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Volumn 9, Issue 5, 2009, Pages 313-323

The gut microbiota shapes intestinal immune responses during health and disease

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 2 RECEPTOR BETA; PATTERN RECOGNITION RECEPTOR; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR;

EID: 67349250428     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri2515     Document Type: Review
Times cited : (3784)

References (103)
  • 1
    • 32944466887 scopus 로고    scopus 로고
    • Ecological and evolutionary forces shaping microbial diversity in the human intestine
    • Ley, R. E., Peterson, D. A. & Gordon, J. I. Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 124, 837-848 (2006).
    • (2006) Cell , vol.124 , pp. 837-848
    • Ley, R.E.1    Peterson, D.A.2    Gordon, J.I.3
  • 2
    • 35348961403 scopus 로고    scopus 로고
    • An ecological and evolutionary perspective on human-microbe mutualism and disease
    • Dethlefsen, L., McFall-Ngai, M. & Relman, D. A. An ecological and evolutionary perspective on human-microbe mutualism and disease. Nature 449, 811-818 (2007).
    • (2007) Nature , vol.449 , pp. 811-818
    • Dethlefsen, L.1    McFall-Ngai, M.2    Relman, D.A.3
  • 3
    • 1542316379 scopus 로고    scopus 로고
    • Bacterial contributions to mammalian gut development
    • Hooper, L. V. Bacterial contributions to mammalian gut development. Trends Microbiol. 12, 129-134 (2004).
    • (2004) Trends Microbiol , vol.12 , pp. 129-134
    • Hooper, L.V.1
  • 4
    • 33750326113 scopus 로고    scopus 로고
    • The love-hate relationship between bacterial polysaccharides and the host immune system
    • Mazmanian, S. K. & Kasper, D. L. The love-hate relationship between bacterial polysaccharides and the host immune system. Nature Rev. Immunol. 6, 849-858 (2006).
    • (2006) Nature Rev. Immunol , vol.6 , pp. 849-858
    • Mazmanian, S.K.1    Kasper, D.L.2
  • 5
    • 44649118583 scopus 로고    scopus 로고
    • Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases
    • Peterson, D. A., Frank, D. N., Pace, N. R. & Gordon, J. I. Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases. Cell Host Microbe 3, 417-427 (2008).
    • (2008) Cell Host Microbe , vol.3 , pp. 417-427
    • Peterson, D.A.1    Frank, D.N.2    Pace, N.R.3    Gordon, J.I.4
  • 6
    • 36549028432 scopus 로고    scopus 로고
    • Gastrointestinal microbiology enters the metagenomics era
    • Frank, D. N. & Pace, N. R. Gastrointestinal microbiology enters the metagenomics era. Curr. Opin. Gastroenterol. 24, 4-10 (2008).
    • (2008) Curr. Opin. Gastroenterol , vol.24 , pp. 4-10
    • Frank, D.N.1    Pace, N.R.2
  • 7
    • 46249085739 scopus 로고    scopus 로고
    • Evolution of mammals and their gut microbes
    • Ley, R. E. et al. Evolution of mammals and their gut microbes. Science 320, 1647-1651 (2008).
    • (2008) Science , vol.320 , pp. 1647-1651
    • Ley, R.E.1
  • 8
    • 0035843993 scopus 로고    scopus 로고
    • Commensal host-bacterial relationships in the gut
    • Hooper, L. V. & Gordon, J. I. Commensal host-bacterial relationships in the gut. Science 292, 1115-1118 (2001).
    • (2001) Science , vol.292 , pp. 1115-1118
    • Hooper, L.V.1    Gordon, J.I.2
  • 9
    • 2942625911 scopus 로고    scopus 로고
    • Interactions between commensal intestinal bacteria and the immune system
    • Macpherson, A. J. & Harris, N. L. Interactions between commensal intestinal bacteria and the immune system. Nature Rev. Immunol. 4, 478-485 (2004).
    • (2004) Nature Rev. Immunol , vol.4 , pp. 478-485
    • Macpherson, A.J.1    Harris, N.L.2
  • 10
    • 40849126449 scopus 로고    scopus 로고
    • Host-bacterial coevolution and the search for new drug targets
    • Zaneveld, J. et al. Host-bacterial coevolution and the search for new drug targets. Curr. Opin. Chem. Biol. 12, 109-114 (2008).
    • (2008) Curr. Opin. Chem. Biol , vol.12 , pp. 109-114
    • Zaneveld, J.1
  • 11
    • 0031768678 scopus 로고    scopus 로고
    • Creating and maintaining the gastrointestinal ecosystem: What we know and need to know from gnotobiology
    • Falk, P. G., Hooper, L. V., Midtvedt, T. & Gordon, J. I. Creating and maintaining the gastrointestinal ecosystem: what we know and need to know from gnotobiology. Microbiol. Mol. Biol. Rev. 62, 1157-1170 (1998).
    • (1998) Microbiol. Mol. Biol. Rev , vol.62 , pp. 1157-1170
    • Falk, P.G.1    Hooper, L.V.2    Midtvedt, T.3    Gordon, J.I.4
  • 12
    • 56749146467 scopus 로고    scopus 로고
    • Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
    • This study shows that peptidoglycans from Gram-negative bacteria induce the generation of ILFs through the recognition of NOD1. In the absence of ILF formation, marked changes in the composition of the microbiota occur
    • Bouskra, D. et al. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature 456, 507-510 (2008). This study shows that peptidoglycans from Gram-negative bacteria induce the generation of ILFs through the recognition of NOD1. In the absence of ILF formation, marked changes in the composition of the microbiota occur.
    • (2008) Nature , vol.456 , pp. 507-510
    • Bouskra, D.1
  • 13
    • 73649204145 scopus 로고    scopus 로고
    • Abrams, G. D., Bauer, H. & Sprinz, H. Influence of the normal flora on mucosal morphology and cellular renewal in the ileum. A comparison of germ-free and conventional mice. Lab. Invest. 12, 355-364 (1963).
    • Abrams, G. D., Bauer, H. & Sprinz, H. Influence of the normal flora on mucosal morphology and cellular renewal in the ileum. A comparison of germ-free and conventional mice. Lab. Invest. 12, 355-364 (1963).
  • 14
    • 0029845965 scopus 로고    scopus 로고
    • A model of host-microbial interactions in an open mammalian ecosystem
    • Bry, L., Falk, P. G., Midtvedt, T. & Gordon, J. I. A model of host-microbial interactions in an open mammalian ecosystem. Science 273, 1380-1383 (1996).
    • (1996) Science , vol.273 , pp. 1380-1383
    • Bry, L.1    Falk, P.G.2    Midtvedt, T.3    Gordon, J.I.4
  • 15
    • 33748039462 scopus 로고    scopus 로고
    • Cash, H. L., Whitham, C. V., Behrendt, C. L. & Hooper, L. V. Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 313, 1126-1130 (2006). These authors show that microbial colonization of germ-free mice induces the production of REG3γ, a secreted C-type lectin. REG3γ is shown to have antimicrobial activity by binding to peptidoglycans, suggesting that microbial species actively shape the intestinal environment to their advantage.
    • Cash, H. L., Whitham, C. V., Behrendt, C. L. & Hooper, L. V. Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 313, 1126-1130 (2006). These authors show that microbial colonization of germ-free mice induces the production of REG3γ, a secreted C-type lectin. REG3γ is shown to have antimicrobial activity by binding to peptidoglycans, suggesting that microbial species actively shape the intestinal environment to their advantage.
  • 16
    • 33845508443 scopus 로고    scopus 로고
    • Sonnenburg, J. L., Chen, C. T. & Gordon, J. I. Genomic and metabolic studies of the impact of probiotics on a model gut symbiont and host. PLoS Biol. 4, e413 (2006). Using co-colonization of germ-free mice with B. thetaiotaomicron (a symbiont) and B. longum (a probiotic), this study shows that B. longum can increase the diversity of polysaccharides that can be degraded by B. thetaiotaomicron, demonstrating that distinct intestinal bacterial species can affect each other's function.
    • Sonnenburg, J. L., Chen, C. T. & Gordon, J. I. Genomic and metabolic studies of the impact of probiotics on a model gut symbiont and host. PLoS Biol. 4, e413 (2006). Using co-colonization of germ-free mice with B. thetaiotaomicron (a symbiont) and B. longum (a probiotic), this study shows that B. longum can increase the diversity of polysaccharides that can be degraded by B. thetaiotaomicron, demonstrating that distinct intestinal bacterial species can affect each other's function.
  • 17
    • 84965088915 scopus 로고
    • The response of the germfree guinea pig to oral bacterial challenge with Escherichia coli and Shigella flexneri
    • Sprinz, H. et al. The response of the germfree guinea pig to oral bacterial challenge with Escherichia coli and Shigella flexneri. Am. J. Pathol. 39, 681-695 (1961).
    • (1961) Am. J. Pathol , vol.39 , pp. 681-695
    • Sprinz, H.1
  • 18
    • 0015377875 scopus 로고
    • Experimental Shigella infections in laboratory animals. I. Antagonism by human normal flora components in gnotobiotic mice
    • Maier, B. R. & Hentges, D. J. Experimental Shigella infections in laboratory animals. I. Antagonism by human normal flora components in gnotobiotic mice. Infect. Immun. 6, 168-173 (1972).
    • (1972) Infect. Immun , vol.6 , pp. 168-173
    • Maier, B.R.1    Hentges, D.J.2
  • 19
    • 0018328199 scopus 로고
    • Microbial interference and colonization of the murine gastrointestinal tract by Listeria monocytogenes
    • Zachar, Z. & Savage, D. C. Microbial interference and colonization of the murine gastrointestinal tract by Listeria monocytogenes. Infect. Immun. 23, 168-174 (1979).
    • (1979) Infect. Immun , vol.23 , pp. 168-174
    • Zachar, Z.1    Savage, D.C.2
  • 20
    • 0030017334 scopus 로고    scopus 로고
    • Increased susceptibility to primary infection with Listeria monocytogenes in germfree mice may be due to lack of accumulation of L-selectin+ CD44+ T cells in sites of inflammation
    • Inagaki, H., Suzuki, T., Nomoto, K. & Yoshikai, Y. Increased susceptibility to primary infection with Listeria monocytogenes in germfree mice may be due to lack of accumulation of L-selectin+ CD44+ T cells in sites of inflammation. Infect. Immun. 64, 3280-3287 (1996).
    • (1996) Infect. Immun , vol.64 , pp. 3280-3287
    • Inagaki, H.1    Suzuki, T.2    Nomoto, K.3    Yoshikai, Y.4
  • 21
    • 0024826672 scopus 로고
    • Intragastric infection of germfree and conventional mice with Salmonella typhimurium
    • Nardi, R. M., Silva, M. E., Vieira, E. C., Bambirra, E. A. & Nicoli, J. R. Intragastric infection of germfree and conventional mice with Salmonella typhimurium. Braz. J. Med. Biol. Res. 22, 1389-1392 (1989).
    • (1989) Braz. J. Med. Biol. Res , vol.22 , pp. 1389-1392
    • Nardi, R.M.1    Silva, M.E.2    Vieira, E.C.3    Bambirra, E.A.4    Nicoli, J.R.5
  • 22
    • 35649026345 scopus 로고    scopus 로고
    • Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota
    • These authors show that the intestinal pathogen S. Typhimurium uses inflammation to disturb the commensal microbiota to induce disease
    • Stecher, B. et al. Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota. PLoS Biol. 5, e244 (2007). These authors show that the intestinal pathogen S. Typhimurium uses inflammation to disturb the commensal microbiota to induce disease.
    • (2007) PLoS Biol , vol.5
    • Stecher, B.1
  • 23
    • 0026239950 scopus 로고
    • Bacteriological and immunological aspects of conventional and germfree mice infected with Salmonella typhimurium
    • Nardi, R. M. et al. Bacteriological and immunological aspects of conventional and germfree mice infected with Salmonella typhimurium. Rev. Latinoam. Microbiol. 33, 239-243 (1991).
    • (1991) Rev. Latinoam. Microbiol , vol.33 , pp. 239-243
    • Nardi, R.M.1
  • 24
    • 0036886298 scopus 로고    scopus 로고
    • The current future understanding of inflammatory bowel disease
    • Podolsky, D. K. The current future understanding of inflammatory bowel disease. Best Pract. Res. Clin. Gastroenterol. 16, 933-943 (2002).
    • (2002) Best Pract. Res. Clin. Gastroenterol , vol.16 , pp. 933-943
    • Podolsky, D.K.1
  • 25
    • 0037022008 scopus 로고    scopus 로고
    • Crohn's disease
    • Shanahan, F. Crohn's disease. Lancet 359, 62-69 (2002).
    • (2002) Lancet , vol.359 , pp. 62-69
    • Shanahan, F.1
  • 26
    • 23344446340 scopus 로고    scopus 로고
    • Defects in mucosal immunity leading to ulcerative colitis
    • Targan, S. R. & Karp, L. C. Defects in mucosal immunity leading to ulcerative colitis. Immunol. Rev. 206, 296-305 (2005).
    • (2005) Immunol. Rev , vol.206 , pp. 296-305
    • Targan, S.R.1    Karp, L.C.2
  • 27
    • 0142053206 scopus 로고    scopus 로고
    • The immunological and genetic basis of inflammatory bowel disease
    • Bouma, G. & Strober, W. The immunological and genetic basis of inflammatory bowel disease. Nature Rev. Immunol. 3, 521-533 (2003).
    • (2003) Nature Rev. Immunol , vol.3 , pp. 521-533
    • Bouma, G.1    Strober, W.2
  • 28
    • 33750530394 scopus 로고    scopus 로고
    • IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
    • Kullberg, M. C. et al. IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J. Exp. Med. 203, 2485-2494 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 2485-2494
    • Kullberg, M.C.1
  • 29
    • 33750505009 scopus 로고    scopus 로고
    • Interleukin-23 drives innate and T cellmediated intestinal inflammation
    • Hue, S. et al. Interleukin-23 drives innate and T cellmediated intestinal inflammation. J. Exp. Med. 203, 2473-2483 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 2473-2483
    • Hue, S.1
  • 30
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr, R. H. et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314, 1461-1463 (2006).
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1
  • 31
    • 39649121919 scopus 로고    scopus 로고
    • Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status
    • Schmechel, S. et al. Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status. Inflamm. Bowel Dis. 14, 204-212 (2008).
    • (2008) Inflamm. Bowel Dis , vol.14 , pp. 204-212
    • Schmechel, S.1
  • 32
    • 56549104968 scopus 로고    scopus 로고
    • IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease
    • Kobayashi, T. et al. IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. Gut 57, 1682-1689 (2008).
    • (2008) Gut , vol.57 , pp. 1682-1689
    • Kobayashi, T.1
  • 33
    • 38649115342 scopus 로고    scopus 로고
    • Microbial influences in inflammatory bowel diseases
    • Sartor, R. B. Microbial influences in inflammatory bowel diseases. Gastroenterology 134, 577-594 (2008).
    • (2008) Gastroenterology , vol.134 , pp. 577-594
    • Sartor, R.B.1
  • 34
    • 16844363097 scopus 로고    scopus 로고
    • A well adapted regulatory contrivance: Regulatory T cell development and the forkhead family transcription factor Foxp3
    • Fontenot, J. D. & Rudensky, A. Y. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nature Immunol. 6, 331-337 (2005).
    • (2005) Nature Immunol , vol.6 , pp. 331-337
    • Fontenot, J.D.1    Rudensky, A.Y.2
  • 36
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β and retinoic aciddependent mechanism
    • Coombes, J. L. et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β and retinoic aciddependent mechanism. J. Exp. Med. 204, 1757-1764 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 1757-1764
    • Coombes, J.L.1
  • 37
    • 0037436121 scopus 로고    scopus 로고
    • Powrie, F. & Maloy, K. J. Immunology. Regulating the regulators. Science 299, 1030-1031 (2003).
    • Powrie, F. & Maloy, K. J. Immunology. Regulating the regulators. Science 299, 1030-1031 (2003).
  • 38
    • 36549030784 scopus 로고    scopus 로고
    • The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    • Collison, L. W. et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 450, 566-569 (2007).
    • (2007) Nature , vol.450 , pp. 566-569
    • Collison, L.W.1
  • 39
    • 53349173070 scopus 로고    scopus 로고
    • Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
    • Ivanov, II. et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 4, 337-349 (2008).
    • (2008) Cell Host Microbe , vol.4 , pp. 337-349
    • Ivanov II1
  • 40
    • 53649100675 scopus 로고    scopus 로고
    • ATP drives lamina propria TH17 cell differentiation
    • Atarashi, K. et al. ATP drives lamina propria TH17 cell differentiation. Nature 455, 808-812 (2008).
    • (2008) Nature , vol.455 , pp. 808-812
    • Atarashi, K.1
  • 41
    • 53349164200 scopus 로고    scopus 로고
    • Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses
    • Hall, J. A. et al. Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity 29, 637-649 (2008).
    • (2008) Immunity , vol.29 , pp. 637-649
    • Hall, J.A.1
  • 42
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis
    • This is one of the first studies to suggest that recognition of TLR ligands from commensal bacteria by the host is important for the maintenance of intestinal homeostasis
    • Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. & Medzhitov, R. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 118, 229-241 (2004). This is one of the first studies to suggest that recognition of TLR ligands from commensal bacteria by the host is important for the maintenance of intestinal homeostasis.
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 44
    • 44949127290 scopus 로고    scopus 로고
    • Effect of intestinal microbiota on the induction of regulatory CD25+ CD4+ T cells
    • Ishikawa, H. et al. Effect of intestinal microbiota on the induction of regulatory CD25+ CD4+ T cells. Clin. Exp. Immunol. 153, 127-135 (2008).
    • (2008) Clin. Exp. Immunol , vol.153 , pp. 127-135
    • Ishikawa, H.1
  • 45
    • 27444440273 scopus 로고    scopus 로고
    • Influence of intestinal bacteria on induction of regulatory T cells: Lessons from a transfer model of colitis
    • Strauch, U. G. et al. Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis. Gut 54, 1546-1552 (2005).
    • (2005) Gut , vol.54 , pp. 1546-1552
    • Strauch, U.G.1
  • 46
    • 53349120339 scopus 로고    scopus 로고
    • Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine
    • Zaph, C. et al. Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine. J. Exp. Med. 205, 2191-2198 (2008).
    • (2008) J. Exp. Med , vol.205 , pp. 2191-2198
    • Zaph, C.1
  • 47
    • 0033039741 scopus 로고    scopus 로고
    • Mucosal immunity and inflammation. II. The yin and yang of T cells in intestinal inflammation: Pathogenic and protective roles in a mouse colitis model
    • De Winter, H., Cheroutre, H. & Kronenberg, M. Mucosal immunity and inflammation. II. The yin and yang of T cells in intestinal inflammation: pathogenic and protective roles in a mouse colitis model. Am. J. Physiol. 276, G1317-G1321 (1999).
    • (1999) Am. J. Physiol , vol.276
    • De Winter, H.1    Cheroutre, H.2    Kronenberg, M.3
  • 48
    • 0034013615 scopus 로고    scopus 로고
    • Pathways of T cell pathology in models of chronic intestinal inflammation
    • Simpson, S. J., de Jong, Y. P., Comiskey, M. & Terhorst, C. Pathways of T cell pathology in models of chronic intestinal inflammation. Int. Rev. Immunol. 19, 1-37 (2000).
    • (2000) Int. Rev. Immunol , vol.19 , pp. 1-37
    • Simpson, S.J.1    de Jong, Y.P.2    Comiskey, M.3    Terhorst, C.4
  • 49
    • 34250026960 scopus 로고    scopus 로고
    • Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice
    • Elson, C. O. et al. Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology 132, 2359-2370 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 2359-2370
    • Elson, C.O.1
  • 50
    • 0031253619 scopus 로고    scopus 로고
    • The influence of normal microbial flora on the development of chronic mucosal inflammation
    • Sartor, R. B. The influence of normal microbial flora on the development of chronic mucosal inflammation. Res. Immunol. 148, 567-576 (1997).
    • (1997) Res. Immunol , vol.148 , pp. 567-576
    • Sartor, R.B.1
  • 51
    • 0029866466 scopus 로고    scopus 로고
    • Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria
    • Macpherson, A., Khoo, U. Y., Forgacs, I., Philpott- Howard, J. & Bjarnason, I. Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria. Gut 38, 365-375 (1996).
    • (1996) Gut , vol.38 , pp. 365-375
    • Macpherson, A.1    Khoo, U.Y.2    Forgacs, I.3    Philpott- Howard, J.4    Bjarnason, I.5
  • 52
    • 0033937341 scopus 로고    scopus 로고
    • Commensal bacteria as targets in Crohn's disease
    • Elson, C. O. Commensal bacteria as targets in Crohn's disease. Gastroenterology 119, 254-257 (2000).
    • (2000) Gastroenterology , vol.119 , pp. 254-257
    • Elson, C.O.1
  • 53
    • 0036425921 scopus 로고    scopus 로고
    • Exploring the relationships between intestinal microflora and inflammatory conditions of the human bowel and spine
    • Tannock, G. W. Exploring the relationships between intestinal microflora and inflammatory conditions of the human bowel and spine. Antonie Van Leeuwenhoek 81, 529-535 (2002).
    • (2002) Antonie Van Leeuwenhoek , vol.81 , pp. 529-535
    • Tannock, G.W.1
  • 55
    • 0027933817 scopus 로고
    • Role of intestinal microflora in chronic inflammation and ulceration of the rat colon
    • Videla, S. et al. Role of intestinal microflora in chronic inflammation and ulceration of the rat colon. Gut 35, 1090-1097 (1994).
    • (1994) Gut , vol.35 , pp. 1090-1097
    • Videla, S.1
  • 56
    • 0028003794 scopus 로고
    • The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats
    • Taurog, J. D. et al. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J. Exp. Med. 180, 2359-2364 (1994).
    • (1994) J. Exp. Med , vol.180 , pp. 2359-2364
    • Taurog, J.D.1
  • 57
    • 0037262748 scopus 로고    scopus 로고
    • Role of commensal bacteria in chronic experimental colitis: Lessons from the HLA-B27 transgenic rat
    • Rath, H. C. Role of commensal bacteria in chronic experimental colitis: lessons from the HLA-B27 transgenic rat. Pathobiology 70, 131-138 (2002).
    • (2002) Pathobiology , vol.70 , pp. 131-138
    • Rath, H.C.1
  • 58
    • 0032412057 scopus 로고    scopus 로고
    • Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10- deficient mice
    • Sellon, R. K. et al. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10- deficient mice. Infect. Immun. 66, 5224-5231 (1998).
    • (1998) Infect. Immun , vol.66 , pp. 5224-5231
    • Sellon, R.K.1
  • 59
    • 0030794060 scopus 로고    scopus 로고
    • Inflammatory bowel disease: An immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus
    • Cahill, R. J. et al. Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus. Infect. Immun. 65, 3126-3131 (1997).
    • (1997) Infect. Immun , vol.65 , pp. 3126-3131
    • Cahill, R.J.1
  • 60
    • 0346734121 scopus 로고    scopus 로고
    • Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope
    • Kullberg, M. C. et al. Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope. Proc. Natl Acad. Sci. USA 100, 15830-15835 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 15830-15835
    • Kullberg, M.C.1
  • 61
    • 34249886868 scopus 로고    scopus 로고
    • CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease
    • Barnich, N. et al. CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. J. Clin. Invest. 117, 1566-1574 (2007).
    • (2007) J. Clin. Invest , vol.117 , pp. 1566-1574
    • Barnich, N.1
  • 62
    • 0035897904 scopus 로고    scopus 로고
    • Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations
    • Hampe, J. et al. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations. Lancet 357, 1925-1928 (2001).
    • (2001) Lancet , vol.357 , pp. 1925-1928
    • Hampe, J.1
  • 63
    • 38049004922 scopus 로고    scopus 로고
    • Dual-association of gnotobiotic Il-10-/- mice with 2 nonpathogenic commensal bacteria induces aggressive pancolitis
    • Kim, S. C., Tonkonogy, S. L., Karrasch, T., Jobin, C. & Sartor, R. B. Dual-association of gnotobiotic Il-10-/- mice with 2 nonpathogenic commensal bacteria induces aggressive pancolitis. Inflamm. Bowel Dis. 13, 1457-1466 (2007).
    • (2007) Inflamm. Bowel Dis , vol.13 , pp. 1457-1466
    • Kim, S.C.1    Tonkonogy, S.L.2    Karrasch, T.3    Jobin, C.4    Sartor, R.B.5
  • 64
    • 33745594044 scopus 로고    scopus 로고
    • The gut flora as a forgotten organ
    • 688-693
    • O'Hara, A. M. & Shanahan, F. The gut flora as a forgotten organ. EMBO Rep. 7, 688-693 (2006).
    • (2006) EMBO Rep , vol.7
    • O'Hara, A.M.1    Shanahan, F.2
  • 65
    • 33846064282 scopus 로고    scopus 로고
    • The human microbiome: Eliminating the biomedical/environmental dichotomy in microbial ecology
    • Ley, R. E., Knight, R. & Gordon, J. I. The human microbiome: eliminating the biomedical/environmental dichotomy in microbial ecology. Environ. Microbiol. 9, 3-4 (2007).
    • (2007) Environ. Microbiol , vol.9 , pp. 3-4
    • Ley, R.E.1    Knight, R.2    Gordon, J.I.3
  • 66
    • 44449106055 scopus 로고    scopus 로고
    • A microbial symbiosis factor prevents intestinal inflammatory disease
    • Mazmanian, S. K., Round, J. L. & Kasper, D. L. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 453, 620-625 (2008).
    • (2008) Nature , vol.453 , pp. 620-625
    • Mazmanian, S.K.1    Round, J.L.2    Kasper, D.L.3
  • 67
    • 34247264407 scopus 로고    scopus 로고
    • Trawling for treasure: Tales of T-bet
    • Glimcher, L. H. Trawling for treasure: tales of T-bet. Nature Immunol. 8, 448-450 (2007).
    • (2007) Nature Immunol , vol.8 , pp. 448-450
    • Glimcher, L.H.1
  • 68
    • 34848889673 scopus 로고    scopus 로고
    • Garrett, W. S. et al. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell 131, 33-45 (2007). This study shows that mice that lack T-bet expression in innate immune cells develop spontaneous colitis. Moreover, transfer of the microbiota from these mice is shown to induce disease in wild-type recipient mice.
    • Garrett, W. S. et al. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell 131, 33-45 (2007). This study shows that mice that lack T-bet expression in innate immune cells develop spontaneous colitis. Moreover, transfer of the microbiota from these mice is shown to induce disease in wild-type recipient mice.
  • 69
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • These authors show that the microbiome from obese mice has an increased capacity for energy harvest. Transfer of the microbiota to non-obese mice increases their mean fat body weight, suggesting that a change in the microbiota can induce obesity
    • Turnbaugh, P. J. et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027-1031 (2006). These authors show that the microbiome from obese mice has an increased capacity for energy harvest. Transfer of the microbiota to non-obese mice increases their mean fat body weight, suggesting that a change in the microbiota can induce obesity.
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1
  • 70
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • Ley, R. E., Turnbaugh, P. J., Klein, S. & Gordon, J. I. Microbial ecology: human gut microbes associated with obesity. Nature 444, 1022-1023 (2006).
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 72
    • 18944401261 scopus 로고    scopus 로고
    • Biodiversity of the mucosa-associated microbiota is stable along the distal digestive tract in healthy individuals and patients with IBD
    • Lepage, P. et al. Biodiversity of the mucosa-associated microbiota is stable along the distal digestive tract in healthy individuals and patients with IBD. Inflamm. Bowel Dis. 11, 473-480 (2005).
    • (2005) Inflamm. Bowel Dis , vol.11 , pp. 473-480
    • Lepage, P.1
  • 73
    • 33750932588 scopus 로고    scopus 로고
    • Culture-independent analyses of temporal variation of the dominant fecal microbiota and targeted bacterial subgroups in Crohn's disease
    • Scanlan, P. D., Shanahan, F., O'Mahony, C. & Marchesi, J. R. Culture-independent analyses of temporal variation of the dominant fecal microbiota and targeted bacterial subgroups in Crohn's disease. J. Clin. Microbiol. 44, 3980-3988 (2006).
    • (2006) J. Clin. Microbiol , vol.44 , pp. 3980-3988
    • Scanlan, P.D.1    Shanahan, F.2    O'Mahony, C.3    Marchesi, J.R.4
  • 74
    • 35348857386 scopus 로고    scopus 로고
    • Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
    • This study indicates that the intestinal microbial populations in patients with IBD and non-IBD patients differ greatly
    • Frank, D. N. et al. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc. Natl Acad. Sci. USA 104, 13780-13785 (2007). This study indicates that the intestinal microbial populations in patients with IBD and non-IBD patients differ greatly.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 13780-13785
    • Frank, D.N.1
  • 75
    • 35348968286 scopus 로고    scopus 로고
    • The human microbiome project
    • Turnbaugh, P. J. et al. The human microbiome project. Nature 449, 804-810 (2007).
    • (2007) Nature , vol.449 , pp. 804-810
    • Turnbaugh, P.J.1
  • 76
    • 2442453484 scopus 로고    scopus 로고
    • Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: Antibiotics, probiotics, and prebiotics
    • Sartor, R. B. Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics. Gastroenterology 126, 1620-1633 (2004).
    • (2004) Gastroenterology , vol.126 , pp. 1620-1633
    • Sartor, R.B.1
  • 77
    • 14844349149 scopus 로고    scopus 로고
    • Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-β-bearing regulatory cells
    • Di Giacinto, C., Marinaro, M., Sanchez, M., Strober, W. & Boirivant, M. Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-β-bearing regulatory cells. J. Immunol. 174, 3237-3246 (2005).
    • (2005) J. Immunol , vol.174 , pp. 3237-3246
    • Di Giacinto, C.1    Marinaro, M.2    Sanchez, M.3    Strober, W.4    Boirivant, M.5
  • 78
    • 50849119097 scopus 로고    scopus 로고
    • O'Mahony, C. et al. Commensal-induced regulatory T cells mediate protection against pathogenstimulated NF-κB activation. PLoS Pathog. 4, e1000112 (2008).
    • O'Mahony, C. et al. Commensal-induced regulatory T cells mediate protection against pathogenstimulated NF-κB activation. PLoS Pathog. 4, e1000112 (2008).
  • 79
    • 34347271190 scopus 로고    scopus 로고
    • A key role for dendritic cells in probiotic functionality
    • Foligne, B. et al. A key role for dendritic cells in probiotic functionality. PLoS ONE 2, e313 (2007).
    • (2007) PLoS ONE , vol.2
    • Foligne, B.1
  • 80
    • 55949124035 scopus 로고    scopus 로고
    • Sokol, H. et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc. Natl Acad. Sci. USA 105, 16731-16736 (2008). These authors show that F. prausnitzii is specifically reduced in the intestine of patients with Crohn's disease. In addition, this bacterium is shown to have an anti-inflammatory capacity and to protect animals from disease when given orally, suggesting that symbiotic microorganisms may be directly involved in maintaining health.
    • Sokol, H. et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc. Natl Acad. Sci. USA 105, 16731-16736 (2008). These authors show that F. prausnitzii is specifically reduced in the intestine of patients with Crohn's disease. In addition, this bacterium is shown to have an anti-inflammatory capacity and to protect animals from disease when given orally, suggesting that symbiotic microorganisms may be directly involved in maintaining health.
  • 81
    • 22144490199 scopus 로고    scopus 로고
    • An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    • Mazmanian, S. K., Liu, C. H., Tzianabos, A. O. & Kasper, D. L. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 122, 107-118 (2005).
    • (2005) Cell , vol.122 , pp. 107-118
    • Mazmanian, S.K.1    Liu, C.H.2    Tzianabos, A.O.3    Kasper, D.L.4
  • 82
    • 34547214205 scopus 로고    scopus 로고
    • Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans
    • Roncarolo, M. G. & Battaglia, M. Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans. Nature Rev. Immunol. 7, 585-598 (2007).
    • (2007) Nature Rev. Immunol , vol.7 , pp. 585-598
    • Roncarolo, M.G.1    Battaglia, M.2
  • 83
    • 14044278784 scopus 로고    scopus 로고
    • Generation of antigen-specific, Foxp3- expressing CD4+ regulatory T cells by inhibition of APC proteosome function
    • Cong, Y. et al. Generation of antigen-specific, Foxp3- expressing CD4+ regulatory T cells by inhibition of APC proteosome function. J. Immunol. 174, 2787-2795 (2005).
    • (2005) J. Immunol , vol.174 , pp. 2787-2795
    • Cong, Y.1
  • 84
    • 7944231342 scopus 로고    scopus 로고
    • Does the microbiota regulate immune responses outside the gut?
    • Noverr, M. C. & Huffnagle, G. B. Does the microbiota regulate immune responses outside the gut? Trends Microbiol. 12, 562-568 (2004).
    • (2004) Trends Microbiol , vol.12 , pp. 562-568
    • Noverr, M.C.1    Huffnagle, G.B.2
  • 85
    • 0032971445 scopus 로고    scopus 로고
    • The environmental influence on childhood asthma
    • Bjorksten, B. The environmental influence on childhood asthma. Allergy 54, S17-S23 (1999).
    • (1999) Allergy , vol.54
    • Bjorksten, B.1
  • 86
    • 34247466932 scopus 로고    scopus 로고
    • Gut microbiota composition and development of atopic manifestations in infancy: The KOALA Birth Cohort Study
    • Penders, J. et al. Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study. Gut 56, 661-667 (2007).
    • (2007) Gut , vol.56 , pp. 661-667
    • Penders, J.1
  • 87
    • 0035985018 scopus 로고    scopus 로고
    • Pandemic of atopic diseases - a lack of microbial exposure in early infancy?
    • Kalliomaki, M. & Isolauri, E. Pandemic of atopic diseases - a lack of microbial exposure in early infancy? Curr. Drug Targets. Infect. Disord. 2, 193-199 (2002).
    • (2002) Curr. Drug Targets. Infect. Disord , vol.2 , pp. 193-199
    • Kalliomaki, M.1    Isolauri, E.2
  • 89
    • 33746342994 scopus 로고    scopus 로고
    • Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease
    • Sakaguchi, S. et al. Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol. Rev. 212, 8-27 (2006).
    • (2006) Immunol. Rev , vol.212 , pp. 8-27
    • Sakaguchi, S.1
  • 90
    • 20544444045 scopus 로고    scopus 로고
    • Diversity of the human intestinal microbial flora
    • Eckburg, P. B. et al. Diversity of the human intestinal microbial flora. Science 308, 1635-1638 (2005).
    • (2005) Science , vol.308 , pp. 1635-1638
    • Eckburg, P.B.1
  • 91
    • 33744804299 scopus 로고    scopus 로고
    • Metagenomic analysis of the human distal gut microbiome
    • Gill, S. R. et al. Metagenomic analysis of the human distal gut microbiome. Science 312, 1355-1359 (2006).
    • (2006) Science , vol.312 , pp. 1355-1359
    • Gill, S.R.1
  • 93
    • 41549160626 scopus 로고    scopus 로고
    • Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis
    • This report shows that FOXP3-deficient T cells can induce colitis in IL-23-deficient recipients, suggesting that disease can occur in the absence of regulation
    • Izcue, A. et al. Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis. Immunity 28, 559-570 (2008). This report shows that FOXP3-deficient T cells can induce colitis in IL-23-deficient recipients, suggesting that disease can occur in the absence of regulation.
    • (2008) Immunity , vol.28 , pp. 559-570
    • Izcue, A.1
  • 94
    • 0018092512 scopus 로고
    • Increase in the population of duodenal immunoglobulin A plasmocytes in axenic mice associated with different living or dead bacterial strains of intestinal origin
    • Moreau, M. C., Ducluzeau, R., Guy-Grand, D. & Muller, M. C. Increase in the population of duodenal immunoglobulin A plasmocytes in axenic mice associated with different living or dead bacterial strains of intestinal origin. Infect. Immun. 21, 532-539 (1978).
    • (1978) Infect. Immun , vol.21 , pp. 532-539
    • Moreau, M.C.1    Ducluzeau, R.2    Guy-Grand, D.3    Muller, M.C.4
  • 95
    • 1242296822 scopus 로고    scopus 로고
    • Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut
    • Suzuki, K. et al. Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc. Natl Acad. Sci. USA 101, 1981-1986 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 1981-1986
    • Suzuki, K.1
  • 96
    • 0029863522 scopus 로고    scopus 로고
    • Kroese, F. G., de Waard, R. & Bos, N. A. B-1 cells and their reactivity with the murine intestinal microflora. Semin. Immunol. 8, 11-18 (1996).
    • Kroese, F. G., de Waard, R. & Bos, N. A. B-1 cells and their reactivity with the murine intestinal microflora. Semin. Immunol. 8, 11-18 (1996).
  • 97
    • 1542618118 scopus 로고    scopus 로고
    • Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria
    • Macpherson, A. J. & Uhr, T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303, 1662-1665 (2004).
    • (2004) Science , vol.303 , pp. 1662-1665
    • Macpherson, A.J.1    Uhr, T.2
  • 98
    • 19544385282 scopus 로고    scopus 로고
    • Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria
    • Macpherson, A. J., Geuking, M. B. & McCoy, K. D. Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria. Immunology 115, 153-162 (2005).
    • (2005) Immunology , vol.115 , pp. 153-162
    • Macpherson, A.J.1    Geuking, M.B.2    McCoy, K.D.3
  • 99
    • 34250205694 scopus 로고    scopus 로고
    • Intestinal bacteria trigger T cellindependent immunoglobulin A2 class switching by inducing epithelial-cell secretion of the cytokine APRIL
    • He, B. et al. Intestinal bacteria trigger T cellindependent immunoglobulin A2 class switching by inducing epithelial-cell secretion of the cytokine APRIL. Immunity 26, 812-826 (2007).
    • (2007) Immunity , vol.26 , pp. 812-826
    • He, B.1
  • 100
    • 44349195660 scopus 로고    scopus 로고
    • The regulation of IgA class switching
    • Cerutti, A. The regulation of IgA class switching. Nature Rev. Immunol. 8, 421-434 (2008).
    • (2008) Nature Rev. Immunol , vol.8 , pp. 421-434
    • Cerutti, A.1
  • 101
    • 34548176272 scopus 로고    scopus 로고
    • Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells
    • Tezuka, H. et al. Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. Nature 448, 929-933 (2007).
    • (2007) Nature , vol.448 , pp. 929-933
    • Tezuka, H.1
  • 102
    • 35848931007 scopus 로고    scopus 로고
    • IgA response to symbiotic bacteria as a mediator of gut homeostasis
    • Peterson, D. A., McNulty, N. P., Guruge, J. L. & Gordon, J. I. IgA response to symbiotic bacteria as a mediator of gut homeostasis. Cell Host Microbe 2, 328-339 (2007).
    • (2007) Cell Host Microbe , vol.2 , pp. 328-339
    • Peterson, D.A.1    McNulty, N.P.2    Guruge, J.L.3    Gordon, J.I.4
  • 103
    • 58149291318 scopus 로고    scopus 로고
    • Early life stress alters behavior, immunity, and microbiota in rats: Implications for irritable bowel syndrome and psychiatric illnesses
    • O'Mahony, S. M. et al. Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses. Biol. Psychiatry 65, 263-267 (2009).
    • (2009) Biol. Psychiatry , vol.65 , pp. 263-267
    • O'Mahony, S.M.1


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