The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism

EMBO Journal

Volumn 15, Issue 10, 1996, Pages 2407-2416

  Martin, Seamus J ^a   Amarante Mendes, Gustavo P ^a   Shi, Lianfa ^b   Chuang, Tsung Hsien ^c   Casiano, Carlos A ^c   O'Brien, Geraldine A ^a   Fitzgerald, Patrick ^a   Tan, Eng M ^c   Bokoch, Gary M ^c   Greenberg, Arnold H ^b   Green, Douglas R ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b UNIVERSITY OF MANITOBA   (Canada)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Apoptosis; Cell free; Cpp32; Granzyme B; Proteolysis

Indexed keywords

ENZYME PRECURSOR; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; PROTEINASE; VIRUS PROTEIN;

APOPTOSIS; ARTICLE; CELL FREE SYSTEM; CONTROLLED STUDY; COWPOX VIRUS; CYTOTOXIC LYMPHOCYTE; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PROCESSING;

EID: 9344261615     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00598.x     Document Type: Article

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