Indoxyl sulfate upregulates renal expression of ICAM-1 via production of ROS and activation of NF-κB and p53 in proximal tubular cells

Life Sciences

Volumn 92, Issue 2, 2013, Pages 143-148

  Shimizu, Hidehisa ^a   Yisireyili, Maimaiti ^a   Higashiyama, Yukihiro ^b   Nishijima, Fuyuhiko ^b   Niwa, Toshimitsu ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KUREHA CORPORATION   (Japan)

Author keywords

Chronic kidney disease; NF B; p53; ROS; Tubulointerstitial injury

Indexed keywords

DIPHENYLIODONIUM SALT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDICAN; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; PIFITHRIN ALPHA; PROTEIN P53; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOPLASM; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; NEPHROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; UPREGULATION;

ANIMALS; CELLS, CULTURED; HUMANS; IMMUNOBLOTTING; INDICAN; INTERCELLULAR ADHESION MOLECULE-1; KIDNEY CORTEX; KIDNEY TUBULES, PROXIMAL; NF-KAPPA B; RATS; RATS, INBRED DAHL; REAL-TIME POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

ANIMALIA; RATTUS;

EID: 84872281329     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.11.012     Document Type: Article

References (21)

1. A. Adijiang, S. Goto, S. Uramoto, F. Nishijima, and T. Niwa Indoxyl sulphate promotes aortic calcification with expression of osteoblast-specific proteins in hypertensive rats Nephrol Dial Transplant 23 2008 1892 1901
2. A. Adijiang, Y. Higuchi, F. Nishijima, H. Shimizu, and T. Niwa Indoxyl sulfate, a uremic toxin, promotes cell senescence in aorta of hypertensive rats Biochem Biophys Res Commun 399 2010 637 641
3. A. Adijiang, H. Shimizu, Y. Higuchi, F. Nishijima, and T. Niwa Indoxyl sulfate reduces klotho expression and promotes senescence in the kidneys of hypertensive rats J Ren Nutr 21 2011 105 109
4. E. Androulakis, D. Tousoulis, N. Papageorgiou, G. Latsios, G. Siasos, and C. Tsioufis Inflammation in hypertension: current therapeutic approaches Curr Pharm Des 17 2011 4121 4131
5. I. Aoyama, K. Shimokata, and T. Niwa An oral adsorbent downregulates renal expression of genes that promote interstitial inflammation and fibrosis in diabetic rats Nephron 92 2002 635 651
6. P. Arrizabalaga, M. Solé, R. Abellana, X. de las Cuevas, J. Soler, and J. Pascual Tubular and interstitial expression of ICAM-1 as a marker of renal injury in IgA nephropathy Am J Nephrol 23 2003 121 128
7. D. Bolati, H. Shimizu, Y. Higashiyama, F. Nishijima, and T. Niwa Indoxyl sulfate induces epithelial-to-mesenchymal transition in rat kidneys and human proximal tubular cells Am J Nephrol 34 2011 318 323
8. A. Enomoto, M. Takeda, A. Tojo, T. Sekine, S.H. Cha, and S. Khamdang Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity J Am Soc Nephrol 13 2002 1711 1720
9. Q. Li, B.C. Liu, L.L. Lv, K.L. Ma, X.L. Zhang, and A.O. Phillips Monocytes induce proximal tubular epithelial-mesenchymal transition through NF-kappa B dependent upregulation of ICAM-1 J Cell Biochem 112 2011 1585 1592
10. D. Mao, S. Lü, N. Li, Y. Zhang, and M. Long Conformational stability analyses of alpha subunit I domain of LFA-1 and Mac-1 PLoS One 6 2011 e24188
11. T. Miyazaki, M. Ise, H. Seo, and T. Niwa Indoxyl sulfate increases the gene expression of TGF-β1, TIMP-1 and pro-α (I) collagen in uremic rat kidneys Kidney Int Suppl. 62 1997 S15 S22
12. T. Niwa, and M. Ise Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis J Lab Clin Med 124 1994 96 104
13. T. Niwa, M. Ise, and T. Miyazaki Progression of glomerular sclerosis in experimental uremic rats by administration of indole, a precursor of indoxyl sulfate Am J Nephrol 14 1994 207 212
14. S. Owada, S. Goto, K. Bannai, H. Hayashi, F. Nishijima, and T. Niwa Indoxyl sulfate reduces superoxide scavenging activity in the kidneys of normal and uremic rats Am J Nephrol 28 2008 446 454
15. R. Rothlein, and C. Wegner Role of intercellular adhesion molecule-1 in the inflammatory response Kidney Int 41 1992 617 619
16. H. Shimizu, Y. Hirose, F. Nishijima, Y. Tsubakihara, and H. Miyazaki ROS and PDGF-β receptors are critically involved in indoxyl sulfate actions that promote vascular smooth muscle cell proliferation and migration Am J Physiol Cell Physiol 297 2009 C389 C396
17. H. Shimizu, D. Bolati, A. Adijiang, A. Enomoto, F. Nishijima, and M. Dateki Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate Am J Physiol Cell Physiol 299 2010 C1110 C1117
18. H. Shimizu, D. Bolati, A. Adijiang, Y. Adelibieke, G. Muteliefu, and A. Enomoto Indoxyl sulfate downregulates renal expression of Klotho through production of ROS and activation of nuclear factor-Ä̧B Am J Nephrol 33 2011 319 324
19. H. Shimizu, D. Bolati, A. Adijiang, G. Muteliefu, A. Enomoto, and F. Nishijima NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression and inhibition of proliferation in proximal tubular cells Am J Physiol Cell Physiol 301 2011 C1201 C1212
20. Z. Tumur, H. Shimizu, A. Enomoto, H. Miyazaki, and T. Niwa Indoxyl sulfate upregulates expression of ICAM-1 and MCP-1 by oxidative stress-induced NF-κB activation Am J Nephrol 31 2010 435 441
21. X.L. Zhang, W. Selbi, C. de la Motte, V. Hascall, and A. Phillips Renal proximal tubular epithelial cell transforming growth factor-beta1 generation and monocyte binding Am J Pathol 165 2004 763 773