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Volumn 535, Issue 7610, 2016, Pages 94-103

Microbiome-wide association studies link dynamic microbial consortia to disease

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BIOLOGICAL MARKER; DISEASE MODIFYING ANTIRHEUMATIC DRUG; DNA; PARACETAMOL; PREBIOTIC AGENT; PROBIOTIC AGENT;

EID: 84978134353     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature18850     Document Type: Review
Times cited : (535)

References (122)
  • 1
    • 84893741669 scopus 로고    scopus 로고
    • Anal gas evacuation and colonic microbiota in patients with flatulence: Effect of diet
    • Manichanh, C. et al. Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet. Gut 63, 401-408 (2014).
    • (2014) Gut , vol.63 , pp. 401-408
    • Manichanh, C.1
  • 2
    • 35348857386 scopus 로고    scopus 로고
    • Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
    • Frank, D. N. et al. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc. Natl Acad. Sci. USA 104, 13780-13785 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 13780-13785
    • Frank, D.N.1
  • 3
    • 84944220492 scopus 로고    scopus 로고
    • Inflammation, antibiotics, and diet as environmental stressors of the gut microbiome in pediatric Crohns disease
    • Lewis, J. D. et al. Inflammation, antibiotics, and diet as environmental stressors of the gut microbiome in pediatric Crohns disease. Cell Host Microbe 18, 489-500 (2015).
    • (2015) Cell Host Microbe , vol.18 , pp. 489-500
    • Lewis, J.D.1
  • 4
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • Ley, R. E., Turnbaugh, P. J., Klein, S. and Gordon, J. I. Microbial ecology: human gut microbes associated with obesity. Nature 444, 1022-1023 (2006).
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 5
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh, P. J. et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027-1031 (2006).
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1
  • 6
    • 84877331372 scopus 로고    scopus 로고
    • Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
    • Koeth, R. A. et al. Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis. Nature Med. 19, 576-585 (2013).
    • (2013) Nature Med. , vol.19 , pp. 576-585
    • Koeth, R.A.1
  • 7
    • 84863022950 scopus 로고    scopus 로고
    • Genomic analysis identifies association of Fusobacterium with colorectal carcinoma
    • Kostic, A. D. et al. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 22, 292-298 (2012).
    • (2012) Genome Res. , vol.22 , pp. 292-298
    • Kostic, A.D.1
  • 8
    • 84887323708 scopus 로고    scopus 로고
    • Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
    • Scher, J. U. et al. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. eLife 2, e01202 (2013).
    • (2013) ELife , vol.2 , pp. e01202
    • Scher, J.U.1
  • 9
    • 84904411548 scopus 로고    scopus 로고
    • Correlation between the human fecal microbiota and depression
    • Naseribafrouei, A. et al. Correlation between the human fecal microbiota and depression. Neurogastroenterol. Motil. 26, 1155-1162 (2014).
    • (2014) Neurogastroenterol. Motil. , vol.26 , pp. 1155-1162
    • Naseribafrouei, A.1
  • 10
    • 84924577956 scopus 로고    scopus 로고
    • Gut microbiota are related to Parkinsons disease and clinical phenotype
    • Scheperjans, F. et al. Gut microbiota are related to Parkinsons disease and clinical phenotype. Mov. Disord. 30, 350-358 (2015).
    • (2015) Mov. Disord. , vol.30 , pp. 350-358
    • Scheperjans, F.1
  • 11
    • 84879760435 scopus 로고    scopus 로고
    • Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children
    • Kang, D. W. et al. Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children. PLoS ONE 8, e68322 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e68322
    • Kang, D.W.1
  • 12
    • 84876237691 scopus 로고    scopus 로고
    • Exploring host-microbiota interactions in animal models and humans
    • Kostic, A. D., Howitt, M. R. and Garrett, W. S. Exploring host-microbiota interactions in animal models and humans. Genes Dev. 27, 701-718 (2013).
    • (2013) Genes Dev. , vol.27 , pp. 701-718
    • Kostic, A.D.1    Howitt, M.R.2    Garrett, W.S.3
  • 13
    • 84879515171 scopus 로고    scopus 로고
    • Bacteriophage adhering to mucus provide a non-host-derived immunity
    • Barr, J. J. et al. Bacteriophage adhering to mucus provide a non-host-derived immunity. Proc. Natl Acad. Sci. USA 110, 10771-10776 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 10771-10776
    • Barr, J.J.1
  • 14
    • 84880439384 scopus 로고    scopus 로고
    • Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta
    • Haiser, H. J. et al. Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta. Science 341, 295-298 (2013).
    • (2013) Science , vol.341 , pp. 295-298
    • Haiser, H.J.1
  • 15
    • 84867192879 scopus 로고    scopus 로고
    • Intestinal inflammation targets cancer-inducing activity of the microbiota
    • Arthur, J. C. et al. Intestinal inflammation targets cancer-inducing activity of the microbiota. Science 338, 120-123 (2012).
    • (2012) Science , vol.338 , pp. 120-123
    • Arthur, J.C.1
  • 16
    • 80052301430 scopus 로고    scopus 로고
    • Bayesian community-wide culture-independent microbial source tracking
    • Knights, D. et al. Bayesian community-wide culture-independent microbial source tracking. Nature Methods 8, 761-763 (2011).
    • (2011) Nature Methods , vol.8 , pp. 761-763
    • Knights, D.1
  • 17
    • 85027927719 scopus 로고    scopus 로고
    • Enterotypes of the human gut microbiome
    • Arumugam, M. et al. Enterotypes of the human gut microbiome. Nature 473, 174-180 (2011).
    • (2011) Nature , vol.473 , pp. 174-180
    • Arumugam, M.1
  • 18
    • 84896092821 scopus 로고    scopus 로고
    • The treatment-naive microbiome in new-onset Crohns disease
    • Gevers, D. et al. The treatment-naive microbiome in new-onset Crohns disease. Cell Host Microbe 15, 382-392 (2014).
    • (2014) Cell Host Microbe , vol.15 , pp. 382-392
    • Gevers, D.1
  • 19
    • 77957672841 scopus 로고    scopus 로고
    • Microbial community resemblance methods differ in their ability to detect biologically relevant patterns
    • Kuczynski, J. et al. Microbial community resemblance methods differ in their ability to detect biologically relevant patterns. Nature Methods 7, 813-819 (2010).
    • (2010) Nature Methods , vol.7 , pp. 813-819
    • Kuczynski, J.1
  • 20
    • 84865733148 scopus 로고    scopus 로고
    • Inferring correlation networks from genomic survey data
    • Friedman, J. and Alm, E. J. Inferring correlation networks from genomic survey data. PLoS Comput. Biol. 8, e1002687 (2012).
    • (2012) PLoS Comput. Biol. , vol.8 , pp. e1002687
    • Friedman, J.1    Alm, E.J.2
  • 22
  • 23
    • 58749112734 scopus 로고    scopus 로고
    • A core gut microbiome in obese and lean twins
    • Turnbaugh, P. J. et al. A core gut microbiome in obese and lean twins. Nature 457, 480-484 (2009).
    • (2009) Nature , vol.457 , pp. 480-484
    • Turnbaugh, P.J.1
  • 24
    • 84862276328 scopus 로고    scopus 로고
    • Structure, function and diversity of the healthy human microbiome
    • The Human Microbiome Project Consortium
    • The Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 486, 207-214 (2012).
    • (2012) Nature , vol.486 , pp. 207-214
  • 25
    • 77950904616 scopus 로고    scopus 로고
    • Forensic identification using skin bacterial communities
    • Fierer, N. et al. Forensic identification using skin bacterial communities. Proc. Natl Acad. Sci. USA 107, 6477-6481 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 6477-6481
    • Fierer, N.1
  • 26
    • 84930649544 scopus 로고    scopus 로고
    • Identifying personal microbiomes using metagenomic codes
    • Franzosa, E. A. et al. Identifying personal microbiomes using metagenomic codes. Proc. Natl Acad. Sci. USA 112, E2930-E2938 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. E2930-E2938
    • Franzosa, E.A.1
  • 27
    • 84889649570 scopus 로고    scopus 로고
    • Oligotyping: Differentiating between closely related microbial taxa using 16S rRNA gene data
    • Eren, A. M. et al. Oligotyping: differentiating between closely related microbial taxa using 16S rRNA gene data. Methods Ecol. Evol. 4, 1111-1119 (2013).
    • (2013) Methods Ecol. Evol. , vol.4 , pp. 1111-1119
    • Eren, A.M.1
  • 28
    • 85041927917 scopus 로고    scopus 로고
    • Metabolic model-based integration of microbiome taxonomic and metabolomic profiles elucidates mechanistic links between ecological and metabolic variation
    • Noecker, C. et al. Metabolic model-based integration of microbiome taxonomic and metabolomic profiles elucidates mechanistic links between ecological and metabolic variation. mSystems 13, http://dx.doi.org/10.1128/mSystems.00013-15 (2015).
    • (2015) MSystems , vol.13
    • Noecker, C.1
  • 29
    • 84922971911 scopus 로고    scopus 로고
    • Dynamics and establishment of Clostridium difficile infection in the murine gastrointestinal tract
    • Koenigsknecht, M. J. et al. Dynamics and establishment of Clostridium difficile infection in the murine gastrointestinal tract. Infect. Immun. 83, 934-941 (2015).
    • (2015) Infect. Immun. , vol.83 , pp. 934-941
    • Koenigsknecht, M.J.1
  • 30
    • 84894118144 scopus 로고    scopus 로고
    • Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
    • Hsiao, E. Y. et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155, 1451-1463 (2013).
    • (2013) Cell , vol.155 , pp. 1451-1463
    • Hsiao, E.Y.1
  • 31
    • 84944065894 scopus 로고    scopus 로고
    • The human oral metaproteome reveals potential biomarkers for caries disease
    • Belda-Ferre, P. et al. The human oral metaproteome reveals potential biomarkers for caries disease. Proteomics 15, 3497-3507 (2015).
    • (2015) Proteomics , vol.15 , pp. 3497-3507
    • Belda-Ferre, P.1
  • 32
    • 78649686679 scopus 로고    scopus 로고
    • A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes
    • Willing, B. P. et al. A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes. Gastroenterology 139, 1844-1854 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 1844-1854
    • Willing, B.P.1
  • 33
    • 84870322666 scopus 로고    scopus 로고
    • Integrated metagenomics/metaproteomics reveals human host-microbiota signatures of Crohns disease
    • Erickson, A. R. et al. Integrated metagenomics/metaproteomics reveals human host-microbiota signatures of Crohns disease. PLoS ONE 7, e49138 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e49138
    • Erickson, A.R.1
  • 34
    • 68149099597 scopus 로고    scopus 로고
    • Metabolomics reveals metabolic biomarkers of Crohns disease
    • Jansson, J. et al. Metabolomics reveals metabolic biomarkers of Crohns disease. PLoS ONE 4, e6386 (2009).
    • (2009) PLoS ONE , vol.4 , pp. e6386
    • Jansson, J.1
  • 35
    • 85003054745 scopus 로고    scopus 로고
    • Altered gut microbial energy and metabolism in children with non-alcoholic fatty liver disease
    • Michail, S. et al. Altered gut microbial energy and metabolism in children with non-alcoholic fatty liver disease. FEMS Microbiol. Ecol. 91, 1-9 (2015).
    • (2015) FEMS Microbiol. Ecol. , vol.91 , pp. 1-9
    • Michail, S.1
  • 36
    • 84949772416 scopus 로고    scopus 로고
    • Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
    • Forslund, K. et al. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Nature 528, 262-266 (2015).
    • (2015) Nature , vol.528 , pp. 262-266
    • Forslund, K.1
  • 37
    • 84883478660 scopus 로고    scopus 로고
    • Gut microbiota from twins discordant for obesity modulate metabolism in mice
    • Ridaura, V. K. et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 341, 1241214 (2013).
    • (2013) Science , vol.341 , pp. 1241214
    • Ridaura, V.K.1
  • 38
    • 84886727251 scopus 로고    scopus 로고
    • Cometabolism of microbes and host: Implications for drug metabolism and drug-induced toxicity
    • Li, H. and Jia, W. Cometabolism of microbes and host: implications for drug metabolism and drug-induced toxicity. Clin. Pharmacol. Ther. 94, 574-581 (2013).
    • (2013) Clin. Pharmacol. Ther. , vol.94 , pp. 574-581
    • Li, H.1    Jia, W.2
  • 39
    • 0032694577 scopus 로고    scopus 로고
    • Metabonomics: Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson, J. K., Lindon, J. C. and Holmes, E. Metabonomics: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29, 1181-1189 (1999).
    • (1999) Xenobiotica , vol.29 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 40
    • 84960387071 scopus 로고    scopus 로고
    • Emerging applications of metabolomics in drug discovery and precision medicine
    • Wishart, D. S. Emerging applications of metabolomics in drug discovery and precision medicine. Nature Rev. Drug Discov. http://dx.doi.org/10.1038/nrd.2016.32 (2016).
    • (2016) Nature Rev. Drug Discov.
    • Wishart, D.S.1
  • 42
    • 84923323409 scopus 로고    scopus 로고
    • Predicting ecosystem emergent properties at multiple scales
    • Gilbert, J. A. and Henry, C. Predicting ecosystem emergent properties at multiple scales. Environ. Microbiol. Rep. 7, 20-22 (2015).
    • (2015) Environ. Microbiol. Rep. , vol.7 , pp. 20-22
    • Gilbert, J.A.1    Henry, C.2
  • 43
    • 14844363440 scopus 로고    scopus 로고
    • Pyocyanin production by Pseudomonas aeruginosa induces neutrophil apoptosis and impairs neutrophil-mediated host defenses in vivo
    • Allen, L. et al. Pyocyanin production by Pseudomonas aeruginosa induces neutrophil apoptosis and impairs neutrophil-mediated host defenses in vivo. J. Immunol. 174, 3643-3649 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 3643-3649
    • Allen, L.1
  • 44
    • 84894090120 scopus 로고    scopus 로고
    • Biological significance of short-chain fatty acid metabolism by the intestinal microbiome
    • Puertollano, E., Kolida, S. and Yaqoob, P. Biological significance of short-chain fatty acid metabolism by the intestinal microbiome. Curr. Opin. Clin. Nutr. Metab. Care 17, 139-144 (2014).
    • (2014) Curr. Opin. Clin. Nutr. Metab. Care , vol.17 , pp. 139-144
    • Puertollano, E.1    Kolida, S.2    Yaqoob, P.3
  • 45
    • 84904554933 scopus 로고    scopus 로고
    • Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters
    • Cimermancic, P. et al. Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. Cell 158, 412-421 (2014).
    • (2014) Cell , vol.158 , pp. 412-421
    • Cimermancic, P.1
  • 46
    • 84908079780 scopus 로고    scopus 로고
    • A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics
    • Donia, M. S. et al. A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics. Cell 158, 1402-1414 (2014).
    • (2014) Cell , vol.158 , pp. 1402-1414
    • Donia, M.S.1
  • 47
    • 0020539371 scopus 로고
    • Fermentation in the human large intestine: Evidence and implications for health
    • Cummings, J. H. Fermentation in the human large intestine: evidence and implications for health. Lancet 1, 1206-1209 (1983).
    • (1983) Lancet , vol.1 , pp. 1206-1209
    • Cummings, J.H.1
  • 48
    • 85056037203 scopus 로고    scopus 로고
    • The impact of the level of the intestinal short chain fatty acids in inflammatory bowel disease patients versus healthy subjects
    • Huda-Faujan, N. et al. The impact of the level of the intestinal short chain fatty acids in inflammatory bowel disease patients versus healthy subjects. Open Biochem. J. 4, 53-58 (2010).
    • (2010) Open Biochem. J. , vol.4 , pp. 53-58
    • Huda-Faujan, N.1
  • 49
    • 84962195820 scopus 로고    scopus 로고
    • Intestinal short chain fatty acids and their link with diet and human health
    • Rios-Covian, D. et al. Intestinal short chain fatty acids and their link with diet and human health. Front. Microbiol. 7, 185 (2016).
    • (2016) Front. Microbiol. , vol.7 , pp. 185
    • Rios-Covian, D.1
  • 50
    • 62649151803 scopus 로고    scopus 로고
    • Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
    • Wikoff, W. R. et al. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc. Natl Acad. Sci. USA 106, 3698-3703 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 3698-3703
    • Wikoff, W.R.1
  • 51
    • 84938244327 scopus 로고    scopus 로고
    • Small molecules from the human microbiota
    • Donia, M. S. and Fischbach, M. A. Small molecules from the human microbiota. Science 349, 1254766 (2015).
    • (2015) Science , vol.349 , pp. 1254766
    • Donia, M.S.1    Fischbach, M.A.2
  • 52
    • 33747137269 scopus 로고    scopus 로고
    • Escherichia coli induces DNA double-strand breaks in eukaryotic cells
    • Nougayrede, J. P. et al. Escherichia coli induces DNA double-strand breaks in eukaryotic cells. Science 313, 848-851 (2006).
    • (2006) Science , vol.313 , pp. 848-851
    • Nougayrede, J.P.1
  • 53
    • 70350439157 scopus 로고    scopus 로고
    • Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae
    • Putze, J. et al. Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae. Infect. Immun. 77, 4696-4703 (2009).
    • (2009) Infect. Immun. , vol.77 , pp. 4696-4703
    • Putze, J.1
  • 54
    • 84925500413 scopus 로고    scopus 로고
    • Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
    • Buffie, C. G. et al. Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature 517, 205-208 (2015).
    • (2015) Nature , vol.517 , pp. 205-208
    • Buffie, C.G.1
  • 55
    • 84884127512 scopus 로고    scopus 로고
    • Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
    • Langille, M. G. et al. Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences. Nature Biotechnol. 31, 814-821 (2013).
    • (2013) Nature Biotechnol. , vol.31 , pp. 814-821
    • Langille, M.G.1
  • 56
    • 84963891450 scopus 로고    scopus 로고
    • Recurrent Clostridium difficile infection associates with distinct bile acid and microbiome profiles
    • Allegretti, J. R. et al. Recurrent Clostridium difficile infection associates with distinct bile acid and microbiome profiles. Aliment. Pharmacol. Ther. 43, 1142-1153 (2016).
    • (2016) Aliment. Pharmacol. Ther. , vol.43 , pp. 1142-1153
    • Allegretti, J.R.1
  • 57
    • 84872535919 scopus 로고    scopus 로고
    • Xenobiotics shape the physiology and gene expression of the active human gut microbiome
    • Maurice, C. F., Haiser, H. J. and Turnbaugh, P. J. Xenobiotics shape the physiology and gene expression of the active human gut microbiome. Cell 152, 39-50 (2013).
    • (2013) Cell , vol.152 , pp. 39-50
    • Maurice, C.F.1    Haiser, H.J.2    Turnbaugh, P.J.3
  • 58
    • 84891848483 scopus 로고    scopus 로고
    • Understanding and modulating mammalian-microbial communication for improved human health
    • Mani, S., Boelsterli, U. A. and Redinbo, M. R. Understanding and modulating mammalian-microbial communication for improved human health. Annu. Rev. Pharmacol. Toxicol. 54, 559-580 (2014).
    • (2014) Annu. Rev. Pharmacol. Toxicol. , vol.54 , pp. 559-580
    • Mani, S.1    Boelsterli, U.A.2    Redinbo, M.R.3
  • 59
    • 78149295964 scopus 로고    scopus 로고
    • Alleviating cancer drug toxicity by inhibiting a bacterial enzyme
    • Wallace, B. D. et al. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science 330, 831-835 (2010).
    • (2010) Science , vol.330 , pp. 831-835
    • Wallace, B.D.1
  • 60
    • 84904012264 scopus 로고    scopus 로고
    • Pharmacomicrobiomics: The impact of human microbiome variations on systems pharmacology and personalized therapeutics
    • ElRakaiby, M. et al. Pharmacomicrobiomics: the impact of human microbiome variations on systems pharmacology and personalized therapeutics. OMICS 18, 402-414 (2014).
    • (2014) OMICS , vol.18 , pp. 402-414
    • ElRakaiby, M.1
  • 61
    • 70149096873 scopus 로고    scopus 로고
    • Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism
    • Clayton, T. A., Baker, D., Lindon, J. C., Everett, J. R. and Nicholson, J. K. Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc. Natl Acad. Sci. USA 106, 14728-14733 (2009). This study provided the first link between the toxicity of a drug (in this case, acetaminophen, a widely used analgesic) and microbial metabolism.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 14728-14733
    • Clayton, T.A.1    Baker, D.2    Lindon, J.C.3    Everett, J.R.4    Nicholson, J.K.5
  • 62
    • 70149092771 scopus 로고    scopus 로고
    • Drugs, bugs, and personalized medicine: Pharmacometabonomics enters the ring
    • Wilson, I. D. Drugs, bugs, and personalized medicine: pharmacometabonomics enters the ring. Proc. Natl Acad. Sci. USA 106, 14187-14188 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 14187-14188
    • Wilson, I.D.1
  • 63
    • 85041651856 scopus 로고    scopus 로고
    • From sample to multi-omics conclusions in under 48 hours
    • Quinn, R. A. et al. From sample to multi-omics conclusions in under 48 hours. mSystems http://dx.doi.org/10.1128/mSystems.00038-16 (2016).
    • (2016) MSystems
    • Quinn, R.A.1
  • 64
    • 84907190237 scopus 로고    scopus 로고
    • Longitudinal analysis of microbial interaction between humans and the indoor environment
    • Lax, S. et al. Longitudinal analysis of microbial interaction between humans and the indoor environment. Science 345, 1048-1052 (2014).
    • (2014) Science , vol.345 , pp. 1048-1052
    • Lax, S.1
  • 65
    • 84920721220 scopus 로고    scopus 로고
    • Ecological succession and viability of human-associated microbiota on restroom surfaces
    • Gibbons, S. M. et al. Ecological succession and viability of human-associated microbiota on restroom surfaces. Appl. Environ. Microbiol. 81, 765-773 (2015).
    • (2015) Appl. Environ. Microbiol. , vol.81 , pp. 765-773
    • Gibbons, S.M.1
  • 66
    • 84941368240 scopus 로고    scopus 로고
    • Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples
    • Korem, T. et al. Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples. Science 349, 1101-1106 (2015).
    • (2015) Science , vol.349 , pp. 1101-1106
    • Korem, T.1
  • 67
    • 84934284959 scopus 로고    scopus 로고
    • Rapid draft sequencing and real-time nanopore sequencing in a hospital outbreak of Salmonella
    • Quick, J. et al. Rapid draft sequencing and real-time nanopore sequencing in a hospital outbreak of Salmonella. Genome Biol. 16, 114 (2015).
    • (2015) Genome Biol. , vol.16 , pp. 114
    • Quick, J.1
  • 68
    • 84978619185 scopus 로고    scopus 로고
    • Partial restoration of the microbiota of cesareanborn infants via vaginal microbial transfer
    • Dominguez-Bello, M. G. et al. Partial restoration of the microbiota of cesareanborn infants via vaginal microbial transfer. Nature Med. 22, 250-253 (2016).
    • (2016) Nature Med. , vol.22 , pp. 250-253
    • Dominguez-Bello, M.G.1
  • 69
    • 84947461438 scopus 로고    scopus 로고
    • Feeding the brain and nurturing the mind: Linking nutrition and the gut microbiota to brain development
    • Goyal, M. S., Venkatesh, S., Milbrandt, J., Gordon, J. I. and Raichle, M. E. Feeding the brain and nurturing the mind: linking nutrition and the gut microbiota to brain development. Proc. Natl Acad. Sci. USA 112, 14105-14112 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. 14105-14112
    • Goyal, M.S.1    Venkatesh, S.2    Milbrandt, J.3    Gordon, J.I.4    Raichle, M.E.5
  • 70
    • 84961406580 scopus 로고    scopus 로고
    • Tools for the microbiome: Nano and beyond
    • Biteen, J. S. et al. Tools for the microbiome: nano and beyond. ACS Nano 10, 6-37 (2016).
    • (2016) ACS Nano , vol.10 , pp. 6-37
    • Biteen, J.S.1
  • 71
    • 84929997716 scopus 로고    scopus 로고
    • Determinants of community structure in the global plankton interactome
    • Lima-Mendez, G. et al. Determinants of community structure in the global plankton interactome. Science 348, 1262073 (2015).
    • (2015) Science , vol.348 , pp. 1262073
    • Lima-Mendez, G.1
  • 72
    • 84953226740 scopus 로고    scopus 로고
    • Network analysis suggests a potentially evil alliance of opportunistic pathogens inhibited by a cooperative network in human milk bacterial communities
    • Sam Ma, Z. et al. Network analysis suggests a potentially evil alliance of opportunistic pathogens inhibited by a cooperative network in human milk bacterial communities. Sci. Rep. 5, 8275 (2015).
    • (2015) Sci. Rep. , vol.5 , pp. 8275
    • Sam Ma, Z.1
  • 73
    • 84929297936 scopus 로고    scopus 로고
    • Dynamics and stabilization of the human gut microbiome during the first year of life
    • erratum 17, 852 (2015)
    • Backhed, F. et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 17, 690-703 (2015); erratum 17, 852 (2015).
    • (2015) Cell Host Microbe , vol.17 , pp. 690-703
    • Backhed, F.1
  • 74
    • 84907686349 scopus 로고    scopus 로고
    • The Integrative Human Microbiome Project: Dynamic analysis of microbiome-host omics profiles during periods of human health and disease
    • The Integrative HMP (iHMP) Research Network Consortium
    • The Integrative HMP (iHMP) Research Network Consortium. The Integrative Human Microbiome Project: dynamic analysis of microbiome-host omics profiles during periods of human health and disease. Cell Host Microbe 16, 276-289 (2014).
    • (2014) Cell Host Microbe , vol.16 , pp. 276-289
  • 75
    • 84991526597 scopus 로고    scopus 로고
    • EMPeror: A tool for visualizing high-throughput microbial community data
    • Vazquez-Baeza, Y., Pirrung, M., Gonzalez, A. and Knight, R. EMPeror: a tool for visualizing high-throughput microbial community data. Gigascience 2, 16 (2013).
    • (2013) Gigascience , vol.2 , pp. 16
    • Vazquez-Baeza, Y.1    Pirrung, M.2    Gonzalez, A.3    Knight, R.4
  • 76
    • 84931355745 scopus 로고    scopus 로고
    • Dynamic changes in short- and long-term bacterial composition following fecal microbiota transplantation for recurrent Clostridium difficile infection
    • Weingarden, A. et al. Dynamic changes in short- and long-term bacterial composition following fecal microbiota transplantation for recurrent Clostridium difficile infection. Microbiome 3, 10 (2015).
    • (2015) Microbiome , vol.3 , pp. 10
    • Weingarden, A.1
  • 77
    • 79952763661 scopus 로고    scopus 로고
    • Succession of microbial consortia in the developing infant gut microbiome
    • Koenig, J. E. et al. Succession of microbial consortia in the developing infant gut microbiome. Proc. Natl Acad. Sci. USA 108 (suppl. 1), 4578-4585 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 4578-4585
    • Koenig, J.E.1
  • 78
    • 84883864245 scopus 로고    scopus 로고
    • Meta-analyses of studies of the human microbiota
    • Lozupone, C. A. et al. Meta-analyses of studies of the human microbiota. Genome Res. 23, 1704-1714 (2013).
    • (2013) Genome Res. , vol.23 , pp. 1704-1714
    • Lozupone, C.A.1
  • 79
    • 84965187800 scopus 로고    scopus 로고
    • Temporal variability is a personalized feature of the human microbiome
    • Flores, G. E. et al. Temporal variability is a personalized feature of the human microbiome. Genome Biol. 15, 531 (2014).
    • (2014) Genome Biol. , vol.15 , pp. 531
    • Flores, G.E.1
  • 80
    • 84908264764 scopus 로고    scopus 로고
    • Conditionally rare taxa disproportionately contribute to temporal changes in microbial diversity
    • Shade, A. et al. Conditionally rare taxa disproportionately contribute to temporal changes in microbial diversity. mBio 5, e01371-14 (2014).
    • (2014) MBio , vol.5 , pp. e01371-e01414
    • Shade, A.1
  • 81
    • 84941005620 scopus 로고    scopus 로고
    • Temporal and spatial variation of the human microbiota during pregnancy
    • DiGiulio, D. B. et al. Temporal and spatial variation of the human microbiota during pregnancy. Proc. Natl Acad. Sci. USA 112, 11060-11065 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. 11060-11065
    • DiGiulio, D.B.1
  • 82
    • 84864614787 scopus 로고    scopus 로고
    • Host remodeling of the gut microbiome and metabolic changes during pregnancy
    • Koren, O. et al. Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell 150, 470-480 (2012).
    • (2012) Cell , vol.150 , pp. 470-480
    • Koren, O.1
  • 83
    • 84898859680 scopus 로고    scopus 로고
    • Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide
    • Wang, Z. et al. Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide. Eur. Heart J. 35, 904-910 (2014).
    • (2014) Eur. Heart J. , vol.35 , pp. 904-910
    • Wang, Z.1
  • 84
    • 84947812071 scopus 로고    scopus 로고
    • Personalized nutrition by prediction of glycemic responses
    • Zeevi, D. et al. Personalized nutrition by prediction of glycemic responses. Cell 163, 1079-1094 (2015).
    • (2015) Cell , vol.163 , pp. 1079-1094
    • Zeevi, D.1
  • 85
    • 84941271231 scopus 로고    scopus 로고
    • Prediction of early childhood caries via spatial-temporal variations of oral microbiota
    • Teng, F. et al. Prediction of early childhood caries via spatial-temporal variations of oral microbiota. Cell Host Microbe 18, 296-306 (2015).
    • (2015) Cell Host Microbe , vol.18 , pp. 296-306
    • Teng, F.1
  • 86
    • 84906942512 scopus 로고    scopus 로고
    • Predictive modeling of gingivitis severity and susceptibility via oral microbiota
    • Huang, S. et al. Predictive modeling of gingivitis severity and susceptibility via oral microbiota. ISME J. 8, 1768-1780 (2014).
    • (2014) ISME J. , vol.8 , pp. 1768-1780
    • Huang, S.1
  • 87
    • 84938817346 scopus 로고    scopus 로고
    • The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment
    • Zhang, X. et al. The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nature Med. 21, 895-905 (2015).
    • (2015) Nature Med. , vol.21 , pp. 895-905
    • Zhang, X.1
  • 88
    • 84900535804 scopus 로고    scopus 로고
    • Dynamics and associations of microbial community types across the human body
    • Ding, T. and Schloss, P. D. Dynamics and associations of microbial community types across the human body. Nature 509, 357-360 (2014).
    • (2014) Nature , vol.509 , pp. 357-360
    • Ding, T.1    Schloss, P.D.2
  • 89
    • 84883057637 scopus 로고    scopus 로고
    • Dietary intervention impact on gut microbial gene richness
    • Cotillard, A. et al. Dietary intervention impact on gut microbial gene richness. Nature 500, 585-588 (2013).
    • (2013) Nature , vol.500 , pp. 585-588
    • Cotillard, A.1
  • 90
    • 84908348194 scopus 로고    scopus 로고
    • Meta-analyses of human gut microbes associated with obesity and IBD
    • Walters, W. A., Xu, Z. and Knight, R. Meta-analyses of human gut microbes associated with obesity and IBD. FEBS Lett. 588, 4223-4233 (2014).
    • (2014) FEBS Lett. , vol.588 , pp. 4223-4233
    • Walters, W.A.1    Xu, Z.2    Knight, R.3
  • 91
    • 84937611678 scopus 로고    scopus 로고
    • Vitamin B12 modulates the transcriptome of the skin microbiota in acne pathogenesis
    • Kang, D., Shi, B., Erfe, M. C., Craft, N. and Li, H. Vitamin B12 modulates the transcriptome of the skin microbiota in acne pathogenesis. Sci. Transl. Med. 7, 293ra103 (2015).
    • (2015) Sci. Transl. Med. , vol.7 , pp. 293ra103
    • Kang, D.1    Shi, B.2    Erfe, M.C.3    Craft, N.4    Li, H.5
  • 92
    • 84949675208 scopus 로고    scopus 로고
    • The microbiome quality control project: Baseline study design and future directions
    • Sinha, R., Abnet, C. C., White, O., Knight, R. and Huttenhower, C. The microbiome quality control project: baseline study design and future directions. Genome Biol. 16, 276 (2015).
    • (2015) Genome Biol. , vol.16 , pp. 276
    • Sinha, R.1    Abnet, C.C.2    White, O.3    Knight, R.4    Huttenhower, C.5
  • 93
    • 84957831145 scopus 로고    scopus 로고
    • Collecting fecal samples for microbiome analyses in epidemiology studies
    • Sinha, R. et al. Collecting fecal samples for microbiome analyses in epidemiology studies. Cancer Epidemiol. Biomarkers Prev. 25, 407-416 (2016).
    • (2016) Cancer Epidemiol. Biomarkers Prev. , vol.25 , pp. 407-416
    • Sinha, R.1
  • 94
    • 55949124035 scopus 로고    scopus 로고
    • Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
    • Sokol, H. et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc. Natl Acad. Sci. USA 105, 16731-16736 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 16731-16736
    • Sokol, H.1
  • 95
    • 84872592295 scopus 로고    scopus 로고
    • Fecal microbiota composition differs between children with -cell autoimmunity and those without
    • de Goffau, M. C. et al. Fecal microbiota composition differs between children with -cell autoimmunity and those without. Diabetes 62, 1238-1244 (2013).
    • (2013) Diabetes , vol.62 , pp. 1238-1244
    • De Goffau, M.C.1
  • 96
    • 78650616947 scopus 로고    scopus 로고
    • Toward defining the autoimmune microbiome for type 1 diabetes
    • Giongo, A. et al. Toward defining the autoimmune microbiome for type 1 diabetes. ISME J. 5, 82-91 (2011).
    • (2011) ISME J. , vol.5 , pp. 82-91
    • Giongo, A.1
  • 97
    • 84922941772 scopus 로고    scopus 로고
    • The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes
    • Kostic, A. D. et al. The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host Microbe 17, 260-273 (2015).
    • (2015) Cell Host Microbe , vol.17 , pp. 260-273
    • Kostic, A.D.1
  • 98
    • 84867054370 scopus 로고    scopus 로고
    • Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis
    • Scher, J. U. et al. Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum. 64, 3083-3094 (2012).
    • (2012) Arthritis Rheum. , vol.64 , pp. 3083-3094
    • Scher, J.U.1
  • 99
    • 79952758083 scopus 로고    scopus 로고
    • Human oral, gut, and plaque microbiota in patients with atherosclerosis
    • Koren, O. et al. Human oral, gut, and plaque microbiota in patients with atherosclerosis. Proc. Natl Acad. Sci. USA 108 (suppl. 1), 4592-4598 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 4592-4598
    • Koren, O.1
  • 100
    • 85006192445 scopus 로고    scopus 로고
    • Dysbiosis of gut microbiota with reduced trimethylamine-N-oxide level in patients with large-artery atherosclerotic stroke or transient ischemic attack
    • Yin, J. et al. Dysbiosis of gut microbiota with reduced trimethylamine-N-oxide level in patients with large-artery atherosclerotic stroke or transient ischemic attack. J. Am. Heart Assoc. 4, e002699 (2015).
    • (2015) J. Am. Heart Assoc. , vol.4 , pp. e002699
    • Yin, J.1
  • 101
    • 84925862053 scopus 로고    scopus 로고
    • Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease
    • Tang, W. H. et al. Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease. Circ. Res. 116, 448-455 (2015).
    • (2015) Circ. Res. , vol.116 , pp. 448-455
    • Tang, W.H.1
  • 102
    • 84969261931 scopus 로고    scopus 로고
    • A genome-wide systems analysis reveals strong link between colorectal cancer and trimethylamine N-oxide (TMAO) a gut microbial metabolite of dietary meat and fat
    • Xu, R., Wang, Q. and Li, L. A genome-wide systems analysis reveals strong link between colorectal cancer and trimethylamine N-oxide (TMAO), a gut microbial metabolite of dietary meat and fat. BMC Genomics 16 (suppl. 7), S4 (2015).
    • (2015) BMC Genomics , vol.16 , pp. S4
    • Xu, R.1    Wang, Q.2    Li, L.3
  • 103
    • 84876563088 scopus 로고    scopus 로고
    • Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
    • Tang, W. H. et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N. Engl. J. Med. 368, 1575-1584 (2013).
    • (2013) N. Engl. J. Med. , vol.368 , pp. 1575-1584
    • Tang, W.H.1
  • 104
    • 84959922537 scopus 로고    scopus 로고
    • Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk
    • Zhu, W. et al. Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk. Cell 165, 111-124 (2016).
    • (2016) Cell , vol.165 , pp. 111-124
    • Zhu, W.1
  • 106
    • 54549106898 scopus 로고    scopus 로고
    • Accurate taxonomy assignments from 16S rRNA sequences produced by highly parallel pyrosequencers
    • Liu, Z., DeSantis, T. Z., Andersen, G. L. and Knight, R. Accurate taxonomy assignments from 16S rRNA sequences produced by highly parallel pyrosequencers. Nucleic Acids Res. 36, e120 (2008).
    • (2008) Nucleic Acids Res. , vol.36 , pp. e120
    • Liu, Z.1    DeSantis, T.Z.2    Andersen, G.L.3    Knight, R.4
  • 107
    • 80052722544 scopus 로고    scopus 로고
    • Meeting report: The terabase metagenomics workshop and the vision of an Earth microbiome project
    • Gilbert, J. A. et al. Meeting report: the terabase metagenomics workshop and the vision of an Earth microbiome project. Stand. Genomic Sci. 3, 243-248 (2010).
    • (2010) Stand. Genomic Sci. , vol.3 , pp. 243-248
    • Gilbert, J.A.1
  • 108
    • 29144464937 scopus 로고    scopus 로고
    • UniFrac: A new phylogenetic method for comparing microbial communities
    • Lozupone, C. and Knight, R. UniFrac: a new phylogenetic method for comparing microbial communities. Appl. Environ. Microbiol. 71, 8228-8235 (2005).
    • (2005) Appl. Environ. Microbiol. , vol.71 , pp. 8228-8235
    • Lozupone, C.1    Knight, R.2
  • 109
    • 84949604733 scopus 로고    scopus 로고
    • Microbial, host and xenobiotic diversity in the cystic fibrosis sputum metabolome
    • Quinn, R. A. et al. Microbial, host and xenobiotic diversity in the cystic fibrosis sputum metabolome. ISME J. 10, 1483-98 (2015).
    • (2015) ISME J. , vol.10 , pp. 1483-1498
    • Quinn, R.A.1
  • 111
    • 33744804299 scopus 로고    scopus 로고
    • Metagenomic analysis of the human distal gut microbiome
    • Gill, S. R. et al. Metagenomic analysis of the human distal gut microbiome. Science 312, 1355-1359 (2006).
    • (2006) Science , vol.312 , pp. 1355-1359
    • Gill, S.R.1
  • 112
    • 77950251400 scopus 로고    scopus 로고
    • A human gut microbial gene catalogue established by metagenomic sequencing
    • Qin, J. et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464, 59-65 (2010).
    • (2010) Nature , vol.464 , pp. 59-65
    • Qin, J.1
  • 113
    • 35348968286 scopus 로고    scopus 로고
    • The human microbiome project
    • Turnbaugh, P. J. et al. The human microbiome project. Nature 449, 804-810 (2007).
    • (2007) Nature , vol.449 , pp. 804-810
    • Turnbaugh, P.J.1
  • 114
    • 66249145772 scopus 로고    scopus 로고
    • Statistical methods for detecting differentially abundant features in clinical metagenomic samples
    • White, J. R., Nagarajan, N. and Pop, M. Statistical methods for detecting differentially abundant features in clinical metagenomic samples. PLoS Comput. Biol. 5, e1000352 (2009).
    • (2009) PLoS Comput. Biol. , vol.5 , pp. e1000352
    • White, J.R.1    Nagarajan, N.2    Pop, M.3
  • 115
    • 84924629414 scopus 로고    scopus 로고
    • Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
    • Love, M. I., Huber, W. and Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).
    • (2014) Genome Biol. , vol.15 , pp. 550
    • Love, M.I.1    Huber, W.2    Anders, S.3
  • 116
    • 84946878517 scopus 로고    scopus 로고
    • Analysis of composition of microbiomes: A novel method for studying microbial composition
    • Mandal, S. et al. Analysis of composition of microbiomes: a novel method for studying microbial composition. Microb. Ecol. Health Dis. 26, 27663 (2015).
    • (2015) Microb. Ecol. Health Dis. , vol.26 , pp. 27663
    • Mandal, S.1
  • 117
  • 118
    • 23344442120 scopus 로고    scopus 로고
    • Obesity alters gut microbial ecology
    • Ley, R. E. et al. Obesity alters gut microbial ecology. Proc. Natl Acad. Sci. USA 102, 11070-11075 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 11070-11075
    • Ley, R.E.1
  • 119
    • 77950250064 scopus 로고    scopus 로고
    • Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5
    • Vijay-Kumar, M. et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 328, 228-231 (2010).
    • (2010) Science , vol.328 , pp. 228-231
    • Vijay-Kumar, M.1
  • 120
    • 84872156123 scopus 로고    scopus 로고
    • Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice
    • Parks, B. W. et al. Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metab. 17, 141-152 (2013).
    • (2013) Cell Metab. , vol.17 , pp. 141-152
    • Parks, B.W.1
  • 121
    • 84862141704 scopus 로고    scopus 로고
    • Human gut microbiome viewed across age and geography
    • Yatsunenko, T. et al. Human gut microbiome viewed across age and geography. Nature 486, 222-227 (2012).
    • (2012) Nature , vol.486 , pp. 222-227
    • Yatsunenko, T.1
  • 122
    • 84910096224 scopus 로고    scopus 로고
    • Human genetics shape the gut microbiome
    • Goodrich, J. K. et al. Human genetics shape the gut microbiome. Cell 159, 789-799 (2014).
    • (2014) Cell , vol.159 , pp. 789-799
    • Goodrich, J.K.1


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