-
1
-
-
79956084444
-
Understand memory, design better vaccines
-
Bevan, M. J. Understand memory, design better vaccines. Nature Immunol. 12, 463-465 (2011).
-
(2011)
Nature Immunol.
, vol.12
, pp. 463-465
-
-
Bevan, M.J.1
-
2
-
-
79956079190
-
Immunological mechanisms of vaccination
-
Pulendran, B. & Ahmed, R. Immunological mechanisms of vaccination. Nature Immunol. 12, 509-517 (2011).
-
(2011)
Nature Immunol.
, vol.12
, pp. 509-517
-
-
Pulendran, B.1
Ahmed, R.2
-
3
-
-
0033554726
-
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
-
Sallusto, F., Lenig, D., Forster, R., Lipp, M. & Lanzavecchia, A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708-712 (1999).
-
(1999)
Nature
, vol.401
, pp. 708-712
-
-
Sallusto, F.1
Lenig, D.2
Forster, R.3
Lipp, M.4
Lanzavecchia, A.5
-
4
-
-
79956125257
-
Origins of CD4+ effector and central memory T cells
-
Pepper, M. & Jenkins, M. K. Origins of CD4+ effector and central memory T cells. Nature Immunol. 12, 467-471 (2011).
-
(2011)
Nature Immunol.
, vol.12
, pp. 467-471
-
-
Pepper, M.1
Jenkins, M.K.2
-
5
-
-
33745193973
-
Gene expression microarrays: Glimpses of the immunological genome
-
DOI 10.1038/ni0706-686, PII N0706686
-
Hyatt, G. et al. Gene expression microarrays: glimpses of the immunological genome. Nature Immunol. 7, 686-691 (2006). (Pubitemid 43905863)
-
(2006)
Nature Immunology
, vol.7
, Issue.7
, pp. 686-691
-
-
Hyatt, G.1
Melamed, R.2
Park, R.3
Seguritan, R.4
Laplace, C.5
Poirot, L.6
Zucchelli, S.7
Obst, R.8
Matos, M.9
Venanzi, E.10
Goldrath, A.11
Nguyen, L.12
Luckey, J.13
Yamagata, T.14
Herman, A.15
Jacobs, J.16
Mathis, D.17
Benoist, C.18
-
6
-
-
76949094687
-
Integrating genomic signatures for immunologic discovery
-
Haining, W. N. & Wherry, E. J. Integrating genomic signatures for immunologic discovery. Immunity 32, 152-161 (2010).
-
(2010)
Immunity
, vol.32
, pp. 152-161
-
-
Haining, W.N.1
Wherry, E.J.2
-
7
-
-
0037074012
-
Molecular and functional profiling of memory CD8 T cell differentiation
-
DOI 10.1016/S0092-8674(02)01139-X
-
Kaech, S. M., Hemby, S., Kersh, E. & Ahmed, R. Molecular and functional profiling of memory CD8 T cell differentiation. Cell 111, 837-851 (2002). (Pubitemid 36106405)
-
(2002)
Cell
, vol.111
, Issue.6
, pp. 837-851
-
-
Kaech, S.M.1
Hemby, S.2
Kersh, E.3
Ahmed, R.4
-
8
-
-
84858795432
-
-
This pioneering study showed the changes in global gene expression that occur as CD8+ naive T cells differentiate into effector and then memory T cells after viral infection and suggested that antigen-specific CD8+ T cells progressively differentiate into memory T cells following viral infection
-
This pioneering study showed the changes in global gene expression that occur as CD8+ naive T cells differentiate into effector and then memory T cells after viral infection and suggested that antigen-specific CD8+ T cells progressively differentiate into memory T cells following viral infection.
-
-
-
-
9
-
-
0035877112
-
+ T cells
-
Liu, K. et al. Augmentation in expression of activation-induced genes differentiates memory from naive CD4+ T cells and is a molecular mechanism for enhanced cellular response of memory CD4+ T cells. J. Immunol. 166, 7335-7344 (2001). (Pubitemid 32525609)
-
(2001)
Journal of Immunology
, vol.166
, Issue.12
, pp. 7335-7344
-
-
Liu, K.1
Li, Y.2
Prabhu, V.3
Young, L.4
Becker, K.G.5
Munson, P.J.6
Weng, N.-P.7
-
10
-
-
17244367884
-
Memory T cells have gene expression patterns intermediate between naïve and effector
-
DOI 10.1073/pnas.0501437102
-
Holmes, S., He, M., Xu, T. & Lee, P. P. Memory T cells have gene expression patterns intermediate between naive and effector. Proc. Natl Acad. Sci. USA 102, 5519-5523 (2005). (Pubitemid 40530290)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.15
, pp. 5519-5523
-
-
Holmes, S.1
He, M.2
Xu, T.3
Lee, P.P.4
-
11
-
-
27144467425
-
Molecular signatures distinguish human central memory from effector memory CD8 T cell subsets
-
Willinger, T., Freeman, T., Hasegawa, H., McMichael, A. J. & Callan, M. F. Molecular signatures distinguish human central memory from effector memory CD8 T cell subsets. J. Immunol. 175, 5895-5903 (2005). (Pubitemid 41508074)
-
(2005)
Journal of Immunology
, vol.175
, Issue.9
, pp. 5895-5903
-
-
Willinger, T.1
Freeman, T.2
Hasegawa, H.3
McMichael, A.J.4
Callan, M.F.C.5
-
12
-
-
33644746220
-
Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells
-
DOI 10.1073/pnas.0511137103
-
Luckey, C. J. et al. Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. Proc. Natl Acad. Sci. USA 103, 3304-3309 (2006). (Pubitemid 43346465)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.9
, pp. 3304-3309
-
-
Luckey, C.J.1
Bhattacharya, D.2
Goldrath, A.W.3
Weissman, I.L.4
Benoist, C.5
Mathis, D.6
-
13
-
-
49649105526
-
Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells
-
Haining, W. N. et al. Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells. J. Immunol. 181, 1859-1868 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 1859-1868
-
-
Haining, W.N.1
-
14
-
-
67349169780
-
Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells
-
Araki, Y. et al. Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells. Immunity 30, 912-925 (2009).
-
(2009)
Immunity
, vol.30
, pp. 912-925
-
-
Araki, Y.1
-
15
-
-
84858793591
-
-
This study identifies four different modes of association between histone methylation and differential gene expression in CD8+ memory T cells, providing a chromatin basis for the differential gene expression and function of memory CD8+ T cells
-
This study identifies four different modes of association between histone methylation and differential gene expression in CD8+ memory T cells, providing a chromatin basis for the differential gene expression and function of memory CD8+ T cells.
-
-
-
-
16
-
-
77954956266
-
Repetitive antigen stimulation induces stepwise transcriptome diversification but preserves a core signature of memory CD8+ T cell differentiation
-
Wirth, T. C. et al. Repetitive antigen stimulation induces stepwise transcriptome diversification but preserves a core signature of memory CD8+ T cell differentiation. Immunity 33, 128-140 (2010).
-
(2010)
Immunity
, vol.33
, pp. 128-140
-
-
Wirth, T.C.1
-
17
-
-
84858793592
-
-
This study reveals signature genes of CD8+ memory T cells and their complex regulation following repeated antigenic challenges
-
This study reveals signature genes of CD8+ memory T cells and their complex regulation following repeated antigenic challenges.
-
-
-
-
18
-
-
79956196930
-
CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses
-
Chevalier, N. et al. CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses. J. Immunol. 186, 5556-5568 (2011).
-
(2011)
J. Immunol.
, vol.186
, pp. 5556-5568
-
-
Chevalier, N.1
-
19
-
-
78651486442
-
Densely interconnected transcriptional circuits control cell states in human hematopoiesis
-
Novershtern, N. et al. Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell 144, 296-309 (2011).
-
(2011)
Cell
, vol.144
, pp. 296-309
-
-
Novershtern, N.1
-
20
-
-
80755163540
-
Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4+ cell properties during viral infection
-
Marshall, H. D. et al. Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4+ cell properties during viral infection. Immunity 35, 633-646 (2011).
-
(2011)
Immunity
, vol.35
, pp. 633-646
-
-
Marshall, H.D.1
-
21
-
-
80052035077
-
Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b
-
Rossi, R. L. et al. Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b. Nature Immunol. 12, 796-803 (2011).
-
(2011)
Nature Immunol.
, vol.12
, pp. 796-803
-
-
Rossi, R.L.1
-
22
-
-
78049414864
-
Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation
-
Hertoghs, K. M. et al. Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation. J. Clin. Invest. 120, 4077-4090 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 4077-4090
-
-
Hertoghs, K.M.1
-
23
-
-
77952574804
-
Identification of stem cell transcriptional programs normally expressed in embryonic and neural stem cells in alloreactive CD8+ T cells mediating graft-versus-host disease
-
Kato, K. et al. Identification of stem cell transcriptional programs normally expressed in embryonic and neural stem cells in alloreactive CD8+ T cells mediating graft-versus-host disease. Biol. Blood Marrow Transplant. 16, 751-771 (2010).
-
(2010)
Biol. Blood Marrow Transplant.
, vol.16
, pp. 751-771
-
-
Kato, K.1
-
24
-
-
80052684354
-
Innate signals overcome acquired TCR signaling pathway regulation and govern the fate of human CD161hi CD8α+ semi-invariant T cells
-
Turtle, C. J. et al. Innate signals overcome acquired TCR signaling pathway regulation and govern the fate of human CD161hi CD8α+ semi-invariant T cells. Blood 118, 2752-2762 (2011).
-
(2011)
Blood
, vol.118
, pp. 2752-2762
-
-
Turtle, C.J.1
-
25
-
-
79960429950
-
Transcriptional control of rapid recall by memory CD4 T cells
-
Lai, W. et al. Transcriptional control of rapid recall by memory CD4 T cells. J. Immunol. 187, 133-140 (2011).
-
(2011)
J. Immunol.
, vol.187
, pp. 133-140
-
-
Lai, W.1
-
26
-
-
78049402859
-
Molecular signals of epigenetic states
-
Bonasio, R., Tu, S. & Reinberg, D. Molecular signals of epigenetic states. Science 330, 612-616 (2010).
-
(2010)
Science
, vol.330
, pp. 612-616
-
-
Bonasio, R.1
Tu, S.2
Reinberg, D.3
-
27
-
-
34249299791
-
The complex language of chromatin regulation during transcription
-
DOI 10.1038/nature05915, PII NATURE05915
-
Berger, S. L. The complex language of chromatin regulation during transcription. Nature 447, 407-412 (2007). (Pubitemid 46816746)
-
(2007)
Nature
, vol.447
, Issue.7143
, pp. 407-412
-
-
Berger, S.L.1
-
28
-
-
64349095390
-
An operational definition of epigenetics
-
Berger, S. L., Kouzarides, T., Shiekhattar, R. & Shilatifard, A. An operational definition of epigenetics. Genes Dev. 23, 781-783 (2009).
-
(2009)
Genes Dev.
, vol.23
, pp. 781-783
-
-
Berger, S.L.1
Kouzarides, T.2
Shiekhattar, R.3
Shilatifard, A.4
-
29
-
-
34447098370
-
A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells
-
DOI 10.1016/j.cell.2007.05.042, PII S0092867407006812
-
Guenther, M. G., Levine, S. S., Boyer, L. A., Jaenisch, R. & Young, R. A. A chromatin landmark and transcription initiation at most promoters in human cells. Cell 130, 77-88 (2007). (Pubitemid 47031323)
-
(2007)
Cell
, vol.130
, Issue.1
, pp. 77-88
-
-
Guenther, M.G.1
Levine, S.S.2
Boyer, L.A.3
Jaenisch, R.4
Young, R.A.5
-
30
-
-
34249026300
-
High-Resolution Profiling of Histone Methylations in the Human Genome
-
DOI 10.1016/j.cell.2007.05.009, PII S0092867407006009
-
Barski, A. et al. High-resolution profiling of histone methylations in the human genome. Cell 129, 823-837 (2007). (Pubitemid 46802390)
-
(2007)
Cell
, vol.129
, Issue.4
, pp. 823-837
-
-
Barski, A.1
Cuddapah, S.2
Cui, K.3
Roh, T.-Y.4
Schones, D.E.5
Wang, Z.6
Wei, G.7
Chepelev, I.8
Zhao, K.9
-
31
-
-
78651477233
-
High-resolution genome-wide mapping of the primary structure of chromatin
-
Zhang, Z. & Pugh, B. F. High-resolution genome-wide mapping of the primary structure of chromatin. Cell 144, 175-186 (2011).
-
(2011)
Cell
, vol.144
, pp. 175-186
-
-
Zhang, Z.1
Pugh, B.F.2
-
32
-
-
79956330964
-
CpG islands and the regulation of transcription
-
Deaton, A. M. & Bird, A. CpG islands and the regulation of transcription. Genes Dev. 25, 1010-1022 (2011).
-
(2011)
Genes Dev.
, vol.25
, pp. 1010-1022
-
-
Deaton, A.M.1
Bird, A.2
-
33
-
-
31944432339
-
A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters
-
DOI 10.1073/pnas.0510310103
-
Saxonov, S., Berg, P. & Brutlag, D. L. A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters. Proc. Natl Acad. Sci. USA 103, 1412-1417 (2006). (Pubitemid 43191179)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.5
, pp. 1412-1417
-
-
Saxonov, S.1
Berg, P.2
Brutlag, D.L.3
-
34
-
-
77954504873
-
Conserved role of intragenic DNA methylation in regulating alternative promoters
-
Maunakea, A. K. et al. Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature 466, 253-257 (2010).
-
(2010)
Nature
, vol.466
, pp. 253-257
-
-
Maunakea, A.K.1
-
35
-
-
0036305450
-
H cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes
-
DOI 10.1038/ni808
-
Avni, O. et al. TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nature Immunol. 3, 643-651 (2002). (Pubitemid 34752473)
-
(2002)
Nature Immunology
, vol.3
, Issue.7
, pp. 643-651
-
-
Avni, O.1
Lee, D.2
Macian, F.3
Szabo, S.J.4
Glimcher, L.H.5
Rao, A.6
-
36
-
-
34250762587
-
Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-γ during the differentiation of T helper type 2 cells
-
DOI 10.1038/ni1473, PII NI1473
-
Chang, S. & Aune, T. M. Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-γ during the differentiation of T helper type 2 cells. Nature Immunol. 8, 723-731 (2007). (Pubitemid 46965348)
-
(2007)
Nature Immunology
, vol.8
, Issue.7
, pp. 723-731
-
-
Chang, S.1
Aune, T.M.2
-
37
-
-
79959360046
-
Application of ChIP-Seq and related techniques to the study of immune function
-
Northrup, D. L. & Zhao, K. Application of ChIP-Seq and related techniques to the study of immune function. Immunity 34, 830-842 (2011).
-
(2011)
Immunity
, vol.34
, pp. 830-842
-
-
Northrup, D.L.1
Zhao, K.2
-
38
-
-
8644250670
-
+ T cells: Evidence for epigenetic regulation of involved glycosyltransferase genes
-
DOI 10.1182/blood-2003-09-3047
-
Syrbe, U. et al. Differential regulation of P-selectin ligand expression in naive versus memory CD4+ T cells: evidence for epigenetic regulation of involved glycosyltransferase genes. Blood 104, 3243-3248 (2004). (Pubitemid 39507142)
-
(2004)
Blood
, vol.104
, Issue.10
, pp. 3243-3248
-
-
Syrbe, U.1
Jennrich, S.2
Schottelius, A.3
Richter, A.4
Radbruch, A.5
Hamann, A.6
-
39
-
-
79955166099
-
Epigenetic reprogramming of the RORC locus during in vitro expansion is a distinctive feature of human memory but not naive Treg
-
Schmidl, C. et al. Epigenetic reprogramming of the RORC locus during in vitro expansion is a distinctive feature of human memory but not naive Treg. Eur. J. Immunol. 41, 1491-1498 (2011).
-
(2011)
Eur. J. Immunol.
, vol.41
, pp. 1491-1498
-
-
Schmidl, C.1
-
40
-
-
79953071769
-
Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells
-
Steinfelder, S. et al. Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells. Blood 117, 2839-2846 (2011).
-
(2011)
Blood
, vol.117
, pp. 2839-2846
-
-
Steinfelder, S.1
-
41
-
-
0033136308
-
+ T lymphocytes
-
Fitzpatrick, D. R., Shirley, K. M. & Kelso, A. Stable epigenetic inheritance of regional IFN-γ promoter demethylation in CD44highCD8+ T lymphocytes. J. Immunol. 162, 5053-5057 (1999). (Pubitemid 29307103)
-
(1999)
Journal of Immunology
, vol.162
, Issue.9
, pp. 5053-5057
-
-
Fitzpatrick, D.R.1
Shirley, K.M.2
Kelso, A.3
-
42
-
-
33646058925
-
Rapid demethylation of the IFN-γ gene occurs in memory but not naive CD8 T cells
-
Kersh, E. N. et al. Rapid demethylation of the IFN-γ gene occurs in memory but not naive CD8 T cells. J. Immunol. 176, 4083-4093 (2006). (Pubitemid 44264387)
-
(2006)
Journal of Immunology
, vol.176
, Issue.7
, pp. 4083-4093
-
-
Kersh, E.N.1
Fitzpatrick, D.R.2
Murali-Krishna, K.3
Shires, J.4
Speck, S.H.5
Boss, J.M.6
Ahmed, R.7
-
43
-
-
33745861718
-
Epigenetic remodeling of the IL-2 and IFN-γ loci in memory CD8 T cells is influenced by CD4 T cells
-
Northrop, J. K., Thomas, R. M., Wells, A. D. & Shen, H. Epigenetic remodeling of the IL-2 and IFN-γ loci in memory CD8 T cells is influenced by CD4 T cells. J. Immunol. 177, 1062-1069 (2006). (Pubitemid 44036608)
-
(2006)
Journal of Immunology
, vol.177
, Issue.2
, pp. 1062-1069
-
-
Northrop, J.K.1
Thomas, R.M.2
Wells, A.D.3
Shen, H.4
-
44
-
-
43549126021
-
Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene
-
DOI 10.1084/jem.20072000
-
Yamashita, M. et al. Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. J. Exp. Med. 205, 1109-1120 (2008). (Pubitemid 351679686)
-
(2008)
Journal of Experimental Medicine
, vol.205
, Issue.5
, pp. 1109-1120
-
-
Yamashita, M.1
Kuwahara, M.2
Suzuki, A.3
Hirahara, K.4
Shinnaksu, R.5
Hosokawa, H.6
Hasegawa, A.7
Motohashi, S.8
Iwama, A.9
Nakayama, T.10
-
45
-
-
80053137239
-
Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8+ T cells
-
Youngblood, B. et al. Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8+ T cells. Immunity 35, 400-412 (2011).
-
(2011)
Immunity
, vol.35
, pp. 400-412
-
-
Youngblood, B.1
-
46
-
-
79959872458
-
Cell type-specific DNA methylation at intragenic CpG islands in the immune system
-
Deaton, A. M. et al. Cell type-specific DNA methylation at intragenic CpG islands in the immune system. Genome Res. 21, 1074-1086 (2011).
-
(2011)
Genome Res.
, vol.21
, pp. 1074-1086
-
-
Deaton, A.M.1
-
47
-
-
0037100265
-
Cutting edge: Changes in histone acetylation at the IL-4 and IFN-γ loci accompany Th1/Th2 differentiation
-
Fields, P. E., Kim, S. T. & Flavell, R. A. Changes in histone acetylation at the IL-4 and IFN-γ loci accompany Th1/Th2 differentiation. J. Immunol. 169, 647-650 (2002). (Pubitemid 34753418)
-
(2002)
Journal of Immunology
, vol.169
, Issue.2
, pp. 647-650
-
-
Fields, P.E.1
Kim, S.T.2
Flavell, R.A.3
-
48
-
-
0037236203
-
H2 lymphocytes
-
DOI 10.1038/ni872
-
Messi, M. et al. Memory and flexibility of cytokine gene expression as separable properties of human TH1 and TH2 lymphocytes. Nature Immunol. 4, 78-86 (2003). (Pubitemid 36104711)
-
(2003)
Nature Immunology
, vol.4
, Issue.1
, pp. 78-86
-
-
Messi, M.1
Giacchetto, I.2
Nagata, K.3
Lanzavecchia, A.4
Natoli, G.5
Sallusto, F.6
-
49
-
-
4544275712
-
Interleukin (IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells
-
DOI 10.1074/jbc.M405989200
-
Yamashita, M. et al. Interleukin (IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells. J. Biol. Chem. 279, 39454-39464 (2004). (Pubitemid 39258211)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.38
, pp. 39454-39464
-
-
Yamashita, M.1
Shinnakasu, R.2
Nigo, Y.3
Kimura, M.4
Hasegawa, A.5
Taniguchi, M.6
Nakayama, T.7
-
50
-
-
33751184610
-
Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8+ T cell response
-
Fann, M. et al. Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8+ T cell response. Blood 108, 3363-3370 (2006).
-
(2006)
Blood
, vol.108
, pp. 3363-3370
-
-
Fann, M.1
-
51
-
-
50949127683
-
Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: Perforin and granzyme B)
-
Araki, Y., Fann, M., Wersto, R. & Weng, N. P. Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B). J. Immunol. 180, 8102-8108 (2008).
-
(2008)
J. Immunol.
, vol.180
, pp. 8102-8108
-
-
Araki, Y.1
Fann, M.2
Wersto, R.3
Weng, N.P.4
-
52
-
-
49049110982
-
Chromatin remodeling as a molecular basis for the enhanced functionality of memory CD8 T cells
-
Northrop, J. K., Wells, A. D. & Shen, H. Chromatin remodeling as a molecular basis for the enhanced functionality of memory CD8 T cells. J. Immunol. 181, 865-868 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 865-868
-
-
Northrop, J.K.1
Wells, A.D.2
Shen, H.3
-
53
-
-
58149214356
-
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
-
Wei, G. et al. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 30, 155-167 (2009).
-
(2009)
Immunity
, vol.30
, pp. 155-167
-
-
Wei, G.1
-
54
-
-
84858797499
-
-
This study identifies the chromatin states of key transcription factor genes and their target genes in naive CD4+ T cells differentiating into distinct lineages (including TH1, TH2, TH17 and inducible regulatory T cells) and suggests that an epigenetic mechanism underlies the specificity and plasticity of effector and regulatory T cells
-
This study identifies the chromatin states of key transcription factor genes and their target genes in naive CD4+ T cells differentiating into distinct lineages (including TH1, TH2, TH17 and inducible regulatory T cells) and suggests that an epigenetic mechanism underlies the specificity and plasticity of effector and regulatory T cells.
-
-
-
-
55
-
-
77956526237
-
C-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development
-
Nakata, Y. et al. c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development. Blood 116, 1280-1290 (2010).
-
(2010)
Blood
, vol.116
, pp. 1280-1290
-
-
Nakata, Y.1
-
56
-
-
33646586637
-
Crucial Role of MLL for the Maintenance of Memory T Helper Type 2 Cell Responses
-
DOI 10.1016/j.immuni.2006.03.017, PII S1074761306002184
-
Yamashita, M. et al. Crucial role of MLL for the maintenance of memory T helper type 2 cell responses. Immunity 24, 611-622 (2006). (Pubitemid 43728153)
-
(2006)
Immunity
, vol.24
, Issue.5
, pp. 611-622
-
-
Yamashita, M.1
Hirahara, K.2
Shinnakasu, R.3
Hosokawa, H.4
Norikane, S.5
Kimura, M.Y.6
Hasegawa, A.7
Nakayama, T.8
-
57
-
-
84858797500
-
-
This study demonstrates that MLL regulates histone modifications and expression at the GATA3 locus, indicating that MLL has a crucial role in the maintenance of memory TH2 cells
-
This study demonstrates that MLL regulates histone modifications and expression at the GATA3 locus, indicating that MLL has a crucial role in the maintenance of memory TH2 cells.
-
-
-
-
58
-
-
79952756708
-
Persistently open chromatin at effector gene loci in resting memory CD8+ T cells independent of transcriptional status.
-
Zediak, V. P., Johnnidis, J. B., Wherry, E. J. & Berger, S. L. Persistently open chromatin at effector gene loci in resting memory CD8+ T cells independent of transcriptional status. J. Immunol. 186, 2705-2709 (2011).
-
(2011)
J. Immunol.
, vol.186
, pp. 2705-2709
-
-
Zediak, V.P.1
Johnnidis, J.B.2
Wherry, E.J.3
Berger, S.L.4
-
59
-
-
33846305724
-
+ T cell immunity
-
DOI 10.1038/ni1403, PII NI1403
-
Cannarile, M. A. et al. Transcriptional regulator Id2 mediates CD8+ T cell immunity. Nature Immunol. 7, 1317-1325 (2006). (Pubitemid 46111253)
-
(2006)
Nature Immunology
, vol.7
, Issue.12
, pp. 1317-1325
-
-
Cannarile, M.A.1
Lind, N.A.2
Rivera, R.3
Sheridan, A.D.4
Camfield, K.A.5
Wu, B.B.6
Cheung, K.P.7
Ding, Z.8
Goldrath, A.W.9
-
60
-
-
33646070846
-
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
-
Bernstein, B. E. et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125, 315-326 (2006).
-
(2006)
Cell
, vol.125
, pp. 315-326
-
-
Bernstein, B.E.1
-
61
-
-
58049191558
-
Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation
-
Cui, K. et al. Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation. Cell Stem Cell 4, 80-93 (2009).
-
(2009)
Cell Stem Cell
, vol.4
, pp. 80-93
-
-
Cui, K.1
-
62
-
-
84855416368
-
MLK4 has negative effect on TLR4 signaling
-
Seit-Nebi, A., Cheng, W., Xu, H. & Han, J. MLK4 has negative effect on TLR4 signaling. Cell. Mol. Immunol. 9, 27-33 (2012).
-
(2012)
Cell. Mol. Immunol.
, vol.9
, pp. 27-33
-
-
Seit-Nebi, A.1
Cheng, W.2
Xu, H.3
Han, J.4
-
63
-
-
77954948735
-
Effector T cell plasticity: Flexibility in the face of changing circumstances
-
Murphy, K. M. & Stockinger, B. Effector T cell plasticity: flexibility in the face of changing circumstances. Nature Immunol. 11, 674-680 (2010).
-
(2010)
Nature Immunol.
, vol.11
, pp. 674-680
-
-
Murphy, K.M.1
Stockinger, B.2
-
64
-
-
80755136623
-
Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells
-
Lu, K. T. et al. Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells. Immunity 35, 622-632 (2011).
-
(2011)
Immunity
, vol.35
, pp. 622-632
-
-
Lu, K.T.1
-
65
-
-
46249112085
-
Combinatorial patterns of histone acetylations and methylations in the human genome
-
DOI 10.1038/ng.154, PII NG154
-
Wang, Z. et al. Combinatorial patterns of histone acetylations and methylations in the human genome. Nature Genet. 40, 897-903 (2008). (Pubitemid 351913645)
-
(2008)
Nature Genetics
, vol.40
, Issue.7
, pp. 897-903
-
-
Wang, Z.1
Zang, C.2
Rosenfeld, J.A.3
Schones, D.E.4
Barski, A.5
Cuddapah, S.6
Cui, K.7
Roh, T.-Y.8
Peng, W.9
Zhang, M.Q.10
Zhao, K.11
-
66
-
-
77951116072
-
CpG islands influence chromatin structure via the CpG-binding protein Cfp1
-
Thomson, J. P. et al. CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Nature 464, 1082-1086 (2010).
-
(2010)
Nature
, vol.464
, pp. 1082-1086
-
-
Thomson, J.P.1
-
67
-
-
69449102464
-
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
-
Wang, Z. et al. Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell 138, 1019-1031 (2009).
-
(2009)
Cell
, vol.138
, pp. 1019-1031
-
-
Wang, Z.1
-
68
-
-
0032751323
-
Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation
-
van der Vlag, J. & Otte, A. P. Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. Nature Genet. 23, 474-478 (1999).
-
(1999)
Nature Genet.
, vol.23
, pp. 474-478
-
-
Van Der Vlag, J.1
Otte, A.P.2
-
69
-
-
79953161303
-
The contribution of epigenetic memory to immunologic memory
-
Zediak, V. P., Wherry, E. J. & Berger, S. L. The contribution of epigenetic memory to immunologic memory. Curr. Opin. Genet. Dev. 21, 154-159 (2011).
-
(2011)
Curr. Opin. Genet. Dev.
, vol.21
, pp. 154-159
-
-
Zediak, V.P.1
Wherry, E.J.2
Berger, S.L.3
-
70
-
-
80051989398
-
Systems biology of vaccination for seasonal influenza in humans
-
Nakaya, H. I. et al. Systems biology of vaccination for seasonal influenza in humans. Nature Immunol. 12, 786-795 (2011).
-
(2011)
Nature Immunol.
, vol.12
, pp. 786-795
-
-
Nakaya, H.I.1
-
71
-
-
38449116161
-
Demethylation of CD40LG on the inactive X in T cells from women with lupus
-
Lu, Q. et al. Demethylation of CD40LG on the inactive X in T cells from women with lupus. J. Immunol. 179, 6352-6358 (2007).
-
(2007)
J. Immunol.
, vol.179
, pp. 6352-6358
-
-
Lu, Q.1
-
72
-
-
44349087706
-
Abnormal histone modification patterns in lupus CD4+ T cells
-
Hu, N. et al. Abnormal histone modification patterns in lupus CD4+ T cells. J. Rheumatol. 35, 804-810 (2008). (Pubitemid 351747120)
-
(2008)
Journal of Rheumatology
, vol.35
, Issue.5
, pp. 804-810
-
-
Hu, N.1
Qiu, X.2
Luo, Y.3
Yuan, J.4
Li, Y.5
Lei, W.6
Zhang, G.7
Zhou, Y.8
Su, Y.9
Lu, Q.10
|