An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system

Cell

Volumn 122, Issue 1, 2005, Pages 107-118

  Mazmanian, Sarkis K ^a   Cui, Hua Liu ^a,b   Tzianabos, Arthur O ^a   Kasper, Dennis L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL POLYSACCHARIDE; CD4 ANTIGEN; CYTOKINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM MUTANT; BACTEROIDES FRAGILIS; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; HOST; IMMUNE SYSTEM; IMMUNOMODULATION; INTESTINE; MICROORGANISM; MOLECULE; MOUSE; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMALIA; BACTEROIDES FRAGILIS; MAMMALIA;

EID: 22144490199     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2005.05.007     Document Type: Article

References (65)

1. B. Adkins Development of neonatal Th1/Th2 function Int. Rev. Immunol. 19 2000 157 171
2. D. Amsen, J.M. Blander, G.R. Lee, K. Tanigaki, T. Honjo, and R.A. Flavell Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells Cell 117 2004 515 526
3. J. Banchereau, and R.M. Steinman Dendritic cells and the control of immunity Nature 392 1998 245 252
4. B. Bjorksten, P. Naaber, E. Sepp, and M. Mikelsaar The intestinal microflora in allergic Estonian and Swedish 2-year-old children Clin. Exp. Allergy 29 1999 342 346
5. L.M. Bowman, and P.G. Holt Selective enhancement of systemic Th1 immunity in immunologically immature rats with an orally administered bacterial extract Infect. Immun. 69 2001 3719 3727
6. J.O. Brubaker, Q. Li, A.O. Tzianabos, D.L. Kasper, and R.W. Finberg Mitogenic activity of purified capsular polysaccharide A from Bacteroides fragilis: differential stimulatory effect on mouse and rat lymphocytes in vitro J. Immunol. 162 1999 2235 2242
7. H.L. Cash, and L.V. Hooper Commensal bacteria shape intestinal immune system development ASM News 71 2005 77 83
8. B.A. Cobb, Q. Wang, A.O. Tzianabos, and D.L. Kasper Polysaccharide processing and presentation by the MHCII pathway Cell 117 2004 677 687
9. M. Colonna, G. Trinchieri, and Y.J. Liu Plasmacytoid dendritic cells in immunity Nat. Immunol. 5 2004 1219 1226
10. M.J. Coyne, A.O. Tzianabos, B.C. Mallory, V.J. Carey, D.L. Kasper, and L.E. Comstock Polysaccharide biosynthesis locus required for virulence of Bacteroides fragilis Infect. Immun. 69 2001 4342 4350
11. R. Dobber, A. Hertogh-Huijbregts, J. Rozing, K. Bottomly, and L. Negelkerken The involvement of intestinal microflora in the expansion of CD4+ T cells with a naïve phenotype in the periphery Dev. Immunol. 2 1992 141 150
12. S. Falkow Molecular Koch's postulates applied to bacterial pathogenicity - a personal recollection 15 years later Nat. Rev. Microbiol. 2 2004 67 72
13. H. Groux, N. Fournier, and F. Cottrez Role of dendritic cells in the generation of regulatory T cells Semin. Immunol. 16 2004 99 106
14. F. Guarner, and J.R. Malagelada Gut flora in health and disease Lancet 361 2003 512 519
15. C. Heufler, F. Koch, U. Stanzl, G. Topar, M. Wysocka, G. Trinchieri, A. Enk, R.M. Steinman, N. Romani, and G. Schuler Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells Eur. J. Immunol. 26 1996 659 668
16. L.V. Hooper Bacterial contributions to mammalian gut development Trends Microbiol. 12 2004 129 134
17. L.V. Hooper, and J.I. Gordon Commensal host-bacterial relationships in the gut Science 292 2001 1115 1118
18. L.V. Hooper, L. Bry, P.G. Falk, and J.I. Gordon Host-microbial symbiosis in the mammalian intestine: exploring an internal ecosystem Bioessays 20 1998 336 343
19. L.V. Hooper, P.G. Falk, and J.I. Gordon Analyzing the molecular foundations of commensalism in the mouse intestine Curr. Opin. Microbiol. 3 2000 79 85
20. L.V. Hooper, T. Midtvedt, and J.I. Gordon How host-microbial interactions shape the nutrient environment of the mammalian intestine Annu. Rev. Nutr. 22 2002 283 307
21. A.J. Infante, and E. Kraig Myasthenia gravis and its animal model: T cell receptor expression in an antibody mediated autoimmune disease Int. Rev. Immunol. 18 1999 83 109
22. C.A. Janeway, P. Travers, M. Walport, and M. Shlomchik Immunobiology 2001 Garland Publishing New York
23. W.M. Kalka-Moll, A.O. Tzianabos, P.W. Bryant, M. Niemeyer, H.L. Ploegh, and D.L. Kasper Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions J. Immunol. 169 2002 6149 6153
24. M. Kalliomaki, P. Kirjavainen, E. Eerola, P. Kero, S. Salminen, and E. Isolauri Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing J. Allergy Clin. Immunol. 107 2001 129 134
25. M.L. Kapsenberg Dendritic-cell control of pathogen-driven T-cell polarization Nat. Rev. Immunol. 3 2003 984 993
26. D.L. Kasper, E. Braunwald, A.S. Fauci, S.L. Hauser, D.L. Longo, and J.L. Jameson Harrison's Principles of Internal Medicine 2005 McGraw-Hill Publishing New York
27. P. Kidd Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease Altern. Med. Rev. 8 2003 223 246
28. P.V. Kirjavainen, and G.R. Gibson Healthy gut microflora and allergy: factors influencing development of the microbiota Ann. Med. 31 1999 288 292
29. P.V. Kirjavainen, E. Apostolou, T. Arvola, S.J. Salminen, G.R. Gibson, and E. Isolauri Characterizing the composition of intestinal microflora as a prospective treatment target in infant allergic disease FEMS Immunol. Med. Microbiol. 32 2001 1 7
30. A.P. Kohm, P.A. Carpentier, H.A. Anger, and S.D. Miller Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis J. Immunol. 169 2002 4712 4716
31. E. Kononen, H. Jousimies-Somer, and S. Asikainen Relationship between oral gram-negative anaerobic bacteria in saliva of the mother and the colonization of her edentulous infant Oral Microbiol. Immunol. 7 1992 273 276
32. C.M. Krinos, M.J. Coyne, K.G. Weinacht, A.O. Tzianabos, D.L. Kasper, and L.E. Comstock Extensive surface diversity of a commensal microorganism by multiple DNA inversions Nature 414 2001 555 558
33. S.E. Macatonia, N.A. Hosken, M. Litton, P. Vieira, C.S. Hsieh, J.A. Culpepper, M. Wysocka, G. Trinchieri, K.M. Murphy, and A. O'Garra Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells J. Immunol. 154 1995 5071 5079
34. A.J. Macpherson, and N.L. Harris Interactions between commensal intestinal bacteria and the immune system Nat. Rev. Immunol. 4 2004 478 485
35. A.J. Macpherson, and T. Uhr Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria Science 303 2004 1662 1665
36. V. Malhotra, M. Tatke, S.K. Khanna, and R. Gondal Thymic histology in myasthenia gravis Indian J. Chest Dis. Allied Sci. 34 1992 117 121
37. K.H. Mills Regulatory T cells: friend or foe in immunity to infection? Nat. Rev. Immunol. 4 2004 841 855
38. D.M. Monack, A. Mueller, and S. Falkow Persistent bacterial infections: the interface of the pathogen and the host immune system Nat. Rev. Microbiol. 2 2004 747 765
39. A.E. Morelli, and A.W. Thomson Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction Immunol. Rev. 196 2003 125 146
40. A.M. Mowat Anatomical basis of tolerance and immunity to intestinal antigens Nat. Rev. Immunol. 3 2003 331 341
41. M.F. Neurath, S. Finotto, and L.H. Glimcher The role of Th1/Th2 polarization in mucosal immunity Nat. Med. 8 2002 567 573
42. M.C. Noverr, and G.B. Huffnagle Does the microbiota regulate immune responses outside the gut? Trends Microbiol. 12 2004 562 568
43. P. Pereira, L. Forni, E. Larsson, M. Cooper, C. Heusser, and A. Coutinho Autonomous activation of B and T cells in antigen-free mice Eur. J. Immunol. 16 1986 685 688
44. S.L. Prescott, C. Macaubas, B.J. Holt, T.B. Smallacombe, R. Loh, P.D. Sly, and P.G. Holt Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile J. Immunol. 160 1998 4730 4737
45. S. Rakoff-Nahoum, J. Paglino, F. Eslami-Varzaneh, S. Edberg, and R. Medzhitov Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis Cell 118 2004 229 241
46. R.A. Rastall Bacteria in the gut: friends and foes and how to alter the balance J. Nutr. 134 2004 2022S 2026S
47. M. Rescigno, G. Rotta, B. Valzasina, and P. Ricciardi-Castagnoli Dendritic cells shuttle microbes across gut epithelial monolayers Immunobiology 204 2001 572 581
48. G.A. Rook, and L.R. Brunet Give us this day our daily germs Biologist (London) 49 2002 145 149
49. A. Sheikh, and D.P. Strachan The hygiene theory: fact or fiction? Curr. Opin. Otolaryngol. Head Neck Surg. 12 2004 232 236
50. H.N. Shi, and A. Walker Bacterial colonization and the development of intestinal defences Can. J. Gastroenterol. 18 2004 493 500
51. D.P. Strachan Hay fever, hygiene, and household size BMJ 299 1989 1259 1260
52. C. Thery, and S. Amigorena The cell biology of antigen presentation in dendritic cells Curr. Opin. Immunol. 13 2001 45 51
53. G. Trinchieri Interleukin-12 and the regulation of innate resistance and adaptive immunity Nat. Rev. Immunol. 3 2003 133 146
54. A.O. Tzianabos, and D.L. Kasper Role of T cells in abscess formation Curr. Opin. Microbiol. 5 2002 92 96
55. A.O. Tzianabos, A. Pantosti, H. Baumann, J.R. Brisson, H.J. Jennings, and D.L. Kasper The capsular polysaccharide of Bacteroides fragilis comprises two ionically linked polysaccharides J. Biol. Chem. 267 1992 18230 18235
56. A.O. Tzianabos, A.B. Onderdonk, B. Rosner, R.L. Cisneros, and D.L. Kasper Structural features of polysaccharides that induce intra-abdominal abscesses Science 262 1993 416 419
57. A.O. Tzianabos, A.B. Onderdonk, D.F. Zaleznik, R.S. Smith, and D.L. Kasper Structural characteristics of polysaccharides that induce protection against intra-abdominal abscess formation Infect. Immun. 62 1994 4881 4886
58. A.O. Tzianabos, P.R. Russell, A.B. Onderdonk, F.C. Gibson 3rd, C. Cywes, M. Chan, R.W. Finberg, and D.L. Kasper IL-2 mediates protection against abscess formation in an experimental model of sepsis J. Immunol. 163 1999 893 897
59. A.O. Tzianabos, R.W. Finberg, Y. Wang, M. Chan, A.B. Onderdonk, H.J. Jennings, and D.L. Kasper T cells activated by zwitterionic molecules prevent abscesses induced by pathogenic bacteria J. Biol. Chem. 275 2000 6733 6740
60. D.T. Umetsu, J.J. McIntire, O. Akbari, C. Macaubas, and R.H. DeKruyff Asthma: an epidemic of dysregulated immunity Nat. Immunol. 3 2002 715 720
61. L.C. Von Hertzen, and T. Haahtela Asthma and atopy - the price of affluence? Allergy 59 2004 124 137
62. M. Wills-Karp, J. Santeliz, and C.L. Karp The germless theory of allergic disease: revisiting the hygiene hypothesis Nat. Rev. Immunol. 1 2001 69 75
63. T. Yamanaka, L. Helgeland, I.N. Farstad, H. Fukushima, T. Midtvedt, and P. Brandtzaeg Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches J. Immunol. 170 2003 816 822
64. G.X. Zhang, V. Navikas, and H. Link Cytokines and the pathogenesis of myasthenia gravis Muscle Nerve 20 1997 543 551
65. L. Zou, B. Barnett, H. Safah, V.F. Larussa, M. Evdemon-Hogan, P. Mottram, S. Wei, O. David, T.J. Curiel, and W. Zou Bone marrow is a reservoir for CD4+CD25+ regulatory T cells that traffic through CXCL12/CXCR4 signals Cancer Res. 64 2004 8451 8455