메뉴 건너뛰기




Volumn 14, Issue 3, 2013, Pages 281-289

Transcriptional reprogramming of mature CD4 + helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes

(25)  Mucida, Daniel a   Husain, Mohammad Mushtaq a   Muroi, Sawako b   Van Wijk, Femke a,g   Shinnakasu, Ryo a,b   Naoe, Yoshinori b,h   Reis, Bernardo Sgarbi c   Huang, Yujun a   Lambolez, Florence a   Docherty, Michael a,i   Attinger, Antoine a,j   Shui, Jr Wen a   Kim, Gisen a   Lena, Christopher J a   Sakaguchi, Shinya d   Miyamoto, Chizuko a   Wang, Peng a,k   Atarashi, Koji b,e   Park, Yunji a,l   Nakayama, Toshinori f   more..


Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

EID: 85027952412     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2523     Document Type: Article
Times cited : (282)

References (48)
  • 1
    • 82755189243 scopus 로고    scopus 로고
    • TOX is required for development of the CD4 T cell lineage gene program
    • Aliahmad, P., Kadavallore, A., de la Torre, B., Kappes, D. & Kaye, J. TOX is required for development of the CD4 T cell lineage gene program. J. Immunol. 187, 5931-5940 (2011).
    • (2011) J. Immunol. , vol.187 , pp. 5931-5940
    • Aliahmad, P.1    Kadavallore, A.2    De La Torre, B.3    Kappes, D.4    Kaye, J.5
  • 3
    • 0348110327 scopus 로고    scopus 로고
    • Critical roles for transcription factor GATA-3 in thymocyte development
    • Pai, S.Y. et al. Critical roles for transcription factor GATA-3 in thymocyte development. Immunity 19, 863-875 (2003).
    • (2003) Immunity , vol.19 , pp. 863-875
    • Pai, S.Y.1
  • 4
    • 14544288635 scopus 로고    scopus 로고
    • The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment
    • He, X. et al. The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature 433, 826-833 (2005).
    • (2005) Nature , vol.433 , pp. 826-833
    • He, X.1
  • 5
    • 16844375768 scopus 로고    scopus 로고
    • The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection
    • Sun, G. et al. The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection. Nat. Immunol. 6, 373-381 (2005).
    • (2005) Nat. Immunol. , vol.6 , pp. 373-381
    • Sun, G.1
  • 6
    • 57449108862 scopus 로고    scopus 로고
    • The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells
    • Wang, L. et al. The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells. Immunity 29, 876-887 (2008).
    • (2008) Immunity , vol.29 , pp. 876-887
    • Wang, L.1
  • 7
    • 18744398397 scopus 로고    scopus 로고
    • Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
    • Taniuchi, I. et al. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 111, 621-633 (2002).
    • (2002) Cell , vol.111 , pp. 621-633
    • Taniuchi, I.1
  • 8
    • 0038610795 scopus 로고    scopus 로고
    • Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis
    • Woolf, E. et al. Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis. Proc. Natl. Acad. Sci. USA 100, 7731-7736 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 7731-7736
    • Woolf, E.1
  • 9
    • 0036604438 scopus 로고    scopus 로고
    • Characterization of CD4+ CTLs ex vivo
    • Appay, V. et al. Characterization of CD4+ CTLs ex vivo. J. Immunol. 168, 5954-5958 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 5954-5958
    • Appay, V.1
  • 10
    • 4644234449 scopus 로고    scopus 로고
    • The physiological role of cytotoxic CD4+ T-cells: The holy grail? Clin
    • Appay, V. The physiological role of cytotoxic CD4+ T-cells: the holy grail? Clin. Exp. Immunol. 138, 10-13 (2004).
    • (2004) Exp. Immunol. , vol.138 , pp. 10-13
    • Appay, V.1
  • 11
    • 77950858633 scopus 로고    scopus 로고
    • Cytolytic CD4 cells: Direct mediators in infectious disease and malignancy
    • Brown, D.M. Cytolytic CD4 cells: Direct mediators in infectious disease and malignancy. Cell. Immunol. 262, 89-95 (2010).
    • (2010) Cell. Immunol. , vol.262 , pp. 89-95
    • Brown, D.M.1
  • 12
    • 84855533370 scopus 로고    scopus 로고
    • Cytotoxic CD4 T cells in antiviral immunity
    • 10.1155/2011/954602
    • Marshall, N.B. & Swain, S.L. Cytotoxic CD4 T cells in antiviral immunity. J. Biomed. Biotechnol. 10.1155/2011/954602 (2011).
    • (2011) J. Biomed. Biotechnol.
    • Marshall, N.B.1    Swain, S.L.2
  • 13
    • 0025794105 scopus 로고
    • Cytotoxic differentiation of mouse gut thymodependent and independent intraepithelial T lymphocytes is induced locally. Correlation between functional assays, presence of perforin and granzyme transcripts, and cytoplasmic granules
    • Guy-Grand, D., Malassis-Seris, M., Briottet, C. & Vassalli, P. Cytotoxic differentiation of mouse gut thymodependent and independent intraepithelial T lymphocytes is induced locally. Correlation between functional assays, presence of perforin and granzyme transcripts, and cytoplasmic granules. J. Exp. Med. 173, 1549-1552 (1991).
    • (1991) J. Exp. Med. , vol.173 , pp. 1549-1552
    • Guy-Grand, D.1    Malassis-Seris, M.2    Briottet, C.3    Vassalli, P.4
  • 14
    • 0027286575 scopus 로고
    • Intestinal intraepithelial lymphocytes are activated and cytolytic but do not proliferate as well as other T cells in response to mitogenic signals
    • Sydora, B.C. et al. Intestinal intraepithelial lymphocytes are activated and cytolytic but do not proliferate as well as other T cells in response to mitogenic signals. J. Immunol. 150, 2179-2191 (1993).
    • (1993) J. Immunol. , vol.150 , pp. 2179-2191
    • Sydora, B.C.1
  • 15
    • 0028326028 scopus 로고
    • Unique properties of a cytotoxic CD4+CD8+ intraepithelial T-cell line established from the mouse intestinal epithelium
    • Sasahara, T., Tamauchi, H., Ikewaki, N. & Kubota, K. Unique properties of a cytotoxic CD4+CD8+ intraepithelial T-cell line established from the mouse intestinal epithelium. Microbiol. Immunol. 38, 191-199 (1994).
    • (1994) Microbiol. Immunol. , vol.38 , pp. 191-199
    • Sasahara, T.1    Tamauchi, H.2    Ikewaki, N.3    Kubota, K.4
  • 16
    • 3142590367 scopus 로고    scopus 로고
    • Peripheral CD4+CD8+ T cells are differentiated effector memory cells with antiviral functions
    • Nascimbeni, M., Shin, E.C., Chiriboga, L., Kleiner, D.E. & Rehermann, B. Peripheral CD4+CD8+ T cells are differentiated effector memory cells with antiviral functions. Blood 104, 478-486 (2004).
    • (2004) Blood , vol.104 , pp. 478-486
    • Nascimbeni, M.1    Shin, E.C.2    Chiriboga, L.3    Kleiner, D.E.4    Rehermann, B.5
  • 17
    • 61849115765 scopus 로고    scopus 로고
    • Functionally diverse subsets in CD4 T cell responses against influenza
    • Strutt, T.M., McKinstry, K.K. & Swain, S.L. Functionally diverse subsets in CD4 T cell responses against influenza. J. Clin. Immunol. 29, 145-150 (2009).
    • (2009) J. Clin. Immunol. , vol.29 , pp. 145-150
    • Strutt, T.M.1    McKinstry, K.K.2    Swain, S.L.3
  • 18
    • 79952389800 scopus 로고    scopus 로고
    • Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens
    • DePaolo, R.W. et al. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature 471, 220-224 (2011).
    • (2011) Nature , vol.471 , pp. 220-224
    • Depaolo, R.W.1
  • 19
    • 52549124338 scopus 로고    scopus 로고
    • Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate
    • Muroi, S. et al. Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate. Nat. Immunol. 9, 1113-1121 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 1113-1121
    • Muroi, S.1
  • 20
    • 2542477129 scopus 로고    scopus 로고
    • Starting at the beginning: New perspectives on the biology of mucosal T cells
    • Cheroutre, H. Starting at the beginning: new perspectives on the biology of mucosal T cells. Annu. Rev. Immunol. 22, 217-246 (2004).
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 217-246
    • Cheroutre, H.1
  • 22
    • 38949185052 scopus 로고    scopus 로고
    • Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development
    • Setoguchi, R. et al. Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Science 319, 822-825 (2008).
    • (2008) Science , vol.319 , pp. 822-825
    • Setoguchi, R.1
  • 23
    • 77952300542 scopus 로고    scopus 로고
    • The role of ThPOK in control of CD4/CD8 lineage commitment
    • He, X., Park, K. & Kappes, D.J. The role of ThPOK in control of CD4/CD8 lineage commitment. Annu. Rev. Immunol. 28, 295-320 (2010).
    • (2010) Annu. Rev. Immunol. , vol.28 , pp. 295-320
    • He, X.1    Park, K.2    Kappes, D.J.3
  • 24
    • 0030670312 scopus 로고    scopus 로고
    • An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells
    • Ellmeier, W., Sunshine, M.J., Losos, K., Hatam, F. & Littman, D.R. An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells. Immunity 7, 537-547 (1997).
    • (1997) Immunity , vol.7 , pp. 537-547
    • Ellmeier, W.1    Sunshine, M.J.2    Losos, K.3    Hatam, F.4    Littman, D.R.5
  • 25
    • 0033848982 scopus 로고    scopus 로고
    • A molecular analysis of NKT cells: Identification of a class-I restricted T cell-associated molecule (CRTAM)
    • Kennedy, J. et al. A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM). J. Leukoc. Biol. 67, 725-734 (2000).
    • (2000) J. Leukoc. Biol. , vol.67 , pp. 725-734
    • Kennedy, J.1
  • 26
    • 23044445246 scopus 로고    scopus 로고
    • The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM
    • Boles, K.S., Barchet, W., Diacovo, T., Cella, M. & Colonna, M. The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. Blood 106, 779-786 (2005).
    • (2005) Blood , vol.106 , pp. 779-786
    • Boles, K.S.1    Barchet, W.2    Diacovo, T.3    Cella, M.4    Colonna, M.5
  • 27
    • 0034905327 scopus 로고    scopus 로고
    • 2B4 (CD244) and CS1: Novel members of the CD2 subset of the immunoglobulin superfamily molecules expressed on natural killer cells and other leukocytes
    • Boles, K.S., Stepp, S.E., Bennett, M., Kumar, V. & Mathew, P.A. 2B4 (CD244) and CS1: novel members of the CD2 subset of the immunoglobulin superfamily molecules expressed on natural killer cells and other leukocytes. Immunol. Rev. 181, 234-249 (2001).
    • (2001) Immunol. Rev. , vol.181 , pp. 234-249
    • Boles, K.S.1    Stepp, S.E.2    Bennett, M.3    Kumar, V.4    Mathew, P.A.5
  • 28
    • 77951284245 scopus 로고    scopus 로고
    • The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes
    • Sakaguchi, S. et al. The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes. Nat. Immunol. 11, 442-448 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 442-448
    • Sakaguchi, S.1
  • 29
    • 76949084912 scopus 로고    scopus 로고
    • Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
    • Park, J.H. et al. Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. Nat. Immunol. 11, 257-264 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 257-264
    • Park, J.H.1
  • 30
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • Ivanov, I.I. et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139, 485-498 (2009).
    • (2009) Cell , vol.139 , pp. 485-498
    • Ivanov, I.I.1
  • 31
    • 38949162969 scopus 로고    scopus 로고
    • Doubting the TCR coreceptor function of CD8αα
    • Cheroutre, H. & Lambolez, F. Doubting the TCR coreceptor function of CD8αα. Immunity 28, 149-159 (2008).
    • (2008) Immunity , vol.28 , pp. 149-159
    • Cheroutre, H.1    Lambolez, F.2
  • 32
    • 0042324649 scopus 로고    scopus 로고
    • Interleukin 15: A key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease
    • Mention, J.J. et al. Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease. Gastroenterology 125, 730-745 (2003).
    • (2003) Gastroenterology , vol.125 , pp. 730-745
    • Mention, J.J.1
  • 33
    • 0031788011 scopus 로고    scopus 로고
    • Interleukin 15 is a potent stimulant of intraepithelial lymphocytes
    • Ebert, E.C. Interleukin 15 is a potent stimulant of intraepithelial lymphocytes. Gastroenterology 115, 1439-1445 (1998).
    • (1998) Gastroenterology , vol.115 , pp. 1439-1445
    • Ebert, E.C.1
  • 34
    • 0031797895 scopus 로고    scopus 로고
    • Interleukin-15 may be responsible for early activation of intestinal intraepithelial lymphocytes after oral infection with Listeria monocytogenes in rats
    • Hirose, K. et al. Interleukin-15 may be responsible for early activation of intestinal intraepithelial lymphocytes after oral infection with Listeria monocytogenes in rats. Infect. Immun. 66, 5677-5683 (1998).
    • (1998) Infect. Immun. , vol.66 , pp. 5677-5683
    • Hirose, K.1
  • 35
    • 0030602187 scopus 로고    scopus 로고
    • Interleukin-15 induces the expression of mRNAs of cytolytic mediators and augments cytotoxic activities in primary murine lymphocytes
    • Ye, W., Young, J.D. & Liu, C.C. Interleukin-15 induces the expression of mRNAs of cytolytic mediators and augments cytotoxic activities in primary murine lymphocytes. Cell. Immunol. 174, 54-62 (1996).
    • (1996) Cell. Immunol. , vol.174 , pp. 54-62
    • Ye, W.1    Young, J.D.2    Liu, C.C.3
  • 36
    • 84866092059 scopus 로고    scopus 로고
    • Intraepithelial lymphocytes in celiac disease immunopathology
    • Abadie, V., Discepolo, V. & Jabri, B. Intraepithelial lymphocytes in celiac disease immunopathology. Semin. Immunopathol. 34, 551-566 (2012).
    • (2012) Semin. Immunopathol. , vol.34 , pp. 551-566
    • Abadie, V.1    Discepolo, V.2    Jabri, B.3
  • 37
    • 33749526537 scopus 로고    scopus 로고
    • Identification of pre- and postselection TCRαβ+ intraepithelial lymphocyte precursors in the thymus
    • Gangadharan, D. et al. Identification of pre- and postselection TCRαβ+ intraepithelial lymphocyte precursors in the thymus. Immunity 25, 631-641 (2006).
    • (2006) Immunity , vol.25 , pp. 631-641
    • Gangadharan, D.1
  • 38
    • 79959664629 scopus 로고    scopus 로고
    • The light and dark sides of intestinal intraepithelial lymphocytes
    • Cheroutre, H., Lambolez, F. & Mucida, D. The light and dark sides of intestinal intraepithelial lymphocytes. Nat. Rev. Immunol. 11, 445-456 (2011).
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 445-456
    • Cheroutre, H.1    Lambolez, F.2    Mucida, D.3
  • 39
    • 0032528838 scopus 로고    scopus 로고
    • Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells
    • Hershberg, R.M. et al. Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells. J. Clin. Invest. 102, 792-803 (1998).
    • (1998) J. Clin. Invest. , vol.102 , pp. 792-803
    • Hershberg, R.M.1
  • 40
    • 0031569518 scopus 로고    scopus 로고
    • Class i processing-defective Burkitt's lymphoma cells are recognized efficiently by CD4+ EBV-specific CTLs
    • Khanna, R. et al. Class I processing-defective Burkitt's lymphoma cells are recognized efficiently by CD4+ EBV-specific CTLs. J. Immunol. 158, 3619-3625 (1997).
    • (1997) J. Immunol. , vol.158 , pp. 3619-3625
    • Khanna, R.1
  • 41
    • 0018428330 scopus 로고
    • Ia determinants on stimulated human T lymphocytes. Occurrence on mitogen- and antigen-activated T cells
    • Ko, H.S., Fu, S.M., Winchester, R.J., Yu, D.T. & Kunkel, H.G. Ia determinants on stimulated human T lymphocytes. Occurrence on mitogen- and antigen-activated T cells. J. Exp. Med. 150, 246-255 (1979).
    • (1979) J. Exp. Med. , vol.150 , pp. 246-255
    • Ko, H.S.1    Fu, S.M.2    Winchester, R.J.3    Yu, D.T.4    Kunkel, H.G.5
  • 42
    • 0033831421 scopus 로고    scopus 로고
    • Viral mechanisms of immune evasion
    • Alcami, A. & Koszinowski, U.H. Viral mechanisms of immune evasion. Immunol. Today 21, 447-455 (2000).
    • (2000) Immunol. Today , vol.21 , pp. 447-455
    • Alcami, A.1    Koszinowski, U.H.2
  • 43
    • 3342897676 scopus 로고    scopus 로고
    • Interleukin-15: A new cytokine target for the treatment of inflammatory diseases
    • McInnes, I.B. & Gracie, J.A. Interleukin-15: a new cytokine target for the treatment of inflammatory diseases. Curr. Opin. Pharmacol. 4, 392-397 (2004).
    • (2004) Curr. Opin. Pharmacol. , vol.4 , pp. 392-397
    • McInnes, I.B.1    Gracie, J.A.2
  • 44
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor ROR?t directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov, I.I. et al. The orphan nuclear receptor ROR?t directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126, 1121-1133 (2006).
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1
  • 45
    • 34447503805 scopus 로고    scopus 로고
    • Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    • Mucida, D. et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317, 256-260 (2007).
    • (2007) Science , vol.317 , pp. 256-260
    • Mucida, D.1
  • 46
    • 40149084641 scopus 로고    scopus 로고
    • Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunity
    • LeBlanc, P.M. et al. Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunity. Cell Host Microbe 3, 146-157 (2008).
    • (2008) Cell Host Microbe , vol.3 , pp. 146-157
    • LeBlanc, P.M.1
  • 47
    • 17944363602 scopus 로고    scopus 로고
    • Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene
    • Kimura, M. et al. Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene. Immunity 15, 275-287 (2001).
    • (2001) Immunity , vol.15 , pp. 275-287
    • Kimura, M.1
  • 48
    • 0142185336 scopus 로고    scopus 로고
    • Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation
    • Betts, M.R. et al. Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J. Immunol. Methods 281, 65-78 (2003).
    • (2003) J. Immunol. Methods , vol.281 , pp. 65-78
    • Betts, M.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.