High levels of expression and nuclear localization of interleukin-1 β converting enzyme (ICE) and CPP32 in favorable human neuroblastomas

Cancer Research

Volumn 57, Issue 20, 1997, Pages 4578-4584

  Nakagawara, Akira ^a   Nakamura, Yohko ^a   Ikeda, Hitoshi ^b   Hiwasa, Takaki ^a   Kuida, Keisuke ^c   Su, Michael S S ^d   Zhao, Huaqing ^e   Cnaan, Avital ^e   Sakiyama, Shigeru ^a  

^a CHIBA CANCER CENTER   (Japan)

^b Gumna Children S Medical Center   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^d VERTEX PHARMACEUTICALS   (United States)

^e CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA CONVERTING ENZYME; NERVE GROWTH FACTOR;

APOPTOSIS; ARTICLE; CANCER REGRESSION; CELL DEATH; CELL DIFFERENTIATION; DNA NICK TRANSLATION; ENZYME ACTIVATION; ENZYME SUBSTRATE; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NEUROBLASTOMA; PRIORITY JOURNAL; RECEPTOR UPREGULATION; TUMOR LOCALIZATION;

AGE FACTORS; APOPTOSIS; BRAIN NEOPLASMS; CASPASE 1; CASPASE 2; CASPASE 3; CASPASES; CELL NUCLEUS; CHILD; CHILD, PRESCHOOL; CYSTEINE ENDOPEPTIDASES; ENZYME PRECURSORS; GANGLIONEUROBLASTOMA; GANGLIONEUROMA; GENES, MYC; HUMANS; INFANT; NEOPLASM STAGING; NEUROBLASTOMA; PROGNOSIS; PROTEIN BIOSYNTHESIS; PROTEINS; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR; SURVIVAL RATE;

EID: 0030882685     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Brodeur, G. M., Azar, C., Brother, M., Hiemstra, J., Kaufman, B., Marshall, H., Moley, J., Nakagawara, A., Saylors, R., Scavarda, N., Schneider, S., Wasson, J., White, P., Seeger, R., Look, T., and Castleberry, R. Neuroblastoma. Effect of genetic factors on prognosis and treatment. Cancer (Phila.), 70: 1685-1694, 1992.
2. Evans, A. E., D'Angio, G. J., and Randolph, J. A. A proposed staging for children with neuroblastoma: Children's Cancer Study Group. Cancer (Phila.), 27: 374-378, 1971.
3. Nakagawara, A., Arima, M., Azar, C. G., Scavarda, N. J., and Brodeur, G. M. Inverse relationship between trk expression and N-myc amplification in human neuroblastomas. Cancer Res., 52: 1364-1368, 1992.
4. Nakagawara, A., Arima-Nakagawara, M., Scavarda, N. J., Azar, C. G., Cantor, A. B., and Brodeur, G. M. Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma. N. Engl. J. Med., 328: 847-854, 1993.
5. Suzuki, T., Bogenmann, E., Shimada, H., Stram, D., and Seeger, R. C. Lack of high-affinity nerve growth factor receptors in aggressive neuroblastomas. J. Natl. Cancer Inst., 85: 377-384, 1993.
6. Kogner, P., Barbany, G., Dominici, C., Castello, M. A., Raschella, G., and Persson, H. Coexpression of messenger RNA for TRK protooncogene and low affinity nerve growth factor receptor in neuroblastomas with favorable prognosis. Cancer Res., 53: 2044-2050, 1993.
7. Borrello, M. G., Bongarzone, I., Pierotti, M. A., Luksch, R., Gasparini, M., Collini, P., Pilotti, S., Rizzetti, M. G., Mondellini, P., Debernardi, B., Dimartino, D., Garaventa, A., Brisigotti, M., and Tonini, G. P. TRK and RET protooncogene expression in human neuroblastoma specimens: high-frequency of TRK expression in non-advanced stages. Int. J Cancer, 54: 540-545, 1993.
8. Nakagawara, A., Azar, C. G., Scavarda, N. J., and Brodeur, G. M. Expression and function of TRK-B and BDNF in human neuroblastomas. Mol. Cell. Biol., 14: 759-767, 1994.
9. Kaplan, D. R., Matsumoto, K., Lucarelli, E., and Thiele, C. J. Induction of TrkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells. Neuron, 11: 321-331, 1993.
10. TrkB affects survival, differentiation, and invasiveness of human neuroblastoma cells. Cancer Res., 55: 1798-1806, 1995.
11. Nakagawara, A., and Brodeur, G. M. Role of neurotrophins and their receptors in human neuroblastomas: a primary culture study. Eur. J. Cancer, in press, 1997.
12. Yuan, J., Shaham, S., Ledoux, S., Ellis, H. M., and Horvitz, H. R. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell, 75: 641-652, 1993.
13. Miura, M., Zhu, H., Rotello, R., Hartwieg, E. A., and Yuan, J. Induction of apoptosis in fibroblasls by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell, 75: 653-660, 1993.
14. Femandes-Alnemri, T., Litwack, G., and Alnemri, E. S. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein CED-3 and mammalian interleukin-1β-converting enzyme. J. Biol. Chem., 269: 30761-30764, 1994.
15. Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., Lazebnik, Y. A., Munday, N. A., Raju, S. M., Smulson, M. E., Yamin, T-T., Yu, V. L., and Miller, D. K. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature (Lond.), 376: 37-43, 1995.
16. Tewari, M., Quan, L. T., O'Rourke, K., Desnoyers, S., Zeng, Z., Beidler, D. R., Poirier, G. G., Salveson, G. S., and Dixit, V. M. Yama/CPP-32b, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell, 81: 801-809, 1995.
17. Kumar, S., Kinoshita, M., Noda, M., Copeland, N. G., and Jenkins, N. A. Induction of apoptosis by the mouse nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1β-converting enzyme. Genes Dev., 8: 1613-1626, 1994.
18. Wang, L., Miura, M., Bergeron, L., Zhu, H., and Yuan, J. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell, 78: 739-750, 1994.
19. Faucheu, C., Diu, A., Chan, A. W. E., Blanchet, A-M., Miossec, C., Herve, F., Collard-Dutilleul, V., Gu, Y., Aldape, R. A., Lippke, J. A., Rocher, C., Su, M. S-S., Livingston, D. J., Hercend, T., and Lalanne, J-L. A novel human protease similar to the interleukin-1β converting enzyme induces apoptosis in transfected cells. EMBO J., 14: 1914-1922, 1995.
20. Kamens, J., Paskind, M., Hugunin, M., Talanian, R. V., Allen, H., Banach, D., Bump, N., Hackett, M., Johnston, C. G., Li. P., Mankovich, J. A., Terranova, M., and Ghayur, T. Identification and characterization of ICH-2, a novel member of the interleukin-1β-converting enzyme family of cystein proteases. J. Biol. Chem., 270: 15250-15256, 1995.
21. Munday, N. A., Vaillancourt, J. P., Ali, A., Casano, F. J., Miller, D. K., Molineaux, S. M., Yamin, T. T., Yu, V. L., and Nicholson, D. W. Molecular cloning and proapoptotic activity of ICE rel-II and ICE rel-III. members of the ICE/CED-3 family of cystein proteases. J. Biol. Chem., 270: 15870-15876, 1995.
22. Fernandes-Alnemri, T., Litwack, G., and Alnemri, E. S. Mch-2, a new member of the apoptotic CED-3/ICE cystein protease gene family. Cancer Res., 55: 2737-2742, 1995.
23. Duan, H., Chinnaiyan, A. M., Hudson, P. L., Wing, J. P., He, W., and Dixit, V. M. ICE-LAP3, a novel mammalian homolog of the Caenorhabditis elegans cell death protein CED-3, is activated during Fas- and tumor necrosis factor-induced apoptosis. J. Biol. Chem., 271: 35013-35035, 1996.
24. Fernandes-Alnemri, T., Takahashi, A., Armstrong, R., Krebs, J., Fritz, L., Tomaselli, K. J., Wang, L., Yu, Z., Croce, C. M., Salveson, G., Earnshaw, W. C., Litwack, G., and Alnemri, E. S. Mch-3, a novel human apoptotic cystein protease highly related to CPP-32. Cancer Res., 55: 6045-6052, 1995.
25. Lippke, J. A., Gu, Y., Samecki, C., Caron, P. R., and Su, M. S-S. Identification and characterization of CPP-32/Mch-2 homolog 1, a novel cystein protease similar to CPP-32. J. Biol. Chem., 271: 1825-1828, 1996.
26. Duan, H., Orth, K., Chinnaiyan, A., Poirier, G., Froelich, C. J., He, W-W., and Dixit, V. M. ICE-LAP6, a novel member of the ICE/ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J. Biol. Chem., 271: 16720-16724, 1996.
27. Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., Mann, M., Krammer, P. H., Peter, M. E., and Dixit, V. M. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell, 85: 817-827, 1996.
28. Boldin, M. P., Goncharov, T. M., Goltsev, Y. V., and Wallach, D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1-and TNF receptor-induced cell death. Cell, 85: 803-815, 1996.
29. Fernandes-Alnemri, T., Armstrong, R. C., Krebs, J., Srinivasula, S. M., Wang, L., Bullrich, F., Fritz, L. C., Trapani, J. A., Tomaselli, K. J., Litwack, G., and Alnemri, E. S. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cystein protease containing two FADD-like domains. Proc. Natl. Acad. Sci. USA, 93: 7464-7469, 1996.
30. Fraser, A., and Evan, G. A license to kill. Cell, 85: 781-784, 1996.
31. Boudreau, N., Sympson, C. J., Werb, Z., and Bissel, M. J. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science (Washington DC), 267: 891-893, 1995.
32. Tamura, T., Ishihara, M., Lamphier, M. S., Tanaka, N., Oishi, I., Aizawa, S., Matsuyama, T., Mak, T. W., Taki, S., and Taniguchi, T. An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature (Lond.), 376: 596-599, 1995.
33. Ikeda, K., Nakagawara, A., Yano, H., Akiyama, H., Tasaka, H., Ueda, K., Hara, T., Ishii, E., Ohgami, H., Sera, Y., Shimoda, H., Kishida, K., Tobo, Y., Hiyoshi, Y., Kawakami, K., Ohmori, H., and Kuwano, S. Improved survival rates in children over 1 year of age with stage III or IV neuroblastoma following an intensive chemotherapeutic regimen. J. Pediatr. Surg., 24: 189-193, 1989.
34. Kaneko, Y., Kanda, N., Maseki, N., Nakachi, K., Takeda, T., Okabe, I., and Sakurai, M. Current urinary mass screening for catecholamine metabolites at 6 months of age may be detecting only a small portion of high risk neuroblastomas: a chromosome and N-myc amplification study. J. Clin. Oncol., 8: 2005-2013, 1990.
35. Castleberry, R. P., Kun, L. E., Shuster, J. J., Altshuler, G., Smith, I. E., Nitschke, R., Wharam, M., McWilliams, N., Joshi, V., and Hayes, F. A. Radiotherapy improves the outlook for patients older than 1 year with Pediatric Oncology Group stage C neuroblastoma. J. Clin. Oncol., 9: 789-795, 1991.
36. Nitschke, R., Smith, E. I., Altshuler, G., Altmiller, D., Shuster, J., Green, A., Castleberry, R., Hayes, F. A., Golembe, B., and Ducos, R. Postoperative treatment of non-metastatic visible residual neuroblastoma: a Pediatric Oncology Group study. J. Clin. Oncol., 9: 1181-1188, 1991.
37. Graham-Pole, J., Casper, J., Elfenbein, G., Gee, A., Gross, S., Janssen, W., Koch, P., Marcus, R., Pick, T., Shuster, J., Spruce, W., Thomas, P., and Yeager, A. High-dose chemoradiotherapy supported by marrow infusions for advanced neuroblastoma: a Pediatric Oncology Group study. J. Clin. Oncol., 9: 152-158, 1991.
38. Brodeur, G. M., Pritchard, J., Berthold, F., Carlsen, N. L. T., Castel, V., Castleberry, R. P., Benardi, B. D., Evans, A. E., Favrot, M., Hedborg, F., Kaneko, M., Kemshead, J., Lampert, F., Lee, R. E. J., Look, A. T., Pearson, A. D. J., Philip, T., Roald, B., Sawada, T., Seeger, R. C., Tsuchida, Y., and Voute, P. A. Revisions of the International Criteria for neuroblastoma diagnosis, staging, and response to treatment. J. Clin. Oncol., 11: 1466-1477, 1993.
39. Brodeur, G. M., Seeger, R. C., Schwab, M., Varmus, H. E., and Bishop, J. M. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science (Washington DC), 224: 1121-1124, 1984.
40. Takenaga, K., Nakamura, Y., and Sakiyama, S. Cellular localization of pEL98 protein, an S100-related calcium binding protein, in fibroblasts and its tissue distribution analyzed by monoclonal antibodies. Cell Struct. Funct., 19: 133-141, 1994.
41. White, P. S., Maris, J. M., Beltinger, C., Sulman, E., Marshall, H. N., Fujimori, M., Kaufman, B. A., Biegel, J. A., Allen, C., Hilliard, C., Valentine, M. B., Look, A. T., Enomoto, H., Sakiyama, S., and Brodeur, G. M. A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3. Proc. Natl. Acad. Sci. USA, 92: 5520-5524, 1995.
42. Ikeda, H., Hirato, J., Akami, M., Suzuki, N., Takahashi, A., Kuroiwa, M., and Matsuyama, S. Massive apoptosis detected by in situ DNA nick end labeling in neuroblastoma. Am. J. Surg. Pathol., 20: 549-655, 1996.
43. Tanaka, T., Slamon, D. J., Shimada, H., Shimoda, H., Fujisawa, T., Ida, N., and Seeger, R. C. A significant association of Ha-ras p21 in neuroblastoma cells with patient prognosis: a retrospective study of 103 cases. Cancer (Phila.), 68: 1296-1302, 1991.
44. Chinnaiyan, A. M., Tepper, C. G., Seldin, M. F., O'Rourke, K., Kischkel, F. C., Hellbardt, S., Krammer, P. H., Peter, M. E., and Dixit, V. M. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1 ) and tumor necrosis factor receptor-induced apoptosis. J. Biol. Chem., 271: 4961-4965, 1996.
45. Schlegel, J., Peters, I., Orrenius, S., Miller, D. K., Thornberry, N. A., Yamin, T-T., and Nicholson, D. W. CPP-32/apopain is the key interleukin-10-converting enzyme-like protease involved in Fas-mediated apoptosis. J. Biol. Chem., 271: 1841-1844, 1996.
46. Boldin, M. P., Varfolomeev, E. E., Pancer, Z., Men, I. L., Camonis, J. H., and Wallach, D. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J. Biol. Chem., 270: 7795-7798, 1995.
47. Gagliardini, V., Fernandez, P-A., Lee, R. K. K., Drexler, H. C. A., Rotello, R. J., Fishman, M. C., and Yuan, J. Prevention of vertebrate neuronal death by crmA gene. Science (Washington DC), 263: 826-828, 1994.
48. Martin, D. P., Schmidt, R. E., DiStefano, P. S., Lowry, O. H., Carter, J. G., and Johnson, E. M., Jr. Inhibitors of protein synthesis prevent neuronal death caused by nerve growth factor deprivation. J. Cell Biol., 106: 829-844, 1988.
49. Reed, J. C. Bcl-2 and the regulation of programmed cell death. J. Cell Biol., 124: 1-6, 1994.
50. Ikegaki, N., Katsumata, M., Tsujimoto, Y., Nakagawara, A., and Brodeur, G. M. Relationship between bcl-2 and myc gene expression in human neuroblastomas. Cancer Lett., 91: 161-168, 1995.
51. Brodeur, G. M., and Nakagawara, A. Molecular basis of clinical heterogeneity in neuroblastoma. Am. J. Pediatr. Hematol. Oncol., 14: 111-116, 1992.