Antibodies Set Boundaries Limiting Microbial Metabolite Penetration and the Resultant Mammalian Host Response

Immunity

Volumn 49, Issue 3, 2018, Pages 545-559.e5

  Uchimura, Yasuhiro ^a,d   Fuhrer, Tobias ^b   Li, Hai ^a   Lawson, Melissa A ^a   Zimmermann, Michael ^b   Yilmaz, Bahtiyar ^a   Zindel, Joel ^a   Ronchi, Francesca ^a   Sorribas, Marcel ^a   Hapfelmeier, Siegfried ^c   Ganal Vonarburg, Stephanie C ^a   Gomez de Agüero, Mercedes ^a   McCoy, Kathy D ^a   Sauer, Uwe ^b   Macpherson, Andrew J ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

^d SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

13C isotope tracing; colonization; germ free; IgA; inflammation; intestinal transit; lipidemia; metabolomics; microbial metabolites; microbiota

Indexed keywords

ANTIBODY; AROMATIC HYDROCARBON RECEPTOR; IMMUNOGLOBULIN; SHORT CHAIN FATTY ACID; CARBON; CARBON-14; IMMUNOGLOBULIN HEAVY CHAIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; AUXOTROPHY; BACTERIAL COLONIZATION; BACTERIAL METABOLISM; CARBON SOURCE; COLON; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOKINE RESPONSE; ESCHERICHIA COLI; GLYCOLYSIS; HOST CELL; HOST PATHOGEN INTERACTION; ILEUM TISSUE; IMMUNE RESPONSE; IN VIVO STUDY; INFANT; INFLAMMATION; INTESTINE FLORA; ISOTOPE TRACING; METABOLITE; METABOLOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMALL INTESTINE MUCOSA; ANIMAL; C57BL MOUSE; GENETICS; HYPERLIPIDEMIA; IMMUNITY; IMMUNOLOGY; KNOCKOUT MOUSE; MAMMAL; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY;

ANIMALS; ANTIBODIES; CARBON RADIOISOTOPES; GASTROINTESTINAL MICROBIOME; GLYCOLYSIS; HOST-PATHOGEN INTERACTIONS; HYPERLIPIDEMIAS; IMMUNITY; IMMUNOGLOBULIN HEAVY CHAINS; INFLAMMATION; MAMMALS; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT;

EID: 85053066099     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2018.08.004     Document Type: Article

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