The presenilins

Neuroscientist

Volumn 5, Issue 2, 1999, Pages 112-124

  Mattson, Mark P ^a,b   Guo, Qing ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Amyloid peptide; Apoptosis; Excitotoxicity; Mitochondrial transmembrane potential; Muscarinic cholinergic; Reactive oxygen species

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; CHROMOSOME 1; CHROMOSOME 14; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE LOCATION; MOLECULAR GENETICS; NONHUMAN; PATHOGENESIS; PROTEIN ANALYSIS; RAT; REVIEW;

EID: 0032964702     PISSN: 10738584     EISSN: None     Source Type: Journal    
DOI: 10.1177/107385849900500215     Document Type: Review

References (61)

1. Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 1995;375:754-760.
2. Levy-Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 1995;269:973-977.
3. Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 1995;376:775-778.
4. Hardy J. Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci 1997;20:154-159.
5. Seeger M, Nordstedt C, Petanceska S, Kovacs DM, Gouras GK, Hahne S, et al. Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proc Natl Acad Sci U S A 1997;94:5090-5094.
6. Walter J, Capell A, Grunberg J, Pesold B, Schindzielorz A, Prior R, et al. The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Mol Med 1996;2:673-691.
7. De Strooper B, Beullens M, Contreras B, Levesque L, Craessaerts K, Cordell B, et al. Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins. J Biol Chem 1997;272:3590-3598.
8. Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, et al. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 1996;17:181-190.
9. Hartmann H, Busciglio J, Baumann KH, Staufenbiel M, Yankner BA. Developmental regulation of presenilin-1 processing in the brain suggests a role in neuronal differentiation. J Biol Chem 1997;272:14505-14508.
10. Cook DB, Sung JC, Golde TE, Felsenstein KM, Wojczyk BS, Tanzi RE, et al. Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites. Proc Natl Acad Sci U S A 1996;93:9223-9228.
11. Elder GA, Tezapsidis N, Carter J, Shioi J, Bouras C, Li HC, et al. Identification and neuron specific expression of the S182/presenilin 1 protein in human and rodent brains. J Neurosci Res 1996;45:308-320.
12. Page K, Hollister R, Tanzi RE, Hyman BT. In situ hybridization of presenilin 1 mRNA in Alzheimer's disease and lesioned rat brain. Proc Natl Acad Sci U S A 1996;93:14020-14024.
13. Berezovska O, Xia MQ, Page K, Wasco W, Tanzi RE, Hyman BT. Developmental regulation of presenilin mRNA expression parallels notch expression. J Neuropathol Exp Neurol 1997;56:40-44.
14. Busciglio J, Hartmann H, Lorenzo A, Wong C, Baumann K, Sommer B, et al. Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease. J Neurosci 1997;17:5101-5107.
15. Rogaev EI, Sherrington R, Wu C, Levesque G, Liang Y, Rogaeva EA, et al. Analysis of the 5′ sequence, genomic structure, and alternative splicing of the presenilin-1 gene associated with early onset Alzheimer's disease. Genomics 1997;40:415-424.
16. Uchihara T, el Hachimi HK, Duyckaerts C, Foncin JF, Fraser PE, Levesque L, et al. Widespread immunoreactivity of presenilin in neurons of normal and Alzheimer's disease brains: double-labeling immunohistochemical study. Acta Neuropathol 1996;92:325-330.
17. Giannakopoulos P, Bouras C, Kovari E, Shioi J, Tezapsidis N, Hof PR, et al. Presenilin-1 immunoreactive neurons are preserved in late-onset Alzheimer's disease. Am J Pathol 1997;150:429-436.
18. Murphy GM Jr, Forno LS, Ellis WG, Nochlin D, Levy-Lahad E, Poorkaj P, et al. Antibodies to presenilin proteins detect neurofibrillary tangles in Alzheimer's disease. Am J Pathol 1996;149:1839-1846.
19. Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S. Skeletal and CNS defects in Presenilin-1-deficient mice. Cell 1997;89:629-639.
20. Wong PC, Zheng H, Chen H, Becher MW, Sirinathsinghji DJ, Trumbauer ME, et al. Presenilin 1 is required for Notch1 and D111 expression in the paraxial mesoderm. Nature 1997;387:288-292.
21. Conlon RA, Reaume AG, Rossant J. Notch1 is required for the coordinate segmentation of somites. Development 1995;121:1533-1545.
22. Levitan D, Doyle TG, Brousseau D, Lee MK, Thinakaran G, Slunt HH, et al. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc Natl Acad Sci U S A 1996;93:14940-14944.
23. Guo Q, Fu W, Sopher BL, et al. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nat Med 1999;5:101-106.
24. Weidemann A, Paliga K, Durrwang U, Czech C, Evin G, Masters CL, et al. Formation of stable complexes between two Alzheimer's disease gene products, presenilin-2 and b-amyloid precursor protein. Nature Med 1997;3:328-332.
25. Xia W, Zhang J, Perez R, Koo EH, Selkoe DJ. Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer's disease. Proc Natl Acad Sci U S A 1997;94:8208-8213.
26. Zhou J, Liyangage U, Medina M, Ho C, Simmons AD, Lovett M, et al. Presenilin 1 interaction in the brain with a novel member of the Armadillo family. Neuroreport 1997;8:1489-1494.
27. Zhang W, Han SW, McKeel DW, Goate A, Wu JY. Interaction of presenilins with the filamin family of actin-binding proteins. J Neurosci 1998;18:914-922.
28. Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, et al. The amyloid β protein deposited in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med 1996;2:864-870.
29. Price DL, Sisodia SS. Mutant genes in familial Alzheimer's disease and transgenic models. Annu Rev Neurosci 1998;21:479-505.
30. Furukawa K, Fu W, Witke W, Kwiatkowski DJ, Mattson MP. The actin-severing protein gelsolin modulates calcium channel activity and vulnerability to excitotoxicity in hippocampal neurons. J Neurosci 1997;17:8178-8186.
31. Guo Q, Furukawa K, Sopher BL, Pham DG, Xie J, Robinson N, et al. Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid b-peptide. Neuroreport 1996;8:379-383.
32. Guo Q, Christakos S, Robinson N, Mattson MP. Calbindin blocks the pro-apoptotic actions of mutant presenilin-1: reduced oxidative stress and preserved mitochondrial function. Proc Natl Acad Sci USA 1998;95:3227-3232.
33. Duff K, Eckman C, Zehr C, Yu X, Prada CM, Perez-Tur J, et al. Increased amyloid-b42(43) in brains of mice expressing mutant presenilin 1. Nature 1996;383:710-713.
34. Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron 1996;17:1005-1013.
35. Mattson MP, Furukawa K, Bruce AJ, Mark RJ, Blanc EM. Calcium homeostasis and free radical metabolism as convergence points in the pathophysiology of dementia. In: Wasco W, Tanzi R, editors. Molecular mechanisms of dementia. Totowa (NJ): Humana Press; 1996. p. 103-143.
36. Gabuzda D, Busciglio J, Chen L, Matsudaira P, Yankner BA. Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol Chem 1994;269:13623-13628.
37. Querfurth HW, Selkoe DJ. Calcium ionophore increases amyloid β peptide production by cultured cells. Biochemistry 1994;33:4550-4561.
38. Guo Q, Sopher BL, Furukawa K, Pham DG, Robinson N, Martin GM, et al. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid β-peptide: involvement of calcium and oxyradicals. J Neurosci 1997;17:4212-4222.
39. Keller JN, Guo Q, Holtsberg FW, Bruce-Keller AJ, Mattson MP. Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production. J Neurosci 1998;18:4439-4450.
40. Furukawa K, Sopher B, Rydel RE, Begley JG, Martin GM, Mattson MP. Increased activity-regulating and neuroprotective efficacy of α-secretase-derived secreted APP is conferred by a C-terminal heparin-binding domain. J Neurochem 1996;67:1882-1896.
41. Mattson MP. Cellular actions of β-amyloid precursor protein, and its soluble and fibrillogenic peptide derivatives. Physiol Rev 1997;77:1081-1132.
42. Guo Q, Robinson N, Mattson MP. Secreted APPα counteracts the pro-apoptotic action of mutant presenilin-1 by activation of NF-κB and stabilization of calcium homeostasis. J Biol Chem 1998;273:12341-12351.
43. Mattson MP, Goodman Y, Luo H, Fu W, Furukawa K. Activation of NF-kB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of Mn-SOD and suppression of peroxynitrite production and protein tyrosine nitration. J Neurosci Res 1997;49:681-697.
44. Ancolio K, Marambaud P, Dauch P, Checler F. a-secretase-derived product of β-amyloid precursor protein is dereased by presenilin-1 mutations linked to familial Alzheimer's disease. J Neurochem 1997;69:2494-2499.
45. Cotman CW, Su JH. Mechanisms of neuronal death in Alzheimer's disease. Brain Pathol. 1996;6:493-506.
46. Deng G, Pike CJ, Cotman CW. Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells. FEBS Lett 1996;397:50-54.
47. Wolozin B, Iwasaki K, Vito P, Ganjei JK, Lacana E, Sunderland T, et al. Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science 1996;274:1710-1713.
48. Mattson MP, Robinson N, Guo Q. Estrogens stabilize mitochondrial function and protect neural cells against the pro-apoptotic action of mutant presenilin-1. Neuroreport 1997;8:3817-3821.
49. Kim T-W, Pettingell WH, Jung Y-K, Kovacs DM, Tanzi RE. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 1997;277:373-376.
50. Sells SF, Han SS, Muthukkumar S, Maddiwar N, Johnstone R, Boghaert E, et al. Expression and function of the leucine zipper protein Par-4 in apoptosis. Mol Cell Biol 1997;17:3823-3832.
51. Guo Q, Fu W, Xie J, Luo H, Sells SF, Geddes JW, et al. Par-4 is a novel mediator of neuronal degeneration associated with the pathogenesis of Alzheimer's disease. Nat Med 1998;4:957-962.
52. 2+ mobilization is altered in fibroblasts from patients with Alzheimer disease. Proc Natl Acad Sci U S A 1994;91:534-538.
53. Liguri G, Cecchi C, Latorraca S, Pieri A, Sorbi S, Degl'Innocenti D, et al. Alteration of acylphosphatase levels in familial Alzheimer's disease fibroblasts with presenilin gene mutations. Neurosci Lett 1996;210:153-156.
54. Haug LS, Ostvold AC, Cowburn RF, Garlind A, Winblad B, Bogdanovich N, et al. Decreased inositol (1,4,5)-trisphosphate receptor levels in Alzheimer's disease cerebral cortex: selectivity of changes and possible correlation to pathological severity. Neurodegeneration 1996;5:169-176.
55. Mattson MP, Fu W, Waeg G, Uchida K. 4-hydroxynonenal, a product of lipid peroxidation, inhibits dephosphorylation of the microtubule-associated protein tau. NeuroReport 1997;8:2275-2281.
56. Bear MF, Malenka RC. Synaptic plasticity: LTP and LTD. Curr Opin Neurobiol 1994;4:389-399.
57. Benzi G, Moretti A. Mitochondrial alterations in brain aging. In: Mattson MP, Geddes JW, editors. Advances in cell aging and gerontology. Vol. 2. The aging brain. Greenwich (CT): JAI Press; 1997. p. 129-160.
58. Mattson MP. Mother's legacy: mitochondrial DNA mutations and Alzheimer's disease. Trends Neurosci 1997;20:373-375.
59. Kelly JF, Roth GS. Changes in neurotransmitter signal transduction pathways in the aging brain. In: Mattson MP, Geddes JW, editors. Advances in cell aging and gerontology. Vol. 2. The aging brain. Greenwich (CT): JAI Press; 1997. p. 243-278.
60. Pedersen WA, Guo Q, Hartman BK, Mattson MP. NGF-independent reduction in choline acetyltransferase activity in PC12 cells expressing mutant presenilin-1. J Biol Chem 1997;272:22397-22400.
61. Furukawa K, Guo Q, Schellenberg GD, Mattson MP. Presenilin-1 mutation alters NGF-induced neurite outgrowth, calcium homeostasis, and transcription factor (AP-1) activation in PC12 cells. J Neurosci Res 1998;52:618-624.