Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 1, 2016, Pages E7-E15

  Kim, Hyun Jung ^a,g   Li, Hu ^a,h   Collins, James J ^a,b,c,d   Ingber, Donald E ^a,e,f  

^a HARVARD UNIVERSITY   (United States)

^b USA   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^e BOSTON CHILDREN S HOSPITAL   (United States)

^f HARVARD UNIVERSITY   (United States)

^g The University of Texas at Austin   (United States)

^h MAYO GRADUATE SCHOOL   (United States)

Author keywords

Gut on a chip; Inflammatory bowel disease; Intestine; Mechanical; Microbiome

Indexed keywords

ANTIBIOTIC AGENT; ENDOTOXIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; PROBIOTIC AGENT; TUMOR NECROSIS FACTOR ALPHA; ANTIINFECTIVE AGENT; TUMOR NECROSIS FACTOR;

ARTICLE; BACTERIAL OVERGROWTH; CYTOKINE PRODUCTION; ENTERITIS; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; ILEUS; IN VITRO STUDY; INFLAMMATORY BOWEL DISEASE; INFLAMMATORY CELL; INTESTINE EPITHELIUM CELL; INTESTINE FLORA; INTESTINE INJURY; MICROBIOME; MICROTECHNOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PERISTALSIS; PRIORITY JOURNAL; ULCERATIVE COLITIS; ANIMAL; BACTERIUM; BIOLOGICAL MODEL; CACO-2 CELL LINE; DRUG EFFECTS; EVALUATION STUDY; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; INFLAMMATORY BOWEL DISEASES; INTESTINE MUCOSA; LAB ON A CHIP; MICROBIOLOGY; MICROFLORA; PHYSIOLOGY;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; CACO-2 CELLS; HUMANS; ILEUS; IN VITRO TECHNIQUES; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERLEUKIN-8; INTESTINAL MUCOSA; LAB-ON-A-CHIP DEVICES; MICROBIOTA; MODELS, BIOLOGICAL; PERISTALSIS; PROBIOTICS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84953273098     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1522193112     Document Type: Article

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