Targeting nitric oxide (NO) delivery in vivo. Design of a liver- selective NO donor prodrug that blocks tumor necrosis factor-α-induced apoptosis and toxicity in the liver

Journal of Medicinal Chemistry

Volumn 40, Issue 13, 1997, Pages 1947-1954

  Saavedra, Joseph E ^a   Billiar, Timothy R ^b   Williams, Debra L ^b   Kim, Young Myeong ^b   Watkins, Simon C ^b   Keefer, Larry K ^c  

^a SAIC FREDERICK INC   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP; DIAZENIUMDIOLATE; GALACTOSAMINE; NITRIC OXIDE; O2 VINYL 1 (PYRROLIDIN 1 YL)DIAZEN 1 IUM 1,2 DIOLATE; PRODRUG; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; ENZYME ACTIVITY; LIVER FAILURE; LIVER TOXICITY; TARGET CELL;

ANIMALS; APOPTOSIS; CELL LINE; CYCLIC GMP; DNA FRAGMENTATION; DRUG DELIVERY SYSTEMS; DRUG DESIGN; GALACTOSAMINE; HEMODYNAMIC PROCESSES; LIVER; MALE; MICE; NITRIC OXIDE; PRODRUGS; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030918451     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9701031     Document Type: Article

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