Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

Journal of Biological Chemistry

Volumn 273, Issue 15, 1998, Pages 9158-9167

  Wellington, Cheryl L ^a   Ellerby, Lisa M ^b   Hackam, Abigail S ^a   Margolis, Russell L ^c   Trifiro, Mark A ^d   Singaraja, Roshni ^a   McCutcheon, Krista ^a   Salvesen, Guy S ^b   Propp, Stephanie S ^b   Bromm, Michael ^a   Rowland, Kathleen J ^a   Zhang, Taiqi ^a   Rasper, Dita ^e   Roy, Sophie ^e   Thornberry, Nancy ^f   Pinsky, Leonard ^d   Kakizuka, Akira ^g   Ross, Christopher A ^c   Nicholson, Donald W ^e   Bredesen, Dale E ^b   Hayden, Michael R ^a,h   more..

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b BURNHAM INSTITUTE   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MCGILL UNIVERSITY   (Canada)

^e MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^f MERCK RESEARCH LABORATORIES   (United States)

^g The Fourth Department Osaka Biosciences Institute   (Japan)

^h BC CHILDREN S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; ENZYME; POLYGLUTAMIC ACID; UNCLASSIFIED DRUG;

ARTICLE; ENZYME CONFORMATION; ENZYME DEGRADATION; HUMAN; HUNTINGTON CHOREA; NERVE DEGENERATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION;

AMINO ACID SEQUENCE; APOPTOSIS; CASPASE 1; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CASPASES; CYSTEINE ENDOPEPTIDASES; HUMANS; JURKAT CELLS; KINETICS; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; NUCLEAR PROTEINS; OSTEOSARCOMA; PEPTIDES; RECEPTORS, ANDROGEN; REPRESSOR PROTEINS; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY; TRINUCLEOTIDE REPEATS; TUMOR CELLS, CULTURED;

EID: 0032502715     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.15.9158     Document Type: Article

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