Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

Nature Medicine

Volumn 2, Issue 7, 1996, Pages 788-794

  Bruce, Annadora J ^a   Boling, Warren ^a   Kindy, Mark S ^a,b   Peschon, Jacques ^c   Kraemer, Philipp J ^b   Carpenter, Melissa K ^c,d   Holtsberg, Frederick W ^b   Mattson, Mark P ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c AMGEN INC   (United States)

^d CytoTherapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXCITOTOXIN; GROWTH FACTOR RECEPTOR; TRANSFORMING GROWTH FACTOR ALPHA RECEPTOR;

ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BRAIN INJURIES; BRAIN ISCHEMIA; CELLS, CULTURED; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROGLIA; NEURONS; NEUROTOXINS; OXIDATIVE STRESS; RECEPTORS, TUMOR NECROSIS FACTOR; SUPEROXIDE DISMUTASE;

ANIMALIA;

EID: 0029899586     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0796-788     Document Type: Article

References (49)

1. Taupin, V. et al. Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre- and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand. J. Neuroimmunol. 42, 177-185 (1993).
2. Minami, M., Kuraishi, Y. & Satoh, M. Effects of kainic acid on messenger RNA levels of IL-1 beta, IL-6, TNFα and LIF in the rat brain. Biochem. Biophys. Res. Commun. 176, 593-598 (1991).
3. Liu, T. et al. Tumor necrosis factor-α expression in ischemic neurons. Stroke 25, 1481-1488 (1994).
4. Tracey, K.J. & Cerami, A. Tumor necrosis factor: A pleiotropic cytokine and therapeutic target. Annu. Rev. Med. 5, 491-503 (1994).
5. van der Poll, T. & Lowry, S.F. Tumor necrosis factor in sepsis: Mediator of multiple organ failure or essential part of host defense? Shock 3, 1-12 (1995).
6. Selmaj, W., Farooq, M., Norton ,W.T., Raine, C.S. & Brosnan, C.F Proliferation of astrocytes in vitro in response to cytokines: A primary role for tumor necrosis factor. J. Immunol. 144, 129-135 (1990).
7. Merrill, J. Effects of interleukin-1 and tumor necrosis factor-α on astrocytes, microglia, oligodendrocytes, and glial precursors in vitro. Dev. Neurosci. 13, 130-137 (1991).
8. Lipton, S.A. HIV-related neuronal injury. Potential therapeutic intervention with calcium channel antagonists and NMDA antagonists. Mol. Neurobiol. 8, 181-196 (1994).
9. Louis, J.C., Magal, E., Takayama, S. & Varon, S. CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death. Science 259, 689-692 (1993).
10. Chao, C.C. & Hu, S. Tumor necrosis factor-alpha potentiates glutamate neurotoxicity in human fetal brain cell cultures. Dev. Neurosci. 16, 172-179 (1994).
11. Cheng, B., Christakos, S. & Mattson, M.P. Tumor necrosis factors protect neurons against excitotoxic/metabolic insults and promote maintenance of calcium homeostasis. Neuron 12, 139-153 (1994).
12. Gruss, H.J. & Dower, S.K. Tumor necrosis factor ligand superfamily: Involvement in the pathology of malignant lymphomas. Blood 85, 3378-3404 (1995).
13. Breder, C.D., Tsujimoto, M., Terano, Y., Scott, D.W. & Saper, C.B. Distribution and characterization of tumor necrosis factor-α-like immunoreactivity in the murine central nervous system. J. Comp. Neurol. 337, 543-567 (1993).
14. Chung, I.Y. & Benveniste, E.N. Tumor necrosis factor alpha production by astrocytes. Induction by lipopolysaccharide, interferon gamma and interleukin-1 beta. J. Immunol. 144, 2999-3007 (1990).
15. Armitage, R.J. Tumor necrosis factor receptor superfamily members and their ligands. Curr. Opin. Immunol. 6, 407-113 (1994).
16. Beutler, B. & Van Huffel, C. An evolutionary and functional approach to the TNF receptor/ligand family. Ann. N.Y. Acad. Sci. 730, 118-133 (1994).
17. Kinouchi, K. et al. Identification and characterization of receptors for tumor necrosis factor-α in the brain. Biochem. Biophys. Res. Commun. 181, 1532-1538 (1991).
18. Wolvers, D.A., Marquette, C., Berkenbosch, F. & Haour, F. Tumor necrosis factor α: Specific binding sites in the rodent brain and pituitary gland. Eur. Cytokine Netw. 4, 377-381 (1993).
19. Kolesnick, R. & Golde, D.W. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 77, 325-328 (1994).
20. Rothe, M., Pan, M.-G., Henzel, W. J., Ayres, T.M. & Goeddel, D.V. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 83, 1243-1252 (1995).
21. Rothe, J. et al. Mice lacking tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature 364, 798-802 (1993).
22. Erickson, S.L. et al. Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice. Nature 372, 560-563 (1994).
23. Zheng, L. et al. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 377, 348-351 (1995).
24. Stein-Behrens, B., Mattson, M.P., Chang, I., Yeh, M. & Sapolsky, R.M. Stress excacerbates neuron loss and cytoskeletal pathology in the hippocampus. J. Neurosci. 14, 5373-5380 (1994).
25. Yang, G. et al. Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia. Stroke 25, 165-170 (1994).
26. Smith-Swintosky, V.L. et al. Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures. J. Cerebr. Blood Flow Metab. 16, 585-598 (1996).
27. Watson, B. D. & Ginsberg, M. D. Ischemic injury in the brain. Role of oxygen radical-mediated processes. Ann. N. Y. Acad. Sci. 559, 269-281 (1989).
28. 2+], and neurotoxicity, and increase antioxidant enzyme activities in hippocampal neurons. J. Neurochem. 65, 1740-1751 (1995).
29. Wong, G.H. Protective roles of cytokines against radiation: Induction of mitochondrial MnSOD. Biochim. Biophys. Acta 1271, 205-209 (1995).
30. 2+ accumulation. Proc. Natl. Acad. Sci. USA 92, 9328-9332 (1995).
31. Jorgensen, M.B. et al. Microglial and astroglial reactions to ischemic and kainic acid-induced lesions of the adult rat hippocampus. Exp. Neurol. 120, 70-88 (1993).
32. Mattson, M.P., Cheng, B. & Smith-Swintosky, V.L. Growth factor-mediated protection from excitotoxicity and disturbances in calcium and free radical metabolism. Semin. Neurosci. 5, 295-307 (1993).
33. Eddy, L.J., Goeddel, D.V. & Wong, G.H. Tumor necrosis factor-alpha pretreatment is protective in a rat model of myocardial ischemia-reperfusion injury. Biochem. Biophys. Res. Commun. 184, 1056-1059 (1992).
34. LaVail, M.M. et al. Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc. Natl. Acatl. Sci. USA 89, 11249-11253 (1992).
35. Meda, L. et al. Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature 374, 647-650 (1995).
36. Peterson, P.K., Hu .S., Anderson, W.R. & Chao, C.C. Nitric oxide production and neurotoxicity mediated by activated microglia from human versus mouse brain. J. Infect. Dis. 170, 457-460 (1994).
37. Araujo, D.M. & Cotman C.W. Basic FGF in astroglial, microglial, and neuronal cultures: Characterization of binding sites and modulation of release by lymphokines and trophic factors. J. Neurosci. 12, 1668-1678 (1992).
38. Wiessner, C., Gehrmann, J., Lindholm, D., Topper, R. & Kreutzberg, G.W. Hossmann K A. Expression of transforming growth factor-beta 1 and interleukin-1 beta mRNA in rat brain following transient forebrain ischemia. Acta Neuropathol. 86, 439-446 (1993).
39. Warner, B.B., Burhans, M.S., Clark, J.C. & Wispe, J.R. Tumor necrosis factor-alpha increases Mn-SOD expression: Protection against oxidant injury. Am. J. Physiol. 260, L296-301 (1991).
40. Barbara, J.A. et al. Dissociation of TNF-α cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-α mutants. EMBO J. 13, 843-850 (1994).
41. Aloisi, F. et al. Astrocyte cultures from human embryonic brain: Characterization and modulation of surface molecules by inflammatory cytokines. J. Neurosci. Res. 32, 494-506 (1992).
42. Panek, R.B. & Benveniste, E.N. Class II MHC gene expression in microglia. Regulation by the cytokines IFN-gamma, TNF-alpha, and TGF-beta. J. Immunol. 154, 2846-2854 (1995).
43. Hopkins, S.J. & Rothwell, N.J. Cytokines and the nervous system. I: Expression and recognition. Trends Neurosci. 18, 83-88 (1995).
44. Feuerstein, G.Z., Liu, T. & Barone, F.C. Cytokines, inflammation, and brain injury: Role of tumor necrosis factor-α. Cerebrovasc. Brain Metab. Rev. 6, 341-360 (1994).
45. Lyden, P.D., Zivin, J.A., Chabolla, D.R., Jacobs M.A. & Gage, F.H. Quantitative effects of cerebral infarction on spatial learning in rats. Exp. Neurol. 116, 122-132 (1992).
46. Gayoso, M.J. et al. Brain lesions and water-maze learning deficits after systemic administration of kainic acid to adult rats. Brain Res. 653, 92-100 (1994).
47. Bruce, A.J., Sakhi, S., Schreiber, S.S. & Baudry, M. Development of kainic acid and N-methyl-D-aspartic acid toxicity in organotypic hippocampal cultures. Exp. Neurol. 132, 209-219 (1995).
48. White, B.C. et al. Fluorescent histochemical localization of lipid peroxidation during brain reperfusion following cardiac arrest. Acta. Neuropathol. 86, 1-9 (1993).
49. Goodman, Y. & Mattson, M.P. Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid β-peptide toxicity. J. Neurochem. 66, 869-872 (1996).