Mechanism of dithiocarbamate inhibition of apoptosis: Thiol oxidation by dithiocarbamate disulfides directly inhibits processing of the caspase-3 proenzyme

Chemical Research in Toxicology

Volumn 10, Issue 6, 1997, Pages 636-643

  Nobel, C Stefan I ^a   Burgess, David H ^a   Zhivotovsky, Boris ^a   Burkitt, Mark J ^b   Orrenius, Sten ^a   Slater, Andrew F G ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; DISULFIDE; DITHIOCARBAMIC ACID; DITHIOCARBAMIC ACID DERIVATIVE; DITHIOTHREITOL; ENZYME PRECURSOR;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL FREE SYSTEM; ENZYME ACTIVATION; LYMPHOCYTE; NONHUMAN; OXIDATION; PROTEIN DEGRADATION; PROTEIN PROCESSING; RAT; T LYMPHOCYTE; THYMOCYTE;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELLS, CULTURED; COPPER; CYSTEINE ENDOPEPTIDASES; DISULFIDES; ENZYME PRECURSORS; GLUTATHIONE; HUMANS; JURKAT CELLS; MALE; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; T-LYMPHOCYTES; THIOCARBAMATES;

ANIMALIA;

EID: 0343376119     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx970006a     Document Type: Article

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