A large fraction of HLA class I ligands are proteasome-generated spliced peptides

Science

Volumn 354, Issue 6310, 2016, Pages 354-358

  Liepe, Juliane ^a   Marino, Fabio ^b,c   Sidney, John ^d   Jeko, Anita ^b,c   Bunting, Daniel E ^a   Sette, Alessandro ^d   Kloetzel, Peter M ^e,f   Stumpf, Michael P H ^a   Heck, Albert J R ^b,c   Mishto, Michele ^e,f  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UTRECHT UNIVERSITY   (Netherlands)

^c NETHERLANDS PROTEOMICS CENTRE   (Netherlands)

^d LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^f BERLIN INSTITUTE OF HEALTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; EPITOPE; HLA ANTIGEN CLASS 1; LIGAND; PEPTIDE; PROTEASOME;

ANTIGEN; CANCER; CELLS AND CELL COMPONENTS; IMMUNE RESPONSE; IMMUNITY; LIGAND; PEPTIDE; PROTEIN; VACCINE;

ALLOTYPE; ARTICLE; AUTOIMMUNITY; BIOINFORMATICS; CANCER IMMUNOTHERAPY; CELL LINEAGE; CELL LYSATE; CELLS BY BODY ANATOMY; CELLULAR IMMUNITY; CONTROLLED STUDY; HLA SYSTEM; HUMAN; HUMAN CELL; HYDROLYSIS; IMMUNOBIOLOGY; IN VITRO STUDY; LYMPHOBLASTOID CELL LINE; LYMPHOID CELL LINE; PRIORITY JOURNAL; PROTEOMICS; ANTIGEN PRESENTATION; BIOLOGY; CD8+ T LYMPHOCYTE; IMMUNOLOGY; METABOLISM; PROTEIN SPLICING; TUMOR CELL LINE;

ANTIGEN PRESENTATION; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; COMPUTATIONAL BIOLOGY; EPITOPES, T-LYMPHOCYTE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; LIGANDS; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN SPLICING;

EID: 84992027493     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf4384     Document Type: Article

References (33)

1. M. Groettrup, C. J. Kirk, M. Basler, Nat. Rev. Immunol. 10, 73-78 (2010).
2. N. Vigneron et al., Science 304, 587-590 (2004).
3. C. K. Frese et al., J. Proteome Res. 12, 1520-1525 (2013).
4. G. P. Mommen et al., Proc. Natl. Acad. Sci. U.S.A. 111, 4507-4512 (2014).
5. E. Caron et al., eLife 4, e07661 (2015).
6. M. Bassani-Sternberg, S. Pletscher-Frankild, L. J. Jensen, M. Mann, Mol. Cell. Proteomics 14, 658-673 (2015).
7. A. F. Kisselev, T. N. Akopian, K. M. Woo, A. L. Goldberg, J. Biol. Chem. 274, 3363-3371 (1999).
8. M. Mishto et al., Mol. Cell. Proteomics 11, 1008-1023 (2012).
9. A. O. Weinzierl et al., Eur. J. Immunol. 38, 1503-1510 (2008).
10. E. Lorente et al., PLOS ONE 8, e59118 (2013).
11. J. Cox et al., Mol. Cell. Proteomics 13, 2513-2526 (2014).
12. E. L. de Graaf, P. Giansanti, A. F. Altelaar, A. J. Heck, Mol. Cell. Proteomics 13, 2426-2434 (2014).
13. F. Ebstein et al., Sci. Rep. 6, 24032 (2016).
14. K. Textoris-Taube et al., J. Biol. Chem. 290, 30417-30428 (2015).
15. E. H. Warren et al., Science 313, 1444-1447 (2006).
16. A. Michaux et al., J. Immunol. 192, 1962-1971 (2014).
17. J. Liepe et al., PLOS Comput. Biol. 6, e1000830 (2010).
18. A. Dalet, N. Vigneron, V. Stroobant, K. Hanada, B. J. Van den Eynde, J. Immunol. 184, 3016-3024 (2010).
19. A. Dalet et al., Proc. Natl. Acad. Sci. U.S.A. 108, E323-E331 (2011).
20. C. R. Berkers et al., J. Immunol. 195, 4085-4095 (2015).
21. C. R. Berkers et al., J. Immunol. 195, 4075-4084 (2015).
22. G. Niedermann et al., Immunol. Rev. 172, 29-48 (1999).
23. B. Peters, A. Sette, BMC Bioinformatics 6, 132 (2005).
24. C. Lundegaard, O. Lund, M. Nielsen, Bioinformatics 24, 1397-1398 (2008).
25. A. Grignolio et al., Front. Immunol. 5, 153 (2014).
26. F. A. Steven, Immunology and Evolution of Infectious Disease (Princeton Univ. Press, 2002).
27. E. Bellavista et al., Autoimmune Dis. 2014, 739705 (2014).
28. H. G. Rammensee, Nature 427, 203-204 (2004).
29. S. A. Rosenberg, N. P. Restifo, Science 348, 62-68 (2015).
30. S. H. van der Burg, R. Arens, C. J. Melief, Trends Immunol. 32, 97-103 (2011).
31. T. Blankenstein, M. Leisegang, W. Uckert, H. Schreiber, Curr. Opin. Immunol. 33, 112-119 (2015).
32. M. M. Gubin et al., Nature 515, 577-581 (2014).
33. P. G. Coulie, B. J. Van den Eynde, P. van der Bruggen, T. Boon, Nat. Rev. Cancer 14, 135-146 (2014).