Up-regulation of the Nedd2 gene encoding an ICE/Ced-3-like cysteine protease in the gerbil brain after transient global ischemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 17, Issue 5, 1997, Pages 507-514

  Kinoshita, Makoto ^a   Tomimoto, Hidekazu ^a   Kinoshita, Ayae ^a   Kumar, Sharad ^b   Noda, Makoto ^a  

^a KYOTO UNIVERSITY   (Japan)

^b INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

Author keywords

apoptosis; calpains; cysteine proteases; delayed neuronal death; necrosis; transient cerebral ischemia

Indexed keywords

CALPAIN; CYSTEINE PROTEINASE; INTERLEUKIN 1BETA CONVERTING ENZYME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GERBIL; HIPPOCAMPUS; MALE; NEMATODE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; TRANSIENT ISCHEMIC ATTACK;

EID: 0030912483     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199705000-00004     Document Type: Article

References (58)

1. Bonnekoh P, Barbier A, Oschlies U, Hossmann K-A (1990) Selective vulnerability in the gerbil hippocampus: morphological changes after 5-min ischemia and long survival times. Acta Neuropathol (Berl) 80:18-25
2. Cerretti DP, Kozlosky CJ, Mosley B, Nelson N, Ness KV, Greenstreet TA, March CJ, Kronheim SR, Druck T, Cannizzaro LA. Huebner K, Black RA (1992) Molecular cloning of the interleukin-1β converting enzyme. Science 256:97-100
3. Charriaut-Marlangue C, Aggoun-Zouaoui D, Represa A, Ben-Ari Y (1996) Apoptotic features of selective neuronal death in ischemia, epilepsy and gp120 toxicity. Trends Neurosci 19:109-114
4. Chopp M, Li Y, Zhang ZG, Freytag SO (1992) p53 expression in brain after middle cerebral artery occlusion in the rat. Biochem Biophys Res Commun 182:1201-1207
5. Cowan WM, Fawcett JW, O'Leary DD, Stanfield BB (1984) Regressive events in neurogenesis. Science 225:1258-1265
6. Deshpande J, Bergstedt K, Lindén T, Kalimo H, Wieloch T (1992) Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia: evidence against programmed cell death. Exp Brain Res 88:91-105
7. Dragunow M, Beilharz E, Sirimanne E, Lawlor P, Williams C, Bravo R, Gluckman P (1994) Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to the young rat brain. Brain Res Mol Brain Res 25:19-33
8. Duan H, Chinnaiyan AM, Hudson PL, Wing JP, He W-W, Dixit VM (1996) ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3, is activated during Fas- and tumor necrosis factor-induced apoptosis. J Biol Chem 271:1621-1625
9. Ellis RE, Yuan J, Horwitz HR (1991) Mechanisms and functions of cell death. Annu Rev Cell Biol 7:663-698
10. Faucheu C, Diu A, Edith Chan AW, Blanchet A-M, Miossec C, Hervé F, Collard-Dutilleul V, Gu Y, Aldape RA, Lippke JA, Rocher C, Su MS-S, Livingston DJ, Hercend T, Lalanne J-L (1995) A novel human protease similar to the interleukin-1β converting enzyme induces apoptosis in transfected cells. EMBO J 14:1914-1922
11. Fernandes-Alnemri T, Litwack G, Alnemri ES (1994) CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1β converting enzyme. J Biol Chem 269:30761-30764
12. Fernandes-Alnemri T, Litwack G, Alnemri ES (1995) MCh2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. Cancer Res 55:2737-2742
13. Goto K, Ishige A, Sekiguchi K, Iizuka S, Sugimoto A, Yuzurihara M, Aburada M, Hosoya E, Kogure K (1990) Effects of cycloheximide on delayed neuronal death in rat hippocampus. Brain Res 534:299-302
14. Hengartner MO, Horvitz HR (1994) C. elegans survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 76:665-676
15. Kerr JFR, Searle J, Harmon BV, Bishop CJ (1987) Apoptosis. In: Perspectives on Mammalian Cell Death (Potten CS, ed), New York. Oxford University Press, pp 93-128
16. Kirino T (1982) Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 239:57-69
17. Krajewski S, Mai JK, Krajewska M, Sikorska M, Mossakowsky MJ, Reed JC (1995) Up-regulation of Bax protein levels in neurons following cerebral ischemia. J Neurosci 15:6364-6376
18. Kuida K, Lippke JA, Ku G, Harding MW, Livingston DJ, Su MS-S, Flavell RA (1995) Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme. Science 267:2000-2003
19. Kumar S (1995a) Inhibition of apoptosis by the expression of antisense Nedd2. FEBS Lett 368:69-72
20. Kumar S (1995b) ICE-like proteases in apoptosis. Trends Biochem Sci 20:198-202
21. Kumar S, Lavin MF (1996) The ICE family of cysteine proteases as effectors of cell death. Cell Death Diff 3:255-267
22. Kumar S, Tomooka Y, Noda M (1992) Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun 185:1155-1161
23. Kumar S, Kinoshita M, Noda M, Copeland NG, Jenkins NA (1994) Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1β-converting enzyme. Genes Dev 8:1613-1626
24. Kure S, Tominaga T, Yoshimoto T, Tada K, Narisawa K (1991) Glutamate triggers internucleosomal DNA cleavage in neuronal cells. Biochem Biophys Res Commun 179:39-45
25. Lee KS, Frank S, Vanderklish P, Aral A, Lynch G (1991) Inhibition of proteolysis protects hippocampal neurons from ischemia. Proc Natl Acad Sci USA 88:7233-7237
26. Li P, Allen H, Banerjee S, Franklin S, Herzog L, Johnston C, McDowell J, Paskind M, Rodman L, Salfeld J, Towne E, Tracey D, Wardwell S, Wei F-Y, Wong W, Kamen R, Seshadri T (1995) Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxin shock. Cell 80:401-411
27. Li Y, Chopp M, Zhang ZG, Zaloga C, Niewenhuis L, Gautam S (1994) p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats. Stroke 25:849-856
28. Linnik MD, Zobrist RH, Hatfield MD (1993) Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 24:2002-2009
29. MacManus JP, Buchan AM, Hill IE, Rasquinha I, Preston E (1993) Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain. Neurosci Lett 164:89-92
30. Martinou J-C, Dubois-Dauphin M, Staple JK, Rodriguez I, Frankowski H, Missotten M, Albertini P, Talabot D, Catsicas S, Pietra C, Huarte J (1994) Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 13:1017-30
31. Matesic DF, Lin RC (1994) Microtubule-associated protein 2 as an early indicator of ischemia-induced neurodegeneration in the gerbil forebrain. J Neurochem 63:1012-1020
32. Matsuyama T, Hata R, Tagaya M, Yamamoto Y, Nakajima T, Furuyama J, Wanaka A, Sugita, M (1994) Fas antigen mRNA induction in postischemic murine brain. Brain Res 657:342-346
33. Miura M, Zhu H, Rotello R, Hartwieg EA, Yuan J (1993) Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C elegans cell death gene ced-3. Cell 75:653-660
34. Miyashita T, Krajewski M, Krajewska M, Wang HG, Lin HK, Liebermann DA, Hoffmann B, Reed JC (1994) Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9:1799-1805
35. Morgan JI, Curran T (1991) Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Annu Rev Neurosci 14:421-451
36. Munday NA, Vaillancourt JP, Ali A, Casano FJ, Miller DK, Molineaux SM, Yamin T-T, Yu VL, Nicholson DW (1995) Molecular cloning and pro-apoptotic activity of ICErellII and ICErelIII, members of the ICE CED-3 family of cysteine proteases. J Biol Chem 270:15870-15876
37. Nicholson DW, Ali A, Thomberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, Munday NA, Raju SM, Smulson ME, Yamin T-T, Yu VL, Miller DK (1995) Identification and inhibition of the ICE CED-3 protease necessary for mammalian apoptosis. Nature 376:37-43
38. Nitatori T, Sato N, Waguri S, Karasawa Y, Araki H, Shibanai K, Kominami E, Uchiyama Y (1995) Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. J Neurosci 15:1001-1011
39. Nowak TS Jr, Osborne OC, Suga S (1993) Stress protein and proto oncogene expression as indicators of neuronal pathophysiology after ischemia. In: Progress in Brain Research 96 (Kogure K, Hossmann K-A, Siesjö BK, eds), Amsterdam, Elsevier Science, pp 195-208
40. Okamoto M, Matsumoto M, Ohtsuki T, Taguchi A, Mikoshiba K, Yanagihara T, Kamada T (1993) Internucleosomal DNA cleavage involved in ischemia-induced neuronal death. Biochem Biophys Res Commun 196:1356-1362
41. Oltvai ZN, Millman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619
42. Ramage P, Cheneval D, Chvei M, Graff P, Hemmig R, Heng R, Kocher HP, Mackenzie A, Memmert K, Revesz L, Wishart W (1995) Expression, refolding, and autocatalytic proteolytic processing of the interleukin-1β-converting enzyme precursor. J Biol Chem 270: 9378-9383
43. Roberts-Lewis JM, Marcy VR, Zhao Y, Vaught JL, Siman R, Lewis ME (1993) Aurintricarboxylic acid protects hippocampal neurons from NMDA and ischemia-induced toxicity in vivo. J Neurochem 61:378-381
44. Saido T, Yokota M, Nagao S, Yamaura I, Tani E, Tsuchiya T, Suzuki K, Kawashima S (1993) Spatial resolution of fodrin proteolysis in postischemic brain. J Biol Chem 268:25239-25243
45. Schreiber SS, Baudry M (1995) Selective neuronal vulnerability in the hippocampus - a role for gene expression? Trends Neurosci 18: 446-451
46. Sei Y, Lubitz KJV, Basile AS, Borner MM, Lin RC, Skolnick P, Fossom LH (1994) Internucleosomal DNA fragmentation in gerbil hippocampus following forebrain ischemia. Neurosci Lett 171: 179-182
47. Sharp FR, Kinouchi H, Koistinaho J, Chan PH, Sagar SM (1993) HSP70 heat shock gene regulation during ischemia. Stroke 24(suppl 1):172-175
48. Shigeno T, Yamasaki Y, Kato G, Kusaka K, Mima T, Takakura K, Graham DI, Furukawa S (1990) Reduction of delayed neuronal death by inhibition of protein synthesis. Neurosci Lett 120:117-119
49. Siman R, Noszek JC (1988) Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo. Neuron 1:279-287
50. Takemoto O, Tomimoto H, Yanagihara T (1995) Induction of c-fos and c-jun gene products and heat shock protein following brief and prolonged cerebral ischemia in gerbil. Stroke 26:1639-1648
51. Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM (1995) Yama CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 81:801-809
52. Thilmann R, Xie Y, Kleihues P, Kiessling M (1986) Persistent inhibition of protein synthesis precedes delayed neuronal death in postischemic gerbil hippocampus. Acta Neuropathol (Berl) 71:88-93
53. Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineaux SM, Weidner JR, Aunins J, Elliston KO, Ayala JM, Casano FJ, Chin J, Ding GJ-F, Egger LA, Gaffney EP, Limjuco G, Palyha OC, Raju SM, Rolando AM, Salley JP, Yamin T-T, Lee TD, Shively JE, MacCross M, Mumford RA, Schmidt JA, Tocci MJ (1992) A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes. Nature 356:768-774
54. Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM (1984) Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 226:1097-1099
55. Uemura Y, Kowall NW, Beal MF (1991) Global ischemia induces NMDA receptor-mediated c-fos expression in neurons resistant to injury in gerbil hippocampus. Brain Res 542:343-347
56. Wang L, Miura M, Bergeron L, Zhu H, Yuan J (1994) Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78:739-750
57. Wilson KP, Black JF, Thomson JA, Kim EE, Griffith JP, Navia MA, Murcko MA, Chambers SP, Aldape RA, Raybuck SA, Livingston DJ (1994) Structure and mechanism of interleukin-1β converting enzyme. Nature 370:270-275
58. Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell 75:641-652