An APAf-1 · cytochrome C multimeric complex is a functional apoptosome that activates procaspase-9

Journal of Biological Chemistry

Volumn 274, Issue 17, 1999, Pages 11549-11556

  Zou, Hua ^a   Li, Yuchen ^a   Liu, Xuesong ^a   Wang, Xiaodong ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CYTOCHROME C; ENZYME PRECURSOR; RECOMBINANT ENZYME; ADENOSINE TRIPHOSPHATE; APAF1 PROTEIN, HUMAN; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASP9 PROTEIN, HUMAN; CASPASE 9; PRIMER DNA; PROTEIN; RECOMBINANT PROTEIN;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME BINDING; ENZYME MECHANISM; ENZYME PURIFICATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STOICHIOMETRY; ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; APOPTOSIS; CELL ORGANELLE; HELA CELL; HYDROLYSIS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN BINDING;

ADENOSINE TRIPHOSPHATE; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; BASE SEQUENCE; CASPASE 9; CASPASES; CYTOCHROME C GROUP; DNA PRIMERS; ENZYME ACTIVATION; ENZYME PRECURSORS; HELA CELLS; HUMANS; HYDROLYSIS; MOLECULAR SEQUENCE DATA; ORGANELLES; PROTEIN BINDING; PROTEINS; RECOMBINANT PROTEINS;

EID: 0033596980     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.17.11549     Document Type: Article

References (31)

1. Cryns, V., and Yuan, J. (1998) Genes Dev. 12, 1551-1570
2. Thornberry, N. A., and Lazebnik, Y. (1998) Science 281, 1312-1316
3. Lazebnik, Y. A., Takahashi, A., Moir, R. D., Goldman, R. D., Poirier,. G. G., Kaufmann S. H., and Earnshaw, W. C. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 9042-9046
4. Martin, S. J., O'Brien, G. A., Nishioka, W. K., McGahon, A. J., Mahboubi, A., Saido, T. C., and Green, D. R. (1995) J. Biol. Chem. 270, 6425-6426
5. Liu, X., Zou, H., Slaughter, C., and Wang, X. (1997) Cell 89, 175-184
6. Enari, M., Sakahira, H., Yokoyama, H., Okawa, K., Iwamatsu, A., and Nagata, S. (1998) Nature 391, 43-50
7. Kothakota, S., Azuma, T., Reinhard, C., Klippel, A., Tang, J., Chu, K., McGarry, T. J., Kirschner, M. W., Koths, K., Kwiatkowski, D. J., and Williams, L. T. (1997) Science 278, 294-298
8. Rudel, T., and Bokoch, G. M. (1997) Science 276, 1571-1573
9. Boldin, M. P., Goncharov, T. M., Goltsev, Y. V., and Wallach, D. (1996) Cell 85, 803-815
10. Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Scaffidi, C., Bretz, J. D., Zhang, M., Ni, J., Gentz, R., Mann, M., Krammer, P. H., Peter, M. E., and Dixit, V. M. (1996) Cell 85, 817-827
11. Srinivasula, S. M., Ahmad, M., Fernandes-Alnemri, T., Litwack. G., and Alnemri, E. S. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 14486-14491
12. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., and Wang, X. (1997) Cell 91, 479-489
13. Zou, H., Henzel, W. J., Liu, X., Lutschg, A., and Wang, X. (1997) Cell 90, 405-413
14. Yuan, J.-Y., and Horvitz, R. H. (1992) Development 116, 309-320
15. Cecconi, F., Alvarez-Bolado, G., Meyer, B. I., Roth, K. A., and Gruss, P. (1998) Cell 94, 727-737
16. Yoshida, H., Kong, Y. Y., Yoshida, R., Elia, A. J., Hakem, A., Hakem, R., Penninger, J. M., and Mak, T. W. (1998) Cell 94, 739-750
17. Srinivasula, S. M., Ahmad, M., Fernandes-Alnemri, T., and Alnemri, E. S. (1998) Mol. Cell 1, 949-957
18. Hu, Y., Ding, L., Spencer, D. M., and Nunez, G. (1998) J. Biol. Chem. 273, 33489-33494
19. Yang, X., Chang, H. Y., and Baltimore, D. (1998) Science 281, 1355-1357
20. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
21. Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., and Pease, L. R. (1989) Gene (Amst.) 77, 51-59
22. Liu, X., Kim, C. N., Yang, J., Jemmerson, R., and Wang, X. (1996) Cell 86, 147-157
23. Kuida, K., Haydar, T. F., Kuan, C. Y., Gu, Y., Taya, C., Karasuyama, H., Su, M. S., Rakic, P., and Flavell, R. A. (1998) Cell 94, 325-337
24. Hakem, R., Hakem, A., Duncan, G. S., Henderson, J. T., Woo, M., Soengas, M. S., Elia, A., de la Pompa, J. L., Kagi, D., Khoo, W., Potter, J., Yoshida, R., Kaufman, S. A., Lowe, S. W., Penninger, J. M., and Mak, T. W. (1998) Cell 94, 339-352
25. Chinnaiyan, A. M., O'Rourke, K., Lane, B. R., and Dixit, V. M. (1997) Science 276, 1122-1126
26. Seshagiri, S., and Miller, L. K. (1997) Curr. Biol. 7, 455-460
27. Skoog, L., and Bjursell, G. (1974) J. Biol. Chem. 249, 6434-6438
28. Neer, E. J., Schmidt, C. J., Nambudripad, R., and Smith, T. F. (1994) Nature 371, 297-300
29. Yang, J., Liu, X., Bhalla, K., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T.-I., Jones, D. P., and Wang, X. (1997) Science 276, 1129-1132
30. Reed, J. C. (1997) Cell 91, 559-562
31. Walker, J. E., Saraste, M., Runswick, M. J., and Gay, N. J. (1982) EMBO J. 1, 945-951