Substrate and inhibitor specificity of interleukin-1β-converting enzyme and related caspases

Journal of Biological Chemistry

Volumn 272, Issue 11, 1997, Pages 7223-7228

  Margolin, Nara ^a   Raybuck, Scott A ^a   Wilson, Keith P ^a   Chen, Wenyong ^a   Fox, Ted ^a   Gu, Yong ^a   Livingston, David J ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYSTEINE PROTEINASE; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; RECOMBINANT ENZYME;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL CULTURE; CRYSTAL STRUCTURE; ENZYME INHIBITION; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME SPECIFICITY; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY;

ANIMALS; CAENORHABDITIS ELEGANS; CASPASE 1; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; ENZYME INHIBITORS; KINETICS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

ANIMALIA; CAENORHABDITIS ELEGANS; NAVIA;

EID: 0030897988     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.11.7223     Document Type: Article

References (43)

1. Alnemri, E. S., Livingston, D. J., Nicholson, D. W., Salvesen, G., Thornberry, N. A., Wong, W. W., and Yuan, J. (1996) Cell 87, 171
2. Cerretti, D. P., Kozlosky, C. J., Mosley, B., Nelson, N., VanNess, K., Greenstreet, T. A., March, C. J., Kronheim, S. R., Druck, T., Cannizzaro, L. A., Huebner, K., and Black, R. A. (1992) Science 256, 97-100
3. Thornberry, N. A., Bull, H. G., Calaycay, J. R., Chapman, K. T., Howard, A. D., Kosture, M. J., Miller, D. K., Molineaux, S. M., Weidner, J. R., Aunins, J., Ellison, K. O., Ayala, J. M., Casano, F. J., Chin, J., Ding, J.-F. G., Egger, L. A., Gaffney, E. P., Limjuco, G., Palyha, O. C., Raju, S. M., Rolando, A. M., Salley, J. P., Yamin, T.-T., Lee, T. D., Shively, J. E., MacCross, M., Mumford, R. A., Schmidt, J. A., and Tocci, M. J. (1992) Nature 356, 768-774
4. Wilson, K. P., Black, J.-A. F., Thomson, J. A., Kim, E. E., Griffith, J. P., Navia, M. A., Mureko, M. A., Chambers, S. P., Aldape, R. A., Raybuck, S. A., and Livingston, D. J. (1994) Nature 370, 270-275
5. Walker, N. P. C., Talanian, R. V., Brady, K D., Dang, L. C., Bump, N. J., Ferenz, C. R., Franklin, S., Ghayur, T., Hackett, M. C., and Hammill, L. D. (1994) Cell 78, 343-352
6. Gu, Y., Sarnecki, C., Aldape, R. A., Livingston, D. J., and Su, M. S.-S. (1995) J. Biol. Chem. 270, 18715-18718
7. Tewari, M., Quan, L. T., O'Rourke, K., Desnoyers, D., Zeng, Z., Beidler, D. R., Poirer, G. G., Salvesen, G. S., and Dixit, V. M. (1995) Cell 81, 801-809
8. Black, R. A., Kronheim, S. R., Cantrell, M., Deeley, M. C., March, C. J., Prickett, K. S., Wignall, J., Conlon, P. J., Cosman, D., Hopp, T. P., and Mochizuki, D. Y. (1988) J. Biol. Chem. 263, 9437-9442
9. Yuan, J., Shaham, S., Ledoux, S., Ellis, H. M., and Horvitz, H. R. (1993) Cell 75, 641-652
10. Muira, M., Zhu, H., Rotello, R., Hartweig, E. A., and Yuan, J. (1993) Cell 75, 653-660
11. Gagliardi, V., Fernandez, P. A., Lee, R. K, Drexier, H. C., Rotello, R. J., Fishman, M. C., and Yuan, J. (1994) Science 263, 826-828
12. Kuida, K., Lippke, J. A., Ku, G., Harding, M. W., Livingston, D. J., Su, M. S.-S., and Flavell, R. A. (1995) Science 267, 2000-2003
13. Kumar, S. (1995) Trends Biochem. Sci. 20, 198-202
14. Takahashi, A., and Earnshaw, W. C. (1996) Curr. Opin. Genet. Dev. 6, 50-56
15. Faucheu, C., Diu, A., Chan, A. W., Blanchet, A. M., Miossec, C., Herve, F., Collard-Dutilleul, V., Gu, Y., Aldape, R. A., Lippke, J. A., Rochet, C., Su, M. S.-S., Livingston, D. J., Hercend, T., and Lalanne, J.-L. (1995) EMBO J. 14, 1914-1922
16. Kamens, J., Paskind, M., Hugunin, M., Talanian, R. V., Allen, H., Banach, D., Bump, N., Hackett, M., Johnston, C. G., Li, P., Mankovich, J. A., Terranova, M., and Ghayur, T. (1995) J. Biol. Chem. 270, 15250-15256
17. Munday, N. A., Vaillancourt, J. P., Ali, A., Casano, F. J., Miller, D. K., Molineaux, S. M., Yamin, T.-T., Yu, V. L., and Nicholson, D. W (1995) J. Biol. Chem. 270, 15870-15876
18. Faucheu, C., Blanchet, A.-M., Collard-Dutilleul, V., Lalanne, J.-L., and Diu-Hercend, A. (1996) Eur. J. Biochem. 236, 207-213
19. Wang, L., Muira, M., Bergeron, L., Zhu, H., and Yuan, J. (1994) Cell 78, 739-750
20. Kumar, S., Kinoshita, M., Noda, M., Copelan, N. G., and Jenkins, N. A. (1994) Genes Dev. 8, 1613-1626
21. Fernandes-Alnemri, T., Litwack, G., and Alnemri, E. S. (1994) J. Biol. Chem. 269, 30761-30764
22. Fernandes-Alnemri, T., Litwack, G., and Alnemri, E. S. (1995) Cancer Res. 55, 2737-2742
23. Lippke, J. A., Gu, Y., Sarnecki, C., Caron, P. R., and Su, M. S.-S. (1996) J. Biol. Chem. 271, 1825-1828
24. Fernandes-Alnemri, T., Takahashi, A., Armstrong, R., Krebs, J., Fritz, L., Tomaselli, K. J., Wang, L., Yu, Z., Croces, C. M., Salveson, G., Earnshaw, W. C., Litwack, G., and Alnemri, E. S. (1995) Cancer Res. 55, 6045-6052
25. Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., Lazebnik, Y. A., Munday, N. A., Raju, S. M., Smulson, M. E., Yamin, T.-T., Yu, V. L., and Miller, D. K. (1995) Nature 376, 37-43
26. Slee, E. A., Zhu, H., Chow, S. C., MacFarlane, M., Nicholson, D. W., and Cohen, G. M. (1996) Biochem J. 315, 21-24
27. Liu, X., Kim, C. N., Pohl, J., and Wang, X. (1996) J. Biol. Chem. 271, 13371-13376
28. Thornberry, N. A. (1994) Methods Enzymol. 244, 615-631
29. Enari, M., Hug, H., and Nagata, S. (1995) Nature 375, 78-81
30. Schlegel, J., Peters, I., Orrenius, S., Miller, D. K., Thornberry, N. A., Yamin, T.-T., and Nicholson, D. W. (1996) J. Biol. Chem. 271, 1841-1844
31. Hasegawa, J., Kamada, S., Kamiike, W., Shimizu, S., Imazu, T., Mtsuda. H., and Tsujimoto, Y. (1996) Cancer Res. 56, 1713-1718
32. Cain, K., Inayat-Hussain, S. H., Couet, C., and Cohen, G. M. (1996) Biochem. J. 314, 27-32
33. Chen, W., Raybuck, S. A., Fulghum, J. R., Petrillo, R. A., Margolin, N . and Chambers, S. P. (1997) Protein Exp. Purif., in press
34. Mullican, M. D., Lauffer, D. J., Gillespie, R. J., Matharu, S. S., Kay, D., Porritt, G. M., Evans, P. L., Golec, J. M. C., Murcko, M. A., Luong, Y.-P., Raybuck, S. A., and Livingston, D. J. (1994) Bioorg. & Med. Chem. Lett. 4, 2359-2364
35. Morrison, J. F. (1969) Biochim. Biophys. Acta 185, 269-286
36. Morrison, J. F. (1985) Comments Mol. Cell. Biophys. 2, 347-368
37. Thornberry, N. A., Peterson, E. P., Zhao, J. J., Howard, A. D., Griffin, P. R, and Chapman, K. T. (1994) Biochemistry 33, 3934-3940
38. Brunger, A. T. (1992) XPLOR Version 3.1 Manual, Yale University Press, New Haven, CT
39. Pennington, M. W., and Thornberry, N. A. (1994) Peptide Res. 7, 72-76
40. Dolle, R. E., Hoyer, D., Prasad, C. V. C., Schmidt, S. J., Helaszek, C. T., Miller, R. E., and Ator, M. A. (1994) J. Med. Chem. 37, 563-564
41. Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirer, G. G., and Earnshaw, W. C. (1994) Nature 371, 346-347
42. Lindahl, T., Satoh, M. S., Poirier, G. G., and Klungland, A. (1995) Trends Biochem. Sci. 20, 405-412
43. Wang, Z.-Q., Auer, B., Stingl, L., Berghammer, H., Haidacher, D., Schweiger, M., and Wagner, E. F. (1995) Genes Dev. 9, 509-520