Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 4, 1999, Pages 1391-1396

  Walter, Jochen ^a   Schindzielorz, Alice ^a   Grünberg, Jürgen ^a   Haass, Christian ^a  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CASPASE; DNA FRAGMENT; GLUTAMIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PRESENILIN 1; PROTEINASE; SERINE;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CERCOPITHECIDAE; CONTROLLED STUDY; GENE; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CASPASES; COS CELLS; HELA CELLS; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PRESENILIN-2; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TRANSFECTION;

CERCOPITHECIDAE;

EID: 0033573936     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.4.1391     Document Type: Article

References (53)

1. Selkoe, D. J. (1991) Neuron 6, 487-498.
2. Haass, C. & Selkoe, D. J. (1993) Cell 75, 487-498.
3. Checler, F. (1995) J. Neurochem. 65, 1431-1444.
4. Jarret, J. T. & and Lansbury, P. T., Jr. (1993) Cell 73, 1055-1058.
5. Yankner, B. A. (1996) Neuron 16, 921-932.
6. Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) Nature (London) 375, 754-760.
7. Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, C.-E., Jondro, P. D., Schmidt, S. D., Wang, K., et al. (1995) Science 269, 973-977.
8. Rogaev, E. I., Sherrington, R., Rogaeva, E. A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C., Holman, K., Tsuda, T., et al. (1995) Nature (London) 376, 775-778.
9. Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) Nat. Med. 2, 864-870.
10. Borchelt, D., Thinakaran, G., Eckman, C., Lee, M., Davenport, F., Ratovitsky, T., Prada, C.-M., Kim, G., Seekins, S., et al. (1996) Neuron 17, 1005-10013.
11. Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C. M., Perez-Tur, J., Hutton, M., Buee, L., Harigaya, Y., Yager, D., et al. (1996) Nature (London) 383, 710-713.
12. Citron, M , Westaway, D., Xia, W., Carlson, G., Diehl, T. S., Levesque, G., Johnson-Wood, K., Lee, M., Seubert, P., Davies, A., et al. (1997) Nat. Med. 3, 67-72.
13. Tomita, T., Maruyama, K., Saido, T. C., Kume, H., Shinozaki, K., Tokuhiro, S., Capell, A., Walter, J., Grünberg, J., Haass, C., et al. (1997) Proc. Natl. Acad. Sci. USA 94, 2025-2030.
14. Doan, A., Thinakaran, G., Borchelt, D. R., Slunt, H. H., Ratovitsky, T., Podlisny, M., Selkoe, D. J., Seeger, M., Gandy, S. E., Price, D. L. & Sisodia, S. S. (1996) Neuron 17, 1023-1030.
15. DeStrooper, B., Beullens, M., Contreras, B., Levesque, L., Craessaerts, K., Cordell, B., Moechars, D., Bollen, M., Fraser, P., St George-Hyslop, P. H. & van Leuven, F. (1997) J. Biol. Chem. 272, 3590-3598.
16. Thinakaran, G., Borchelt, D. R., Lee, M. K., Slunt, H. H., Spitzer, L., Kim, G., Ratovitsky, T., Davenport, F., Nordstedt, C., Seeger, M., et al. (1996) Neuron 17, 181-190.
17. Kim, T.-W., Pettingell, W. H., Hallmark, O. G., Moir, R. D., Wasco, W. & Tanzi, R. E. (1997) J. Biol. Chem. 272, 11006-11010.
18. Shirotani, K., Takahashi, K., Ozawa, K., Kunishita, T. & Tabira, T. (1997) Biochem. Biophys. Res. Comm. 240, 728-731.
19. Vito, P., Ghayur, T. & D'Adamio, L. (1997) J. Biol. Chem. 271, 31025-31028.
20. Prihar, G., Fuldner, R. A., Perez-Tur, J., Lincoln, S., Duff, K., Crook, R., Hardy, J., Philips, C. A., Venter, C., Talbot, C., et al. (1996) NeuroReport 7, 1680-1684.
21. Grünberg, J., Walter, J., Eckman, C., Capell, A., Schindzielorz, A., Younkin, S, Mehta, N., Hardy, J. & Haass, C. (1998) NeuroReport 9, 3293-3299.
22. Lee, M. K., Borchelt, D. R., Kim, G., Thinakaran, G., Slunt, H. H., Ratovitski, T., Martin, L. J., Kittur, A., Gandy, S., Levey, A. I., et al. (1997) Nat. Med. 3, 756-760.
23. Capell, A., Grünberg, J., Pesold, B., Diehlmann, A., Citron, M., Nixon, R., Beyreuther, K., Selkoe, D. J. & Haass, C. (1998) J. Biol. Chem. 273, 3203-3211.
24. Thinakaran, G., Regard, J. B., Bouton, C. M. L., Harris, C. L., Sabo, S., Price, D. L., Borchelt, D. R. & Sisodia, S. S. (1998) Neurobiol. Dis. 4, 438-453.
25. Yu, G., Chen, F., Levesque, G., Nishimura, M., Zhang, D. M., Levesque, L., Rogaeva, E., Xu, D., Liang, Y., Duthie, M., et al. (1998) J. Biol. Chem. 273, 16470-16475.
26. Steiner, H., Capell, A., Pesold, B., Citron, M., Kloetzel, P.-M., Selkoe, D., Romig, H, Mendla, K. & Haass, C. (1998) J. Biol. Chem. 273, 32322-32331.
27. Vito, P., Lacaná, F. & D'Adamio, L. (1996) Science 271, 521-525.
28. Wolozin, B., Iwasaki, K., Vito, P., Ganjei, J. K., Lacana, E., Sunderland, T., Zhao, B., Kusiak, J. W., Wasco, W. & D'Adamio, L. (1996) Science 274, 1710-1713.
29. Roperch, J.-P., Alvaro, V., Prieur, S., Tuynder, M., Nemani M., Lethrosne, F., Piouffre, I., Gendron, M.-C., Israeli, D., Dausset, J., et al. (1998) Nat. Med. 4, 835-838.
30. Kim, T.-W., Pettingel, W. H., Jung, Y.-K. Kovacs, D. M. & Tanzi, R. E. (1997) Science 277, 373-376.
31. Loetscher, H., Deuschle, U., Brockhaus, M., Reinhardt, D., Nelboeck, Mous, J., Grünberg, J., Haass, C. & Jacobsen, H. (1997) J. Biol. Chem. 272, 20655-20659.
32. Grünberg, J., Walter, J., Loetscher, H., Deuschle, U., Jacobsen, H. & Haass, C. (1998) Biochemistry 273, 3205-3211.
33. Nicholson, D. W. & Thornberry, N. A. (1997) Trends Biochem. Sci. 22, 299-306.
34. Cohen, G. M. (1997) Biochem. J. 326, 1-16.
35. Thornberry, N. A., Rano, T. A., Peterson, E. P., Rasper, D. M., Timkey, T., Garcia-Calvo, M., Houtzager, V. M., Nordstorm, P. A., Roy, S., Vaillancourt, J. P., et al. (1997) J. Biol. Chem. 272, 17907-17911.
36. Walter, J., Grünberg, J., Schindzielorz, A. & Haass, C. (1998) Biochemistry 37, 5961-5967.
37. Egelhoff, T. T., Lee, R. J. & Spudich, J. A. (1993) Cell 75, 363-371.
38. Huang, W. & Erikson, R. L. (1994) Proc. Natl. Acad. Sci. USA 91, 8960-8963.
39. Haldar, S., Jena, N. & Crocce, C. M. (1995) Proc. Natl. Acad. Sci. USA 92, 4507-4511.
40. Oyama, F., Sawamura, N., Kobayashi, K., Morishima-Kawashima, M., Kuramochi, T., Ito, M., Tomita, T., Maruyama, Saido, T.-C., Iwatsubo, T., et al. (1998) J. Neurochem. 71, 313-322.
41. Tomita, T., Tokuhiro, S., Hashimoto, T., Aiba, K., Saido, T. C., Maruyama, K. & Iwatsubo, T. (1998) J. Biol. Chem. 273, 21153-21160.
42. Seeger, M., Nordstedt, C., Petanceska, S., Kovacs, D. M., Gouras, G. K., Hahne, S., Fraser, P., Levesque, L., Czernik, A. J., St. George-Hyslop, P., et al. (1997) Proc. Natl. Acad. Sci. USA 94, 5090-5094.
43. Walter, J., Grünberg, J., Capell, A., Pesold, B., Schindzielorz, A., Citron, M., Mendla, K., St. George-Hyslop, P., Multhaup, G., Selkoe, D. J. & Haass, C. (1997) Proc. Natl. Acad. Sci. USA 94, 5349-5354.
44. Barkett, M., Xue, D., Horvitz, H. R. & Gilmore, T. D. (1997) J. Biol. Chem. 272, 29419-29422.
45. Morana, S. J., Wolf, C. M., Li, J., Reynolds, J. E., Brown, M. K. & Eastman, A. (1996) J. Biol. Chem. 271, 118263-182271.
46. Yan, Y., Shay, J. W., Wright, W. E. & Mumby, M. C. (1997) J. Biol. Chem. 272, 15220-15226.
47. Emoto, Y., Manome, Y., Meinhard, G., Kisaki, H., Kharbanda, S., Robertson, M., Ghayur, T., Wong, W. W., Kamen, R., Weichselbaum, R. & Kufe, D. (1995) EMBO J. 14, 6148-6156.
48. Cardone, M. H., Salvesen, G. S., Widman, C., Johnson, G. & Frisch, S. M. (1997) Cell 90, 315-323.
49. Wen, L-P., Fahrni, J. A., Troie, S., Guan, J.-L., Orth, K. & Rosen, G. D. (1997) J. Biol. Chem. 272, 26056-26061.
50. Cryns, V. L., Byun, Y., Rana, A., Mellor, H., Lustig, K. D., Ghanem, L., Parker, P. J., Kirschner, M. W. & Yuan, J. (1997) J. Biol. Chem. 272, 29449-29453.
51. Santoro, M. F., Annand, R. R., Robertson, M. M., Peng, Y.-W., Brady, M. J., Mankovich, J. A., Hackett, M. C., Ghayur, T., Walter, G., Wong, W. W. & Giegel, D. A. (1998) J. Biol. Chem. 273, 13119-13128.
52. Gomez-Isla, T., Price, J. L., McKeel, D. W., Morris, J. C., Growdon, J. H. & Hyman, B. T. (1996) J. Neurosci. 16, 4491-4500.
53. Anderson, A., Su, J. H. & Cotman, C. W. (1996) J. Neurosci. 16, 1710-1719.