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Volumn 2, Issue 2, 2016, Pages 95-109

Anti-CD73 in Cancer Immunotherapy: Awakening New Opportunities

Author keywords

adenosine; cancer; CD73; immunotherapy; tumor microenvironment

Indexed keywords

ADENOSINE; ECTO 5' NUCLEOTIDASE; MONOCLONAL ANTIBODY;

EID: 84959262007     PISSN: 24058033     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trecan.2016.01.003     Document Type: Review
Times cited : (176)

References (161)
  • 1
    • 84864708409 scopus 로고    scopus 로고
    • The tumor microenvironment
    • C.E. Weber, and P.C. Kuo The tumor microenvironment Surg. Oncol. 21 2012 172 177
    • (2012) Surg. Oncol. , vol.21 , pp. 172-177
    • Weber, C.E.1    Kuo, P.C.2
  • 2
    • 79251517382 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism
    • R.A. Cairns, and et al. Regulation of cancer cell metabolism Nat. Rev. Cancer 11 2011 85 95
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 85-95
    • Cairns, R.A.1
  • 3
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 4
    • 84888385324 scopus 로고    scopus 로고
    • Immunity, inflammation and cancer: A leading role for adenosine
    • L. Antonioli, and et al. Immunity, inflammation and cancer: a leading role for adenosine Nat. Rev. Cancer 13 2013 842 857
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 842-857
    • Antonioli, L.1
  • 5
    • 84878614399 scopus 로고    scopus 로고
    • CD39 and CD73 in immunity and inflammation
    • L. Antonioli, and et al. CD39 and CD73 in immunity and inflammation Trends Mol. Med. 19 2013 355 367
    • (2013) Trends Mol. Med. , vol.19 , pp. 355-367
    • Antonioli, L.1
  • 6
    • 84912096578 scopus 로고    scopus 로고
    • Enzymes involved in metabolism of extracellular nucleotides and nucleosides: Functional implications and measurement of activities
    • G.G. Yegutkin Enzymes involved in metabolism of extracellular nucleotides and nucleosides: functional implications and measurement of activities Crit. Rev. Biochem. Mol. Biol. 49 2014 473 497
    • (2014) Crit. Rev. Biochem. Mol. Biol. , vol.49 , pp. 473-497
    • Yegutkin, G.G.1
  • 7
    • 77955750932 scopus 로고    scopus 로고
    • CD73: A novel target for cancer immunotherapy
    • B. Zhang CD73: a novel target for cancer immunotherapy Cancer Res. 70 2010 6407 6411
    • (2010) Cancer Res. , vol.70 , pp. 6407-6411
    • Zhang, B.1
  • 8
    • 84860388676 scopus 로고    scopus 로고
    • CD73: A potent suppressor of antitumor immune responses
    • P.A. Beavis, and et al. CD73: a potent suppressor of antitumor immune responses Trends Immunol. 33 2012 231 237
    • (2012) Trends Immunol. , vol.33 , pp. 231-237
    • Beavis, P.A.1
  • 9
    • 84929057232 scopus 로고    scopus 로고
    • The roles of CD73 in cancer
    • Z.W. Gao, and et al. The roles of CD73 in cancer Biomed. Res. Int. 2014 2014 460654
    • (2014) Biomed. Res. Int. , vol.2014 , pp. 460654
    • Gao, Z.W.1
  • 10
    • 84867351931 scopus 로고    scopus 로고
    • Opportunities and challenges for anti-CD73 cancer therapy
    • B. Zhang Opportunities and challenges for anti-CD73 cancer therapy Immunotherapy 4 2012 861 865
    • (2012) Immunotherapy , vol.4 , pp. 861-865
    • Zhang, B.1
  • 11
    • 84891824680 scopus 로고    scopus 로고
    • Anti-CD73 therapy impairs tumor angiogenesis
    • B. Allard, and et al. Anti-CD73 therapy impairs tumor angiogenesis Int. J. Cancer 134 2014 1466 1473
    • (2014) Int. J. Cancer , vol.134 , pp. 1466-1473
    • Allard, B.1
  • 12
    • 84929455792 scopus 로고    scopus 로고
    • Gene expression markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: Results from CALGB 80203 (Alliance)
    • S. Cushman, and et al. Gene expression markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: results from CALGB 80203 (Alliance) Clin. Cancer. Res. 21 2015 1078 1086
    • (2015) Clin. Cancer. Res. , vol.21 , pp. 1078-1086
    • Cushman, S.1
  • 13
    • 79955153842 scopus 로고    scopus 로고
    • Altered purinergic signaling in CD73-deficient mice inhibits tumor progression
    • G.G. Yegutkin, and et al. Altered purinergic signaling in CD73-deficient mice inhibits tumor progression Eur. J. Immunol. 41 2011 1231 1241
    • (2011) Eur. J. Immunol. , vol.41 , pp. 1231-1241
    • Yegutkin, G.G.1
  • 14
    • 84860382842 scopus 로고    scopus 로고
    • CD73-deficient mice are resistant to carcinogenesis
    • J. Stagg, and et al. CD73-deficient mice are resistant to carcinogenesis Cancer Res. 72 2012 2190 2196
    • (2012) Cancer Res. , vol.72 , pp. 2190-2196
    • Stagg, J.1
  • 15
    • 79954576658 scopus 로고    scopus 로고
    • CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis
    • J. Stagg, and et al. CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis Cancer Res. 71 2011 2892 2900
    • (2011) Cancer Res. , vol.71 , pp. 2892-2900
    • Stagg, J.1
  • 16
    • 84902292720 scopus 로고    scopus 로고
    • A monastrol-derived compound, LaSOM 63, inhibits ecto-5′nucleotidase/CD73 activity and induces apoptotic cell death of glioma cell lines
    • F. Figueiro, and et al. A monastrol-derived compound, LaSOM 63, inhibits ecto-5′nucleotidase/CD73 activity and induces apoptotic cell death of glioma cell lines Anticancer Res. 34 2014 1837 1842
    • (2014) Anticancer Res. , vol.34 , pp. 1837-1842
    • Figueiro, F.1
  • 17
    • 84892958157 scopus 로고    scopus 로고
    • Anti-CD39 and anti-CD73 antibodies A1 and 7G2 improve targeted therapy in ovarian cancer by blocking adenosine-dependent immune evasion
    • S.F. Hausler, and et al. Anti-CD39 and anti-CD73 antibodies A1 and 7G2 improve targeted therapy in ovarian cancer by blocking adenosine-dependent immune evasion Am. J. Transl. Res. 6 2014 129 139
    • (2014) Am. J. Transl. Res. , vol.6 , pp. 129-139
    • Hausler, S.F.1
  • 18
    • 84892413054 scopus 로고    scopus 로고
    • Inhibition of CD73 stimulates the migration and invasion of B16F10 melanoma cells in vitro, but results in impaired angiogenesis and reduced melanoma growth in vivo
    • P. Koszalka, and et al. Inhibition of CD73 stimulates the migration and invasion of B16F10 melanoma cells in vitro, but results in impaired angiogenesis and reduced melanoma growth in vivo Oncol. Rep. 31 2014 819 827
    • (2014) Oncol. Rep. , vol.31 , pp. 819-827
    • Koszalka, P.1
  • 19
    • 84885437317 scopus 로고    scopus 로고
    • Anti-human CD73 monoclonal antibody inhibits metastasis formation in human breast cancer by inducing clustering and internalization of CD73 expressed on the surface of cancer cells
    • M.G. Terp, and et al. Anti-human CD73 monoclonal antibody inhibits metastasis formation in human breast cancer by inducing clustering and internalization of CD73 expressed on the surface of cancer cells J. Immunol. 191 2013 4165 4173
    • (2013) J. Immunol. , vol.191 , pp. 4165-4173
    • Terp, M.G.1
  • 20
    • 84870424506 scopus 로고    scopus 로고
    • 5′-ectonucleotidase mediates multiple-drug resistance in glioblastoma multiforme cells
    • C. Quezada, and et al. 5′-ectonucleotidase mediates multiple-drug resistance in glioblastoma multiforme cells J. Cell. Physiol. 228 2013 602 608
    • (2013) J. Cell. Physiol. , vol.228 , pp. 602-608
    • Quezada, C.1
  • 21
    • 84865429151 scopus 로고    scopus 로고
    • Inhibition of CD73 improves B cell-mediated anti-tumor immunity in a mouse model of melanoma
    • G. Forte, and et al. Inhibition of CD73 improves B cell-mediated anti-tumor immunity in a mouse model of melanoma J. Immunol. 189 2012 2226 2233
    • (2012) J. Immunol. , vol.189 , pp. 2226-2233
    • Forte, G.1
  • 22
    • 78449305587 scopus 로고    scopus 로고
    • RNAi-mediated CD73 suppression induces apoptosis and cell-cycle arrest in human breast cancer cells
    • X. Zhi, and et al. RNAi-mediated CD73 suppression induces apoptosis and cell-cycle arrest in human breast cancer cells Cancer Sci. 101 2010 2561 2569
    • (2010) Cancer Sci. , vol.101 , pp. 2561-2569
    • Zhi, X.1
  • 23
    • 75949112218 scopus 로고    scopus 로고
    • Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis
    • J. Stagg, and et al. Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis Proc. Natl. Acad. Sci. U.S.A. 107 2010 1547 1552
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 1547-1552
    • Stagg, J.1
  • 24
    • 84879705407 scopus 로고    scopus 로고
    • CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer
    • S. Loi, and et al. CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer Proc. Natl. Acad. Sci. U.S.A. 110 2013 11091 11096
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 11091-11096
    • Loi, S.1
  • 25
    • 84886432843 scopus 로고    scopus 로고
    • Targeting CD73 enhances the antitumor activity of anti-PD-1 and anti-CTLA-4 mAbs
    • B. Allard, and et al. Targeting CD73 enhances the antitumor activity of anti-PD-1 and anti-CTLA-4 mAbs Clin. Cancer Res. 19 2013 5626 5635
    • (2013) Clin. Cancer Res. , vol.19 , pp. 5626-5635
    • Allard, B.1
  • 26
    • 84886698315 scopus 로고    scopus 로고
    • Innate and adaptive immune cells in the tumor microenvironment
    • T.F. Gajewski, and et al. Innate and adaptive immune cells in the tumor microenvironment Nat. Immunol. 14 2013 1014 1022
    • (2013) Nat. Immunol. , vol.14 , pp. 1014-1022
    • Gajewski, T.F.1
  • 27
    • 34250351459 scopus 로고    scopus 로고
    • Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    • S. Deaglio, and et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression J. Exp. Med. 204 2007 1257 1265
    • (2007) J. Exp. Med. , vol.204 , pp. 1257-1265
    • Deaglio, S.1
  • 28
    • 84942447109 scopus 로고    scopus 로고
    • CD73 activity is dispensable for the polarization of M2 macrophages
    • D. Eichin, and et al. CD73 activity is dispensable for the polarization of M2 macrophages PLoS ONE 10 2015 e0134721
    • (2015) PLoS ONE , vol.10 , pp. e0134721
    • Eichin, D.1
  • 29
    • 84858795377 scopus 로고    scopus 로고
    • Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression
    • F. Chalmin, and et al. Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression Immunity 36 2012 362 373
    • (2012) Immunity , vol.36 , pp. 362-373
    • Chalmin, F.1
  • 30
    • 84908155316 scopus 로고    scopus 로고
    • Enhancement of T cell recruitment and infiltration into tumours
    • C. Oelkrug, and J.M. Ramage Enhancement of T cell recruitment and infiltration into tumours Clin. Exp. Immunol. 178 2014 1 8
    • (2014) Clin. Exp. Immunol. , vol.178 , pp. 1-8
    • Oelkrug, C.1    Ramage, J.M.2
  • 31
    • 28444433059 scopus 로고    scopus 로고
    • Failure of immune homeostasis - The consequences of under and over reactivity
    • B. Crimeen-Irwin, and et al. Failure of immune homeostasis - the consequences of under and over reactivity Curr. Drug. Targets Immune. Endocr. Metabol. Disord. 5 2005 413 422
    • (2005) Curr. Drug. Targets Immune. Endocr. Metabol. Disord. , vol.5 , pp. 413-422
    • Crimeen-Irwin, B.1
  • 32
    • 84928005339 scopus 로고    scopus 로고
    • CD4+Foxp3+ regulatory T cell differentiation mediated by endometrial stromal cell-derived TECK promotes the growth and invasion of endometriotic lesions
    • M.Q. Li, and et al. CD4+Foxp3+ regulatory T cell differentiation mediated by endometrial stromal cell-derived TECK promotes the growth and invasion of endometriotic lesions Cell Death Dis. 5 2014 e1436
    • (2014) Cell Death Dis. , vol.5 , pp. e1436
    • Li, M.Q.1
  • 33
    • 84870539986 scopus 로고    scopus 로고
    • Host CD73 impairs anti-tumor immunity
    • M. Salmi, and S. Jalkanen Host CD73 impairs anti-tumor immunity Oncoimmunology 1 2012 247 248
    • (2012) Oncoimmunology , vol.1 , pp. 247-248
    • Salmi, M.1    Jalkanen, S.2
  • 34
    • 79957921286 scopus 로고    scopus 로고
    • CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice
    • L. Wang, and et al. CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice J. Clin. Invest. 121 2011 2371 2382
    • (2011) J. Clin. Invest. , vol.121 , pp. 2371-2382
    • Wang, L.1
  • 35
    • 84903936227 scopus 로고    scopus 로고
    • Human CD4+ CD39+ regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+ exosomes or CD73+ cells
    • P.J. Schuler, and et al. Human CD4+ CD39+ regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+ exosomes or CD73+ cells Clin. Exp. Immunol. 177 2014 531 543
    • (2014) Clin. Exp. Immunol. , vol.177 , pp. 531-543
    • Schuler, P.J.1
  • 36
    • 84870465551 scopus 로고    scopus 로고
    • CD73 and adenosine generation in the creation of regulatory microenvironments
    • F.S. Regateiro, and et al. CD73 and adenosine generation in the creation of regulatory microenvironments Clin. Exp. Immunol. 171 2013 1 7
    • (2013) Clin. Exp. Immunol. , vol.171 , pp. 1-7
    • Regateiro, F.S.1
  • 37
    • 77950249826 scopus 로고    scopus 로고
    • A2A adenosine receptor may allow expansion of T cells lacking effector functions in extracellular adenosine-rich microenvironments
    • A. Ohta, and et al. A2A adenosine receptor may allow expansion of T cells lacking effector functions in extracellular adenosine-rich microenvironments J. Immunol. 183 2009 5487 5493
    • (2009) J. Immunol. , vol.183 , pp. 5487-5493
    • Ohta, A.1
  • 38
    • 79961008951 scopus 로고    scopus 로고
    • Extracellular purine metabolism and signaling of CD73-derived adenosine in murine Treg and Teff cells
    • M. Romio, and et al. Extracellular purine metabolism and signaling of CD73-derived adenosine in murine Treg and Teff cells Am. J. Physiol. Cell Physiol. 301 2011 C530 C539
    • (2011) Am. J. Physiol. Cell Physiol. , vol.301 , pp. C530-C539
    • Romio, M.1
  • 39
    • 38049141544 scopus 로고    scopus 로고
    • A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells
    • P.E. Zarek, and et al. A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells Blood 111 2008 251 259
    • (2008) Blood , vol.111 , pp. 251-259
    • Zarek, P.E.1
  • 40
    • 84881192927 scopus 로고    scopus 로고
    • MTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function
    • H. Zeng, and et al. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function Nature 499 2013 485 490
    • (2013) Nature , vol.499 , pp. 485-490
    • Zeng, H.1
  • 41
    • 84855393963 scopus 로고    scopus 로고
    • Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells
    • R.J. Martinez, and et al. Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells J. Immunol. 188 2012 170 181
    • (2012) J. Immunol. , vol.188 , pp. 170-181
    • Martinez, R.J.1
  • 42
    • 77950231071 scopus 로고    scopus 로고
    • CD73 on tumor cells impairs antitumor T-cell responses: A novel mechanism of tumor-induced immune suppression
    • D. Jin, and et al. CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression Cancer Res. 70 2010 2245 2255
    • (2010) Cancer Res. , vol.70 , pp. 2245-2255
    • Jin, D.1
  • 43
    • 0028838712 scopus 로고
    • CD73 is involved in lymphocyte binding to the endothelium: Characterization of lymphocyte-vascular adhesion protein 2 identifies it as CD73
    • L. Airas, and et al. CD73 is involved in lymphocyte binding to the endothelium: characterization of lymphocyte-vascular adhesion protein 2 identifies it as CD73 J. Exp. Med. 182 1995 1603 1608
    • (1995) J. Exp. Med. , vol.182 , pp. 1603-1608
    • Airas, L.1
  • 44
    • 0034669958 scopus 로고    scopus 로고
    • CD73 engagement promotes lymphocyte binding to endothelial cells via a lymphocyte function-associated antigen-1-dependent mechanism
    • L. Airas, and et al. CD73 engagement promotes lymphocyte binding to endothelial cells via a lymphocyte function-associated antigen-1-dependent mechanism J. Immunol. 165 2000 5411 5417
    • (2000) J. Immunol. , vol.165 , pp. 5411-5417
    • Airas, L.1
  • 45
    • 84880922175 scopus 로고    scopus 로고
    • Dendritic cells in the cancer microenvironment
    • Y. Ma, and et al. Dendritic cells in the cancer microenvironment J. Cancer 4 2013 36 44
    • (2013) J. Cancer , vol.4 , pp. 36-44
    • Ma, Y.1
  • 46
    • 84855408091 scopus 로고    scopus 로고
    • Adenosine A2B receptor blockade slows growth of bladder and breast tumors
    • C. Cekic, and et al. Adenosine A2B receptor blockade slows growth of bladder and breast tumors J. Immunol. 188 2012 198 205
    • (2012) J. Immunol. , vol.188 , pp. 198-205
    • Cekic, C.1
  • 47
    • 84918577973 scopus 로고    scopus 로고
    • Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment
    • C. Cekic, and et al. Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment Cancer Res. 74 2014 7250 7259
    • (2014) Cancer Res. , vol.74 , pp. 7250-7259
    • Cekic, C.1
  • 48
    • 84863691003 scopus 로고    scopus 로고
    • Macrophages in tumor microenvironments and the progression of tumors
    • N.B. Hao, and et al. Macrophages in tumor microenvironments and the progression of tumors Clin. Dev. Immunol. 2012 2012 948098
    • (2012) Clin. Dev. Immunol. , vol.2012 , pp. 948098
    • Hao, N.B.1
  • 49
    • 84856873768 scopus 로고    scopus 로고
    • Differential macrophage activation alters the expression profile of NTPDase and ecto-5′-nucleotidase
    • R.F. Zanin, and et al. Differential macrophage activation alters the expression profile of NTPDase and ecto-5′-nucleotidase PLoS ONE 7 2012 e31205
    • (2012) PLoS ONE , vol.7 , pp. e31205
    • Zanin, R.F.1
  • 50
    • 84855369818 scopus 로고    scopus 로고
    • Adenosine promotes alternative macrophage activation via A2A and A2B receptors
    • B. Csoka, and et al. Adenosine promotes alternative macrophage activation via A2A and A2B receptors FASEB J. 26 2012 376 386
    • (2012) FASEB J. , vol.26 , pp. 376-386
    • Csoka, B.1
  • 51
    • 84888781899 scopus 로고    scopus 로고
    • Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages
    • B. Koscso, and et al. Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages J. Leukoc. Biol. 94 2013 1309 1315
    • (2013) J. Leukoc. Biol. , vol.94 , pp. 1309-1315
    • Koscso, B.1
  • 52
    • 84894422046 scopus 로고    scopus 로고
    • A2B adenosine receptors prevent insulin resistance by inhibiting adipose tissue inflammation via maintaining alternative macrophage activation
    • B. Csoka, and et al. A2B adenosine receptors prevent insulin resistance by inhibiting adipose tissue inflammation via maintaining alternative macrophage activation Diabetes 63 2014 850 866
    • (2014) Diabetes , vol.63 , pp. 850-866
    • Csoka, B.1
  • 53
    • 84880265532 scopus 로고    scopus 로고
    • The adenosine-dependent angiogenic switch of macrophages to an M2-like phenotype is independent of interleukin-4 receptor alpha (IL-4Ralpha) signaling
    • C.J. Ferrante, and et al. The adenosine-dependent angiogenic switch of macrophages to an M2-like phenotype is independent of interleukin-4 receptor alpha (IL-4Ralpha) signaling Inflammation 36 2013 921 931
    • (2013) Inflammation , vol.36 , pp. 921-931
    • Ferrante, C.J.1
  • 54
    • 0030588630 scopus 로고    scopus 로고
    • Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice
    • G. Hasko, and et al. Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice J. Immunol. 157 1996 4634 4640
    • (1996) J. Immunol. , vol.157 , pp. 4634-4640
    • Hasko, G.1
  • 55
    • 29144501467 scopus 로고    scopus 로고
    • Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism
    • Z.H. Nemeth, and et al. Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism J. Immunol. 175 2005 8260 8270
    • (2005) J. Immunol. , vol.175 , pp. 8260-8270
    • Nemeth, Z.H.1
  • 56
    • 0033820684 scopus 로고    scopus 로고
    • Adenosine inhibits IL-12 and TNF- [alpha] production via adenosine A2a receptor-dependent and independent mechanisms
    • G. Hasko, and et al. Adenosine inhibits IL-12 and TNF- [alpha] production via adenosine A2a receptor-dependent and independent mechanisms FASEB J. 14 2000 2065 2074
    • (2000) FASEB J. , vol.14 , pp. 2065-2074
    • Hasko, G.1
  • 57
    • 84927746895 scopus 로고    scopus 로고
    • New therapeutic options for advanced non-resectable malignant melanoma
    • S. Stadler, and et al. New therapeutic options for advanced non-resectable malignant melanoma Adv. Med. Sci. 60 2014 83 88
    • (2014) Adv. Med. Sci. , vol.60 , pp. 83-88
    • Stadler, S.1
  • 58
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • S.L. Topalian, and et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer N. Engl. J. Med. 366 2012 2443 2454
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2443-2454
    • Topalian, S.L.1
  • 59
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • D.I. Gabrilovich, and S. Nagaraj Myeloid-derived suppressor cells as regulators of the immune system Nat. Rev. Immunol. 9 2009 162 174
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 60
    • 84921629667 scopus 로고    scopus 로고
    • Role of TGF-beta signaling in generation of CD39+CD73+ myeloid cells in tumors
    • S.V. Ryzhov, and et al. Role of TGF-beta signaling in generation of CD39+CD73+ myeloid cells in tumors J. Immunol. 193 2014 3155 3164
    • (2014) J. Immunol. , vol.193 , pp. 3155-3164
    • Ryzhov, S.V.1
  • 61
    • 84884556145 scopus 로고    scopus 로고
    • History of myeloid-derived suppressor cells
    • J.E. Talmadge, and D.I. Gabrilovich History of myeloid-derived suppressor cells Nat. Rev. Cancer 13 2013 739 752
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 739-752
    • Talmadge, J.E.1    Gabrilovich, D.I.2
  • 62
    • 82755162136 scopus 로고    scopus 로고
    • Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells
    • S. Ryzhov, and et al. Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells J. Immunol. 187 2011 6120 6129
    • (2011) J. Immunol. , vol.187 , pp. 6120-6129
    • Ryzhov, S.1
  • 63
    • 84881030156 scopus 로고    scopus 로고
    • Cancer associated fibroblasts' - More than meets the eye
    • S. Madar, and et al. 'Cancer associated fibroblasts' - more than meets the eye Trends Mol. Med. 19 2013 447 453
    • (2013) Trends Mol. Med. , vol.19 , pp. 447-453
    • Madar, S.1
  • 64
    • 84859949610 scopus 로고    scopus 로고
    • The extracellular matrix: A dynamic niche in cancer progression
    • P. Lu, and et al. The extracellular matrix: a dynamic niche in cancer progression J. Cell. Biol. 196 2012 395 406
    • (2012) J. Cell. Biol. , vol.196 , pp. 395-406
    • Lu, P.1
  • 65
    • 84857826513 scopus 로고    scopus 로고
    • Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors
    • H. Salmon, and et al. Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors J. Clin. Invest. 122 2012 899 910
    • (2012) J. Clin. Invest. , vol.122 , pp. 899-910
    • Salmon, H.1
  • 66
    • 79953309908 scopus 로고    scopus 로고
    • Tumour-associated fibroblasts and mesenchymal stem cells: More similarities than differences
    • V. Paunescu, and et al. Tumour-associated fibroblasts and mesenchymal stem cells: more similarities than differences J. Cell. Mol. Med. 15 2011 635 646
    • (2011) J. Cell. Mol. Med. , vol.15 , pp. 635-646
    • Paunescu, V.1
  • 67
    • 84915749670 scopus 로고    scopus 로고
    • CD117 expression in fibroblasts-like stromal cells indicates unfavorable clinical outcomes in ovarian carcinoma patients
    • R. Huang, and et al. CD117 expression in fibroblasts-like stromal cells indicates unfavorable clinical outcomes in ovarian carcinoma patients PLoS ONE 9 2014 e112209
    • (2014) PLoS ONE , vol.9 , pp. e112209
    • Huang, R.1
  • 68
    • 0026029631 scopus 로고
    • Expression of ecto-5′-nucleotidase (CD73) in normal mammary gland and in breast carcinoma
    • K.H. Kruger, and et al. Expression of ecto-5′-nucleotidase (CD73) in normal mammary gland and in breast carcinoma Br. J. Cancer 63 1991 114 118
    • (1991) Br. J. Cancer , vol.63 , pp. 114-118
    • Kruger, K.H.1
  • 69
    • 84938202009 scopus 로고    scopus 로고
    • The expression and clinical significance of CD73 molecule in human rectal adenocarcinoma
    • B. Zhang, and et al. The expression and clinical significance of CD73 molecule in human rectal adenocarcinoma Tumour Biol. 36 2015 5459 5466
    • (2015) Tumour Biol. , vol.36 , pp. 5459-5466
    • Zhang, B.1
  • 70
    • 84863722239 scopus 로고    scopus 로고
    • High expression of CD73 as a poor prognostic biomarker in human colorectal cancer
    • X.R. Wu, and et al. High expression of CD73 as a poor prognostic biomarker in human colorectal cancer J. Surg. Oncol. 106 2012 130 137
    • (2012) J. Surg. Oncol. , vol.106 , pp. 130-137
    • Wu, X.R.1
  • 71
    • 84946599682 scopus 로고    scopus 로고
    • CD73 is associated with poor prognosis in high-grade serous ovarian cancer
    • M. Turcotte, and et al. CD73 is associated with poor prognosis in high-grade serous ovarian cancer Cancer Res. 75 2015 4494 4503
    • (2015) Cancer Res. , vol.75 , pp. 4494-4503
    • Turcotte, M.1
  • 72
    • 84894618283 scopus 로고    scopus 로고
    • Mesenchymal stem cells and cancer: Friends or enemies?
    • I.S. Hong, and et al. Mesenchymal stem cells and cancer: friends or enemies? Mutat. Res. Fundam. Mol. Mech. Mutagen. 768 2014 98 106
    • (2014) Mutat. Res. Fundam. Mol. Mech. Mutagen. , vol.768 , pp. 98-106
    • Hong, I.S.1
  • 73
    • 84923631755 scopus 로고    scopus 로고
    • Mesenchymal stem cells are enriched in head neck squamous cell carcinoma, correlates with tumour size and inhibit T-cell proliferation
    • F. Liotta, and et al. Mesenchymal stem cells are enriched in head neck squamous cell carcinoma, correlates with tumour size and inhibit T-cell proliferation Br. J. Cancer 112 2015 745 754
    • (2015) Br. J. Cancer , vol.112 , pp. 745-754
    • Liotta, F.1
  • 74
    • 84925590260 scopus 로고    scopus 로고
    • Bone marrow derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo
    • S. Amarnath, and et al. Bone marrow derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo Stem Cells 33 2014 1200 1212
    • (2014) Stem Cells , vol.33 , pp. 1200-1212
    • Amarnath, S.1
  • 75
    • 84855389100 scopus 로고    scopus 로고
    • Mesenchymal stromal cell mutations and wound healing contribute to the etiology of desmoid tumors
    • A.M. Carothers, and et al. Mesenchymal stromal cell mutations and wound healing contribute to the etiology of desmoid tumors Cancer Res. 72 2012 346 355
    • (2012) Cancer Res. , vol.72 , pp. 346-355
    • Carothers, A.M.1
  • 76
    • 84920935172 scopus 로고    scopus 로고
    • Role of mesenchymal stem cells in cell life and their signaling
    • S. Tanabe Role of mesenchymal stem cells in cell life and their signaling World. J. Stem. Cells 6 2014 24 32
    • (2014) World. J. Stem. Cells , vol.6 , pp. 24-32
    • Tanabe, S.1
  • 77
    • 84904129414 scopus 로고    scopus 로고
    • Mechanisms of T-cell immunosuppression by mesenchymal stromal cells: What do we know so far?
    • R. Haddad, and F. Saldanha-Araujo Mechanisms of T-cell immunosuppression by mesenchymal stromal cells: what do we know so far? Biomed. Res. Int. 2014 216806
    • (2014) Biomed. Res. Int. , pp. 216806
    • Haddad, R.1    Saldanha-Araujo, F.2
  • 78
    • 84918515627 scopus 로고    scopus 로고
    • Purinergic receptors and nucleotide processing ectoenzymes: Their roles in regulating mesenchymal stem cell functions
    • S. Scarfi Purinergic receptors and nucleotide processing ectoenzymes: their roles in regulating mesenchymal stem cell functions World. J. Stem Cells 6 2014 153 162
    • (2014) World. J. Stem Cells , vol.6 , pp. 153-162
    • Scarfi, S.1
  • 79
    • 84878614399 scopus 로고    scopus 로고
    • CD39 and CD73 in immunity and inflammation
    • L. Antonioli, and et al. CD39 and CD73 in immunity and inflammation Trends. Mol. Med. 19 2013 355 367
    • (2013) Trends. Mol. Med. , vol.19 , pp. 355-367
    • Antonioli, L.1
  • 80
    • 34548008177 scopus 로고    scopus 로고
    • Effects of ecto-5′-nucleotidase on human breast cancer cell growth in vitro and in vivo
    • X. Zhou, and et al. Effects of ecto-5′-nucleotidase on human breast cancer cell growth in vitro and in vivo Oncol. Rep. 17 2007 1341 1346
    • (2007) Oncol. Rep. , vol.17 , pp. 1341-1346
    • Zhou, X.1
  • 81
    • 34548435229 scopus 로고    scopus 로고
    • RNA interference of ecto-5′-nucleotidase (CD73) inhibits human breast cancer cell growth and invasion
    • X. Zhi, and et al. RNA interference of ecto-5′-nucleotidase (CD73) inhibits human breast cancer cell growth and invasion Clin. Exp. Metastasis 24 2007 439 448
    • (2007) Clin. Exp. Metastasis , vol.24 , pp. 439-448
    • Zhi, X.1
  • 82
    • 34547840321 scopus 로고    scopus 로고
    • Ecto-5′-nucleotidase/CD73 inhibition by quercetin in the human U138MG glioma cell line
    • E. Braganhol, and et al. Ecto-5′-nucleotidase/CD73 inhibition by quercetin in the human U138MG glioma cell line Biochim. Biophys. Acta 1770 2007 1352 1359
    • (2007) Biochim. Biophys. Acta , vol.1770 , pp. 1352-1359
    • Braganhol, E.1
  • 83
    • 55649124110 scopus 로고    scopus 로고
    • The role of ecto-5′-nucleotidase/CD73 in glioma cell line proliferation
    • L. Bavaresco, and et al. The role of ecto-5′-nucleotidase/CD73 in glioma cell line proliferation Mol. Cell. Biochem. 319 2008 61 68
    • (2008) Mol. Cell. Biochem. , vol.319 , pp. 61-68
    • Bavaresco, L.1
  • 84
    • 82955217840 scopus 로고    scopus 로고
    • CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death
    • S. Serra, and et al. CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death Blood 118 2011 6141 6152
    • (2011) Blood , vol.118 , pp. 6141-6152
    • Serra, S.1
  • 85
    • 84869039651 scopus 로고    scopus 로고
    • CD73-generated adenosine: Orchestrating the tumor-stroma interplay to promote cancer growth
    • B. Allard, and et al. CD73-generated adenosine: orchestrating the tumor-stroma interplay to promote cancer growth J. Biomed. Biotechnol. 2012 2012 485156
    • (2012) J. Biomed. Biotechnol. , vol.2012 , pp. 485156
    • Allard, B.1
  • 86
    • 84878569519 scopus 로고    scopus 로고
    • Ecto-5′-nucleotidase (CD73) promotes tumor angiogenesis
    • L. Wang, and et al. Ecto-5′-nucleotidase (CD73) promotes tumor angiogenesis Clin. Exp. Metastasis 30 2013 671 680
    • (2013) Clin. Exp. Metastasis , vol.30 , pp. 671-680
    • Wang, L.1
  • 87
    • 84924373634 scopus 로고    scopus 로고
    • Growth and metastasis of B16-F10 melanoma cells is not critically dependent on host CD73 expression in mice
    • S. Burghoff, and et al. Growth and metastasis of B16-F10 melanoma cells is not critically dependent on host CD73 expression in mice BMC Cancer 14 2014 898
    • (2014) BMC Cancer , vol.14 , pp. 898
    • Burghoff, S.1
  • 88
    • 84875809217 scopus 로고    scopus 로고
    • Mouse models for studying angiogenesis and lymphangiogenesis in cancer
    • L. Eklund, and et al. Mouse models for studying angiogenesis and lymphangiogenesis in cancer Mol. Oncol. 7 2013 259 282
    • (2013) Mol. Oncol. , vol.7 , pp. 259-282
    • Eklund, L.1
  • 89
    • 0036310316 scopus 로고    scopus 로고
    • The role of tumor lymphangiogenesis in metastatic spread
    • S.A. Stacker The role of tumor lymphangiogenesis in metastatic spread FASEB. J. 16 2002 922 934
    • (2002) FASEB. J. , vol.16 , pp. 922-934
    • Stacker, S.A.1
  • 90
    • 84923069290 scopus 로고    scopus 로고
    • Ecto-5′-nucleotidase/CD73 enhances endothelial barrier function and sprouting in blood but not lymphatic vasculature
    • G.G. Yegutkin, and et al. Ecto-5′-nucleotidase/CD73 enhances endothelial barrier function and sprouting in blood but not lymphatic vasculature Eur. J. Immunol. 45 2015 562 573
    • (2015) Eur. J. Immunol. , vol.45 , pp. 562-573
    • Yegutkin, G.G.1
  • 91
    • 79955944679 scopus 로고    scopus 로고
    • Different role of CD73 in leukocyte trafficking via blood and lymph vessels
    • A. Algars, and et al. Different role of CD73 in leukocyte trafficking via blood and lymph vessels Blood 117 2011 4387 4393
    • (2011) Blood , vol.117 , pp. 4387-4393
    • Algars, A.1
  • 92
    • 84916625554 scopus 로고    scopus 로고
    • Immune escape mechanisms in colorectal cancer pathogenesis and liver metastasis
    • M. Pancione, and et al. Immune escape mechanisms in colorectal cancer pathogenesis and liver metastasis J. Immunol. Res. 2014 2014 686879
    • (2014) J. Immunol. Res. , vol.2014 , pp. 686879
    • Pancione, M.1
  • 93
    • 84896523581 scopus 로고    scopus 로고
    • Requirement of NK cells for selective A2A receptor blockade to suppress CD73+ tumor metastasis
    • L. Qin, and et al. Requirement of NK cells for selective A2A receptor blockade to suppress CD73+ tumor metastasis Immunotherapy 6 2014 19 21
    • (2014) Immunotherapy , vol.6 , pp. 19-21
    • Qin, L.1
  • 94
    • 84883422236 scopus 로고    scopus 로고
    • Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors
    • P.A. Beavis, and et al. Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors Proc. Natl. Acad. Sci. U.S.A. 110 2013 14711 14716
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 14711-14716
    • Beavis, P.A.1
  • 95
    • 84885140969 scopus 로고    scopus 로고
    • Overexpression of CD73 in prostate cancer is associated with lymph node metastasis
    • Q. Yang, and et al. Overexpression of CD73 in prostate cancer is associated with lymph node metastasis Pathol. Oncol. Res. 19 2013 811 814
    • (2013) Pathol. Oncol. Res. , vol.19 , pp. 811-814
    • Yang, Q.1
  • 96
    • 84867638014 scopus 로고    scopus 로고
    • Characterization of ectonucleotidases in human medulloblastoma cell lines: Ecto-5′NT/CD73 in metastasis as potential prognostic factor
    • A.R. Cappellari, and et al. Characterization of ectonucleotidases in human medulloblastoma cell lines: ecto-5′NT/CD73 in metastasis as potential prognostic factor PLoS ONE 7 2012 e47468
    • (2012) PLoS ONE , vol.7 , pp. e47468
    • Cappellari, A.R.1
  • 97
    • 84869058675 scopus 로고    scopus 로고
    • CD73 promotes tumor growth and metastasis
    • B. Zhang CD73 promotes tumor growth and metastasis Oncoimmunology 1 2012 67 70
    • (2012) Oncoimmunology , vol.1 , pp. 67-70
    • Zhang, B.1
  • 98
    • 38649133357 scopus 로고    scopus 로고
    • Ecto-5′-nucleotidase promotes invasion, migration and adhesion of human breast cancer cells
    • L. Wang, and et al. Ecto-5′-nucleotidase promotes invasion, migration and adhesion of human breast cancer cells J. Cancer Res. Clin. Oncol. 134 2008 365 372
    • (2008) J. Cancer Res. Clin. Oncol. , vol.134 , pp. 365-372
    • Wang, L.1
  • 99
    • 33750472374 scopus 로고    scopus 로고
    • Ecto-5′-nucleotidase (eN, CD73) is coexpressed with metastasis promoting antigens in human melanoma cells
    • R. Sadej, and et al. Ecto-5′-nucleotidase (eN, CD73) is coexpressed with metastasis promoting antigens in human melanoma cells Nucleosides Nucleotides Nucleic Acids 25 2006 1119 1123
    • (2006) Nucleosides Nucleotides Nucleic Acids , vol.25 , pp. 1119-1123
    • Sadej, R.1
  • 100
    • 34548255860 scopus 로고    scopus 로고
    • Overexpression of Ecto-5′-nucleotidase (CD73) promotes T-47D human breast cancer cells invasion and adhesion to extracellular matrix
    • P. Zhou, and et al. Overexpression of Ecto-5′-nucleotidase (CD73) promotes T-47D human breast cancer cells invasion and adhesion to extracellular matrix Cancer Biol. Ther. 6 2007 426 431
    • (2007) Cancer Biol. Ther. , vol.6 , pp. 426-431
    • Zhou, P.1
  • 101
    • 84907956049 scopus 로고    scopus 로고
    • Regulation of tumor growth and metastasis: The role of tumor microenvironment
    • H.A. Goubran, and et al. Regulation of tumor growth and metastasis: the role of tumor microenvironment Cancer Growth Metastasis 7 2014 9 18
    • (2014) Cancer Growth Metastasis , vol.7 , pp. 9-18
    • Goubran, H.A.1
  • 102
    • 84896702712 scopus 로고    scopus 로고
    • NT5E and FcGBP as key regulators of TGF-1-induced epithelial-mesenchymal transition (EMT) are associated with tumor progression and survival of patients with gallbladder cancer
    • L. Xiong, and et al. NT5E and FcGBP as key regulators of TGF-1-induced epithelial-mesenchymal transition (EMT) are associated with tumor progression and survival of patients with gallbladder cancer Cell. Tissue Res. 355 2014 365 374
    • (2014) Cell. Tissue Res. , vol.355 , pp. 365-374
    • Xiong, L.1
  • 103
    • 84928749945 scopus 로고    scopus 로고
    • New horizons in tumor microenvironment biology: Challenges and opportunities
    • F. Chen, and et al. New horizons in tumor microenvironment biology: challenges and opportunities BMC Med. 13 2015 45
    • (2015) BMC Med. , vol.13 , pp. 45
    • Chen, F.1
  • 104
    • 84939182460 scopus 로고    scopus 로고
    • Alpha,beta-Methylene-ADP (AOPCP) derivatives and analogues: Development of potent and selective ecto-5′-nucleotidase (CD73) inhibitors
    • S. Bhattarai, and et al. alpha,beta-Methylene-ADP (AOPCP) derivatives and analogues: development of potent and selective ecto-5′-nucleotidase (CD73) inhibitors J. Med. Chem. 58 2015 6248 6263
    • (2015) J. Med. Chem. , vol.58 , pp. 6248-6263
    • Bhattarai, S.1
  • 105
    • 84905455228 scopus 로고    scopus 로고
    • Targeting cancer-derived adenosine: New therapeutic approaches
    • A. Young, and et al. Targeting cancer-derived adenosine: new therapeutic approaches Cancer Discov. 4 2014 879 888
    • (2014) Cancer Discov. , vol.4 , pp. 879-888
    • Young, A.1
  • 106
    • 33947225356 scopus 로고    scopus 로고
    • Physiological roles for ecto-5′-nucleotidase (CD73)
    • S.P. Colgan, and et al. Physiological roles for ecto-5′-nucleotidase (CD73) Purinergic Signal. 2 2006 351 360
    • (2006) Purinergic Signal. , vol.2 , pp. 351-360
    • Colgan, S.P.1
  • 107
    • 84941797037 scopus 로고    scopus 로고
    • Classifying cancers based on T-cell infiltration and PD-L1
    • M.W. Teng, and et al. Classifying cancers based on T-cell infiltration and PD-L1 Cancer Res. 75 2015 2139 2145
    • (2015) Cancer Res. , vol.75 , pp. 2139-2145
    • Teng, M.W.1
  • 108
    • 77952568396 scopus 로고    scopus 로고
    • Hallmarks of cancer: Interactions with the tumor stroma
    • K. Pietras, and A. Ostman Hallmarks of cancer: interactions with the tumor stroma Exp. Cell Res. 316 2010 1324 1331
    • (2010) Exp. Cell Res. , vol.316 , pp. 1324-1331
    • Pietras, K.1    Ostman, A.2
  • 109
    • 0026729643 scopus 로고
    • 5′-Nucleotidase: Molecular structure and functional aspects
    • H. Zimmermann 5′-Nucleotidase: molecular structure and functional aspects Biochem. J. 285 1992 345 365
    • (1992) Biochem. J. , vol.285 , pp. 345-365
    • Zimmermann, H.1
  • 110
    • 85047685683 scopus 로고    scopus 로고
    • Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia
    • K. Synnestvedt, and et al. Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia J. Clin. Invest. 110 2002 993 1002
    • (2002) J. Clin. Invest. , vol.110 , pp. 993-1002
    • Synnestvedt, K.1
  • 111
    • 79954994463 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5′-nucleotidase (CD73) and the A2B adenosine receptor
    • M.L. Hart, and et al. Hypoxia-inducible factor-1alpha-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5′-nucleotidase (CD73) and the A2B adenosine receptor J. Immunol. 186 2011 4367 4374
    • (2011) J. Immunol. , vol.186 , pp. 4367-4374
    • Hart, M.L.1
  • 112
    • 37349048502 scopus 로고    scopus 로고
    • Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition
    • A. Robinson, and et al. Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition Gastroenterology 134 2008 145 155
    • (2008) Gastroenterology , vol.134 , pp. 145-155
    • Robinson, A.1
  • 113
    • 84908492287 scopus 로고    scopus 로고
    • Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases
    • H.K. Eltzschig, and et al. Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases Nat. Rev. Drug. Discov. 13 2014 852 869
    • (2014) Nat. Rev. Drug. Discov. , vol.13 , pp. 852-869
    • Eltzschig, H.K.1
  • 114
    • 37549022214 scopus 로고    scopus 로고
    • IFN-beta protects from vascular leakage via up-regulation of CD73
    • J. Kiss, and et al. IFN-beta protects from vascular leakage via up-regulation of CD73 Eur. J. Immunol. 37 2007 3334 3338
    • (2007) Eur. J. Immunol. , vol.37 , pp. 3334-3338
    • Kiss, J.1
  • 115
    • 34047250594 scopus 로고    scopus 로고
    • Ecto-5′-nucleotidase: Structure function relationships
    • N. Strater Ecto-5′-nucleotidase: Structure function relationships Purinergic Signal. 2 2006 343 350
    • (2006) Purinergic Signal. , vol.2 , pp. 343-350
    • Strater, N.1
  • 116
    • 84868101286 scopus 로고    scopus 로고
    • Crystal structure of a soluble form of human CD73 with ecto-5′-nucleotidase activity
    • D.P. Heuts, and et al. Crystal structure of a soluble form of human CD73 with ecto-5′-nucleotidase activity Chembiochem 13 2012 2384 2391
    • (2012) Chembiochem , vol.13 , pp. 2384-2391
    • Heuts, D.P.1
  • 117
    • 41949083203 scopus 로고    scopus 로고
    • Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade
    • G.G. Yegutkin Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade Biochim. Biophys. Acta 1783 2008 673 694
    • (2008) Biochim. Biophys. Acta , vol.1783 , pp. 673-694
    • Yegutkin, G.G.1
  • 118
    • 84871048026 scopus 로고    scopus 로고
    • Purinergic signaling during inflammation
    • H.K. Eltzschig, and et al. Purinergic signaling during inflammation N. Engl. J. Med. 367 2012 2322 2333
    • (2012) N. Engl. J. Med. , vol.367 , pp. 2322-2333
    • Eltzschig, H.K.1
  • 119
    • 79957538240 scopus 로고    scopus 로고
    • NAD+-metabolizing ecto-enzymes shape tumor-host interactions: The chronic lymphocytic leukemia model
    • T. Vaisitti, and et al. NAD+-metabolizing ecto-enzymes shape tumor-host interactions: the chronic lymphocytic leukemia model FEBS Lett. 585 2011 1514 1520
    • (2011) FEBS Lett. , vol.585 , pp. 1514-1520
    • Vaisitti, T.1
  • 120
    • 33947621054 scopus 로고    scopus 로고
    • Extracellular NAD and ATP: Partners in immune cell modulation
    • F. Haag, and et al. Extracellular NAD and ATP: partners in immune cell modulation Purinergic Signal. 3 2007 71 81
    • (2007) Purinergic Signal. , vol.3 , pp. 71-81
    • Haag, F.1
  • 121
    • 84890276750 scopus 로고    scopus 로고
    • A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes
    • A.L. Horenstein, and et al. A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes Oncoimmunology 2 2013 e26246
    • (2013) Oncoimmunology , vol.2 , pp. e26246
    • Horenstein, A.L.1
  • 122
    • 84873739372 scopus 로고    scopus 로고
    • Dual, enzymatic and non-enzymatic, function of ecto-5′-nucleotidase (eN, CD73) in migration and invasion of A375 melanoma cells
    • R. Sadej, and A.C. Skladanowski Dual, enzymatic and non-enzymatic, function of ecto-5′-nucleotidase (eN, CD73) in migration and invasion of A375 melanoma cells Acta Biochim. Pol. 59 2012 647 652
    • (2012) Acta Biochim. Pol. , vol.59 , pp. 647-652
    • Sadej, R.1    Skladanowski, A.C.2
  • 123
    • 77951623666 scopus 로고    scopus 로고
    • Differential ectonucleotidase expression in human bladder cancer cell lines
    • J. Stella, and et al. Differential ectonucleotidase expression in human bladder cancer cell lines Urol. Oncol. 28 2010 260 267
    • (2010) Urol. Oncol. , vol.28 , pp. 260-267
    • Stella, J.1
  • 124
    • 84867832930 scopus 로고    scopus 로고
    • Potential prognostic biomarker CD73 regulates epidermal growth factor receptor expression in human breast cancer
    • X. Zhi, and et al. Potential prognostic biomarker CD73 regulates epidermal growth factor receptor expression in human breast cancer IUBMB Life 64 2012 911 920
    • (2012) IUBMB Life , vol.64 , pp. 911-920
    • Zhi, X.1
  • 125
    • 84938202009 scopus 로고    scopus 로고
    • The expression and clinical significance of CD73 molecule in human rectal adenocarcinoma
    • B. Zhang, and et al. The expression and clinical significance of CD73 molecule in human rectal adenocarcinoma Tumour. Biol. 36 2015 5459 5466
    • (2015) Tumour. Biol. , vol.36 , pp. 5459-5466
    • Zhang, B.1
  • 126
    • 84883192286 scopus 로고    scopus 로고
    • Synergy between the ectoenzymes CD39 and CD73 contributes to adenosinergic immunosuppression in human malignant gliomas
    • S. Xu, and et al. Synergy between the ectoenzymes CD39 and CD73 contributes to adenosinergic immunosuppression in human malignant gliomas Neuro. Oncol. 15 2013 1160 1172
    • (2013) Neuro. Oncol. , vol.15 , pp. 1160-1172
    • Xu, S.1
  • 127
    • 70350231926 scopus 로고    scopus 로고
    • Increased ectonucleotidase expression and activity in regulatory T cells of patients with head and neck cancer
    • M. Mandapathil, and et al. Increased ectonucleotidase expression and activity in regulatory T cells of patients with head and neck cancer Clin. Cancer Res. 15 2009 6348 6357
    • (2009) Clin. Cancer Res. , vol.15 , pp. 6348-6357
    • Mandapathil, M.1
  • 128
    • 33746116078 scopus 로고    scopus 로고
    • Expression of ecto-5′-nucleotidase (eN, CD73) in cell lines from various stages of human melanoma
    • R. Sadej, and et al. Expression of ecto-5′-nucleotidase (eN, CD73) in cell lines from various stages of human melanoma Melanoma Res. 16 2006 213 222
    • (2006) Melanoma Res. , vol.16 , pp. 213-222
    • Sadej, R.1
  • 129
    • 84867173653 scopus 로고    scopus 로고
    • Overexpression of CD73 in epithelial ovarian carcinoma is associated with better prognosis, lower stage, better differentiation and lower regulatory T cell infiltration
    • H.K. Oh, and et al. Overexpression of CD73 in epithelial ovarian carcinoma is associated with better prognosis, lower stage, better differentiation and lower regulatory T cell infiltration J. Gynecol. Oncol. 2012 23274 23281
    • (2012) J. Gynecol. Oncol. , pp. 23274-23281
    • Oh, H.K.1
  • 130
    • 84945476729 scopus 로고    scopus 로고
    • Bioorthogonal labeling cell-surface proteins expressed in pancreatic cancer cells to identify potential diagnostic/therapeutic biomarkers
    • R.S. Haun, and et al. Bioorthogonal labeling cell-surface proteins expressed in pancreatic cancer cells to identify potential diagnostic/therapeutic biomarkers Cancer Biol. Ther. 16 2015 1557 1565
    • (2015) Cancer Biol. Ther. , vol.16 , pp. 1557-1565
    • Haun, R.S.1
  • 131
    • 33645396217 scopus 로고    scopus 로고
    • Expression of CD73 and its ecto-5′-nucleotidase activity are elevated in papillary thyroid carcinomas
    • T. Kondo, and et al. Expression of CD73 and its ecto-5′-nucleotidase activity are elevated in papillary thyroid carcinomas Histopathology 48 2006 612 614
    • (2006) Histopathology , vol.48 , pp. 612-614
    • Kondo, T.1
  • 132
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • C.L. Chaffer, and R.A. Weinberg A perspective on cancer cell metastasis Science 331 2011 1559 1564
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 133
    • 79953300698 scopus 로고    scopus 로고
    • The seed and soil hypothesis revisited - The role of tumor-stroma interactions in metastasis to different organs
    • R.R. Langley, and I.J. Fidler The seed and soil hypothesis revisited - the role of tumor-stroma interactions in metastasis to different organs Int. J. Cancer 128 2011 2527 2535
    • (2011) Int. J. Cancer , vol.128 , pp. 2527-2535
    • Langley, R.R.1    Fidler, I.J.2
  • 134
    • 84879603171 scopus 로고    scopus 로고
    • Exosomes in tumor microenvironment influence cancer progression and metastasis
    • C. Kahlert, and R. Kalluri Exosomes in tumor microenvironment influence cancer progression and metastasis J. Mol. Med. (Berl) 91 2013 431 437
    • (2013) J. Mol. Med. (Berl) , vol.91 , pp. 431-437
    • Kahlert, C.1    Kalluri, R.2
  • 135
    • 84928032376 scopus 로고    scopus 로고
    • Exosomes as divine messengers: Are they the HERMES of modern molecular oncology?
    • C. Braicu, and et al. Exosomes as divine messengers: are they the Hermes of modern molecular oncology? Cell Death Differ. 22 2015 34 45
    • (2015) Cell Death Differ. , vol.22 , pp. 34-45
    • Braicu, C.1
  • 136
    • 84855573739 scopus 로고    scopus 로고
    • The roles of tumor-derived exosomes in cancer pathogenesis
    • C. Yang, and P.D. Robbins The roles of tumor-derived exosomes in cancer pathogenesis Clin. Dev. Immunol 2011 2011 842849
    • (2011) Clin. Dev. Immunol , vol.2011 , pp. 842849
    • Yang, C.1    Robbins, P.D.2
  • 137
    • 79960516623 scopus 로고    scopus 로고
    • Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production
    • A. Clayton, and et al. Cancer exosomes express CD39 and CD73, which suppress T cells through adenosine production J. Immunol. 187 2011 676 683
    • (2011) J. Immunol. , vol.187 , pp. 676-683
    • Clayton, A.1
  • 138
    • 84883391630 scopus 로고    scopus 로고
    • CD73 expression on extracellular vesicles derived from CD4+ CD25+ Foxp3+ T cells contributes to their regulatory function
    • L.A. Smyth, and et al. CD73 expression on extracellular vesicles derived from CD4+ CD25+ Foxp3+ T cells contributes to their regulatory function Eur. J. Immunol. 43 2013 2430 2440
    • (2013) Eur. J. Immunol. , vol.43 , pp. 2430-2440
    • Smyth, L.A.1
  • 139
    • 84865747829 scopus 로고    scopus 로고
    • Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities
    • G.G. Yegutkin, and et al. Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities FASEB J. 26 2012 3875 3883
    • (2012) FASEB J. , vol.26 , pp. 3875-3883
    • Yegutkin, G.G.1
  • 140
    • 84891824680 scopus 로고    scopus 로고
    • Anti-CD73 therapy impairs tumor angiogenesis
    • B. Allard, and et al. Anti-CD73 therapy impairs tumor angiogenesis Int. J. Cancer 134 2013 1466 1473
    • (2013) Int. J. Cancer , vol.134 , pp. 1466-1473
    • Allard, B.1
  • 141
    • 84874283227 scopus 로고    scopus 로고
    • Combining phenotypic and proteomic approaches to identify membrane targets in a 'triple negative' breast cancer cell type
    • S. Rust, and et al. Combining phenotypic and proteomic approaches to identify membrane targets in a 'triple negative' breast cancer cell type Mol. Cancer 12 2013 11
    • (2013) Mol. Cancer , vol.12 , pp. 11
    • Rust, S.1
  • 142
    • 84868360790 scopus 로고    scopus 로고
    • CD73 as a novel prognostic biomarker for human colorectal cancer
    • N. Liu, and et al. CD73 as a novel prognostic biomarker for human colorectal cancer J. Surg. Oncol. 106 2012 918 919
    • (2012) J. Surg. Oncol. , vol.106 , pp. 918-919
    • Liu, N.1
  • 143
    • 84875590401 scopus 로고    scopus 로고
    • Expression and clinical significance of CD73 and hypoxia-inducible factor-1alpha in gastric carcinoma
    • X.X. Lu, and et al. Expression and clinical significance of CD73 and hypoxia-inducible factor-1alpha in gastric carcinoma World. J. Gastroenterol. 19 2013 1912 1918
    • (2013) World. J. Gastroenterol. , vol.19 , pp. 1912-1918
    • Lu, X.X.1
  • 144
    • 84862786328 scopus 로고    scopus 로고
    • NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity
    • H. Wang, and et al. NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity Br. J. Cancer 106 2012 1446 1452
    • (2012) Br. J. Cancer , vol.106 , pp. 1446-1452
    • Wang, H.1
  • 145
    • 80051789855 scopus 로고    scopus 로고
    • CD73 (5′-nucleotidase) expression has no prognostic value in children with acute lymphoblastic leukemia
    • E. Wieten, and et al. CD73 (5′-nucleotidase) expression has no prognostic value in children with acute lymphoblastic leukemia Leukemia 25 2011 1374 1376
    • (2011) Leukemia , vol.25 , pp. 1374-1376
    • Wieten, E.1
  • 146
    • 84945749131 scopus 로고    scopus 로고
    • CD73 expression as a potential marker of good prognosis in breast carcinoma
    • A. Supernat, and et al. CD73 expression as a potential marker of good prognosis in breast carcinoma Appl. Immunohistochem. Mol. Morphol. 20 2012 103 107
    • (2012) Appl. Immunohistochem. Mol. Morphol. , vol.20 , pp. 103-107
    • Supernat, A.1
  • 147
    • 84884535896 scopus 로고    scopus 로고
    • Cancer drug resistance: An evolving paradigm
    • C. Holohan, and et al. Cancer drug resistance: an evolving paradigm Nat. Rev. Cancer 13 2013 714 726
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 714-726
    • Holohan, C.1
  • 148
    • 0029835821 scopus 로고    scopus 로고
    • Evidence for the involvement of ecto-5′-nucleotidase (CD73) in drug resistance
    • P. Ujhazy, and et al. Evidence for the involvement of ecto-5′-nucleotidase (CD73) in drug resistance Int. J. Cancer 68 1996 493 500
    • (1996) Int. J. Cancer , vol.68 , pp. 493-500
    • Ujhazy, P.1
  • 149
    • 79960566297 scopus 로고    scopus 로고
    • FK506 confers chemosensitivity to anticancer drugs in glioblastoma multiforme cells by decreasing the expression of the multiple resistance-associated protein-1
    • W. Garrido, and et al. FK506 confers chemosensitivity to anticancer drugs in glioblastoma multiforme cells by decreasing the expression of the multiple resistance-associated protein-1 Biochem. Biophys. Res. Commun. 411 2011 62 68
    • (2011) Biochem. Biophys. Res. Commun. , vol.411 , pp. 62-68
    • Garrido, W.1
  • 150
    • 0028124867 scopus 로고
    • Ecto-5′-nucleotidase (CD73) in multidrug-resistant cell lines generated by doxorubicin
    • P. Ujhazy, and et al. Ecto-5′-nucleotidase (CD73) in multidrug-resistant cell lines generated by doxorubicin Int. J. Cancer 59 1994 83 93
    • (1994) Int. J. Cancer , vol.59 , pp. 83-93
    • Ujhazy, P.1
  • 151
    • 84929455792 scopus 로고    scopus 로고
    • Gene expression markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: Results from CALGB 80203 (Alliance)
    • S.M. Cushman, and et al. Gene expression markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: results from CALGB 80203 (Alliance) Clin. Cancer Res. 21 2015 1078 1086
    • (2015) Clin. Cancer Res. , vol.21 , pp. 1078-1086
    • Cushman, S.M.1
  • 152
    • 49149088707 scopus 로고    scopus 로고
    • Next generation of immunotherapy for melanoma
    • J.M. Kirkwood, and et al. Next generation of immunotherapy for melanoma J. Clin. Oncol. 26 2008 3445 3455
    • (2008) J. Clin. Oncol. , vol.26 , pp. 3445-3455
    • Kirkwood, J.M.1
  • 153
    • 84880721353 scopus 로고    scopus 로고
    • Dendritic-cell-based therapeutic cancer vaccines
    • K. Palucka, and J. Banchereau Dendritic-cell-based therapeutic cancer vaccines Immunity 39 2013 38 48
    • (2013) Immunity , vol.39 , pp. 38-48
    • Palucka, K.1    Banchereau, J.2
  • 154
    • 80053378780 scopus 로고    scopus 로고
    • Viral vector-based therapeutic cancer vaccines
    • C. Larocca, and J. Schlom Viral vector-based therapeutic cancer vaccines Cancer J. 17 2011 359 371
    • (2011) Cancer J. , vol.17 , pp. 359-371
    • Larocca, C.1    Schlom, J.2
  • 155
    • 84948807547 scopus 로고    scopus 로고
    • RNA-based vaccines in cancer immunotherapy
    • M.A. McNamara, and et al. RNA-based vaccines in cancer immunotherapy J. Immunol. Res. 2015 2015 794528
    • (2015) J. Immunol. Res. , vol.2015 , pp. 794528
    • McNamara, M.A.1
  • 156
    • 80053343794 scopus 로고    scopus 로고
    • The present and future of peptide vaccines for cancer: Single or multiple, long or short, alone or in combination?
    • C.L. Slingluff Jr. The present and future of peptide vaccines for cancer: single or multiple, long or short, alone or in combination? Cancer J. 17 2011 343 350
    • (2011) Cancer J. , vol.17 , pp. 343-350
    • Slingluff, C.L.1
  • 157
    • 84883642231 scopus 로고    scopus 로고
    • Oncolytic viruses as therapeutic cancer vaccines
    • D.L. Bartlett, and et al. Oncolytic viruses as therapeutic cancer vaccines Mol. Cancer 12 2013 103
    • (2013) Mol. Cancer , vol.12 , pp. 103
    • Bartlett, D.L.1
  • 158
    • 84859471907 scopus 로고    scopus 로고
    • Adoptive T-cell therapy using autologous tumor-infiltrating lymphocytes for metastatic melanoma: Current status and future outlook
    • R. Wu, and et al. Adoptive T-cell therapy using autologous tumor-infiltrating lymphocytes for metastatic melanoma: current status and future outlook Cancer J. 18 2012 160 175
    • (2012) Cancer J. , vol.18 , pp. 160-175
    • Wu, R.1
  • 159
    • 84940947070 scopus 로고    scopus 로고
    • Cancer gene therapy with T cell receptors and chimeric antigen receptors
    • H.J. Stauss, and et al. Cancer gene therapy with T cell receptors and chimeric antigen receptors Curr. Opin. Pharmacol. 24 2015 113 118
    • (2015) Curr. Opin. Pharmacol. , vol.24 , pp. 113-118
    • Stauss, H.J.1
  • 160
    • 84890181067 scopus 로고    scopus 로고
    • Design and development of therapies using chimeric antigen receptor-expressing T cells
    • G. Dotti, and et al. Design and development of therapies using chimeric antigen receptor-expressing T cells Immunol. Rev. 257 2014 107 126
    • (2014) Immunol. Rev. , vol.257 , pp. 107-126
    • Dotti, G.1
  • 161
    • 84937846973 scopus 로고    scopus 로고
    • Evolving synergistic combinations of targeted immunotherapies to combat cancer
    • I. Melero, and et al. Evolving synergistic combinations of targeted immunotherapies to combat cancer Nat. Rev. Cancer 15 2015 457 472
    • (2015) Nat. Rev. Cancer , vol.15 , pp. 457-472
    • Melero, I.1


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