-dependent protein kinase IV is cleaved by caspase-3 and calpain in SH-SY5Y human neuroblastoma cells undergoing apoptosis

Journal of Biological Chemistry

Volumn 273, Issue 32, 1998, Pages 19993-20000

  McGinnis, Kim M ^a   Whitton, Margaret M ^c   Gnegy, Margaret E ^a   Wang, Kevin K W ^a,b,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b Laboratory of Neuro biochemistry   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE IV; CALPAIN; CALPASTATIN; CASPASE 3; CELL PROTEIN; PROTEIN KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN); THAPSIGARGIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; SEQUENCE HOMOLOGY;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; ASPARTIC ACID; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALPAIN; CASPASE 3; CASPASES; CHLOROBENZOATES; CYSTEINE ENDOPEPTIDASES; ENZYME INHIBITORS; HUMANS; MICE; NEUROBLASTOMA; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; STAUROSPORINE; THAPSIGARGIN; TUMOR CELLS, CULTURED;

EID: 0032493743     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.32.19993     Document Type: Article

References (12)

1. Yuan, J., Shaham, S., Ledoux, S., Ellis, H. M., and Horvitz, H. R. (1993) Cell 75, 641-652
2. Vaux, D. L., and Strasser, A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 2239-2244
3. Fernandes-Alnemri, T., Litwack, G., and Alnemri, E. S. (1994) J. Biol. Chem. 269, 30761-30764
4. Fraser, A., and Evan, G. (1996) Cell 85, 781-784
5. Cerretti, D. P., Kozlosky, C. J., Mosley, B., Nelson, N., Van Ness, K., Greenstreet, T. A., March, C. J., Kronheim, S. R., Druck, T., Cannizzaro, L. A., Huebner, K., and Black, R. A. (1992) Science 256, 97-100
6. Thornberry, N. A., Bull, H. G., Calaycay, J. R., Chapman, K. T., Howard, A. D., Kostura, M. J., Miller, D. K., Molineaux, S. M., Weidner, J. R., Aunins, J., Elliston, K. O., Ayala, J. M., Casano, F. J., Chin, J., Ding, G. J.-F., Egger, L. A., Gaffney, E. P., Limjuco, G., Palyha, O. C., Raju, S. M., Rolando, A. M., Salley, J. P., Yamin, T.-T., Lee, T. D., Shively, J. E., MacCross, M., Mumford, R. A., Schmidt, J. A., and Tocci, M. J. (1992) Nature 356, 768-774
7. Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., Lazebnik, Y. A., Munday, N. A., Raju, S. M., Smulson, M. E., Yamin, T.-T., Yu, V. L., and Miller, D. K. (1995) Nature 376, 37-43
8. Schlegel, J., Peters, I., Orrenius, S., Miller, D. K., Thornberry, N. A., Yamin, T.-T., and Nicholson, D. W. (1996) J. Biol. Chem. 271, 1841-1844
9. Slee, E. A., Zhu, H., Chow, S. C., MacFarlane, M., Nicholson, D. W., and Cohen, G. M. (1996) Biochem. J. 315, 21-24
10. Nath, R., Raser, K. J., McGinnis, K., Nadimpalli, R., Stafford, D., and Wang, K. K. (1996) Neuroreport 8, 249-255
11. Posmantur, R. M., McGinnis, K., Nadimpalli, R., Gilbertsen, R. B., and Wang, K. K. W. (1997) J. Neurochem. 68, 2328-2337
12. Nath, R., Raser, K. J., Stafford, D., Hajimohammadreza, I., Posner, A., Allen, H., Talanian, R. V., Yuen, P., Gilbertsen, R. B., and Wang, K. K. (1996) Biochem. J. 319, 683-690