-
1
-
-
85047692172
-
Therapeutic vaccines for cancer: An overview of clinical trials
-
Melero I, Gaudernack G, Gerritsen W, Huber C, ParmianiG, Scholl S, et al. Therapeutic vaccines for cancer: An overview of clinical trials. Nat Rev Clin Oncol 2014;11:509-24.
-
(2014)
Nat Rev Clin Oncol
, vol.11
, pp. 509-524
-
-
Melero, I.1
Gaudernack, G.2
Gerritsen, W.3
Huber, C.4
Parmiani, F.5
Scholl, S.6
-
2
-
-
84928774156
-
The future of immune checkpoint therapy
-
Sharma P, Allison JP. The future of immune checkpoint therapy. Science 2015;348:56-61.
-
(2015)
Science
, vol.348
, pp. 56-61
-
-
Sharma, P.1
Allison, J.P.2
-
3
-
-
84928759208
-
Adoptive cell transfer as personalized immunotherapy for human cancer
-
Rosenberg SA, Restifo NP. Adoptive cell transfer as personalized immunotherapy for human cancer. Science 2015;348:62-8.
-
(2015)
Science
, vol.348
, pp. 62-68
-
-
Rosenberg, S.A.1
Restifo, N.P.2
-
4
-
-
0345060466
-
Potentiation of therapeutic immune responses against malignancies with monoclonal antibodies
-
Murillo O, Arina A, Tirapu I, Alfaro C, Mazzolini G, Palencia B, et al. Potentiation of therapeutic immune responses against malignancies with monoclonal antibodies. Clin Cancer Res 2003;9: 5454-64.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5454-5464
-
-
Murillo, O.1
Arina, A.2
Tirapu, I.3
Alfaro, C.4
Mazzolini, G.5
Palencia, B.6
-
5
-
-
0029947568
-
Enhancement of antitumor immunity by CTLA-4 blockade
-
Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996;271:1734-6.
-
(1996)
Science
, vol.271
, pp. 1734-1736
-
-
Leach, D.R.1
Krummel, M.F.2
Allison, J.P.3
-
6
-
-
18544380239
-
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
-
Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion. Nat Med 2002;8:793-800.
-
(2002)
Nat Med
, vol.8
, pp. 793-800
-
-
Dong, H.1
Strome, S.E.2
Salomao, D.R.3
Tamura, H.4
Hirano, F.5
Flies, D.B.6
-
7
-
-
0037126021
-
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
-
Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, Minato N. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A 2002;99: 12293-7.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 12293-12297
-
-
Iwai, Y.1
Ishida, M.2
Tanaka, Y.3
Okazaki, T.4
Honjo, T.5
Minato, N.6
-
8
-
-
5844264920
-
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
-
Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol 2001;2:261-8.
-
(2001)
Nat Immunol
, vol.2
, pp. 261-268
-
-
Latchman, Y.1
Wood, C.R.2
Chernova, T.3
Chaudhary, D.4
Borde, M.5
Chernova, I.6
-
9
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010;363:711-23.
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
Weber, R.W.4
Sosman, J.A.5
Haanen, J.B.6
-
10
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
Robert C, Thomas L, Bondarenko I, O'Day S, Weber J, Garbe C, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 2011;364:2517-26.
-
(2011)
N Engl J Med
, vol.364
, pp. 2517-2526
-
-
Robert, C.1
Thomas, L.2
Bondarenko, I.3
O'Day, S.4
Weber, J.5
Garbe, C.6
-
11
-
-
84946607195
-
Nivolumab versus everolimus in advanced renal-cell carcinoma
-
Motzer RJ, Escudier B, McDermott DF, George S, Hammers HJ, Srinivas S, et al. Nivolumab versus everolimus in advanced renal-cell carcinoma. N Engl J Med 2015;373:1803-13.
-
(2015)
N Engl J Med
, vol.373
, pp. 1803-1813
-
-
Motzer, R.J.1
Escudier, B.2
McDermott, D.F.3
George, S.4
Hammers, H.J.5
Srinivas, S.6
-
12
-
-
84923078390
-
MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
-
Powles T, Eder JP, Fine GD, Braiteh FS, Loriot Y, Cruz C, et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature 2014;515:558-62.
-
(2014)
Nature
, vol.515
, pp. 558-562
-
-
Powles, T.1
Eder, J.P.2
Fine, G.D.3
Braiteh, F.S.4
Loriot, Y.5
Cruz, C.6
-
13
-
-
84925221855
-
PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma
-
Ansell SM, Lesokhin AM, Borrello I, Halwani A, Scott EC, Gutierrez M, et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N Engl J Med 2015;372:311-9.
-
(2015)
N Engl J Med
, vol.372
, pp. 311-319
-
-
Ansell, S.M.1
Lesokhin, A.M.2
Borrello, I.3
Halwani, A.4
Scott, E.C.5
Gutierrez, M.6
-
14
-
-
84989299723
-
KEYNOTE-040: A phase III randomized trial of pembrolizumab (MK-3475) versus standard treatment in patients with recurrent or metastatic head and neck cancer
-
(suppl; abstr TPS6084)
-
Cohen EEW, Machiels JPH, Harrington KJ, Burtness B, Shin SW, Gause CK, et al. KEYNOTE-040: A phase III randomized trial of pembrolizumab (MK-3475) versus standard treatment in patients with recurrent or metastatic head and neck cancer. J Clin Oncol 33, 2015 (suppl; abstr TPS6084).
-
(2015)
J Clin Oncol
, vol.33
-
-
Cohen, E.E.W.1
Machiels, J.P.H.2
Harrington, K.J.3
Burtness, B.4
Shin, S.W.5
Gause, C.K.6
-
15
-
-
84951126341
-
Safety and antitumor activity of anti-PD-1 antibody, nivolumab, in patients with platinum-resistant ovarian cancer
-
Hamanishi J, Mandai M, Ikeda T, Minami M, Kawaguchi A, Murayama T, et al. Safety and antitumor activity of anti-PD-1 antibody, nivolumab, in patients with platinum-resistant ovarian cancer. J Clin Oncol 2015;33: 4015-22.
-
(2015)
J Clin Oncol
, vol.33
, pp. 4015-4022
-
-
Hamanishi, J.1
Mandai, M.2
Ikeda, T.3
Minami, M.4
Kawaguchi, A.5
Murayama, T.6
-
16
-
-
84932628341
-
PD-1 blockade in tumors with mismatch-repair deficiency
-
Le DT, Uram JN, WangH, Bartlett BR, KemberlingH, Eyring AD, et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med 2015;372:2509-20.
-
(2015)
N Engl J Med
, vol.372
, pp. 2509-2520
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
Bartlett, B.R.4
Kemberling, H.5
Eyring, A.D.6
-
17
-
-
80053567512
-
Cell transfer immunotherapy for metastatic solid cancer-what clinicians need to know
-
Rosenberg SA. Cell transfer immunotherapy for metastatic solid cancer-what clinicians need to know. Nat Rev Clin Oncol 2011;8: 577-85.
-
(2011)
Nat Rev Clin Oncol
, vol.8
, pp. 577-585
-
-
Rosenberg, S.A.1
-
18
-
-
84883472041
-
Adoptive transfer of tumor-infiltrating lymphocytes in patients with metastatic melanoma: Intent-to-treat analysis and efficacy after failure to prior immunotherapies
-
Besser MJ, Shapira-Frommer R, Itzhaki O, Treves AJ, Zippel DB, Levy D, et al. Adoptive transfer of tumor-infiltrating lymphocytes in patients with metastatic melanoma: intent-to-treat analysis and efficacy after failure to prior immunotherapies. Clin Cancer Res 2013; 19:4792-800.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 4792-4800
-
-
Besser, M.J.1
Shapira-Frommer, R.2
Itzhaki, O.3
Treves, A.J.4
Zippel, D.B.5
Levy, D.6
-
19
-
-
0027471898
-
Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors
-
Eshhar Z, Waks T, GrossG, Schindler DG. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. Proc Natl Acad Sci U S A 1993;90:720-4.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 720-724
-
-
Eshhar, Z.1
Waks, T.2
Gross, F.3
Schindler, D.G.4
-
20
-
-
84967145937
-
Making better chimeric antigen receptors for adoptive T-cell therapy
-
Maus MV, June CH. Making better chimeric antigen receptors for adoptive T-cell therapy. Clin Cancer Res 2016;22:1875-84.
-
(2016)
Clin Cancer Res
, vol.22
, pp. 1875-1884
-
-
Maus, M.V.1
June, C.H.2
-
21
-
-
84908073316
-
Chimeric antigen receptor T cells for sustained remissions in leukemia
-
Maude SL, Frey N, Shaw PA, Aplenc R, Barrett DM, Bunin NJ, et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med 2014;371:1507-17.
-
(2014)
N Engl J Med
, vol.371
, pp. 1507-1517
-
-
Maude, S.L.1
Frey, N.2
Shaw, P.A.3
Aplenc, R.4
Barrett, D.M.5
Bunin, N.J.6
-
22
-
-
84940881287
-
Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
-
Porter DL, Hwang WT, Frey NV, Lacey SF, Shaw PA, Loren AW, et al. Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia. Sci Transl Med 2015;7:303ra139.
-
(2015)
Sci Transl Med
, vol.7
, pp. 303ra139
-
-
Porter, D.L.1
Hwang, W.T.2
Frey, N.V.3
Lacey, S.F.4
Shaw, P.A.5
Loren, A.W.6
-
23
-
-
84941312389
-
Chimeric antigen receptor T cells against CD19 for multiple myeloma
-
Garfall AL, Maus MV, Hwang WT, Lacey SF, Mahnke YD, Melenhorst JJ, et al. Chimeric antigen receptor T cells against CD19 for multiple myeloma. N Engl J Med 2015;373:1040-7.
-
(2015)
N Engl J Med
, vol.373
, pp. 1040-1047
-
-
Garfall, A.L.1
Maus, M.V.2
Hwang, W.T.3
Lacey, S.F.4
Mahnke, Y.D.5
Melenhorst, J.J.6
-
24
-
-
84923118622
-
Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor
-
Kochenderfer JN, Dudley ME, Kassim SH, Somerville RP, Carpenter RO, Stetler-Stevenson M, et al. Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor. J Clin Oncol 2015;33:540-9.
-
(2015)
J Clin Oncol
, vol.33
, pp. 540-549
-
-
Kochenderfer, J.N.1
Dudley, M.E.2
Kassim, S.H.3
Somerville, R.P.4
Carpenter, R.O.5
Stetler-Stevenson, M.6
-
25
-
-
84966769739
-
Targeting the heterogeneity of cancer with individualized neoepitope vaccines
-
Tureci O, Vormehr M, Diken M, Kreiter S, Huber C, Sahin U. Targeting the heterogeneity of cancer with individualized neoepitope vaccines. Clin Cancer Res 2016;22:1885-96.
-
(2016)
Clin Cancer Res
, vol.22
, pp. 1885-1896
-
-
Tureci, O.1
Vormehr, M.2
Diken, M.3
Kreiter, S.4
Huber, C.5
Sahin, U.6
-
26
-
-
84967293088
-
Reversing T-cell dysfunction and exhaustion in cancer
-
Zarour HM. Reversing T-cell dysfunction and exhaustion in cancer. Clin Cancer Res 2016;22:1856-64.
-
(2016)
Clin Cancer Res
, vol.22
, pp. 1856-1864
-
-
Zarour, H.M.1
-
27
-
-
84899673110
-
T-cell and NK-cell infiltration into solid tumors: A key limiting factor for efficacious cancer immunotherapy
-
Melero I, Rouzaut A, Motz GT, Coukos G. T-cell and NK-cell infiltration into solid tumors: A key limiting factor for efficacious cancer immunotherapy. Cancer Discov 2014;4:522-6.
-
(2014)
Cancer Discov
, vol.4
, pp. 522-526
-
-
Melero, I.1
Rouzaut, A.2
Motz, G.T.3
Coukos, G.4
-
28
-
-
84967321420
-
The where, the when, and the how of immune monitoring for cancer immunotherapies in the era of checkpoint inhibition
-
Hegde PS, Karanikas V, Evers S. The where, the when, and the how of immune monitoring for cancer immunotherapies in the era of checkpoint inhibition. Clin Cancer Res 2016;22:1865-74.
-
(2016)
Clin Cancer Res
, vol.22
, pp. 1865-1874
-
-
Hegde, P.S.1
Karanikas, V.2
Evers, S.3
-
29
-
-
84966862666
-
Dendritic cell-based immunotherapy: State of the art and beyond
-
Bol KF, Schreibelt G, Gerritsen WR, de Vries IJM, Figdor CG. Dendritic cell-based immunotherapy: state of the art and beyond. Clin Cancer Res 2016;22:1897-906.
-
(2016)
Clin Cancer Res
, vol.22
, pp. 1897-1906
-
-
Bol, K.F.1
Schreibelt, G.2
Gerritsen, W.R.3
De Vries, I.J.M.4
Figdor, C.G.5
-
30
-
-
84937846973
-
Evolving synergistic combinations of targeted immunotherapies to combat cancer
-
Melero I, Berman DM, Aznar MA, Korman AJ, Perez Gracia JL, Haanen J. Evolving synergistic combinations of targeted immunotherapies to combat cancer. Nat Rev Cancer 2015;15:457-72.
-
(2015)
Nat Rev Cancer
, vol.15
, pp. 457-472
-
-
Melero, I.1
Berman, D.M.2
Aznar, M.A.3
Korman, A.J.4
Perez Gracia, J.L.5
Haanen, J.6
-
31
-
-
84959133719
-
Combination cancer immunotherapies tailored to the tumour microenvironment
-
Smyth MJ, Ngiow SF, Ribas A, Teng MW. Combination cancer immunotherapies tailored to the tumour microenvironment. Nat Rev Clin Oncol 2015;13:143-58.
-
(2015)
Nat Rev Clin Oncol
, vol.13
, pp. 143-158
-
-
Smyth, M.J.1
Ngiow, S.F.2
Ribas, A.3
Teng, M.W.4
-
32
-
-
84929481482
-
Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
-
Postow MA, Chesney J, Pavlick AC, Robert C, Grossmann K, McDermott D, et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N Engl J Med 2015;372:2006-17.
-
(2015)
N Engl J Med
, vol.372
, pp. 2006-2017
-
-
Postow, M.A.1
Chesney, J.2
Pavlick, A.C.3
Robert, C.4
Grossmann, K.5
McDermott, D.6
-
33
-
-
84936147067
-
Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
-
Larkin J, Hodi FS, Wolchok JD. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med 2015; 373:1270-1.
-
(2015)
N Engl J Med
, vol.373
, pp. 1270-1271
-
-
Larkin, J.1
Hodi, F.S.2
Wolchok, J.D.3
-
34
-
-
84879777241
-
Nivolumab plus ipilimumab in advanced melanoma
-
Wolchok JD, Kluger H, Callahan MK, Postow MA, Rizvi NA, Lesokhin AM, et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med 2013;369:122-33.
-
(2013)
N Engl J Med
, vol.369
, pp. 122-133
-
-
Wolchok, J.D.1
Kluger, H.2
Callahan, M.K.3
Postow, M.A.4
Rizvi, N.A.5
Lesokhin, A.M.6
-
35
-
-
63449088194
-
Palettes of vaccines and immunostimulatory monoclonal antibodies for combination
-
Melero I, Martinez-Forero I, Dubrot J, Suarez N, Palazon A, Chen L. Palettes of vaccines and immunostimulatory monoclonal antibodies for combination. Clin Cancer Res 2009;15:1507-9.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1507-1509
-
-
Melero, I.1
Martinez-Forero, I.2
Dubrot, J.3
Suarez, N.4
Palazon, A.5
Chen, L.6
-
36
-
-
84995684655
-
Preliminary results from a phase I/II study of epacadostat (incb024360) in combination with pembrolizumab in patients with selected advanced cancers
-
Gangadhar TC, Hamid O, Smith DC, Bauer TM, Wasser JS, Luke JJ, et al. Preliminary results from a phase I/II study of epacadostat (incb024360) in combination with pembrolizumab in patients with selected advanced cancers. J Immunother Cancer 2015;3 (Suppl 2):O7.
-
(2015)
J Immunother Cancer
, vol.3
, pp. O7
-
-
Gangadhar, T.C.1
Hamid, O.2
Smith, D.C.3
Bauer, T.M.4
Wasser, J.S.5
Luke, J.J.6
-
38
-
-
53549102755
-
The tumor microenvironment and its role in promoting tumor growth
-
Whiteside TL. The tumor microenvironment and its role in promoting tumor growth. Oncogene 2008;27:5904-12.
-
(2008)
Oncogene
, vol.27
, pp. 5904-5912
-
-
Whiteside, T.L.1
-
39
-
-
84947804600
-
Immune suppressive mechanisms in the tumor microenvironment
-
Munn DH, Bronte V. Immune suppressive mechanisms in the tumor microenvironment. Curr Opin Immunol 2015;39:1-6.
-
(2015)
Curr Opin Immunol
, vol.39
, pp. 1-6
-
-
Munn, D.H.1
Bronte, V.2
-
40
-
-
84907055119
-
Induced regulatory T cells in inhibitory microenvironments created by cancer
-
Whiteside TL. Induced regulatory T cells in inhibitory microenvironments created by cancer. Expert Opin Biol Ther 2014;14:1411-25.
-
(2014)
Expert Opin Biol Ther
, vol.14
, pp. 1411-1425
-
-
Whiteside, T.L.1
-
41
-
-
84952720594
-
Myeloid-derived suppressor cells: Critical cells driving immune suppression in the tumor microenvironment
-
Parker KH, Beury DW, Ostrand-Rosenberg S. Myeloid-derived suppressor cells: critical cells driving immune suppression in the tumor microenvironment. Adv Cancer Res 2015;128:95-139.
-
(2015)
Adv Cancer Res
, vol.128
, pp. 95-139
-
-
Parker, K.H.1
Beury, D.W.2
Ostrand-Rosenberg, S.3
-
42
-
-
84941784875
-
Control of regulatory T cell migration, function, and homeostasis
-
Campbell DJ. Control of regulatory T cell migration, function, and homeostasis. J Immunol 2015;195:2507-13.
-
(2015)
J Immunol
, vol.195
, pp. 2507-2513
-
-
Campbell, D.J.1
-
44
-
-
84901334642
-
Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy
-
Highfill SL, Cui Y, Giles AJ, Smith JP, Zhang H, Morse E, et al. Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy. Sci Transl Med 2014;6:237ra67.
-
(2014)
Sci Transl Med
, vol.6
, pp. 237ra67
-
-
Highfill, S.L.1
Cui, Y.2
Giles, A.J.3
Smith, J.P.4
Zhang, H.5
Morse, E.6
-
45
-
-
84902546715
-
Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy
-
Ries CH, Cannarile MA, Hoves S, Benz J, Wartha K, Runza V, et al. Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Cancer Cell 2014;25:846-59.
-
(2014)
Cancer Cell
, vol.25
, pp. 846-859
-
-
Ries, C.H.1
Cannarile, M.A.2
Hoves, S.3
Benz, J.4
Wartha, K.5
Runza, V.6
-
46
-
-
84864005209
-
Phenotypic and functional characteristics ofCD4CD39FOXP3 and CD4 CD39 FOXP3neg T-cell subsets in cancer patients
-
Schuler PJ, Schilling B, HarasymczukM, Hoffmann TK, Johnson J, Lang S, et al. Phenotypic and functional characteristics ofCD4CD39FOXP3 and CD4 CD39 FOXP3neg T-cell subsets in cancer patients. Eur J Immunol 2012;42:1876-85.
-
(2012)
Eur J Immunol
, vol.42
, pp. 1876-1885
-
-
Schuler, P.J.1
Schilling, B.2
Harasymczuk, M.3
Hoffmann, T.K.4
Johnson, J.5
Lang, S.6
-
47
-
-
84887832812
-
Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients
-
Jie HB, Gildener-LeapmanN, Li J, Srivastava RM, Gibson SP, Whiteside TL, et al. Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients. Br J Cancer 2013;109: 2629-35.
-
(2013)
Br J Cancer
, vol.109
, pp. 2629-2635
-
-
Jie, H.B.1
Gildener-Leapmann2
Li, J.3
Srivastava, R.M.4
Gibson, S.P.5
Whiteside, T.L.6
-
48
-
-
73949088551
-
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
-
Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, et al. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med 2009;206: 3015-29.
-
(2009)
J Exp Med
, vol.206
, pp. 3015-3029
-
-
Francisco, L.M.1
Salinas, V.H.2
Brown, K.E.3
Vanguri, V.K.4
Freeman, G.J.5
Kuchroo, V.K.6
-
49
-
-
40549094648
-
Interleukin-2 receptor downstream events in regulatory T cells: Implications for the choice of immunosuppressive drug therapy
-
Zeiser R, Negrin RS. Interleukin-2 receptor downstream events in regulatory T cells: implications for the choice of immunosuppressive drug therapy. Cell Cycle 2008;7:458-62.
-
(2008)
Cell Cycle
, vol.7
, pp. 458-462
-
-
Zeiser, R.1
Negrin, R.S.2
-
50
-
-
84884271914
-
Fc-dependent depletion of tumor-infiltrating regulatory T cells codefines the efficacy of anti-CTLA-4 therapy against melanoma
-
Simpson TR, Li F, Montalvo-Ortiz W, SepulvedaMA, Bergerhoff K, Arce F, et al. Fc-dependent depletion of tumor-infiltrating regulatory T cells codefines the efficacy of anti-CTLA-4 therapy against melanoma. J Exp Med 2013;210:1695-710.
-
(2013)
J Exp Med
, vol.210
, pp. 1695-1710
-
-
Simpson, T.R.1
Li, F.2
Montalvo-Ortiz, W.3
Sepulveda, M.A.4
Bergerhoff, K.5
Arce, F.6
-
51
-
-
84892448554
-
Regulatory T cells in cancer immunotherapy
-
Nishikawa H, Sakaguchi S. Regulatory T cells in cancer immunotherapy. Curr Opin Immunol 2014;27:1-7.
-
(2014)
Curr Opin Immunol
, vol.27
, pp. 1-7
-
-
Nishikawa, H.1
Sakaguchi, S.2
-
52
-
-
84968874219
-
The role of regulatory T cells in cancer immunology
-
Whiteside TL. The role of regulatory T cells in cancer immunology. ImmunoTargets Ther 2015;4:159-71.
-
(2015)
ImmunoTargets Ther
, vol.4
, pp. 159-171
-
-
Whiteside, T.L.1
-
53
-
-
84890298761
-
Effects of adjuvant chemoradiotherapy on the frequency and function of regulatory T cells in patients with head and neck cancer
-
Schuler PJ, Harasymczuk M, Schilling B, Saze Z, Strauss L, Lang S, et al. Effects of adjuvant chemoradiotherapy on the frequency and function of regulatory T cells in patients with head and neck cancer. Clin Cancer Res 2013;19:6585-96.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 6585-6596
-
-
Schuler, P.J.1
Harasymczuk, M.2
Schilling, B.3
Saze, Z.4
Strauss, L.5
Lang, S.6
-
54
-
-
84954349779
-
Consensus nomenclature for CD8 T cell phenotypes in cancer
-
Apetoh L, Smyth MJ, Drake CG, Abastado JP, Apte RN, Ayyoub M, et al. Consensus nomenclature for CD8 T cell phenotypes in cancer. Oncoimmunology 2015;4:e998538.
-
(2015)
Oncoimmunology
, vol.4
, pp. e998538
-
-
Apetoh, L.1
Smyth, M.J.2
Drake, C.G.3
Abastado, J.P.4
Apte, R.N.5
Ayyoub, M.6
-
55
-
-
84863393290
-
CD8() T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1
-
Fourcade J, Sun Z, Pagliano O, Guillaume P, Luescher IF, Sander C, et al. CD8() T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res 2012; 72:887-96.
-
(2012)
Cancer Res
, vol.72
, pp. 887-896
-
-
Fourcade, J.1
Sun, Z.2
Pagliano, O.3
Guillaume, P.4
Luescher, I.F.5
Sander, C.6
-
56
-
-
84935432896
-
Inhibitory receptors as targets for cancer immunotherapy
-
Turnis ME, Andrews LP, Vignali DA. Inhibitory receptors as targets for cancer immunotherapy. Eur J Immunol 2015;45:1892-905.
-
(2015)
Eur J Immunol
, vol.45
, pp. 1892-1905
-
-
Turnis, M.E.1
Andrews, L.P.2
Vignali, D.A.3
-
57
-
-
84922391334
-
Tim-3: An emerging target in the cancer immunotherapy landscape
-
Anderson AC. Tim-3: An emerging target in the cancer immunotherapy landscape. Cancer Immunol Res 2014;2:393-8.
-
(2014)
Cancer Immunol Res
, vol.2
, pp. 393-398
-
-
Anderson, A.C.1
-
58
-
-
84876481083
-
Interfering with coinhibitory molecules: BTLA/HVEM as new targets to enhance anti-tumor immunity
-
Pasero C, Olive D. Interfering with coinhibitory molecules: BTLA/HVEM as new targets to enhance anti-tumor immunity. Immunol Lett 2013; 151:71-5.
-
(2013)
Immunol Lett
, vol.151
, pp. 71-75
-
-
Pasero, C.1
Olive, D.2
-
59
-
-
84925743331
-
Balancing natural killer cell activation through paired receptors
-
Martinet L, Smyth MJ. Balancing natural killer cell activation through paired receptors. Nat Rev Immunol 2015;15:243-54.
-
(2015)
Nat Rev Immunol
, vol.15
, pp. 243-254
-
-
Martinet, L.1
Smyth, M.J.2
-
60
-
-
84874909144
-
Agonist antibodies to TNFR molecules that costimulate T and NK cells
-
Melero I, Hirschhorn-Cymerman D, Morales-Kastresana A, Sanmamed MF, Wolchok JD. Agonist antibodies to TNFR molecules that costimulate T and NK cells. Clin Cancer Res 2013;19:1044-53.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 1044-1053
-
-
Melero, I.1
Hirschhorn-Cymerman, D.2
Morales-Kastresana, A.3
Sanmamed, M.F.4
Wolchok, J.D.5
-
61
-
-
78449237499
-
Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies
-
Ascierto PA, Simeone E, Sznol M, Fu YX, Melero I. Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. Semin Oncol 2010;37:508-16.
-
(2010)
Semin Oncol
, vol.37
, pp. 508-516
-
-
Ascierto, P.A.1
Simeone, E.2
Sznol, M.3
Fu, Y.X.4
Melero, I.5
-
62
-
-
84877059530
-
The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy
-
Moran AE, Kovacsovics-Bankowski M, Weinberg AD. The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy. Curr Opin Immunol 2013;25:230-7.
-
(2013)
Curr Opin Immunol
, vol.25
, pp. 230-237
-
-
Moran, A.E.1
Kovacsovics-Bankowski, M.2
Weinberg, A.D.3
-
64
-
-
84940372582
-
The next hurdle in cancer immunotherapy: Overcoming the non-T-cell-inflamed tumor microenvironment
-
Gajewski TF. The next hurdle in cancer immunotherapy: Overcoming the non-T-cell-inflamed tumor microenvironment. Semin Oncol 2015;42: 663-71.
-
(2015)
Semin Oncol
, vol.42
, pp. 663-671
-
-
Gajewski, T.F.1
-
65
-
-
84929705879
-
Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity
-
Corrales L, Glickman LH, McWhirter SM, Kanne DB, Sivick KE, Katibah GE, et al. Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep 2015;11:1018-30.
-
(2015)
Cell Rep
, vol.11
, pp. 1018-1030
-
-
Corrales, L.1
Glickman, L.H.2
McWhirter, S.M.3
Kanne, D.B.4
Sivick, K.E.5
Katibah, G.E.6
-
66
-
-
84936953099
-
Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity
-
Spranger S, Bao R, Gajewski TF. Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity. Nature 2015;523:231-5.
-
(2015)
Nature
, vol.523
, pp. 231-235
-
-
Spranger, S.1
Bao, R.2
Gajewski, T.F.3
-
67
-
-
84883787417
-
Immunologically augmented cancer treatment using modern radiotherapy
-
Durante M, Reppingen N, Held KD. Immunologically augmented cancer treatment using modern radiotherapy. Trends Mol Med 2013; 19:565-82.
-
(2013)
Trends Mol Med
, vol.19
, pp. 565-582
-
-
Durante, M.1
Reppingen, N.2
Held, K.D.3
-
68
-
-
84919464054
-
Radiotherapy and immunogenic cell death
-
Golden EB, Apetoh L. Radiotherapy and immunogenic cell death. Semin Radiat Oncol 2015;25:11-7.
-
(2015)
Semin Radiat Oncol
, vol.25
, pp. 11-17
-
-
Golden, E.B.1
Apetoh, L.2
-
69
-
-
84875039618
-
Combining radiotherapy and cancer immunotherapy: A paradigm shift
-
Formenti SC, Demaria S. Combining radiotherapy and cancer immunotherapy: A paradigm shift. J Natl Cancer Inst 2013;105:256-65.
-
(2013)
J Natl Cancer Inst
, vol.105
, pp. 256-265
-
-
Formenti, S.C.1
Demaria, S.2
-
71
-
-
84872026647
-
Radiotherapy to convert the tumor into an in situ vaccine
-
Formenti SC, Demaria S. Radiotherapy to convert the tumor into an in situ vaccine. Int J Radiat Oncol Biol Phys 2012;84:879-80.
-
(2012)
Int J Radiat Oncol Biol Phys
, vol.84
, pp. 879-880
-
-
Formenti, S.C.1
Demaria, S.2
-
72
-
-
70149113060
-
Therapeutic effects of ablative radiation on local tumor require CD8 T cells: Changing strategies for cancer treatment
-
Lee Y, Auh SL, Wang Y, Burnette B, Wang Y, Meng Y, et al. Therapeutic effects of ablative radiation on local tumor require CD8 T cells: Changing strategies for cancer treatment. Blood 2009;114:589-95.
-
(2009)
Blood
, vol.114
, pp. 589-595
-
-
Lee, Y.1
Auh, S.L.2
Wang, Y.3
Burnette, B.4
Wang, Y.5
Meng, Y.6
-
73
-
-
0018569985
-
Effect of host immune capability on radiocurability and subsequent transplantability of a murine fibrosarcoma
-
Stone HB, Peters LJ, Milas L. Effect of host immune capability on radiocurability and subsequent transplantability of a murine fibrosarcoma. J Natl Cancer Inst 1979;63:1229-35.
-
(1979)
J Natl Cancer Inst
, vol.63
, pp. 1229-1235
-
-
Stone, H.B.1
Peters, L.J.2
Milas, L.3
-
74
-
-
1242315588
-
Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated
-
Demaria S, Ng B, Devitt M-L, Babb JS, Kawashima N, Liebes L, et al. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol Biol Phys 2004;58: 862-70.
-
(2004)
Int J Radiat Oncol Biol Phys
, vol.58
, pp. 862-870
-
-
Demaria, S.1
Ng, B.2
Devitt, M.-L.3
Babb, J.S.4
Kawashima, N.5
Liebes, L.6
-
75
-
-
84937640449
-
The abscopal effect of local radiotherapy: Using immunotherapy to make a rare event clinically relevant
-
Reynders K, Illidge T, Siva S, Chang JY, De Ruysscher D. The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant. Cancer Treat Rev 2015;41:503-10.
-
(2015)
Cancer Treat Rev
, vol.41
, pp. 503-510
-
-
Reynders, K.1
Illidge, T.2
Siva, S.3
Chang, J.Y.4
De Ruysscher, D.5
-
76
-
-
84912120595
-
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors
-
Woo SR, Fuertes MB, Corrales L, Spranger S, Furdyna MJ, Leung MY, et al. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity 2014;41: 830-42.
-
(2014)
Immunity
, vol.41
, pp. 830-842
-
-
Woo, S.R.1
Fuertes, M.B.2
Corrales, L.3
Spranger, S.4
Furdyna, M.J.5
Leung, M.Y.6
-
77
-
-
84912128872
-
STINGDependent cytosolic DNA sensing promotes radiation-induced type i interferon-dependent antitumor immunity in immunogenic tumors
-
Deng L, Liang H, Xu M, Yang X, Burnette B, Arina A, et al. STINGDependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors. Immunity 2014;41:843-52.
-
(2014)
Immunity
, vol.41
, pp. 843-852
-
-
Deng, L.1
Liang, H.2
Xu, M.3
Yang, X.4
Burnette, B.5
Arina, A.6
-
78
-
-
84955417454
-
In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment
-
Vanpouille-Box C, Pilones KA, Wennerberg E, Formenti SC, Demaria S. In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment. Vaccine 2015;33:7415-22.
-
(2015)
Vaccine
, vol.33
, pp. 7415-7422
-
-
Vanpouille-Box, C.1
Pilones, K.A.2
Wennerberg, E.3
Formenti, S.C.4
Demaria, S.5
-
79
-
-
84886805255
-
Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy
-
Bos PD, Plitas G, Rudra D, Lee SY, Rudensky AY. Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy. J Exp Med 2010;11:2435-66.
-
(2010)
J Exp Med
, vol.11
, pp. 2435-2466
-
-
Bos, P.D.1
Plitas, G.2
Rudra, D.3
Lee, S.Y.4
Rudensky, A.Y.5
-
80
-
-
84877738839
-
CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer
-
Xu J, Escamilla J, Mok S, David J, Priceman S, West B, et al. CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer. Cancer Res 2013;73:2782-94.
-
(2013)
Cancer Res
, vol.73
, pp. 2782-2794
-
-
Xu, J.1
Escamilla, J.2
Mok, S.3
David, J.4
Priceman, S.5
West, B.6
-
81
-
-
84983489005
-
Role of local radiation therapy in cancer immunotherapy
-
Demaria S, Golden EB, Formenti SC. Role of local radiation therapy in cancer immunotherapy. JAMA Oncol 2015;1:1325-32.
-
(2015)
JAMA Oncol
, vol.1
, pp. 1325-1332
-
-
Demaria, S.1
Golden, E.B.2
Formenti, S.C.3
-
82
-
-
78049420571
-
In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: A phase I/II study
-
Brody JD, Ai WZ, Czerwinski DK, Torchia JA, Levy M, Advani RH, et al. In situ vaccination with a TLR9 agonist induces systemic lymphoma regression: A phase I/II study. J Clin Oncol 2010;28:4324-32.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4324-4332
-
-
Brody, J.D.1
Ai, W.Z.2
Czerwinski, D.K.3
Torchia, J.A.4
Levy, M.5
Advani, R.H.6
-
83
-
-
84937525789
-
Local radiotherapy and GM-CSF in patients with metastatic solid tumors: A proof of principle trial to generate abscopal responses
-
Golden EB, Chhabra A, Chachoua A, Adams S, Donach M, Fenton-Kerimian M, et al. Local radiotherapy and GM-CSF in patients with metastatic solid tumors: A proof of principle trial to generate abscopal responses. Lancet Oncol 2015;16:795-803.
-
(2015)
Lancet Oncol
, vol.16
, pp. 795-803
-
-
Golden, E.B.1
Chhabra, A.2
Chachoua, A.3
Adams, S.4
Donach, M.5
Fenton-Kerimian, M.6
-
84
-
-
84862124594
-
Phase 1 study of stereotactic body radiotherapy and interleukin-2-tumor and immunological responses
-
Seung SK, Curti BD, Crittenden M, Walker E, Coffey T, Siebert JC, et al. Phase 1 study of stereotactic body radiotherapy and interleukin-2-tumor and immunological responses. Sci Transl Med 2012;4:137ra74.
-
(2012)
Sci Transl Med
, vol.4
, pp. 137ra74
-
-
Seung, S.K.1
Curti, B.D.2
Crittenden, M.3
Walker, E.4
Coffey, T.5
Siebert, J.C.6
-
85
-
-
84919494209
-
Current clinical trials testing combinations of immunotherapy and radiation
-
Crittenden M, Kohrt H, Levy R, Jones J, Camphausen K, Dicker A, et al. Current clinical trials testing combinations of immunotherapy and radiation. Semin Radiat Oncol 2015;25:54-64.
-
(2015)
Semin Radiat Oncol
, vol.25
, pp. 54-64
-
-
Crittenden, M.1
Kohrt, H.2
Levy, R.3
Jones, J.4
Camphausen, K.5
Dicker, A.6
-
87
-
-
84857815877
-
Immunologic correlates of the abscopal effect in a patient with melanoma
-
Postow MA, Callahan MK, Barker CA, Yamada Y, Yuan J, Kitano S, et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med 2012;366:925-31.
-
(2012)
N Engl J Med
, vol.366
, pp. 925-931
-
-
Postow, M.A.1
Callahan, M.K.2
Barker, C.A.3
Yamada, Y.4
Yuan, J.5
Kitano, S.6
-
88
-
-
84904061705
-
Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy
-
Grimaldi AM, Simeone E, Giannarelli D, Muto P, Falivene S, Borzillo V, et al. Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy. Oncoimmunology 2014;3:e28780.
-
(2014)
Oncoimmunology
, vol.3
, pp. e28780
-
-
Grimaldi, A.M.1
Simeone, E.2
Giannarelli, D.3
Muto, P.4
Falivene, S.5
Borzillo, V.6
-
89
-
-
85003053854
-
An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer
-
Golden EB, Demaria S, Schiff PB, Chachoua A, Formenti SC. An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer. Cancer Immunol Res 2013;1: 365-72.
-
(2013)
Cancer Immunol Res
, vol.1
, pp. 365-372
-
-
Golden, E.B.1
Demaria, S.2
Schiff, P.B.3
Chachoua, A.4
Formenti, S.C.5
-
90
-
-
76749084659
-
Randomized phase II clinical trial comparing tremelimumab (CP-675, 206) with best supportive care (BSC) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC)
-
Zatloukal P, Heo DS, Park K, Kang J, Butts C, Bradford D, et al. Randomized phase II clinical trial comparing tremelimumab (CP-675, 206) with best supportive care (BSC) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2009;27:8071.
-
(2009)
J Clin Oncol
, vol.27
, pp. 8071
-
-
Zatloukal, P.1
Heo, D.S.2
Park, K.3
Kang, J.4
Butts, C.5
Bradford, D.6
-
91
-
-
84964229943
-
Abscopla responses in metastatic non-small cell lung cancer (NSCLC) patients treatded on a phase 2 study of combined radiation therapy and ipilimumab: Evidence for the in situ vaccination hypothesis of radiation
-
Golden EB, Chachoua A, Fenton-Kerimian MB, Demaria S, Formenti SC. Abscopla responses in metastatic non-small cell lung cancer (NSCLC) patients treatded on a phase 2 study of combined radiation therapy and ipilimumab: evidence for the in situ vaccination hypothesis of radiation. Int J Radiat Oncol Biol Phys 2015; 93:S66-7.
-
(2015)
Int J Radiat Oncol Biol Phys
, vol.93
, pp. S66-S67
-
-
Golden, E.B.1
Chachoua, A.2
Fenton-Kerimian, M.B.3
Demaria, S.4
Formenti, S.C.5
-
92
-
-
84901641673
-
Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): A multicentre, randomised, double-blind, phase 3 trial
-
Kwon ED, Drake CG, Scher HI, Fizazi K, Bossi A, van den Eertwegh AJ, et al. Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): A multicentre, randomised, double-blind, phase 3 trial. Lancet Oncol 2014;15: 700-12.
-
(2014)
Lancet Oncol
, vol.15
, pp. 700-712
-
-
Kwon, E.D.1
Drake, C.G.2
Scher, H.I.3
Fizazi, K.4
Bossi, A.5
Van Den Eertwegh, A.J.6
-
93
-
-
69949085196
-
Fractionated but not single dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
-
Dewan MZ, Galloway AE, Kawashima N, Dewyngaert JK, Babb JS, Formenti SC, et al. Fractionated but not single dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res 2009;15: 5379-88.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5379-5388
-
-
Dewan, M.Z.1
Galloway, A.E.2
Kawashima, N.3
Dewyngaert, J.K.4
Babb, J.S.5
Formenti, S.C.6
-
94
-
-
84928770388
-
Neoantigens in cancer immunotherapy
-
Schumacher TN, Schreiber RD. Neoantigens in cancer immunotherapy. Science 2015;348:69-74.
-
(2015)
Science
, vol.348
, pp. 69-74
-
-
Schumacher, T.N.1
Schreiber, R.D.2
-
95
-
-
84942855711
-
FDA approval: Blinatumomab
-
Przepiorka D, Ko CW, Deisseroth A, Yancey CL, Candau-Chacon R, Chiu HJ, et al. FDA approval: Blinatumomab. Clin Cancer Res 2015; 21:4035-9.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 4035-4039
-
-
Przepiorka, D.1
Ko, C.W.2
Deisseroth, A.3
Yancey, C.L.4
Candau-Chacon, R.5
Chiu, H.J.6
-
96
-
-
84898733422
-
Intratumoral immunization: A new paradigm for cancer therapy
-
Marabelle A, Kohrt H, Caux C, Levy R. Intratumoral immunization: A new paradigm for cancer therapy. Clin Cancer Res 2014;20: 1747-56.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 1747-1756
-
-
Marabelle, A.1
Kohrt, H.2
Caux, C.3
Levy, R.4
-
97
-
-
84933586864
-
Talimogene laherparepvec improves durable response rate in patients with advanced melanoma
-
Andtbacka RH, Kaufman HL, Collichio F, Amatruda T, Senzer N, Chesney J, et al. Talimogene laherparepvec improves durable response rate in patients with advanced melanoma. J Clin Oncol 2015;33:2780-8.
-
(2015)
J Clin Oncol
, vol.33
, pp. 2780-2788
-
-
Andtbacka, R.H.1
Kaufman, H.L.2
Collichio, F.3
Amatruda, T.4
Senzer, N.5
Chesney, J.6
-
98
-
-
84942944907
-
Nivolumab and urelumab enhance antitumor activity of human T lymphocytes engrafted in Rag2-/-IL2Rgammanull immunodeficient mice
-
Sanmamed MF, Rodriguez I, Schalper KA, Onate C, Azpilikueta A, Rodriguez-Ruiz ME, et al. Nivolumab and urelumab enhance antitumor activity of human T lymphocytes engrafted in Rag2-/-IL2Rgammanull immunodeficient mice. Cancer Res 2015; 75:3466-78.
-
(2015)
Cancer Res
, vol.75
, pp. 3466-3478
-
-
Sanmamed, M.F.1
Rodriguez, I.2
Schalper, K.A.3
Onate, C.4
Azpilikueta, A.5
Rodriguez-Ruiz, M.E.6
-
99
-
-
84929481481
-
Pembrolizumab versus ipilimumab in advanced melanoma
-
Robert C, Schachter J, Long GV, Arance A, Grob JJ, Mortier L, et al. Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med 2015;372:2521-32.
-
(2015)
N Engl J Med
, vol.372
, pp. 2521-2532
-
-
Robert, C.1
Schachter, J.2
Long, G.V.3
Arance, A.4
Grob, J.J.5
Mortier, L.6
-
100
-
-
84938205998
-
Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): A randomised, controlled, phase 2 trial
-
Ribas A, Puzanov I, Dummer R, Schadendorf D, Hamid O, Robert C, et al. Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): A randomised, controlled, phase 2 trial. Lancet Oncol 2015;16:908-18.
-
(2015)
Lancet Oncol
, vol.16
, pp. 908-918
-
-
Ribas, A.1
Puzanov, I.2
Dummer, R.3
Schadendorf, D.4
Hamid, O.5
Robert, C.6
-
101
-
-
84925222119
-
Nivolumab in previously untreated melanoma without BRAF mutation
-
Robert C, Long GV, Brady B, Dutriaux C, Maio M, Mortier L, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med 2015;372:320-30.
-
(2015)
N Engl J Med
, vol.372
, pp. 320-330
-
-
Robert, C.1
Long, G.V.2
Brady, B.3
Dutriaux, C.4
Maio, M.5
Mortier, L.6
-
102
-
-
84931083080
-
Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): A randomised, controlled, open-label, phase 3 trial
-
Weber JS, D'Angelo SP, Minor D, Hodi FS, Gutzmer R, Neyns B, et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): A randomised, controlled, open-label, phase 3 trial. Lancet Oncol 2015;16: 375-84.
-
(2015)
Lancet Oncol
, vol.16
, pp. 375-384
-
-
Weber, J.S.1
D'Angelo, S.P.2
Minor, D.3
Hodi, F.S.4
Gutzmer, R.5
Neyns, B.6
-
103
-
-
84936791837
-
Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
-
Brahmer J, Reckamp KL, Baas P, Crino L, Eberhardt WE, Poddubskaya E, et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med 2015; 373:123-35.
-
(2015)
N Engl J Med
, vol.373
, pp. 123-135
-
-
Brahmer, J.1
Reckamp, K.L.2
Baas, P.3
Crino, L.4
Eberhardt, W.E.5
Poddubskaya, E.6
-
104
-
-
84960187594
-
Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): A randomised controlled trial
-
Dec 18. pii: S0140-6736(15) 01281-7
-
Herbst RS, Baas P, Kim DW, Felip E, Perez-Gracia JL, Han JY, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): A randomised controlled trial. Lancet 2015 Dec 18. pii: S0140-6736(15) 01281-7
-
(2015)
Lancet
-
-
Herbst, R.S.1
Baas, P.2
Kim, D.W.3
Felip, E.4
Perez-Gracia, J.L.5
Han, J.Y.6
-
105
-
-
84944937210
-
Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
-
Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med 2015;373:1627-39.
-
(2015)
N Engl J Med
, vol.373
, pp. 1627-1639
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
Spigel, D.R.4
Steins, M.5
Ready, N.E.6
-
106
-
-
84933678156
-
Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): A randomised, double-blind, phase 3 trial
-
Eggermont AM, Chiarion-Sileni V, Grob JJ, Dummer R, Wolchok JD, Schmidt H, et al. Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): A randomised, double-blind, phase 3 trial. Lancet Oncol 2015;16:522-30.
-
(2015)
Lancet Oncol
, vol.16
, pp. 522-530
-
-
Eggermont, A.M.1
Chiarion-Sileni, V.2
Grob, J.J.3
Dummer, R.4
Wolchok, J.D.5
Schmidt, H.6
-
107
-
-
84928760665
-
Anti-programmed cell death protein-1/ligand-1 therapy in different cancers
-
Homet Moreno B, Ribas A. Anti-programmed cell death protein-1/ligand-1 therapy in different cancers. Br J Cancer 2015;112:1421-7.
-
(2015)
Br J Cancer
, vol.112
, pp. 1421-1427
-
-
Homet Moreno, B.1
Ribas, A.2
-
108
-
-
84928062583
-
Immune checkpoint blockade: A common denominator approach to cancer therapy
-
Topalian SL, Drake CG, Pardoll DM. Immune checkpoint blockade: A common denominator approach to cancer therapy. Cancer Cell 2015; 27:450-61.
-
(2015)
Cancer Cell
, vol.27
, pp. 450-461
-
-
Topalian, S.L.1
Drake, C.G.2
Pardoll, D.M.3
-
109
-
-
84942890083
-
IL10 and PD-1 cooperate to limit the activity of tumor-specific CD8 T cells
-
Sun Z, Fourcade J, Pagliano O, Chauvin JM, Sander C, Kirkwood JM, et al. IL10 and PD-1 cooperate to limit the activity of tumor-specific CD8 T cells. Cancer Res 2015;75:1635-44.
-
(2015)
Cancer Res
, vol.75
, pp. 1635-1644
-
-
Sun, Z.1
Fourcade, J.2
Pagliano, O.3
Chauvin, J.M.4
Sander, C.5
Kirkwood, J.M.6
-
110
-
-
0035496946
-
Interleukin-10 promotes the maintenance of antitumor CD8() T-cell effector function in situ
-
Fujii S, Shimizu K, Shimizu T, Lotze MT. Interleukin-10 promotes the maintenance of antitumor CD8() T-cell effector function in situ. Blood 2001;98:2143-51.
-
(2001)
Blood
, vol.98
, pp. 2143-2151
-
-
Fujii, S.1
Shimizu, K.2
Shimizu, T.3
Lotze, M.T.4
-
111
-
-
84865787544
-
Molecular pathways: Targeting the TGF-beta pathway for cancer therapy
-
Smith AL, Robin TP, Ford HL. Molecular pathways: Targeting the TGF-beta pathway for cancer therapy. Clin Cancer Res 2012;18: 4514-21.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 4514-4521
-
-
Smith, A.L.1
Robin, T.P.2
Ford, H.L.3
-
113
-
-
84908005764
-
A first in man phase i trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors
-
Soliman HH, Jackson E, Neuger T, Dees EC, Harvey RD, Han H, et al. A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors. Oncotarget 2014;5:8136-46.
-
(2014)
Oncotarget
, vol.5
, pp. 8136-8146
-
-
Soliman, H.H.1
Jackson, E.2
Neuger, T.3
Dees, E.C.4
Harvey, R.D.5
Han, H.6
-
115
-
-
41149148269
-
Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: Mechanisms and therapeutic perspectives
-
Rodriguez PC, Ochoa AC. Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: Mechanisms and therapeutic perspectives. Immunol Rev 2008;222:180-91.
-
(2008)
Immunol Rev
, vol.222
, pp. 180-191
-
-
Rodriguez, P.C.1
Ochoa, A.C.2
-
116
-
-
80051508106
-
Targeting human inducible regulatory T cells (Tr1) in patients with cancer: Blocking of adenosineprostaglandin E(2) cooperation
-
Mandapathil M, Whiteside TL. Targeting human inducible regulatory T cells (Tr1) in patients with cancer: Blocking of adenosineprostaglandin E(2) cooperation. Expert Opin Biol Ther 2011;11: 1203-14.
-
(2011)
Expert Opin Biol Ther
, vol.11
, pp. 1203-1214
-
-
Mandapathil, M.1
Whiteside, T.L.2
-
117
-
-
84916605955
-
The role of prostaglandin E2 in renal cell cancer development: Future implications for prognosis and therapy
-
Kaminska K, Szczylik C, Lian F, Czarnecka AM. The role of prostaglandin E2 in renal cell cancer development: Future implications for prognosis and therapy. Future Oncol 2014;10: 2177-87.
-
(2014)
Future Oncol
, vol.10
, pp. 2177-2187
-
-
Kaminska, K.1
Szczylik, C.2
Lian, F.3
Czarnecka, A.M.4
-
118
-
-
84883673050
-
Adenosine and prostaglandin e2 production by human inducible regulatory T cells in health and disease
-
Whiteside TL, Jackson EK. Adenosine and prostaglandin e2 production by human inducible regulatory T cells in health and disease. Front Immunol 2013;4:212.
-
(2013)
Front Immunol
, vol.4
, pp. 212
-
-
Whiteside, T.L.1
Jackson, E.K.2
-
119
-
-
84886432843
-
Targeting CD73 enhances the antitumor activity of anti-PD-1 and anti-CTLA-4 mAbs
-
Allard B, Pommey S, Smyth MJ, Stagg J. Targeting CD73 enhances the antitumor activity of anti-PD-1 and anti-CTLA-4 mAbs. Clin Cancer Res 2013;19:5626-35.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 5626-5635
-
-
Allard, B.1
Pommey, S.2
Smyth, M.J.3
Stagg, J.4
-
120
-
-
84904254163
-
Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor
-
Mittal D, Young A, Stannard K, Yong M, Teng MW, Allard B, et al. Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor. Cancer Res 2014;74:3652-8.
-
(2014)
Cancer Res
, vol.74
, pp. 3652-3658
-
-
Mittal, D.1
Young, A.2
Stannard, K.3
Yong, M.4
Teng, M.W.5
Allard, B.6
-
121
-
-
84887940292
-
Oxidative stress in carcinogenesis: New synthetic compounds with dual effects upon free radicals and cancer
-
Tekiner-Gulbas B, Westwell AD, Suzen S. Oxidative stress in carcinogenesis: New synthetic compounds with dual effects upon free radicals and cancer. Curr Med Chem 2013;20:4451-9.
-
(2013)
Curr Med Chem
, vol.20
, pp. 4451-4459
-
-
Tekiner-Gulbas, B.1
Westwell, A.D.2
Suzen, S.3
-
122
-
-
84939261397
-
Reactive oxygen species in redox cancer therapy
-
Tong L, Chuang CC, Wu S, Zuo L. Reactive oxygen species in redox cancer therapy. Cancer Lett 2015;367:18-25.
-
(2015)
Cancer Lett
, vol.367
, pp. 18-25
-
-
Tong, L.1
Chuang, C.C.2
Wu, S.3
Zuo, L.4
-
123
-
-
84861175955
-
CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients
-
Rech AJ, Mick R, Martin S, Recio A, Aqui NA, Powell DJ Jr., et al. CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients. Sci Transl Med 2012; 4:134ra62.
-
(2012)
Sci Transl Med
, vol.4
, pp. 134ra62
-
-
Rech, A.J.1
Mick, R.2
Martin, S.3
Recio, A.4
Aqui, N.A.5
Powell, D.J.6
-
124
-
-
36148939150
-
IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity
-
Litzinger MT, Fernando R, Curiel TJ, Grosenbach DW, Schlom J, Palena C. IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity. Blood 2007;110:3192-201.
-
(2007)
Blood
, vol.110
, pp. 3192-3201
-
-
Litzinger, M.T.1
Fernando, R.2
Curiel, T.J.3
Grosenbach, D.W.4
Schlom, J.5
Palena, C.6
-
125
-
-
84897116498
-
Diphtheria toxin-based bivalent human IL-2 fusion toxin with improved efficacy for targeting human CD25() cells
-
Peraino JS, Zhang H, Rajasekera PV, Wei M, Madsen JC, Sachs DH, et al. Diphtheria toxin-based bivalent human IL-2 fusion toxin with improved efficacy for targeting human CD25() cells. J Immunol Methods 2014;405:57-66.
-
(2014)
J Immunol Methods
, vol.405
, pp. 57-66
-
-
Peraino, J.S.1
Zhang, H.2
Rajasekera, P.V.3
Wei, M.4
Madsen, J.C.5
Sachs, D.H.6
-
126
-
-
15944410592
-
Inhibition of CD4()25 T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
-
Lutsiak ME, Semnani RT, De Pascalis R, Kashmiri SV, Schlom J, Sabzevari H. Inhibition of CD4()25 T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide. Blood 2005;105:2862-8.
-
(2005)
Blood
, vol.105
, pp. 2862-2868
-
-
Lutsiak, M.E.1
Semnani, R.T.2
De Pascalis, R.3
Kashmiri, S.V.4
Schlom, J.5
Sabzevari, H.6
-
127
-
-
84862143053
-
Melanoma-induced immunosuppression and its neutralization
-
Umansky V, Sevko A. Melanoma-induced immunosuppression and its neutralization. Semin Cancer Biol 2012;22:319-26.
-
(2012)
Semin Cancer Biol
, vol.22
, pp. 319-326
-
-
Umansky, V.1
Sevko, A.2
-
128
-
-
84896523643
-
Ipilimumab treatment results in an early decrease in the frequency of circulating granulocytic myeloid-derived suppressor cells as well as their Arginase1 production
-
Pico de Coana Y, Poschke I, Gentilcore G, Mao Y, NystromM, Hansson J, et al. Ipilimumab treatment results in an early decrease in the frequency of circulating granulocytic myeloid-derived suppressor cells as well as their Arginase1 production. Cancer Immunol Res 2013;1: 158-62.
-
(2013)
Cancer Immunol Res
, vol.1
, pp. 158-162
-
-
Pico De Coana, Y.1
Poschke, I.2
Gentilcore, G.3
Mao, Y.4
Nystrom, M.5
Hansson, J.6
-
129
-
-
78649674576
-
Targeting immune suppressing myeloid-derived suppressor cells in oncology
-
Kao J, Ko EC, Eisenstein S, Sikora AG, Fu S, Chen SH. Targeting immune suppressing myeloid-derived suppressor cells in oncology. Crit Rev Oncol Hematol 2011;77:12-9.
-
(2011)
Crit Rev Oncol Hematol
, vol.77
, pp. 12-19
-
-
Kao, J.1
Ko, E.C.2
Eisenstein, S.3
Sikora, A.G.4
Fu, S.5
Chen, S.H.6
-
130
-
-
77951086882
-
5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T celldependent antitumor immunity
-
Vincent J, Mignot G, Chalmin F, Ladoire S, Bruchard M, Chevriaux A, et al. 5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T celldependent antitumor immunity. Cancer Res 2010;70:3052-61.
-
(2010)
Cancer Res
, vol.70
, pp. 3052-3061
-
-
Vincent, J.1
Mignot, G.2
Chalmin, F.3
Ladoire, S.4
Bruchard, M.5
Chevriaux, A.6
-
132
-
-
77953718827
-
"Hard" and "soft" lesions underlying the HLA class i alterations in cancer cells: Implications for immunotherapy
-
Garrido F, Cabrera T, Aptsiauri N. "Hard" and "soft" lesions underlying the HLA class I alterations in cancer cells: implications for immunotherapy. Int J Cancer 2010;127:249-56.
-
(2010)
Int J Cancer
, vol.127
, pp. 249-256
-
-
Garrido, F.1
Cabrera, T.2
Aptsiauri, N.3
-
133
-
-
27944434228
-
Molecular mechanisms of HLA class i antigen abnormalities following viral infection and transformation
-
Seliger B, Ritz U, Ferrone S. Molecular mechanisms of HLA class I antigen abnormalities following viral infection and transformation. Int J Cancer 2006;118:129-38.
-
(2006)
Int J Cancer
, vol.118
, pp. 129-138
-
-
Seliger, B.1
Ritz, U.2
Ferrone, S.3
-
134
-
-
84941366350
-
Phosphoenolpyruvate is a metabolic checkpoint of antitumor T cell responses
-
Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, et al. Phosphoenolpyruvate is a metabolic checkpoint of antitumor T cell responses. Cell 2015;162:1217-28.
-
(2015)
Cell
, vol.162
, pp. 1217-1228
-
-
Ho, P.C.1
Bihuniak, J.D.2
Macintyre, A.N.3
Staron, M.4
Liu, X.5
Amezquita, R.6
-
135
-
-
84941344937
-
Metabolic competition in the tumor microenvironment is a driver of cancer progression
-
Chang CH, Qiu J, O'Sullivan D, Buck MD, Noguchi T, Curtis JD, et al. Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell 2015;162:1229-41.
-
(2015)
Cell
, vol.162
, pp. 1229-1241
-
-
Chang, C.H.1
Qiu, J.2
O'Sullivan, D.3
Buck, M.D.4
Noguchi, T.5
Curtis, J.D.6
|