-
1
-
-
84933050304
-
The tumour microenvironment after radiotherapy: Mechanisms of resistance and recurrence
-
Barker, H. E., Paget, J. T. E., Khan, A. A. & Harrington, K. J. The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat. Rev. Cancer 15, 409-425 (2015).
-
(2015)
Nat. Rev. Cancer
, vol.15
, pp. 409-425
-
-
Barker, H.E.1
Paget, J.T.E.2
Khan, A.A.3
Harrington, K.J.4
-
2
-
-
0032983271
-
How does radiation kill cells?
-
Jonathan, E. C., Bernhard, E. J. & McKenna, W. G. How does radiation kill cells? Curr. Opin. Chem. Biol. 3, 77-83 (1999).
-
(1999)
Curr. Opin. Chem. Biol.
, vol.3
, pp. 77-83
-
-
Jonathan, E.C.1
Bernhard, E.J.2
McKenna, W.G.3
-
3
-
-
68249096784
-
Persistent DNA damage signalling triggers senescence-associated infammatory cytokine secretion
-
Rodier, F. et al. Persistent DNA damage signalling triggers senescence-associated infammatory cytokine secretion. Nat. Cell Biol. 11, 973-979 (2009).
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 973-979
-
-
Rodier, F.1
-
4
-
-
84928676601
-
Portrait of infammatory response to ionizing radiation treatment
-
Di Maggio, F. M. et al. Portrait of infammatory response to ionizing radiation treatment. J. Infamm. 12, http://dx.doi.org/10.1186/s12950-015-0058-3 (2015).
-
(2015)
J. Infamm.
, vol.12
-
-
Di Maggio, F.M.1
-
5
-
-
84856424908
-
DNA breaks and chromosome pulverization from errors in mitosis
-
Crasta, K. et al. DNA breaks and chromosome pulverization from errors in mitosis. Nature 482, 53-58 (2012).
-
(2012)
Nature
, vol.482
, pp. 53-58
-
-
Crasta, K.1
-
6
-
-
70149107457
-
DNA lesions sequestered in micronuclei induce a local defective-damage response
-
Terradas, M., Martín, M., Tusell, L. & Genescà, A. DNA lesions sequestered in micronuclei induce a local defective-damage response. DNA Repair 8, 1225-1234 (2009).
-
(2009)
DNA Repair
, vol.8
, pp. 1225-1234
-
-
Terradas, M.1
Martín, M.2
Tusell, L.3
Genescà, A.4
-
7
-
-
77952585411
-
Genetic activities in micronuclei: Is the DNA entrapped in micronuclei lost for the cell?
-
Terradas, M., Martín, M., Tusell, L. & Genescà, A. Genetic activities in micronuclei: is the DNA entrapped in micronuclei lost for the cell? Mutat. Res. 705, 60-67 (2010).
-
(2010)
Mutat. Res.
, vol.705
, pp. 60-67
-
-
Terradas, M.1
Martín, M.2
Tusell, L.3
Genescà, A.4
-
8
-
-
70349943834
-
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
-
Ishikawa, H., Ma, Z. & Barber, G. N. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461, 788-792 (2009).
-
(2009)
Nature
, vol.461
, pp. 788-792
-
-
Ishikawa, H.1
Ma, Z.2
Barber, G.N.3
-
9
-
-
84873711885
-
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
-
Sun, L., Wu, J., Du, F., Chen, X. & Chen, Z. J. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339, 786-791 (2013).
-
(2013)
Science
, vol.339
, pp. 786-791
-
-
Sun, L.1
Wu, J.2
Du, F.3
Chen, X.4
Chen, Z.J.5
-
10
-
-
85015752214
-
A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1
-
Erdal, E., Haider, S., Rehwinkel, J., Harris, A. L. & McHugh, P. J. A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1. Genes Dev. 31, 353-369 (2017).
-
(2017)
Genes Dev.
, vol.31
, pp. 353-369
-
-
Erdal, E.1
Haider, S.2
Rehwinkel, J.3
Harris, A.L.4
McHugh, P.J.5
-
11
-
-
84907996785
-
Dnase2a defciency uncovers lysosomal clearance of damaged nuclear DNA via autophagy
-
Lan, Y. Y., Londoño, D., Bouley, R., Rooney, M. S. & Hacohen, N. Dnase2a defciency uncovers lysosomal clearance of damaged nuclear DNA via autophagy. Cell Reports 9, 180-192 (2014).
-
(2014)
Cell Reports
, vol.9
, pp. 180-192
-
-
Lan, Y.Y.1
Londoño, D.2
Bouley, R.3
Rooney, M.S.4
Hacohen, N.5
-
12
-
-
84875224757
-
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity
-
Ferguson, B. J., Mansur, D. S., Peters, N. E., Ren, H. & Smith, G. L. DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. Life Sci. 1, e00047 (2012).
-
(2012)
Life Sci.
, vol.1
, pp. e00047
-
-
Ferguson, B.J.1
Mansur, D.S.2
Peters, N.E.3
Ren, H.4
Smith, G.L.5
-
13
-
-
84994507182
-
The DNA-sensing AIM2 infammasome controls radiation-induced cell death and tissue injury
-
Hu, B. et al. The DNA-sensing AIM2 infammasome controls radiation-induced cell death and tissue injury. Science 354, 765-768 (2016).
-
(2016)
Science
, vol.354
, pp. 765-768
-
-
Hu, B.1
-
14
-
-
0037022639
-
Interferon regulatory factor-3 is an in vivo target of DNA-PK
-
Karpova, A. Y., Trost, M., Murray, J. M., Cantley, L. C. & Howley, P. M. Interferon regulatory factor-3 is an in vivo target of DNA-PK. Proc. Natl Acad. Sci. USA 99, 2818-2823 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 2818-2823
-
-
Karpova, A.Y.1
Trost, M.2
Murray, J.M.3
Cantley, L.C.4
Howley, P.M.5
-
15
-
-
84912120595
-
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors
-
Woo, S.-R. et al. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity 41, 830-842 (2014).
-
(2014)
Immunity
, vol.41
, pp. 830-842
-
-
Woo, S.-R.1
-
16
-
-
84912128872
-
STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors
-
Deng, L. et al. STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors. Immunity 41, 843-852 (2014).
-
(2014)
Immunity
, vol.41
, pp. 843-852
-
-
Deng, L.1
-
17
-
-
40449141669
-
IRF-3-dependent and augmented target genes during viral infection
-
Andersen, J., VanScoy, S., Cheng, T.-F., Gomez, D. & Reich, N. C. IRF-3-dependent and augmented target genes during viral infection. Genes Immun. 9, 168-175 (2008).
-
(2008)
Genes Immun.
, vol.9
, pp. 168-175
-
-
Andersen, J.1
VanScoy, S.2
Cheng, T.-F.3
Gomez, D.4
Reich, N.C.5
-
18
-
-
0036092049
-
Transcriptional profling of interferon regulatory factor 3 target genes: Direct involvement in the regulation of interferon-stimulated genes
-
Grandvaux, N. et al. Transcriptional profling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes. J. Virol. 76, 5532-5539 (2002).
-
(2002)
J. Virol.
, vol.76
, pp. 5532-5539
-
-
Grandvaux, N.1
-
19
-
-
84879956366
-
Catastrophic nuclear envelope collapse in cancer cell micronuclei
-
Hatch, E. M., Fischer, A. H., Deerinck, T. J. & Hetzer, M. W. Catastrophic nuclear envelope collapse in cancer cell micronuclei. Cell 154, 47-60 (2013).
-
(2013)
Cell
, vol.154
, pp. 47-60
-
-
Hatch, E.M.1
Fischer, A.H.2
Deerinck, T.J.3
Hetzer, M.W.4
-
20
-
-
85008391993
-
DNA damage follows repair factor depletion and portends genome variation in cancer cells after pore migration
-
Irianto, J. et al. DNA damage follows repair factor depletion and portends genome variation in cancer cells after pore migration. Curr. Biol. 27, 210-223 (2017).
-
(2017)
Curr. Biol.
, vol.27
, pp. 210-223
-
-
Irianto, J.1
-
21
-
-
84922986861
-
DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity
-
Härtlova, A. et al. DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity. Immunity 42, 332-343 (2015).
-
(2015)
Immunity
, vol.42
, pp. 332-343
-
-
Härtlova, A.1
-
22
-
-
84940459327
-
Opportunities and challenges of radiotherapy for treating cancer
-
Schaue, D. & McBride, W. H. Opportunities and challenges of radiotherapy for treating cancer. Nat. Rev. Clin. Oncol. 12, 527-540 (2015).
-
(2015)
Nat. Rev. Clin. Oncol.
, vol.12
, pp. 527-540
-
-
Schaue, D.1
McBride, W.H.2
-
23
-
-
84857815877
-
Immunologic correlates of the abscopal efect in a patient with melanoma
-
Postow, M. A. et al. Immunologic correlates of the abscopal efect in a patient with melanoma. N. Engl. J. Med. 366, 925-931 (2012).
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 925-931
-
-
Postow, M.A.1
-
24
-
-
84926525215
-
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
-
Twyman-Saint Victor, C. et al. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature 520, 373-377 (2015).
-
(2015)
Nature
, vol.520
, pp. 373-377
-
-
Twyman-Saint Victor, C.1
-
25
-
-
85001996779
-
Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade
-
Benci, J. L. et al. Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade. Cell 167, 1540-1554 (2016).
-
(2016)
Cell
, vol.167
, pp. 1540-1554
-
-
Benci, J.L.1
-
26
-
-
84991790808
-
Abscopal efects of radiotherapy are enhanced by combined immunostimulatory mAbs and are dependent on CD8 T cells and crosspriming
-
Rodriguez-Ruiz, M. E. et al. Abscopal efects of radiotherapy are enhanced by combined immunostimulatory mAbs and are dependent on CD8 T cells and crosspriming. Cancer Res. 76, 5994-6005 (2016).
-
(2016)
Cancer Res.
, vol.76
, pp. 5994-6005
-
-
Rodriguez-Ruiz, M.E.1
-
27
-
-
33751301357
-
Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases
-
Syljuåsen, R. G., Jensen, S., Bartek, J. & Lukas, J. Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases. Cancer Res. 66, 10253-10257 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 10253-10257
-
-
Syljuåsen, R.G.1
Jensen, S.2
Bartek, J.3
Lukas, J.4
-
28
-
-
79960812015
-
Understanding the limitations of radiation-induced cell cycle checkpoints
-
Deckbar, D., Jeggo, P. A. & Löbrich, M. Understanding the limitations of radiation-induced cell cycle checkpoints. Crit. Rev. Biochem. Mol. Biol. 46, 271-283 (2011).
-
(2011)
Crit. Rev. Biochem. Mol. Biol.
, vol.46
, pp. 271-283
-
-
Deckbar, D.1
Jeggo, P.A.2
Löbrich, M.3
-
29
-
-
84944069159
-
ATM dependent silencing links nucleolar chromatin reorganization to DNA damage recognition
-
Harding, S. M., Boiarsky, J. A. & Greenberg, R. A. ATM dependent silencing links nucleolar chromatin reorganization to DNA damage recognition. Cell Reports 13, 251-259 (2015).
-
(2015)
Cell Reports
, vol.13
, pp. 251-259
-
-
Harding, S.M.1
Boiarsky, J.A.2
Greenberg, R.A.3
-
30
-
-
84905262730
-
Improved vectors and genome-wide libraries for CRISPR screening
-
Sanjana, N. E., Shalem, O. & Zhang, F. Improved vectors and genome-wide libraries for CRISPR screening. Nat. Methods 11, 783-784 (2014).
-
(2014)
Nat. Methods
, vol.11
, pp. 783-784
-
-
Sanjana, N.E.1
Shalem, O.2
Zhang, F.3
-
31
-
-
84907482360
-
Interchromosomal homology searches drive directional ALT telomere movement and synapsis
-
Cho, N. W., Dilley, R. L., Lampson, M. A. & Greenberg, R. A. Interchromosomal homology searches drive directional ALT telomere movement and synapsis. Cell 159, 108-121 (2014).
-
(2014)
Cell
, vol.159
, pp. 108-121
-
-
Cho, N.W.1
Dilley, R.L.2
Lampson, M.A.3
Greenberg, R.A.4
-
32
-
-
77954498022
-
Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive
-
Coschi, C. H. et al. Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive. Genes Dev. 24, 1351-1363 (2010).
-
(2010)
Genes Dev.
, vol.24
, pp. 1351-1363
-
-
Coschi, C.H.1
-
33
-
-
84860343773
-
Discordance between phosphorylation and recruitment of 53BP1 in response to DNA double-strand breaks
-
Harding, S. M. & Bristow, R. G. Discordance between phosphorylation and recruitment of 53BP1 in response to DNA double-strand breaks. Cell Cycle 11, 1432-1444 (2012).
-
(2012)
Cell Cycle
, vol.11
, pp. 1432-1444
-
-
Harding, S.M.1
Bristow, R.G.2
-
34
-
-
84878572947
-
The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING
-
Diner, E. J. et al. The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. Cell Reports 3, 1355-1361 (2013).
-
(2013)
Cell Reports
, vol.3
, pp. 1355-1361
-
-
Diner, E.J.1
|