Synthetic microbes as drug delivery systems

ACS Synthetic Biology

Volumn 4, Issue 4, 2015, Pages 358-364

  Claesen, Jan ^a   Fischbach, Michael A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

bacterial therapeutic; biosafety; delivery; diagnosis; human microbiome; signal integration

Indexed keywords

BACTERIAL ANTIGEN;

ARTICLE; BACTERIAL CELL; BACTERIAL STRAIN; BIOSAFETY; BIOSYNTHESIS; CELL FUNCTION; CELL THERAPY; CLINICAL TRIAL (TOPIC); COMMENSALISM; DIET SUPPLEMENTATION; DRUG DELIVERY SYSTEM; FEEDBACK SYSTEM; GENE CLUSTER; GENE EXPRESSION; GENE TRANSFER; HETEROLOGOUS EXPRESSION; HUMAN; IMMUNE SYSTEM; INTRACELLULAR SIGNALING; MICROFLORA; MOLECULAR ECOLOGY; NONHUMAN; ORGANISMAL INTERACTION; PRIORITY JOURNAL; QUORUM SENSING; SYNTHETIC BIOLOGY; SYNTHETIC MICROBE; SYSTEMIC THERAPY; ANIMAL; BACTERIUM; CELL ENGINEERING; PROCEDURES;

BACTERIA (MICROORGANISMS);

ANIMALS; BACTERIA; CELL ENGINEERING; DRUG DELIVERY SYSTEMS; HUMANS; SYNTHETIC BIOLOGY;

EID: 84928112296     PISSN: None     EISSN: 21615063     Source Type: Journal    
DOI: 10.1021/sb500258b     Document Type: Article

References (51)

1. Lu, T. K. and Collins, J. J. (2007) Dispersing biofilms with engineered enzymatic bacteriophage Proc. Natl. Acad. Sci. U.S.A. 104, 11197-11202
2. Lu, T. K. and Collins, J. J. (2009) Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy Proc. Natl. Acad. Sci. U.S.A. 106, 4629-4634
3. Chen, D. J., Osterrieder, N., Metzger, S. M., Buckles, E., Doody, A. M., DeLisa, M. P., and Putnam, D. (2010) Delivery of foreign antigens by engineered outer membrane vesicle vaccines Proc. Natl. Acad. Sci. U.S.A. 107, 3099-3104
4. Xie, Z., Wroblewska, L., Prochazka, L., Weiss, R., and Benenson, Y. (2011) Multi-Input RNAi-Based Logic Circuit for Identification of Specific Cancer Cells Science 333, 1307-1311
5. Hamady, Z. Z. R., Scott, N., Farrar, M. D., Lodge, J. P. A., Holland, K. T., Whitehead, T., and Carding, S. R. (2010) Xylan-regulated delivery of human keratinocyte growth factor-2 to the inflamed colon by the human anaerobic commensal bacterium Bacteroides ovatus Gut 59, 461-469
6. Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W., and Remaut, E. (2000) Treatment of murine colitis by Lactococcus lactis secreting interleukin-10 Science 289, 1352-1355
7. Belkaid, Y. and Hand, T. W. (2014) Role of the microbiota in immunity and inflammation Cell 157, 121-141
8. Van Nood, E., Vrieze, A., Nieuwdorp, M., Fuentes, S., Zoetendal, E. G., de Vos, W. M., Visser, C. E., Kuijper, E. J., Bartelsman, J. F. W. M., Tijssen, J. G. P., Speelman, P., Dijkgraaf, M. G. W., and Keller, J. J. (2013) Duodenal infusion of donor feces for recurrent Clostridium difficile N. Engl. J. Med. 368, 407-415
9. Lawley, T. D., Clare, S., Walker, A. W., Stares, M. D., Connor, T. R., Raisen, C., Goulding, D., Rad, R., Schreiber, F., Brandt, C., Deakin, L. J., Pickard, D. J., Duncan, S. H., Flint, H. J., Clark, T. G., Parkhill, J., and Dougan, G. (2012) Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice PLoS Pathog. 8, e1002995
10. Checa, S. K., Zurbriggen, M. D., and Soncini, F. C. (2012) Bacterial signaling systems as platforms for rational design of new generations of biosensors Curr. Opin. Biotechnol. 23, 766-772
11. Staroń, A., Sofia, H. J., Dietrich, S., Ulrich, L. E., Liesegang, H., and Mascher, T. (2009) The third pillar of bacterial signal transduction: classification of the extracytoplasmic function (ECF) σ factor protein family Mol. Microbiol. 74, 557-581
12. Clarke, E. J. and Voigt, C. A. (2011) Characterization of combinatorial patterns generated by multiple two-component sensors in E. coli that respond to many stimuli Biotechnol. Bioeng. 108, 666-675
13. Saeidi, N., Wong, C. K., Lo, T.-M., Nguyen, H. X., Ling, H., Leong, S. S. J., Poh, C. L., and Chang, M. W. (2011) Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen Mol. Syst. Biol. 7, 521
14. Miller, M. B. and Bassler, B. L. (2001) Quorum sensing in bacteria Annu. Rev. Microbiol. 55, 165-199
15. Waters, C. M. and Bassler, B. L. (2005) Quorum sensing: Cell-to-Cell Communication in Bacteria Annu. Rev. Cell Dev. Biol. 21, 319-346
16. Wu, H.-C., Tsao, C.-Y., Quan, D. N., Cheng, Y., Servinsky, M. D., Carter, K. K., Jee, K. J., Terrell, J. L., Zargar, A., Rubloff, G. W., Payne, G. F., Valdes, J. J., and Bentley, W. E. (2013) Autonomous bacterial localization and gene expression based on nearby cell receptor density Mol. Syst. Biol. 9, 636
17. Anderson, J. C., Clarke, E. J., Arkin, A. P., and Voigt, C. A. (2006) Environmentally controlled invasion of cancer cells by engineered bacteria J. Mol. Biol. 355, 619-627
18. Xiang, S., Fruehauf, J., and Li, C. J. (2006) Short hairpin RNA-expressing bacteria elicit RNA interference in mammals Nat. Biotechnol. 24, 697-702
19. Chen, J., Yang, B., Cheng, X., Qiao, Y., Tang, B., Chen, G., Wei, J., Liu, X., Cheng, W., Du, P., Huang, X., Jiang, W., Hu, Q., Hu, Y., Li, J., and Hua, Z.-C. (2012) Salmonella-mediated tumor-targeting TRAIL gene therapy significantly suppresses melanoma growth in mouse model Cancer Sci. 103, 325-333
20. Archer, E. J., Robinson, A. B., and Süel, G. M. (2012) Engineered E. coli that detect and respond to gut inflammation through nitric oxide sensing ACS Synth. Biol. 1, 451-457
21. Royo, J. L., Becker, P. D., Camacho, E. M., Cebolla, A., Link, C., Santero, E., and Guzmán, C. A. (2007) In vivo gene regulation in Salmonella spp. by a salicylate-dependent control circuit Nat. Methods 4, 937-942
22. Brophy, J. A. N. and Voigt, C. A. (2014) Principles of genetic circuit design Nat. Methods 11, 508-520
23. Anderson, J. C., Voigt, C. A., and Arkin, A. P. (2007) Environmental signal integration by a modular AND gate Mol. Syst. Biol. 3, 133
24. Moon, T. S., Lou, C., Tamsir, A., Stanton, B. C., and Voigt, C. A. (2012) Genetic programs constructed from layered logic gates in single cells Nature 491, 249-253
25. Stanton, B. C., Nielsen, A. A. K., Tamsir, A., Clancy, K., Peterson, T., and Voigt, C. A. (2014) Genomic mining of prokaryotic repressors for orthogonal logic gates Nat. Chem. Biol. 10, 99-105
26. Mijakovic, I., Petranovic, D., and Jensen, P. R. (2005) Tunable promoters in systems biology Curr. Opin. Biotechnol. 16, 329-335
27. Kemmer, C., Gitzinger, M., Baba, M. D.-E., Djonov, V., Stelling, J., and Fussenegger, M. (2010) Self-sufficient control of urate homeostasis in mice by a synthetic circuit Nat. Biotechnol. 28, 355-360
28. Kotula, J. W., Kerns, S. J., Shaket, L. A., Siraj, L., Collins, J. J., Way, J. C., and Silver, P. A. (2014) Programmable bacteria detect and record an environmental signal in the mammalian gut Proc. Natl. Acad. Sci. U.S.A. 111, 4838-4843
29. Fischbach, M. and Voigt, C. A. (2010) Prokaryotic gene clusters: A rich toolbox for synthetic biology Biotechnol. J. 5, 1277-1296
30. Temme, K., Zhao, D., and Voigt, C. A. (2012) Refactoring the nitrogen fixation gene cluster from Klebsiella oxytoca Proc. Natl. Acad. Sci. U.S.A. 109, 7085-7090
31. Arnison, P. G., Bibb, M. J., Bierbaum, G., Bowers, A. A., Bugni, T. S., Bulaj, G., Camarero, J. A., Campopiano, D. J., Challis, G. L., Clardy, J., Cotter, P. D., Craik, D. J., Dawson, M., Dittmann, E., Donadio, S., Dorrestein, P. C., Entian, K.-D., Fischbach, M. A., Garavelli, J. S., Göransson, U., Gruber, C. W., Haft, D. H., Hemscheidt, T. K., Hertweck, C., Hill, C., Horswill, A. R., Jaspars, M., Kelly, W. L., Klinman, J. P., Kuipers, O. P., Link, A. J., Liu, W., Marahiel, M. A., Mitchell, D. A., Moll, G. N., Moore, B. S., Müller, R., Nair, S. K., Nes, I. F., Norris, G. E., Olivera, B. M., Onaka, H., Patchett, M. L., Piel, J., Reaney, M. J. T., Rebuffat, S., Ross, R. P., Sahl, H.-G., Schmidt, E. W., Selsted, M. E., Severinov, K., Shen, B., Sivonen, K., Smith, L., Stein, T., Süssmuth, R. D., Tagg, J. R., Tang, G.-L., Truman, A. W., Vederas, J. C., Walsh, C. T., Walton, J. D., Wenzel, S. C., Willey, J. M., and van der Donk, W. A. (2013) Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature Nat. Prod. Rep. 30, 108-160
32. Kleerebezem, M. (2004) Quorum sensing control of lantibiotic production; nisin and subtilin autoregulate their own biosynthesis Peptides 25, 1405-1414
33. De Ruyter, P. G., Kuipers, O. P., and de Vos, W. M. (1996) Controlled gene expression systems for Lactococcus lactis with the food-grade inducer nisin Appl. Environ. Microbiol. 62, 3662-3667
34. Ng, D. T. W. and Sarkar, C. A. (2011) Nisin-inducible secretion of a biologically active single-chain insulin analog by Lactococcus lactis NZ9000 Biotechnol. Bioeng. 108, 1987-1996
35. Braat, H., Rottiers, P., Hommes, D. W., Huyghebaert, N., Remaut, E., Remon, J.-P., van Deventer, S. J. H., Neirynck, S., Peppelenbosch, M. P., and Steidler, L. (2006) A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease Clin. Gastroenterol. Hepatol. 4, 754-759
36. Vandenbroucke, K., de Haard, H., Beirnaert, E., Dreier, T., Lauwereys, M., Huyck, L., Van Huysse, J., Demetter, P., Steidler, L., Remaut, E., Cuvelier, C., and Rottiers, P. (2010) Orally administered L. lactis secreting an anti-TNF nanobody demonstrate efficacy in chronic colitis Mucosal Immunol. 3, 49-56
37. Duan, F., Curtis, K. L., and March, J. C. (2008) Secretion of insulinotropic proteins by commensal bacteria: Rewiring the gut to treat diabetes Appl. Environ. Microbiol. 74, 7437-7438
38. Mohamadzadeh, M., Duong, T., Sandwick, S. J., Hoover, T., and Klaenhammer, T. R. (2009) Dendritic cell targeting of Bacillus anthracis protective antigen expressed by Lactobacillus acidophilus protects mice from lethal challenge Proc. Natl. Acad. Sci. U.S.A. 106, 4331-4336
39. Kong, W., Brovold, M., Koeneman, B. A., Clark-Curtiss, J., and Curtiss, R. (2012) Turning self-destructing Salmonella into a universal DNA vaccine delivery platform Proc. Natl. Acad. Sci. U.S.A. 109, 19414-19419
40. Lagenaur, L. A., Sanders-Beer, B. E., Brichacek, B., Pal, R., Liu, X., Liu, Y., Yu, R., Venzon, D., Lee, P. P., and Hamer, D. H. (2011) Prevention of vaginal SHIV transmission in macaques by a live recombinant Lactobacillus Mucosal Immunol. 4, 648-657
41. Duan, F. and March, J. C. (2010) Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model Proc. Natl. Acad. Sci. U.S.A. 107, 11260-11264
42. Focareta, A., Paton, J. C., Morona, R., Cook, J., and Paton, A. W. (2006) A recombinant probiotic for treatment and prevention of cholera Gastroenterology 130, 1688-1695
43. Natale, P., Brüser, T., and Driessen, A. J. M. (2008) Sec- and Tat-mediated protein secretion across the bacterial cytoplasmic membrane-Distinct translocases and mechanisms Biochim. Biophys. Acta, Biomembr. 1778, 1735-1756
44. Widmaier, D. M., Tullman-Ercek, D., Mirsky, E. A., Hill, R., Govindarajan, S., Minshull, J., and Voigt, C. A. (2009) Engineering the Salmonella type III secretion system to export spider silk monomers Mol. Syst. Biol. 5, 309
45. Galán, J. E. and Collmer, A. (1999) Type III secretion machines: Bacterial devices for protein delivery into host cells Science 284, 1322-1328
46. Danino, T., Lo, J., Prindle, A., Hasty, J., and Bhatia, S. N. (2012) In vivo gene expression dynamics of tumor-targeted bacteria ACS Synth. Biol. 1, 465-470
47. Steidler, L., Neirynck, S., Huyghebaert, N., Snoeck, V., Vermeire, A., Goddeeris, B., Cox, E., Remon, J. P., and Remaut, E. (2003) Biological containment of genetically modified Lactococcus lactis for intestinal delivery of human interleukin 10 Nat. Biotechnol. 21, 785-789
48. Kong, W., Wanda, S.-Y., Zhang, X., Bollen, W., Tinge, S. A., Roland, K. L., and Curtiss, R. (2008) Regulated programmed lysis of recombinant Salmonella in host tissues to release protective antigens and confer biological containment Proc. Natl. Acad. Sci. U.S.A. 105, 9361-9366
49. Fischbach, M. A., Bluestone, J. A., and Lim, W. A. (2013) Cell-based therapeutics: The next pillar of medicine Sci. Transl. Med. 5, 179ps7
50. Burton, J. P., Wescombe, P. A., Moore, C. J., Chilcott, C. N., and Tagg, J. R. (2006) Safety assessment of the oral cavity probiotic Streptococcus salivarius K12 Appl. Environ. Microbiol. 72, 3050-3053
51. Caluwaerts, S., Vandenbroucke, K., Steidler, L., Neirynck, S., Vanhoenacker, P., Corveleyn, S., Watkins, B., Sonis, S., Coulie, B., and Rottiers, P. (2010) AG013, a mouth rinse formulation of Lactococcus lactis secreting human Trefoil Factor 1, provides a safe and efficacious therapeutic tool for treating oral mucositis Oral Oncol. 46, 564-570