Role of troponin I proteolysis in the pathogenesis of stunned myocardium

Circulation Research

Volumn 80, Issue 3, 1997, Pages 393-399

  Gao, Wei Dong ^a   Atar, Dan ^a   Liu, Yongge ^a   Perez, Nestor Gustavo ^a   Murphy, Anne M ^a   Marban, Eduardo ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

myocardial stunning; myofilament; troponin I; Western blot

Indexed keywords

ACTIN; CALPAIN; MYOSIN LIGHT CHAIN; TROPOMYOSIN; TROPONIN C; TROPONIN I; TROPONIN T;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HEART MUSCLE REPERFUSION; ISOLATED HEART; MALE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; STUNNED HEART MUSCLE;

EID: 0000104030     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.res.0000435855.49359.47     Document Type: Article

References (38)

1. 2+ activation of contraction as a consequence of reperfusion-induced cellular calcium overload in ferret hearts, J Clin Invest. 1987;79:950-961.
2. Carrozza JP Jr. Bentivegna LA, Williams CP, Kuntz RE, Grossman W, Morgan JP. Decreased myofilament responsiveness in myocardial stunning follows transient calcium overload during ischemia and reperfusion. Circ Res. 1992;71:1334-1340.
3. Hofmann PA, Miller WP, Moss RL. Altered calcium sensitivity of isometric tension in myocyte-sized preparations of porcine postischemic stunned myocardium. Circ Res. 1993;72:50-56.
4. 2+ responsiveness and altered diastolic function in intact ventricular muscle, Circ Res, 1995;76:1036-1048.
5. Kusuoka H, Marban E, Cellular mechanisms of myocardial stunning. Annu Rev Physiol. 1992;54:243-256. Review.
6. 2+-dependent proteolysis? Circ Res. 1996; 78:435-465.
7. Atar D, Gao WD, Backx PH, Murphy AM, Marban E. Immunoblot analysis of stunned myocardium reveals structural alterations of the myofilaments predicted by modelling of cross-bridge kinetics. Circulation. 1994;90(suppl I):I-646. Abstract.
8. Gao WD, Atar D, Liu Y, Murphy AM, Marban E, Degradation of troponin I in ischemic/reperfused myocardium: molecular basis of myocardial stunning? Biophys J. 1995;68:A112. Abstract.
9. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K. Analysis of proteins, In: Current Protocols in Molecular Biology. 9th ed. New York, NY: John Wiley & Sons Inc; 1995.
10. Bodor GS, Porter S, Landt Y, Ladenson JH, Development of monoclonal antibodies for an assay of cardiac troponin-I and preliminary results in suspected cases of myocardial infarction. Clin Chem. 1992;38:2203-2214.
11. Nassar R, Malouf NN, Kelly MB, Oakeley AE, Anderson PAW. Force-pCa relation and troponin T isoforms of rabbit myocardium. Circ Res. 1991;69:1470-1475.
12. Toyota N, Shimada Y, Differentiation of troponin in cardiac and skeletal muscles in chicken embryos as studied by immunofluorescence microscopy, J Cell Biol. 1981;91(pt 1):497-504.
13. Ranucci D, Yamakita Y, Matsumura F, Hitchcock-DeGregori SE. Incorporation of microinjected mutant and wildtype recombinant tropomyosins into stress fibers in fibroblasts. Cell Motil Cytoskeleton. 1993;24:119-128.
14. Daoud E, Porter S, Landt Y, Ladenson J, Development and characterization of monoclonal antibodies specific for myosin light chains. Clin Chem. 1992;38:989. Abstract.
15. Kitakaze M, Weisfeldt ML, Marban E, Acidosis during early reperfusion prevents myocardial stunning in perfused ferret hearts, J Clin Invest. 1988;82:920-927.
16. 2+ sensitivity in intact versus skinned rat ventricular muscle, Circ Res. 1994;74:408-415.
17. Murphy AM, Jones L II, Sims HF, Strauss AW. Molecular cloning of rat cardiac troponin I and analysis of troponin I isoform expression in developing rat heart. Biochemistry. 1991;30:707-712.
18. Krudy GA, Kleerekoper Q, Guo X, Howarth JW, Solaro RJ, Rosevear PR. NMR studies delineating spatial relationships within the cardiac troponin I-troponin C complex. J Biol Chem, 1994;269:23731-23735.
19. Farah CS, Miyamoto CA, Ramos CH, da Silva AC, Quaggio RB, Fujimori K, Smillie LB, Reinach FC. Structural and regulatory functions of the NH2- and COOH-terminal regions of skeletal muscle troponin I. J Biol Chem. 1994;269:5230-5240.
20. 2+ activation. Biochemistry. 1994;33:8464-8471.
21. 2+ sensitivity in cardiotrabeculae. Biochemistry. 1995;34:2309-2316.
22. Wattanapermpool J, Guo X, Solaro RJ. The unique amino-terminal peptide of cardiac troponin I regulates myofibrillar activity only when it is phosphorylated. J Mol Cell Cardiol, 1995;27:1383-1391.
23. 2+ transients and contractile properties by beta-adrenoceptor stimulation in ferret ventricular muscles. J Physiol (Land). 1990;423: 221-240.
24. i-force relationship in intact twitching cardiac muscle: direct evidence for modulation by isoproterenol and EMD 53998. Biophys J. 1995;69:189-201.
25. Guo X, Martin AF, Solaro RJ, Modulatory role of the N-terminal TnC binding site of cardiac troponin I on activation of cardiac myofilament. Biophys J. 1996;70:A170. Abstract.
26. Andres J, Moczarska A, Stepkowski D, Kakol I. Contractile proteins in globally 'stunned' rabbit myocardium. Basic Res Cardiol. 1991; 86:219-226.
27. 2+ in myofibrils isolated from stunned and nonstunned porcine and human myocardium. Biochem Pharmacol. 1996;51:1211-1220.
28. 2+)-ATPase activity. Am J Physiol. 1991;261(pt 2):H229-H235.
29. Takahashi K. Calpain substrate specificity, In: Mellgrn RL, Murachi T, eds, Intracellular Calcium-Dependent Protenlysis, Boca Raton, Fla: CRC Press Inc; 1990:56-74.
30. Di Lisa F, De Tullio R, Salamino F, Barbato R, Melloni E, Siliprandi N, Schiaffino S, Pontremoli S. Specific degradation of troponin T and I by mu-calpain and its modulation by substrate phosphorylation. Biochem J. 1995;308:57-61.
31. Westfall MV, Solaro RJ. Alterations in myofibrillar function and protein profiles after complete global ischemia in rat hearts, Circ Res, 1992;70:302-313.
32. Barbato R, Menabò R, Dainese P, Carafoli E, Schiaffino S, Di Lisa F, Binding of cytosolic proteins to myofibrils in ischemic rat hearts, Circ Res, 1996;78:821-828.
33. Yoshida K, Inui M, Harada K, Saido TC, Sorimachi Y, Ishihara T, Kawashima S, Sobue K, Reperfusion of rat heart after brief ischemia induces proteolysis of calspectin (nonerythroid spectrin or fodrin) by calpain. Circ Res. 1995;77:603-610.
34. Matsumura Y, Saeki E, Inoue M, Hori M, Kamada T, Kusuoka H, Inhomogeneous disappearance of myofilament-related cytoskeletal proteins in stunned myocardium of guinea pig, Circ Res. 1996;79:447-454.
35. Bolli R. Mechanism of myoeardial 'stunning,' Circulation, 1990;82:723-738. Review.
36. 2+ transients underlie stunning? Circ Res. 1990; 66:1268-1276.
37. McDonald KS, Mammen PP, Strang KT, Moss RL, Miller WP. Isometric and dynamic contractile properties of porcine skinned cardiac myocytes after stunning, Circ Res. 1995;77;964-972.
38. Martin AF. Turnover of cardiac troponin subunits: kinetic evidence for a precursor pool of troponin-1. J Biol Chem. 1981;256:964-968.