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Volumn 22, Issue 8, 2016, Pages 1845-1855

Emerging opportunities and challenges in cancer immunotherapy

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; IPILIMUMAB; NIVOLUMAB; PEMBROLIZUMAB; TALIMOGENE LAHERPAREPVEC; ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY;

EID: 84967179683     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-16-0049     Document Type: Article
Times cited : (252)

References (135)
  • 2
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • Sharma P, Allison JP. The future of immune checkpoint therapy. Science 2015;348:56-61.
    • (2015) Science , vol.348 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2
  • 3
    • 84928759208 scopus 로고    scopus 로고
    • Adoptive cell transfer as personalized immunotherapy for human cancer
    • Rosenberg SA, Restifo NP. Adoptive cell transfer as personalized immunotherapy for human cancer. Science 2015;348:62-8.
    • (2015) Science , vol.348 , pp. 62-68
    • Rosenberg, S.A.1    Restifo, N.P.2
  • 4
    • 0345060466 scopus 로고    scopus 로고
    • Potentiation of therapeutic immune responses against malignancies with monoclonal antibodies
    • Murillo O, Arina A, Tirapu I, Alfaro C, Mazzolini G, Palencia B, et al. Potentiation of therapeutic immune responses against malignancies with monoclonal antibodies. Clin Cancer Res 2003;9: 5454-64.
    • (2003) Clin Cancer Res , vol.9 , pp. 5454-5464
    • Murillo, O.1    Arina, A.2    Tirapu, I.3    Alfaro, C.4    Mazzolini, G.5    Palencia, B.6
  • 5
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996;271:1734-6.
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 6
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion. Nat Med 2002;8:793-800.
    • (2002) Nat Med , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3    Tamura, H.4    Hirano, F.5    Flies, D.B.6
  • 7
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, Minato N. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A 2002;99: 12293-7.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 12293-12297
    • Iwai, Y.1    Ishida, M.2    Tanaka, Y.3    Okazaki, T.4    Honjo, T.5    Minato, N.6
  • 10
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I, O'Day S, Weber J, Garbe C, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 2011;364:2517-26.
    • (2011) N Engl J Med , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3    O'Day, S.4    Weber, J.5    Garbe, C.6
  • 12
    • 84923078390 scopus 로고    scopus 로고
    • MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
    • Powles T, Eder JP, Fine GD, Braiteh FS, Loriot Y, Cruz C, et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature 2014;515:558-62.
    • (2014) Nature , vol.515 , pp. 558-562
    • Powles, T.1    Eder, J.P.2    Fine, G.D.3    Braiteh, F.S.4    Loriot, Y.5    Cruz, C.6
  • 14
    • 84989299723 scopus 로고    scopus 로고
    • KEYNOTE-040: A phase III randomized trial of pembrolizumab (MK-3475) versus standard treatment in patients with recurrent or metastatic head and neck cancer
    • (suppl; abstr TPS6084)
    • Cohen EEW, Machiels JPH, Harrington KJ, Burtness B, Shin SW, Gause CK, et al. KEYNOTE-040: A phase III randomized trial of pembrolizumab (MK-3475) versus standard treatment in patients with recurrent or metastatic head and neck cancer. J Clin Oncol 33, 2015 (suppl; abstr TPS6084).
    • (2015) J Clin Oncol , vol.33
    • Cohen, E.E.W.1    Machiels, J.P.H.2    Harrington, K.J.3    Burtness, B.4    Shin, S.W.5    Gause, C.K.6
  • 15
    • 84951126341 scopus 로고    scopus 로고
    • Safety and antitumor activity of anti-PD-1 antibody, nivolumab, in patients with platinum-resistant ovarian cancer
    • Hamanishi J, Mandai M, Ikeda T, Minami M, Kawaguchi A, Murayama T, et al. Safety and antitumor activity of anti-PD-1 antibody, nivolumab, in patients with platinum-resistant ovarian cancer. J Clin Oncol 2015;33: 4015-22.
    • (2015) J Clin Oncol , vol.33 , pp. 4015-4022
    • Hamanishi, J.1    Mandai, M.2    Ikeda, T.3    Minami, M.4    Kawaguchi, A.5    Murayama, T.6
  • 17
    • 80053567512 scopus 로고    scopus 로고
    • Cell transfer immunotherapy for metastatic solid cancer-what clinicians need to know
    • Rosenberg SA. Cell transfer immunotherapy for metastatic solid cancer-what clinicians need to know. Nat Rev Clin Oncol 2011;8: 577-85.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 577-585
    • Rosenberg, S.A.1
  • 18
    • 84883472041 scopus 로고    scopus 로고
    • Adoptive transfer of tumor-infiltrating lymphocytes in patients with metastatic melanoma: Intent-to-treat analysis and efficacy after failure to prior immunotherapies
    • Besser MJ, Shapira-Frommer R, Itzhaki O, Treves AJ, Zippel DB, Levy D, et al. Adoptive transfer of tumor-infiltrating lymphocytes in patients with metastatic melanoma: intent-to-treat analysis and efficacy after failure to prior immunotherapies. Clin Cancer Res 2013; 19:4792-800.
    • (2013) Clin Cancer Res , vol.19 , pp. 4792-4800
    • Besser, M.J.1    Shapira-Frommer, R.2    Itzhaki, O.3    Treves, A.J.4    Zippel, D.B.5    Levy, D.6
  • 19
    • 0027471898 scopus 로고
    • Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors
    • Eshhar Z, Waks T, GrossG, Schindler DG. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. Proc Natl Acad Sci U S A 1993;90:720-4.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 720-724
    • Eshhar, Z.1    Waks, T.2    Gross, F.3    Schindler, D.G.4
  • 20
    • 84967145937 scopus 로고    scopus 로고
    • Making better chimeric antigen receptors for adoptive T-cell therapy
    • Maus MV, June CH. Making better chimeric antigen receptors for adoptive T-cell therapy. Clin Cancer Res 2016;22:1875-84.
    • (2016) Clin Cancer Res , vol.22 , pp. 1875-1884
    • Maus, M.V.1    June, C.H.2
  • 22
    • 84940881287 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
    • Porter DL, Hwang WT, Frey NV, Lacey SF, Shaw PA, Loren AW, et al. Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia. Sci Transl Med 2015;7:303ra139.
    • (2015) Sci Transl Med , vol.7 , pp. 303ra139
    • Porter, D.L.1    Hwang, W.T.2    Frey, N.V.3    Lacey, S.F.4    Shaw, P.A.5    Loren, A.W.6
  • 24
    • 84923118622 scopus 로고    scopus 로고
    • Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor
    • Kochenderfer JN, Dudley ME, Kassim SH, Somerville RP, Carpenter RO, Stetler-Stevenson M, et al. Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor. J Clin Oncol 2015;33:540-9.
    • (2015) J Clin Oncol , vol.33 , pp. 540-549
    • Kochenderfer, J.N.1    Dudley, M.E.2    Kassim, S.H.3    Somerville, R.P.4    Carpenter, R.O.5    Stetler-Stevenson, M.6
  • 25
    • 84966769739 scopus 로고    scopus 로고
    • Targeting the heterogeneity of cancer with individualized neoepitope vaccines
    • Tureci O, Vormehr M, Diken M, Kreiter S, Huber C, Sahin U. Targeting the heterogeneity of cancer with individualized neoepitope vaccines. Clin Cancer Res 2016;22:1885-96.
    • (2016) Clin Cancer Res , vol.22 , pp. 1885-1896
    • Tureci, O.1    Vormehr, M.2    Diken, M.3    Kreiter, S.4    Huber, C.5    Sahin, U.6
  • 26
    • 84967293088 scopus 로고    scopus 로고
    • Reversing T-cell dysfunction and exhaustion in cancer
    • Zarour HM. Reversing T-cell dysfunction and exhaustion in cancer. Clin Cancer Res 2016;22:1856-64.
    • (2016) Clin Cancer Res , vol.22 , pp. 1856-1864
    • Zarour, H.M.1
  • 27
    • 84899673110 scopus 로고    scopus 로고
    • T-cell and NK-cell infiltration into solid tumors: A key limiting factor for efficacious cancer immunotherapy
    • Melero I, Rouzaut A, Motz GT, Coukos G. T-cell and NK-cell infiltration into solid tumors: A key limiting factor for efficacious cancer immunotherapy. Cancer Discov 2014;4:522-6.
    • (2014) Cancer Discov , vol.4 , pp. 522-526
    • Melero, I.1    Rouzaut, A.2    Motz, G.T.3    Coukos, G.4
  • 28
    • 84967321420 scopus 로고    scopus 로고
    • The where, the when, and the how of immune monitoring for cancer immunotherapies in the era of checkpoint inhibition
    • Hegde PS, Karanikas V, Evers S. The where, the when, and the how of immune monitoring for cancer immunotherapies in the era of checkpoint inhibition. Clin Cancer Res 2016;22:1865-74.
    • (2016) Clin Cancer Res , vol.22 , pp. 1865-1874
    • Hegde, P.S.1    Karanikas, V.2    Evers, S.3
  • 31
    • 84959133719 scopus 로고    scopus 로고
    • Combination cancer immunotherapies tailored to the tumour microenvironment
    • Smyth MJ, Ngiow SF, Ribas A, Teng MW. Combination cancer immunotherapies tailored to the tumour microenvironment. Nat Rev Clin Oncol 2015;13:143-58.
    • (2015) Nat Rev Clin Oncol , vol.13 , pp. 143-158
    • Smyth, M.J.1    Ngiow, S.F.2    Ribas, A.3    Teng, M.W.4
  • 33
    • 84936147067 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • Larkin J, Hodi FS, Wolchok JD. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med 2015; 373:1270-1.
    • (2015) N Engl J Med , vol.373 , pp. 1270-1271
    • Larkin, J.1    Hodi, F.S.2    Wolchok, J.D.3
  • 36
    • 84995684655 scopus 로고    scopus 로고
    • Preliminary results from a phase I/II study of epacadostat (incb024360) in combination with pembrolizumab in patients with selected advanced cancers
    • Gangadhar TC, Hamid O, Smith DC, Bauer TM, Wasser JS, Luke JJ, et al. Preliminary results from a phase I/II study of epacadostat (incb024360) in combination with pembrolizumab in patients with selected advanced cancers. J Immunother Cancer 2015;3 (Suppl 2):O7.
    • (2015) J Immunother Cancer , vol.3 , pp. O7
    • Gangadhar, T.C.1    Hamid, O.2    Smith, D.C.3    Bauer, T.M.4    Wasser, J.S.5    Luke, J.J.6
  • 38
    • 53549102755 scopus 로고    scopus 로고
    • The tumor microenvironment and its role in promoting tumor growth
    • Whiteside TL. The tumor microenvironment and its role in promoting tumor growth. Oncogene 2008;27:5904-12.
    • (2008) Oncogene , vol.27 , pp. 5904-5912
    • Whiteside, T.L.1
  • 39
    • 84947804600 scopus 로고    scopus 로고
    • Immune suppressive mechanisms in the tumor microenvironment
    • Munn DH, Bronte V. Immune suppressive mechanisms in the tumor microenvironment. Curr Opin Immunol 2015;39:1-6.
    • (2015) Curr Opin Immunol , vol.39 , pp. 1-6
    • Munn, D.H.1    Bronte, V.2
  • 40
    • 84907055119 scopus 로고    scopus 로고
    • Induced regulatory T cells in inhibitory microenvironments created by cancer
    • Whiteside TL. Induced regulatory T cells in inhibitory microenvironments created by cancer. Expert Opin Biol Ther 2014;14:1411-25.
    • (2014) Expert Opin Biol Ther , vol.14 , pp. 1411-1425
    • Whiteside, T.L.1
  • 41
    • 84952720594 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: Critical cells driving immune suppression in the tumor microenvironment
    • Parker KH, Beury DW, Ostrand-Rosenberg S. Myeloid-derived suppressor cells: critical cells driving immune suppression in the tumor microenvironment. Adv Cancer Res 2015;128:95-139.
    • (2015) Adv Cancer Res , vol.128 , pp. 95-139
    • Parker, K.H.1    Beury, D.W.2    Ostrand-Rosenberg, S.3
  • 42
    • 84941784875 scopus 로고    scopus 로고
    • Control of regulatory T cell migration, function, and homeostasis
    • Campbell DJ. Control of regulatory T cell migration, function, and homeostasis. J Immunol 2015;195:2507-13.
    • (2015) J Immunol , vol.195 , pp. 2507-2513
    • Campbell, D.J.1
  • 44
    • 84901334642 scopus 로고    scopus 로고
    • Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy
    • Highfill SL, Cui Y, Giles AJ, Smith JP, Zhang H, Morse E, et al. Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy. Sci Transl Med 2014;6:237ra67.
    • (2014) Sci Transl Med , vol.6 , pp. 237ra67
    • Highfill, S.L.1    Cui, Y.2    Giles, A.J.3    Smith, J.P.4    Zhang, H.5    Morse, E.6
  • 45
    • 84902546715 scopus 로고    scopus 로고
    • Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy
    • Ries CH, Cannarile MA, Hoves S, Benz J, Wartha K, Runza V, et al. Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Cancer Cell 2014;25:846-59.
    • (2014) Cancer Cell , vol.25 , pp. 846-859
    • Ries, C.H.1    Cannarile, M.A.2    Hoves, S.3    Benz, J.4    Wartha, K.5    Runza, V.6
  • 46
    • 84864005209 scopus 로고    scopus 로고
    • Phenotypic and functional characteristics ofCD4CD39FOXP3 and CD4 CD39 FOXP3neg T-cell subsets in cancer patients
    • Schuler PJ, Schilling B, HarasymczukM, Hoffmann TK, Johnson J, Lang S, et al. Phenotypic and functional characteristics ofCD4CD39FOXP3 and CD4 CD39 FOXP3neg T-cell subsets in cancer patients. Eur J Immunol 2012;42:1876-85.
    • (2012) Eur J Immunol , vol.42 , pp. 1876-1885
    • Schuler, P.J.1    Schilling, B.2    Harasymczuk, M.3    Hoffmann, T.K.4    Johnson, J.5    Lang, S.6
  • 47
    • 84887832812 scopus 로고    scopus 로고
    • Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients
    • Jie HB, Gildener-LeapmanN, Li J, Srivastava RM, Gibson SP, Whiteside TL, et al. Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients. Br J Cancer 2013;109: 2629-35.
    • (2013) Br J Cancer , vol.109 , pp. 2629-2635
    • Jie, H.B.1    Gildener-Leapmann2    Li, J.3    Srivastava, R.M.4    Gibson, S.P.5    Whiteside, T.L.6
  • 49
    • 40549094648 scopus 로고    scopus 로고
    • Interleukin-2 receptor downstream events in regulatory T cells: Implications for the choice of immunosuppressive drug therapy
    • Zeiser R, Negrin RS. Interleukin-2 receptor downstream events in regulatory T cells: implications for the choice of immunosuppressive drug therapy. Cell Cycle 2008;7:458-62.
    • (2008) Cell Cycle , vol.7 , pp. 458-462
    • Zeiser, R.1    Negrin, R.S.2
  • 50
    • 84884271914 scopus 로고    scopus 로고
    • Fc-dependent depletion of tumor-infiltrating regulatory T cells codefines the efficacy of anti-CTLA-4 therapy against melanoma
    • Simpson TR, Li F, Montalvo-Ortiz W, SepulvedaMA, Bergerhoff K, Arce F, et al. Fc-dependent depletion of tumor-infiltrating regulatory T cells codefines the efficacy of anti-CTLA-4 therapy against melanoma. J Exp Med 2013;210:1695-710.
    • (2013) J Exp Med , vol.210 , pp. 1695-1710
    • Simpson, T.R.1    Li, F.2    Montalvo-Ortiz, W.3    Sepulveda, M.A.4    Bergerhoff, K.5    Arce, F.6
  • 51
    • 84892448554 scopus 로고    scopus 로고
    • Regulatory T cells in cancer immunotherapy
    • Nishikawa H, Sakaguchi S. Regulatory T cells in cancer immunotherapy. Curr Opin Immunol 2014;27:1-7.
    • (2014) Curr Opin Immunol , vol.27 , pp. 1-7
    • Nishikawa, H.1    Sakaguchi, S.2
  • 52
    • 84968874219 scopus 로고    scopus 로고
    • The role of regulatory T cells in cancer immunology
    • Whiteside TL. The role of regulatory T cells in cancer immunology. ImmunoTargets Ther 2015;4:159-71.
    • (2015) ImmunoTargets Ther , vol.4 , pp. 159-171
    • Whiteside, T.L.1
  • 53
    • 84890298761 scopus 로고    scopus 로고
    • Effects of adjuvant chemoradiotherapy on the frequency and function of regulatory T cells in patients with head and neck cancer
    • Schuler PJ, Harasymczuk M, Schilling B, Saze Z, Strauss L, Lang S, et al. Effects of adjuvant chemoradiotherapy on the frequency and function of regulatory T cells in patients with head and neck cancer. Clin Cancer Res 2013;19:6585-96.
    • (2013) Clin Cancer Res , vol.19 , pp. 6585-6596
    • Schuler, P.J.1    Harasymczuk, M.2    Schilling, B.3    Saze, Z.4    Strauss, L.5    Lang, S.6
  • 55
    • 84863393290 scopus 로고    scopus 로고
    • CD8() T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1
    • Fourcade J, Sun Z, Pagliano O, Guillaume P, Luescher IF, Sander C, et al. CD8() T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res 2012; 72:887-96.
    • (2012) Cancer Res , vol.72 , pp. 887-896
    • Fourcade, J.1    Sun, Z.2    Pagliano, O.3    Guillaume, P.4    Luescher, I.F.5    Sander, C.6
  • 56
    • 84935432896 scopus 로고    scopus 로고
    • Inhibitory receptors as targets for cancer immunotherapy
    • Turnis ME, Andrews LP, Vignali DA. Inhibitory receptors as targets for cancer immunotherapy. Eur J Immunol 2015;45:1892-905.
    • (2015) Eur J Immunol , vol.45 , pp. 1892-1905
    • Turnis, M.E.1    Andrews, L.P.2    Vignali, D.A.3
  • 57
    • 84922391334 scopus 로고    scopus 로고
    • Tim-3: An emerging target in the cancer immunotherapy landscape
    • Anderson AC. Tim-3: An emerging target in the cancer immunotherapy landscape. Cancer Immunol Res 2014;2:393-8.
    • (2014) Cancer Immunol Res , vol.2 , pp. 393-398
    • Anderson, A.C.1
  • 58
    • 84876481083 scopus 로고    scopus 로고
    • Interfering with coinhibitory molecules: BTLA/HVEM as new targets to enhance anti-tumor immunity
    • Pasero C, Olive D. Interfering with coinhibitory molecules: BTLA/HVEM as new targets to enhance anti-tumor immunity. Immunol Lett 2013; 151:71-5.
    • (2013) Immunol Lett , vol.151 , pp. 71-75
    • Pasero, C.1    Olive, D.2
  • 59
    • 84925743331 scopus 로고    scopus 로고
    • Balancing natural killer cell activation through paired receptors
    • Martinet L, Smyth MJ. Balancing natural killer cell activation through paired receptors. Nat Rev Immunol 2015;15:243-54.
    • (2015) Nat Rev Immunol , vol.15 , pp. 243-254
    • Martinet, L.1    Smyth, M.J.2
  • 61
    • 78449237499 scopus 로고    scopus 로고
    • Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies
    • Ascierto PA, Simeone E, Sznol M, Fu YX, Melero I. Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. Semin Oncol 2010;37:508-16.
    • (2010) Semin Oncol , vol.37 , pp. 508-516
    • Ascierto, P.A.1    Simeone, E.2    Sznol, M.3    Fu, Y.X.4    Melero, I.5
  • 64
    • 84940372582 scopus 로고    scopus 로고
    • The next hurdle in cancer immunotherapy: Overcoming the non-T-cell-inflamed tumor microenvironment
    • Gajewski TF. The next hurdle in cancer immunotherapy: Overcoming the non-T-cell-inflamed tumor microenvironment. Semin Oncol 2015;42: 663-71.
    • (2015) Semin Oncol , vol.42 , pp. 663-671
    • Gajewski, T.F.1
  • 65
    • 84929705879 scopus 로고    scopus 로고
    • Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity
    • Corrales L, Glickman LH, McWhirter SM, Kanne DB, Sivick KE, Katibah GE, et al. Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep 2015;11:1018-30.
    • (2015) Cell Rep , vol.11 , pp. 1018-1030
    • Corrales, L.1    Glickman, L.H.2    McWhirter, S.M.3    Kanne, D.B.4    Sivick, K.E.5    Katibah, G.E.6
  • 66
    • 84936953099 scopus 로고    scopus 로고
    • Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity
    • Spranger S, Bao R, Gajewski TF. Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity. Nature 2015;523:231-5.
    • (2015) Nature , vol.523 , pp. 231-235
    • Spranger, S.1    Bao, R.2    Gajewski, T.F.3
  • 67
    • 84883787417 scopus 로고    scopus 로고
    • Immunologically augmented cancer treatment using modern radiotherapy
    • Durante M, Reppingen N, Held KD. Immunologically augmented cancer treatment using modern radiotherapy. Trends Mol Med 2013; 19:565-82.
    • (2013) Trends Mol Med , vol.19 , pp. 565-582
    • Durante, M.1    Reppingen, N.2    Held, K.D.3
  • 68
    • 84919464054 scopus 로고    scopus 로고
    • Radiotherapy and immunogenic cell death
    • Golden EB, Apetoh L. Radiotherapy and immunogenic cell death. Semin Radiat Oncol 2015;25:11-7.
    • (2015) Semin Radiat Oncol , vol.25 , pp. 11-17
    • Golden, E.B.1    Apetoh, L.2
  • 69
    • 84875039618 scopus 로고    scopus 로고
    • Combining radiotherapy and cancer immunotherapy: A paradigm shift
    • Formenti SC, Demaria S. Combining radiotherapy and cancer immunotherapy: A paradigm shift. J Natl Cancer Inst 2013;105:256-65.
    • (2013) J Natl Cancer Inst , vol.105 , pp. 256-265
    • Formenti, S.C.1    Demaria, S.2
  • 71
    • 84872026647 scopus 로고    scopus 로고
    • Radiotherapy to convert the tumor into an in situ vaccine
    • Formenti SC, Demaria S. Radiotherapy to convert the tumor into an in situ vaccine. Int J Radiat Oncol Biol Phys 2012;84:879-80.
    • (2012) Int J Radiat Oncol Biol Phys , vol.84 , pp. 879-880
    • Formenti, S.C.1    Demaria, S.2
  • 72
    • 70149113060 scopus 로고    scopus 로고
    • Therapeutic effects of ablative radiation on local tumor require CD8 T cells: Changing strategies for cancer treatment
    • Lee Y, Auh SL, Wang Y, Burnette B, Wang Y, Meng Y, et al. Therapeutic effects of ablative radiation on local tumor require CD8 T cells: Changing strategies for cancer treatment. Blood 2009;114:589-95.
    • (2009) Blood , vol.114 , pp. 589-595
    • Lee, Y.1    Auh, S.L.2    Wang, Y.3    Burnette, B.4    Wang, Y.5    Meng, Y.6
  • 73
    • 0018569985 scopus 로고
    • Effect of host immune capability on radiocurability and subsequent transplantability of a murine fibrosarcoma
    • Stone HB, Peters LJ, Milas L. Effect of host immune capability on radiocurability and subsequent transplantability of a murine fibrosarcoma. J Natl Cancer Inst 1979;63:1229-35.
    • (1979) J Natl Cancer Inst , vol.63 , pp. 1229-1235
    • Stone, H.B.1    Peters, L.J.2    Milas, L.3
  • 75
    • 84937640449 scopus 로고    scopus 로고
    • The abscopal effect of local radiotherapy: Using immunotherapy to make a rare event clinically relevant
    • Reynders K, Illidge T, Siva S, Chang JY, De Ruysscher D. The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant. Cancer Treat Rev 2015;41:503-10.
    • (2015) Cancer Treat Rev , vol.41 , pp. 503-510
    • Reynders, K.1    Illidge, T.2    Siva, S.3    Chang, J.Y.4    De Ruysscher, D.5
  • 76
    • 84912120595 scopus 로고    scopus 로고
    • STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors
    • Woo SR, Fuertes MB, Corrales L, Spranger S, Furdyna MJ, Leung MY, et al. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity 2014;41: 830-42.
    • (2014) Immunity , vol.41 , pp. 830-842
    • Woo, S.R.1    Fuertes, M.B.2    Corrales, L.3    Spranger, S.4    Furdyna, M.J.5    Leung, M.Y.6
  • 77
    • 84912128872 scopus 로고    scopus 로고
    • STINGDependent cytosolic DNA sensing promotes radiation-induced type i interferon-dependent antitumor immunity in immunogenic tumors
    • Deng L, Liang H, Xu M, Yang X, Burnette B, Arina A, et al. STINGDependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors. Immunity 2014;41:843-52.
    • (2014) Immunity , vol.41 , pp. 843-852
    • Deng, L.1    Liang, H.2    Xu, M.3    Yang, X.4    Burnette, B.5    Arina, A.6
  • 78
  • 79
    • 84886805255 scopus 로고    scopus 로고
    • Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy
    • Bos PD, Plitas G, Rudra D, Lee SY, Rudensky AY. Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy. J Exp Med 2010;11:2435-66.
    • (2010) J Exp Med , vol.11 , pp. 2435-2466
    • Bos, P.D.1    Plitas, G.2    Rudra, D.3    Lee, S.Y.4    Rudensky, A.Y.5
  • 80
    • 84877738839 scopus 로고    scopus 로고
    • CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer
    • Xu J, Escamilla J, Mok S, David J, Priceman S, West B, et al. CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer. Cancer Res 2013;73:2782-94.
    • (2013) Cancer Res , vol.73 , pp. 2782-2794
    • Xu, J.1    Escamilla, J.2    Mok, S.3    David, J.4    Priceman, S.5    West, B.6
  • 81
    • 84983489005 scopus 로고    scopus 로고
    • Role of local radiation therapy in cancer immunotherapy
    • Demaria S, Golden EB, Formenti SC. Role of local radiation therapy in cancer immunotherapy. JAMA Oncol 2015;1:1325-32.
    • (2015) JAMA Oncol , vol.1 , pp. 1325-1332
    • Demaria, S.1    Golden, E.B.2    Formenti, S.C.3
  • 82
    • 78049420571 scopus 로고    scopus 로고
    • In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: A phase I/II study
    • Brody JD, Ai WZ, Czerwinski DK, Torchia JA, Levy M, Advani RH, et al. In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: A phase I/II study. J Clin Oncol 2010;28:4324-32.
    • (2010) J Clin Oncol , vol.28 , pp. 4324-4332
    • Brody, J.D.1    Ai, W.Z.2    Czerwinski, D.K.3    Torchia, J.A.4    Levy, M.5    Advani, R.H.6
  • 83
    • 84937525789 scopus 로고    scopus 로고
    • Local radiotherapy and GM-CSF in patients with metastatic solid tumors: A proof of principle trial to generate abscopal responses
    • Golden EB, Chhabra A, Chachoua A, Adams S, Donach M, Fenton-Kerimian M, et al. Local radiotherapy and GM-CSF in patients with metastatic solid tumors: A proof of principle trial to generate abscopal responses. Lancet Oncol 2015;16:795-803.
    • (2015) Lancet Oncol , vol.16 , pp. 795-803
    • Golden, E.B.1    Chhabra, A.2    Chachoua, A.3    Adams, S.4    Donach, M.5    Fenton-Kerimian, M.6
  • 84
    • 84862124594 scopus 로고    scopus 로고
    • Phase 1 study of stereotactic body radiotherapy and interleukin-2-tumor and immunological responses
    • Seung SK, Curti BD, Crittenden M, Walker E, Coffey T, Siebert JC, et al. Phase 1 study of stereotactic body radiotherapy and interleukin-2-tumor and immunological responses. Sci Transl Med 2012;4:137ra74.
    • (2012) Sci Transl Med , vol.4 , pp. 137ra74
    • Seung, S.K.1    Curti, B.D.2    Crittenden, M.3    Walker, E.4    Coffey, T.5    Siebert, J.C.6
  • 86
  • 88
    • 84904061705 scopus 로고    scopus 로고
    • Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy
    • Grimaldi AM, Simeone E, Giannarelli D, Muto P, Falivene S, Borzillo V, et al. Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy. Oncoimmunology 2014;3:e28780.
    • (2014) Oncoimmunology , vol.3 , pp. e28780
    • Grimaldi, A.M.1    Simeone, E.2    Giannarelli, D.3    Muto, P.4    Falivene, S.5    Borzillo, V.6
  • 89
    • 85003053854 scopus 로고    scopus 로고
    • An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer
    • Golden EB, Demaria S, Schiff PB, Chachoua A, Formenti SC. An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer. Cancer Immunol Res 2013;1: 365-72.
    • (2013) Cancer Immunol Res , vol.1 , pp. 365-372
    • Golden, E.B.1    Demaria, S.2    Schiff, P.B.3    Chachoua, A.4    Formenti, S.C.5
  • 90
    • 76749084659 scopus 로고    scopus 로고
    • Randomized phase II clinical trial comparing tremelimumab (CP-675, 206) with best supportive care (BSC) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC)
    • Zatloukal P, Heo DS, Park K, Kang J, Butts C, Bradford D, et al. Randomized phase II clinical trial comparing tremelimumab (CP-675, 206) with best supportive care (BSC) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2009;27:8071.
    • (2009) J Clin Oncol , vol.27 , pp. 8071
    • Zatloukal, P.1    Heo, D.S.2    Park, K.3    Kang, J.4    Butts, C.5    Bradford, D.6
  • 91
    • 84964229943 scopus 로고    scopus 로고
    • Abscopla responses in metastatic non-small cell lung cancer (NSCLC) patients treatded on a phase 2 study of combined radiation therapy and ipilimumab: Evidence for the in situ vaccination hypothesis of radiation
    • Golden EB, Chachoua A, Fenton-Kerimian MB, Demaria S, Formenti SC. Abscopla responses in metastatic non-small cell lung cancer (NSCLC) patients treatded on a phase 2 study of combined radiation therapy and ipilimumab: evidence for the in situ vaccination hypothesis of radiation. Int J Radiat Oncol Biol Phys 2015; 93:S66-7.
    • (2015) Int J Radiat Oncol Biol Phys , vol.93 , pp. S66-S67
    • Golden, E.B.1    Chachoua, A.2    Fenton-Kerimian, M.B.3    Demaria, S.4    Formenti, S.C.5
  • 92
    • 84901641673 scopus 로고    scopus 로고
    • Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): A multicentre, randomised, double-blind, phase 3 trial
    • Kwon ED, Drake CG, Scher HI, Fizazi K, Bossi A, van den Eertwegh AJ, et al. Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): A multicentre, randomised, double-blind, phase 3 trial. Lancet Oncol 2014;15: 700-12.
    • (2014) Lancet Oncol , vol.15 , pp. 700-712
    • Kwon, E.D.1    Drake, C.G.2    Scher, H.I.3    Fizazi, K.4    Bossi, A.5    Van Den Eertwegh, A.J.6
  • 93
    • 69949085196 scopus 로고    scopus 로고
    • Fractionated but not single dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
    • Dewan MZ, Galloway AE, Kawashima N, Dewyngaert JK, Babb JS, Formenti SC, et al. Fractionated but not single dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res 2009;15: 5379-88.
    • (2009) Clin Cancer Res , vol.15 , pp. 5379-5388
    • Dewan, M.Z.1    Galloway, A.E.2    Kawashima, N.3    Dewyngaert, J.K.4    Babb, J.S.5    Formenti, S.C.6
  • 94
    • 84928770388 scopus 로고    scopus 로고
    • Neoantigens in cancer immunotherapy
    • Schumacher TN, Schreiber RD. Neoantigens in cancer immunotherapy. Science 2015;348:69-74.
    • (2015) Science , vol.348 , pp. 69-74
    • Schumacher, T.N.1    Schreiber, R.D.2
  • 96
    • 84898733422 scopus 로고    scopus 로고
    • Intratumoral immunization: A new paradigm for cancer therapy
    • Marabelle A, Kohrt H, Caux C, Levy R. Intratumoral immunization: A new paradigm for cancer therapy. Clin Cancer Res 2014;20: 1747-56.
    • (2014) Clin Cancer Res , vol.20 , pp. 1747-1756
    • Marabelle, A.1    Kohrt, H.2    Caux, C.3    Levy, R.4
  • 98
    • 84942944907 scopus 로고    scopus 로고
    • Nivolumab and urelumab enhance antitumor activity of human T lymphocytes engrafted in Rag2-/-IL2Rgammanull immunodeficient mice
    • Sanmamed MF, Rodriguez I, Schalper KA, Onate C, Azpilikueta A, Rodriguez-Ruiz ME, et al. Nivolumab and urelumab enhance antitumor activity of human T lymphocytes engrafted in Rag2-/-IL2Rgammanull immunodeficient mice. Cancer Res 2015; 75:3466-78.
    • (2015) Cancer Res , vol.75 , pp. 3466-3478
    • Sanmamed, M.F.1    Rodriguez, I.2    Schalper, K.A.3    Onate, C.4    Azpilikueta, A.5    Rodriguez-Ruiz, M.E.6
  • 100
    • 84938205998 scopus 로고    scopus 로고
    • Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): A randomised, controlled, phase 2 trial
    • Ribas A, Puzanov I, Dummer R, Schadendorf D, Hamid O, Robert C, et al. Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): A randomised, controlled, phase 2 trial. Lancet Oncol 2015;16:908-18.
    • (2015) Lancet Oncol , vol.16 , pp. 908-918
    • Ribas, A.1    Puzanov, I.2    Dummer, R.3    Schadendorf, D.4    Hamid, O.5    Robert, C.6
  • 102
    • 84931083080 scopus 로고    scopus 로고
    • Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): A randomised, controlled, open-label, phase 3 trial
    • Weber JS, D'Angelo SP, Minor D, Hodi FS, Gutzmer R, Neyns B, et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): A randomised, controlled, open-label, phase 3 trial. Lancet Oncol 2015;16: 375-84.
    • (2015) Lancet Oncol , vol.16 , pp. 375-384
    • Weber, J.S.1    D'Angelo, S.P.2    Minor, D.3    Hodi, F.S.4    Gutzmer, R.5    Neyns, B.6
  • 104
    • 84960187594 scopus 로고    scopus 로고
    • Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): A randomised controlled trial
    • Dec 18. pii: S0140-6736(15) 01281-7
    • Herbst RS, Baas P, Kim DW, Felip E, Perez-Gracia JL, Han JY, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): A randomised controlled trial. Lancet 2015 Dec 18. pii: S0140-6736(15) 01281-7
    • (2015) Lancet
    • Herbst, R.S.1    Baas, P.2    Kim, D.W.3    Felip, E.4    Perez-Gracia, J.L.5    Han, J.Y.6
  • 105
    • 84944937210 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
    • Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med 2015;373:1627-39.
    • (2015) N Engl J Med , vol.373 , pp. 1627-1639
    • Borghaei, H.1    Paz-Ares, L.2    Horn, L.3    Spigel, D.R.4    Steins, M.5    Ready, N.E.6
  • 106
    • 84933678156 scopus 로고    scopus 로고
    • Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): A randomised, double-blind, phase 3 trial
    • Eggermont AM, Chiarion-Sileni V, Grob JJ, Dummer R, Wolchok JD, Schmidt H, et al. Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): A randomised, double-blind, phase 3 trial. Lancet Oncol 2015;16:522-30.
    • (2015) Lancet Oncol , vol.16 , pp. 522-530
    • Eggermont, A.M.1    Chiarion-Sileni, V.2    Grob, J.J.3    Dummer, R.4    Wolchok, J.D.5    Schmidt, H.6
  • 107
    • 84928760665 scopus 로고    scopus 로고
    • Anti-programmed cell death protein-1/ligand-1 therapy in different cancers
    • Homet Moreno B, Ribas A. Anti-programmed cell death protein-1/ligand-1 therapy in different cancers. Br J Cancer 2015;112:1421-7.
    • (2015) Br J Cancer , vol.112 , pp. 1421-1427
    • Homet Moreno, B.1    Ribas, A.2
  • 108
    • 84928062583 scopus 로고    scopus 로고
    • Immune checkpoint blockade: A common denominator approach to cancer therapy
    • Topalian SL, Drake CG, Pardoll DM. Immune checkpoint blockade: A common denominator approach to cancer therapy. Cancer Cell 2015; 27:450-61.
    • (2015) Cancer Cell , vol.27 , pp. 450-461
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 110
    • 0035496946 scopus 로고    scopus 로고
    • Interleukin-10 promotes the maintenance of antitumor CD8() T-cell effector function in situ
    • Fujii S, Shimizu K, Shimizu T, Lotze MT. Interleukin-10 promotes the maintenance of antitumor CD8() T-cell effector function in situ. Blood 2001;98:2143-51.
    • (2001) Blood , vol.98 , pp. 2143-2151
    • Fujii, S.1    Shimizu, K.2    Shimizu, T.3    Lotze, M.T.4
  • 111
    • 84865787544 scopus 로고    scopus 로고
    • Molecular pathways: Targeting the TGF-beta pathway for cancer therapy
    • Smith AL, Robin TP, Ford HL. Molecular pathways: Targeting the TGF-beta pathway for cancer therapy. Clin Cancer Res 2012;18: 4514-21.
    • (2012) Clin Cancer Res , vol.18 , pp. 4514-4521
    • Smith, A.L.1    Robin, T.P.2    Ford, H.L.3
  • 113
    • 84908005764 scopus 로고    scopus 로고
    • A first in man phase i trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors
    • Soliman HH, Jackson E, Neuger T, Dees EC, Harvey RD, Han H, et al. A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors. Oncotarget 2014;5:8136-46.
    • (2014) Oncotarget , vol.5 , pp. 8136-8146
    • Soliman, H.H.1    Jackson, E.2    Neuger, T.3    Dees, E.C.4    Harvey, R.D.5    Han, H.6
  • 114
    • 84948728185 scopus 로고    scopus 로고
    • Galectin expression in cancer diagnosis and prognosis: A systematic review
    • Thijssen VL, Heusschen R, Caers J, Griffioen AW. Galectin expression in cancer diagnosis and prognosis: A systematic review. Biochim Biophys Acta 2015;1855:235-47.
    • (2015) Biochim Biophys Acta , vol.1855 , pp. 235-247
    • Thijssen, V.L.1    Heusschen, R.2    Caers, J.3    Griffioen, A.W.4
  • 115
    • 41149148269 scopus 로고    scopus 로고
    • Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: Mechanisms and therapeutic perspectives
    • Rodriguez PC, Ochoa AC. Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: Mechanisms and therapeutic perspectives. Immunol Rev 2008;222:180-91.
    • (2008) Immunol Rev , vol.222 , pp. 180-191
    • Rodriguez, P.C.1    Ochoa, A.C.2
  • 116
    • 80051508106 scopus 로고    scopus 로고
    • Targeting human inducible regulatory T cells (Tr1) in patients with cancer: Blocking of adenosineprostaglandin E(2) cooperation
    • Mandapathil M, Whiteside TL. Targeting human inducible regulatory T cells (Tr1) in patients with cancer: Blocking of adenosineprostaglandin E(2) cooperation. Expert Opin Biol Ther 2011;11: 1203-14.
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 1203-1214
    • Mandapathil, M.1    Whiteside, T.L.2
  • 117
    • 84916605955 scopus 로고    scopus 로고
    • The role of prostaglandin E2 in renal cell cancer development: Future implications for prognosis and therapy
    • Kaminska K, Szczylik C, Lian F, Czarnecka AM. The role of prostaglandin E2 in renal cell cancer development: Future implications for prognosis and therapy. Future Oncol 2014;10: 2177-87.
    • (2014) Future Oncol , vol.10 , pp. 2177-2187
    • Kaminska, K.1    Szczylik, C.2    Lian, F.3    Czarnecka, A.M.4
  • 118
    • 84883673050 scopus 로고    scopus 로고
    • Adenosine and prostaglandin e2 production by human inducible regulatory T cells in health and disease
    • Whiteside TL, Jackson EK. Adenosine and prostaglandin e2 production by human inducible regulatory T cells in health and disease. Front Immunol 2013;4:212.
    • (2013) Front Immunol , vol.4 , pp. 212
    • Whiteside, T.L.1    Jackson, E.K.2
  • 119
    • 84886432843 scopus 로고    scopus 로고
    • Targeting CD73 enhances the antitumor activity of anti-PD-1 and anti-CTLA-4 mAbs
    • Allard B, Pommey S, Smyth MJ, Stagg J. Targeting CD73 enhances the antitumor activity of anti-PD-1 and anti-CTLA-4 mAbs. Clin Cancer Res 2013;19:5626-35.
    • (2013) Clin Cancer Res , vol.19 , pp. 5626-5635
    • Allard, B.1    Pommey, S.2    Smyth, M.J.3    Stagg, J.4
  • 120
    • 84904254163 scopus 로고    scopus 로고
    • Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor
    • Mittal D, Young A, Stannard K, Yong M, Teng MW, Allard B, et al. Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor. Cancer Res 2014;74:3652-8.
    • (2014) Cancer Res , vol.74 , pp. 3652-3658
    • Mittal, D.1    Young, A.2    Stannard, K.3    Yong, M.4    Teng, M.W.5    Allard, B.6
  • 121
    • 84887940292 scopus 로고    scopus 로고
    • Oxidative stress in carcinogenesis: New synthetic compounds with dual effects upon free radicals and cancer
    • Tekiner-Gulbas B, Westwell AD, Suzen S. Oxidative stress in carcinogenesis: New synthetic compounds with dual effects upon free radicals and cancer. Curr Med Chem 2013;20:4451-9.
    • (2013) Curr Med Chem , vol.20 , pp. 4451-4459
    • Tekiner-Gulbas, B.1    Westwell, A.D.2    Suzen, S.3
  • 122
    • 84939261397 scopus 로고    scopus 로고
    • Reactive oxygen species in redox cancer therapy
    • Tong L, Chuang CC, Wu S, Zuo L. Reactive oxygen species in redox cancer therapy. Cancer Lett 2015;367:18-25.
    • (2015) Cancer Lett , vol.367 , pp. 18-25
    • Tong, L.1    Chuang, C.C.2    Wu, S.3    Zuo, L.4
  • 123
    • 84861175955 scopus 로고    scopus 로고
    • CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients
    • Rech AJ, Mick R, Martin S, Recio A, Aqui NA, Powell DJ Jr., et al. CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients. Sci Transl Med 2012; 4:134ra62.
    • (2012) Sci Transl Med , vol.4 , pp. 134ra62
    • Rech, A.J.1    Mick, R.2    Martin, S.3    Recio, A.4    Aqui, N.A.5    Powell, D.J.6
  • 124
    • 36148939150 scopus 로고    scopus 로고
    • IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity
    • Litzinger MT, Fernando R, Curiel TJ, Grosenbach DW, Schlom J, Palena C. IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity. Blood 2007;110:3192-201.
    • (2007) Blood , vol.110 , pp. 3192-3201
    • Litzinger, M.T.1    Fernando, R.2    Curiel, T.J.3    Grosenbach, D.W.4    Schlom, J.5    Palena, C.6
  • 125
    • 84897116498 scopus 로고    scopus 로고
    • Diphtheria toxin-based bivalent human IL-2 fusion toxin with improved efficacy for targeting human CD25() cells
    • Peraino JS, Zhang H, Rajasekera PV, Wei M, Madsen JC, Sachs DH, et al. Diphtheria toxin-based bivalent human IL-2 fusion toxin with improved efficacy for targeting human CD25() cells. J Immunol Methods 2014;405:57-66.
    • (2014) J Immunol Methods , vol.405 , pp. 57-66
    • Peraino, J.S.1    Zhang, H.2    Rajasekera, P.V.3    Wei, M.4    Madsen, J.C.5    Sachs, D.H.6
  • 126
    • 15944410592 scopus 로고    scopus 로고
    • Inhibition of CD4()25 T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
    • Lutsiak ME, Semnani RT, De Pascalis R, Kashmiri SV, Schlom J, Sabzevari H. Inhibition of CD4()25 T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide. Blood 2005;105:2862-8.
    • (2005) Blood , vol.105 , pp. 2862-2868
    • Lutsiak, M.E.1    Semnani, R.T.2    De Pascalis, R.3    Kashmiri, S.V.4    Schlom, J.5    Sabzevari, H.6
  • 127
    • 84862143053 scopus 로고    scopus 로고
    • Melanoma-induced immunosuppression and its neutralization
    • Umansky V, Sevko A. Melanoma-induced immunosuppression and its neutralization. Semin Cancer Biol 2012;22:319-26.
    • (2012) Semin Cancer Biol , vol.22 , pp. 319-326
    • Umansky, V.1    Sevko, A.2
  • 128
    • 84896523643 scopus 로고    scopus 로고
    • Ipilimumab treatment results in an early decrease in the frequency of circulating granulocytic myeloid-derived suppressor cells as well as their Arginase1 production
    • Pico de Coana Y, Poschke I, Gentilcore G, Mao Y, NystromM, Hansson J, et al. Ipilimumab treatment results in an early decrease in the frequency of circulating granulocytic myeloid-derived suppressor cells as well as their Arginase1 production. Cancer Immunol Res 2013;1: 158-62.
    • (2013) Cancer Immunol Res , vol.1 , pp. 158-162
    • Pico De Coana, Y.1    Poschke, I.2    Gentilcore, G.3    Mao, Y.4    Nystrom, M.5    Hansson, J.6
  • 130
    • 77951086882 scopus 로고    scopus 로고
    • 5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T celldependent antitumor immunity
    • Vincent J, Mignot G, Chalmin F, Ladoire S, Bruchard M, Chevriaux A, et al. 5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T celldependent antitumor immunity. Cancer Res 2010;70:3052-61.
    • (2010) Cancer Res , vol.70 , pp. 3052-3061
    • Vincent, J.1    Mignot, G.2    Chalmin, F.3    Ladoire, S.4    Bruchard, M.5    Chevriaux, A.6
  • 131
    • 84920767728 scopus 로고    scopus 로고
    • Therapeutic applications of extracellular vesicles: Clinical promise and open questions
    • Gyorgy B, Hung ME, Breakefield XO, Leonard JN. Therapeutic applications of extracellular vesicles: clinical promise and open questions. Annu Rev Pharmacol Toxicol 2015;55: 439-64.
    • (2015) Annu Rev Pharmacol Toxicol , vol.55 , pp. 439-464
    • Gyorgy, B.1    Hung, M.E.2    Breakefield, X.O.3    Leonard, J.N.4
  • 132
    • 77953718827 scopus 로고    scopus 로고
    • "Hard" and "soft" lesions underlying the HLA class i alterations in cancer cells: Implications for immunotherapy
    • Garrido F, Cabrera T, Aptsiauri N. "Hard" and "soft" lesions underlying the HLA class I alterations in cancer cells: implications for immunotherapy. Int J Cancer 2010;127:249-56.
    • (2010) Int J Cancer , vol.127 , pp. 249-256
    • Garrido, F.1    Cabrera, T.2    Aptsiauri, N.3
  • 133
    • 27944434228 scopus 로고    scopus 로고
    • Molecular mechanisms of HLA class i antigen abnormalities following viral infection and transformation
    • Seliger B, Ritz U, Ferrone S. Molecular mechanisms of HLA class I antigen abnormalities following viral infection and transformation. Int J Cancer 2006;118:129-38.
    • (2006) Int J Cancer , vol.118 , pp. 129-138
    • Seliger, B.1    Ritz, U.2    Ferrone, S.3
  • 134
    • 84941366350 scopus 로고    scopus 로고
    • Phosphoenolpyruvate is a metabolic checkpoint of antitumor T cell responses
    • Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, et al. Phosphoenolpyruvate is a metabolic checkpoint of antitumor T cell responses. Cell 2015;162:1217-28.
    • (2015) Cell , vol.162 , pp. 1217-1228
    • Ho, P.C.1    Bihuniak, J.D.2    Macintyre, A.N.3    Staron, M.4    Liu, X.5    Amezquita, R.6
  • 135
    • 84941344937 scopus 로고    scopus 로고
    • Metabolic competition in the tumor microenvironment is a driver of cancer progression
    • Chang CH, Qiu J, O'Sullivan D, Buck MD, Noguchi T, Curtis JD, et al. Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell 2015;162:1229-41.
    • (2015) Cell , vol.162 , pp. 1229-1241
    • Chang, C.H.1    Qiu, J.2    O'Sullivan, D.3    Buck, M.D.4    Noguchi, T.5    Curtis, J.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.