A combinatorial approach defines specificities of members of the caspase family and granzyme B: Functional relationships established for key mediators of apoptosis

Journal of Biological Chemistry

Volumn 272, Issue 29, 1997, Pages 17907-17911

  Thornberry, Nancy A ^a   Rano, Thomas A ^a   Peterson, Erin P ^a   Rasper, Dita M ^b   Timkey, Tracy ^a   Garcia Calvo, Margarita ^a   Houtzager, Vicky M ^b   Nordstrom, Penny A ^b   Roy, Sophie ^b   Vaillancourt, John P ^b   Chapman, Kevin T ^a   Nicholson, Donald W ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; GRANZYME B; INTERLEUKIN 1BETA CONVERTING ENZYME;

APOPTOSIS; ARTICLE; CAENORHABDITIS ELEGANS; CELL DEATH; CYTOTOXIC T LYMPHOCYTE; DNA SEQUENCE; EFFECTOR CELL; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HOMEOSTASIS; MEDIATOR RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CASPASES; CYSTEINE ENDOPEPTIDASES; GRANZYMES; HUMANS; MAMMALS; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY;

CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 0030849093     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.29.17907     Document Type: Article

References (42)

1. Ellis, R. E., Yuan, J., and Horvitz, H. R. (1991) Annu. Rev. Cell Biol. 7, 663-698
2. Thompson, C. B. (1995) Science 267, 1456-1462
3. Yuan, J., Shaham, S., Ledoux, S., Ellis, H. M., and Horvitz, H. R. (1993) Cell 75, 641-652
4. Alnemri, E. S., Livingston, D. J., Nicholson, D. W., Salvesen, G., Thornberry, N. A., Wong, W. W., and Yuan, J. (1996) Cell 87, 171
5. Pinilla, C., Appel, J. R., Blanc, P., and Houghten, R. A. (1992) Biotechniques 13, 901-905
6. Rano, T. A., Timkey, T., Peterson, E. P., Rotonda, J., Nicholson, D. W., Becker, J. W., Chapman, K. T., and Thornberry, N. A. (1997) Chem. Biol. 4, 149-155
7. Rotonda, J., Nicholson, D. W., Fazil, K. M., Gallant, M., Gareau, Y., Labelle, M., Peterson, E. P., Rasper, D. M., Ruel, R., Vaillancourt, J. P., Thornberry, N. A., and Becker, J. W. (1996) Nat. Struct. Biol. 3, 619-625
8. Hanna, W. L., Zhang, X., Turbov, J., Winkler, U., Hudig, D., and Froelich, C. J. (1993) Protein Expression Purif. 4, 398-404
9. Quan, L. T., Caputo, A., Bleackley, R. C., Pickup, D. J., and Salvesen, G. S. (1995) J. Biol. Chem. 270, 10377-10379
10. Shi, L., Kam, C.-M., Powers, J. C., Aebersold, R., and Greenberg, A. H. (1992) J. Exp. Med. 176, 1521-1529
11. Odake, S., Kam, C.-M., Narasimhan, L., Poe, M., Blake, J. T., Krahenbuhl, O., Tschopp, J., and Powers, J. C. (1991) Biochemistry 30, 2217-2227
12. Wilson, K. P., Black, J. F., Thomson, J. A., Kim, E. E., Griffith, J. P., Navia, M. A., Murcko, M. A., Chambers, S. P., Aldape, R. A., Raybuck, S. A., and Livingston, D. J. (1994) Nature 370, 270-275
13. Walker, N. P. C., Talanian, R. V., Brady, K. D., Dang, L. C., Bump, N. J., Ferenz, C. R., Franklin, S., Ghayur, T., Hackett, M. C., Hammill, L. D., Herzog, L., Hugunin, M., Houy, W., Mankovich, J. A., McGuiness, L., Orlewicz, E., Paskind, M., Pratt, C. A., Reis, P., Summani, A., Terranova, M., Welch, J. P., Xiong, L., Moller, A., Tracey, D. E., Kamen, R., and Wong, W. W. (1994) Cell 78, 343-352
14. Wang, X., Pai, J., Wiedenfeld, E. A., Medina, J. C., Slaughter, C. A., Goldstein, J. L., and Brown, M. S. (1995) J. Biol. Chem. 270, 18044-18050
15. Na, S., Chuang, T.-H., Cunningham, A., Turi, T. G., Hanke, J. H., Bokoch, G. M., and Danley, D. E. (1996) J. Biol. Chem. 271, 11209-11213
16. Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G., and Earnshaw, W. C. (1994) Nature 371, 346-347
17. Casuola-Rosen, L. A., Nicholson, D. W., Chong, T., Rowan, K. R., Thornberry, N. A., Miller, D. K., and Rosen, A. (1996) J. Exp. Med. 183, 1957-1964
18. Emoto, Y., Manome, Y., Meinhardt, G., Kisaki, H., Kharbanda, S., Robertson, M., Ghayur, T., Wong, W. W., Kamen, R., Weichselbaum, R., and Kufe, D. (1995) EMBO J. 14, 6148-6156
19. Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., Lazebnik, Y. A., Munday, N. A., Raju, A. M., Smulson, M. E., Yamin, T.-T., Yu, V. L., and Miller, D. K. (1995) Nature 376, 37-43
20. Kuida, K., Zheng, T. S., Na, S., Kuan, C., Yang, D., Karasuyama, H., Rakic, P., and Flavell, R. A. (1996) Nature 384, 368-372
21. Darmon, A. J., Nicholson, D. W., and Bleackley, R. C. (1995) Nature 377, 446-448
22. Martin, S. J., Amarante-Mendes, G. P., Shi, L., Chuang, T.-H., Casiano, C. A., O'Brien, G. A., Fitzgerald, P., Tan, E. M., G. M., B., Greenberg, A. H., and Green, D. R. (1996) EMBO J. 15, 2407-2416
23. Quan, L. T., Tewari, M., O'Rourke, K., Dixit, V., Snipas, S. J., Poirier, G. G., Ray, C., Pickup, D. J., and Salvesen, G. S. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 1972-1976
24. Fernandes-Alnemri, T., Armstrong, R. C., Krebs, J., Srinivasula, S. M., Wang, L., Bullrich, F., Fritz, L. C., Trapani, J. A., Tomaselli, K. J., Litwack, G., and Alnemri, E. S. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 7464-7469
25. Duan, H., Chinnaiyan, A. M., Hudson, P. L., Wing, J. P., Wei-Wu, H., and Dixit, V. M. (1996) J. Biol. Chem. 271, 1621-1625
26. Duan, H., Orth, K., Chinnaiyan, A. M., Poirier, G. G., Froelich, C. J., He, W.-W., and Dixit, V. M. (1996) J. Biol. Chem. 271, 16720-16724
27. Orth, K., Chinnaiyan, A. M., Garg, M., Froelich, C. J., and Dixit, V. M. (1996) J. Biol. Chem. 271, 16443-16446
28. Chinnaiyan, A. M., Hanna, W. L., Orth, K., Duan, H., Poirier, G. G., Froelich, C. J., and Dixit, V. M. (1996) Curr. Biol. 6, 897-899
29. Orth, K., O'Rourke, K., Salvesen, G. S., and Dixit, V. M. (1996) J. Biol. Chem. 271, 20977-20980
30. Boldin, M. P., Goncharov, T. M., Goltsev, Y. V., and Wallach, D. (1996) Cell 85, 803-815
31. Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., Mann, M., Krammer, P. J., Peter, M. E., and Dixit, V. M. (1996) Cell 85, 817-827
32. Enari, M., Talanian, R. V., Wong, W. W., and Nagata, S. (1996) Nature 380, 723-726
33. Takahashi, A., Alnemri, E. S., Lazebnik, Y. A., Fernandes-Alnemri, T., Litwack, G., Moir, R. D., Goldman, R. D., Poirier, G. G., Kaufmann, S. H., and Earnshaw, W. C. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 8395-8400
34. Van Criekinge, W., Beyaert, R., Van de Craen, M., Vandenabeele, P., Schotte, P., De Valck, D., and Fiers, W. (1996) J. Biol. Chem. 271, 27245-27248
35. Kuida, K., Lippke, J. A., Ku, F., Harding, M. W., Livingston, D. J., Su, M. S.-S., and Flavell, R. A. (1995) Science 267, 2000-2003
36. Li, P., Allen, H., Banerjee, S., Franklin, S., Herzog, L., Johnston, C., McDowell, J., Paskind, M., Rodman, L., Salfeld, J., Towne, E., Tracey, D., Wardwell, S., Wei, F.-Y., Wong, W., Kamen, R., and Seshadri, T. (1995) Cell 80, 401-411
37. Gu, Y., Kuida, K., Tsutsui, H., Ku, G., Hsiao, K., Fleming, M. A., Hayashi, N., Higashino, K., Okamura, H., Nakanishi, K., Kurimoto, M., Tanimoto, T., Flavell, R. A., Sato, V., Harding, M. W., Livingston, D. J., and Su, M. S.-S. (1997) Science 275, 206-209
38. Srinivasula, S. M., Fernandes-Alnemri, T., Zangrilli, J., Robertson, N., Armstrong, R. C., Wang, L., Trapani, J. A., Tomaselli, K. J., Litwack, G., and Alnemri, E. S. (1996) J. Biol. Chem. 271, 27099-27106
39. Ramage, P., Cheneval, D., Chvei, M., Graff, P., Hemmig, R., Heng, R., Kocher, H. P., Mackenzie, A., Memmert, K., Revesz, L., and Wishart, W. (1995) J. Biol. Chem. 270, 9378-9383
40. Yamin, T. T., Ayala, J. M., and Miller, D. K. (1996) J. Biol. Chem. 271, 13273-13282
41. Howard, A. D., Kostura, M. J., Thornberry, N., Ding, G. J. F., Limjuco, G., Weidner, J., Salley, J. P., Hogquist, K. A., Chaplin, D. D., Mumford, R. A., Schmidt, J. A., and Tocci, M. J. (1991) J. Immunol. 147, 2964-2969
42. Goldberg, Y. P., Nicholson, D. W., Rasper, D. M., Kalchman, M. A., Koide, H. B., Graham, R. K., Bromm, M., Kazemi-Esfarjani, P., Thornberry, N. A., Vaillancourt, J. P., and Hayden, M. R. (1996) Nat. Genet. 13, 442-449