The release of cytochrome c from mitochondria: A primary site for Bcl- 2 regulation of apoptosis

Science

Volumn 275, Issue 5303, 1997, Pages 1132-1136

  Kluck, Ruth M ^a   Bossy Wetzel, Ella ^a   Green, Douglas R ^a   Newmeyer, Donald D ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; CYTOCHROME C; FODRIN; PROTEIN BCL 2;

ARTICLE; CELL DEATH; CELL FREE SYSTEM; ENZYME ACTIVATION; ENZYME RELEASE; GENE EXPRESSION REGULATION; MITOCHONDRIAL MEMBRANE; OOCYTE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; XENOPUS;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; CARRIER PROTEINS; CELL EXTRACTS; CELL-FREE SYSTEM; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; CYTOCHROME C GROUP; CYTOSOL; MEMBRANE POTENTIALS; MICROFILAMENT PROTEINS; MITOCHONDRIA; OVUM; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT PROTEINS; XENOPUS;

EID: 0031037897     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.275.5303.1132     Document Type: Article

References (52)

1. J. C. Reed, J. Cell Biol. 124, 1 (1994).
2. G. Nuñez and M. F. Clarke, Trends Cell Biol. 4, 399 (1994).
3. E. Yang and S. J. Korsmeyer, Blood 88, 386 (1996).
4. Y. Akao, Y. Otsuki, S. Kataoka, Y. lto, Y. Tsujimoto, Cancer Res. 54, 2468 (1994).
5. P. Monaghan et al., J. Histochem. Cytochem. 40, 1819 (1992).
6. S. Krajewski et al., Cancer Res. 53, 4701 (1993).
7. D. de Jong et al., ibid. 54, 256 (1994).
8. T. Lithgow, R. Van Driel, J. F. Bertram, A. Strasser, Cell Growth Differ. 5, 411 (1994).
9. A. M. Chinnaiyan et al., J. Biol. Chem. 271, 4573 (1996).
10. P. Erhardt and G. M. Cooper, ibid., p. 17601.
11. R. C. Armstrong et al., ibid., p. 16850.
12. S. Shimizu, Y. Eguchi, W. Kamiike, H. Matsuda, Y. Tsujimoto, Oncogene 12, 2251 (1996).
13. D. D. Newmeyer, D. M. Farschon, J. C. Reed, Cell 79, 353 (1994).
14. S. J. Martin et al., EMBO J. 14, 5191 (1995).
15. S. C. Cosulich, S. Green, P. R. Clarke, Curr. Biol. 6, 997 (1996).
16. R. M. Kluck, S. J. Martin, D. R. Green, D. D. Newmeyer, in preparation.
17. Y. A. Lazebnik, S. Cole, C. A. Cooke, W. G. Nelson, W. C. Earnshaw, J. Cell Biol. 123, 7 (1993).
18. Y. A. Lazebnik, S. H. Kaufmann, S. Desnoyers, G. G. Poirier, W. C. Earnshaw, Nature 371, 346 (1994).
19. M. Enari, H. Hug, S. Nagata, ibid. 375, 78 (1995).
20. A. Takahashi et al., Proc. Natl. Acad. Sci. U.S.A. 93, 8395 (1996).
21. X. Liu, C. N. Kim, J. Yang, R. Jemmerson, X. Wang, Cell 86, 147 (1996).
22. A. Mayer, W. Neupert, R. Lill, J. Biol. Chem. 270, 12390 (1995).
23. M. E. Dumont, T. S. Cardillo, M. K. Hayes, F. Sherman, Mol. Cell. Biol. 11, 5487 (1991).
24. S. J. Martin et al., J. Biol. Chem. 270, 6425 (1995).
25. S. J. Martin, D. M. Finucane, G. P. Amarante-Mendes, G. A. O'Brien, D. R. Green, ibid. 271, 28753 (1996).
26. R. M. Kluck, E. Bossy-Wetzel, D. R. Green, D. D. Newmeyer, data not shown.
27. P. X. Petit et al., J. Cell Biol. 130, 157 (1995).
28. N. Zamzami et al., J. Exp. Med. 181, 1661 (1995).
29. S. Shimizu et al., Oncogene 13, 21 (1996).
30. M. Zoratti and I. Szabo, Biochim. Biophys. Acta 1241, 139 (1995).
31. N. Zamzami et al., J. Exp. Med. 182, 367 (1995).
32. P. Marchetti et al., ibid. 184, 1155 (1996).
33. N. Zamzami et al., ibid. 183, 1533 (1996).
34. J. G. Pastorino et al., J. Biol. Chem. 271, 29792 (1996).
35. S. A. Susin et al., J. Exp. Med. 184, 1331 (1996).
36. D. M. Farschon, C. Couture, T. Mustelin, D. D. Newmeyer, in preparation.
37. J. Yuan and H. R. Horvitz, Dev. Biol. 138, 33 (1990).
38. K. Kuida et. al., Nature 384, 368 (1996).
39. S. W. Muchmore et al., ibid. 381, 335 (1996).
40. B. A. Vance, C. M. Zacharchuk, D. M. Segal, J. Biol. Chem. 271, 30811 (1996).
41. G. Baffy, T. Miyashita, J. R. Williamson, J. C. Reed, ibid. 268, 6511 (1993).
42. M. Lam et al., Proc. Natl. Acad. Sci. U.S.A. 91, 6569 (1994).
43. M. Zörnig et al., Oncogene 11, 2165 (1995).
44. C. W. Distelhorst, M. Lam, T. S. McCormick, ibid. 12, 2051 (1996).
45. M. C. Marin et al., ibid., p. 2259.
46. A. N. Murphy, D. E. Bredesen, G. Cortopassi, E. Wang, G. Fiskum, Proc. Natl. Acad. Sci. U.S.A. 93, 9893 (1996).
47. W. Zhu et al., EMBO J. 15, 4130 (1996).
48. H.-G. Wang, U. R. Rapp, J. C. Reed, Cell 87, 629 (1996).
49. M. L. Baba, L. L. Darga, M. Goodman. J. Czelusniak, J. Mol. Evol. 17, 197 (1996).
50. A. J. Rivett, P. J. Savory, H. Djaballah, Methods Enzymol. 244, 331 (1994).
51. S. J. Martin et al., J. Exp. Med. 182, 1545 (1995).
52. We thank R. Jemmerson, J. Reed, D. Farschon, G. Corradin, and B. Singh for reagents; S. Martin, G. Amarante-Mendes, H. M. Beere, and T. Gunter for helpful discussions, critical reading of the manuscript, or both; and M. Schibler, B. Ranscht, and E. Koller for help with confocal microscopy. Supported by grants from the American Cancer Society (DB-97 to D.D.N.), NIH (grants GM50284 to D.D.N. and GM52735 and CA69381 to D.R.G.), and from the Swiss National Science Foundation (fellowship 823A-046638 to E.B.-W.).