-
1
-
-
0017199306
-
Selective in vitro growth of T lymphocytes from normal human bone marrows
-
181845
-
D.A.Morgan, F.W.Ruscetti, R.Gallo. Selective in vitro growth of T lymphocytes from normal human bone marrows. Science 1976; 193:1007-8; PMID:181845; 10.1126/science.181845
-
(1976)
Science
, vol.193
, pp. 1007-1008
-
-
Morgan, D.A.1
Ruscetti, F.W.2
Gallo, R.3
-
2
-
-
41949097030
-
The biology of interleukin-2
-
18062768
-
T.R.Malek. The biology of interleukin-2. Annu Rev Immunol 2008; 26:453-79; PMID:18062768; 10.1146/annurev.immunol.26.021607.090357
-
(2008)
Annu Rev Immunol
, vol.26
, pp. 453-479
-
-
Malek, T.R.1
-
3
-
-
67649846643
-
Structural biology of shared cytokine receptors
-
18817510
-
X.Wang, P.Lupardus, S.L.Laporte, K.C.Garcia. Structural biology of shared cytokine receptors. Annu Rev Immunol 2009; 27:29-60; PMID:18817510; 10.1146/annurev.immunol.24.021605.090616
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 29-60
-
-
Wang, X.1
Lupardus, P.2
Laporte, S.L.3
Garcia, K.C.4
-
4
-
-
84872790689
-
Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy
-
23352221
-
W.Liao, J.X.Lin, W.J.Leonard. Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy. Immunity 2013; 38:13-25; PMID:23352221; 10.1016/j.immuni.2013.01.004
-
(2013)
Immunity
, vol.38
, pp. 13-25
-
-
Liao, W.1
Lin, J.X.2
Leonard, W.J.3
-
5
-
-
84893136588
-
Challenges and developing solutions for increasing the benefits of IL-2 treatment in tumor therapy
-
24410537
-
D.Skrombolas, J.G.Frelinger. Challenges and developing solutions for increasing the benefits of IL-2 treatment in tumor therapy. Expert Rev Clin Immunol 2014; 10:207-17; PMID:24410537; 10.1586/1744666X.2014.875856
-
(2014)
Expert Rev Clin Immunol
, vol.10
, pp. 207-217
-
-
Skrombolas, D.1
Frelinger, J.G.2
-
6
-
-
0023782871
-
Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones
-
2969394
-
X.Paliard, R.de Waal Malefijt, H.Yssel, D.Blanchard, I.Chretien, J.Abrams, J.de Vries, H.Spits. Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones. J Immunol 1988; 141:849-55; PMID:2969394; 10.0022-l767/88/1413-084902.00
-
(1988)
J Immunol
, vol.141
, pp. 849-855
-
-
Paliard, X.1
de Waal Malefijt, R.2
Yssel, H.3
Blanchard, D.4
Chretien, I.5
Abrams, J.6
de Vries, J.7
Spits, H.8
-
7
-
-
0035752146
-
Cytokines and immunodeficiency diseases
-
11905829
-
W.J.Leonard. Cytokines and immunodeficiency diseases. Nat Rev Immunol 2001; 1:200-8; PMID:11905829; 10.1038/35105066
-
(2001)
Nat Rev Immunol
, vol.1
, pp. 200-208
-
-
Leonard, W.J.1
-
8
-
-
1842581852
-
Preferential activation of an IL-2 regulatory sequence transgene in TCR gamma delta and NKT cells: subset-specific differences in IL-2 regulation
-
15067044
-
M.A.Yui, L.L.Sharp, W.L.Havran, E.V.Rothenberg. Preferential activation of an IL-2 regulatory sequence transgene in TCR gamma delta and NKT cells: subset-specific differences in IL-2 regulation. J Immunol 2004; 172:4691-9; PMID:15067044; 10.4049/jimmunol.172.8.4691
-
(2004)
J Immunol
, vol.172
, pp. 4691-4699
-
-
Yui, M.A.1
Sharp, L.L.2
Havran, W.L.3
Rothenberg, E.V.4
-
9
-
-
77950261975
-
How are T(H)2-type immune responses initiated and amplified?
-
20336151
-
W.E.Paul, J.Zhu. How are T(H)2-type immune responses initiated and amplified? Nat Rev Immunol 2010; 10:225-35; PMID:20336151; 10.1038/nri2735
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 225-235
-
-
Paul, W.E.1
Zhu, J.2
-
10
-
-
0038195719
-
Molecular mechanisms regulating Th1 immune responses
-
12500979
-
S.J.Szabo, B.M.Sullivan, S.L.Peng, L.H.Glimcher. Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol 2003; 21:713-58; PMID:12500979; 10.1146/annurev.immunol.21.120601.140942
-
(2003)
Annu Rev Immunol
, vol.21
, pp. 713-758
-
-
Szabo, S.J.1
Sullivan, B.M.2
Peng, S.L.3
Glimcher, L.H.4
-
11
-
-
77950349016
-
Th17 and regulatory T cells in mediating and restraining inflammation
-
20303875
-
D.R.Littman, A.Y.Rudensky. Th17 and regulatory T cells in mediating and restraining inflammation. Cell 2010; 140:845-58; PMID:20303875; 10.1016/j.cell.2010.02.021
-
(2010)
Cell
, vol.140
, pp. 845-858
-
-
Littman, D.R.1
Rudensky, A.Y.2
-
12
-
-
79954486763
-
Regulatory T cells and Foxp3
-
21488902
-
A.Y.Rudensky. Regulatory T cells and Foxp3. Immunol Rev 2011; 241:260-8; PMID:21488902; 10.1111/j.1600-065X.2011.01018.x
-
(2011)
Immunol Rev
, vol.241
, pp. 260-268
-
-
Rudensky, A.Y.1
-
13
-
-
0342823440
-
Interleukin 2 receptor gene expression in normal human T lymphocytes
-
3929255
-
W.J.Leonard, M.Kronke, N.J.Peffer, J.M.Depper, W.C.Greene. Interleukin 2 receptor gene expression in normal human T lymphocytes. Proc Natl Acad Sci U S A 1985; 82:6281-5; PMID:3929255; 10.1073/pnas.82.18.6281
-
(1985)
Proc Natl Acad Sci U S A
, vol.82
, pp. 6281-6285
-
-
Leonard, W.J.1
Kronke, M.2
Peffer, N.J.3
Depper, J.M.4
Greene, W.C.5
-
14
-
-
33645023400
-
Phenotypic and functional characterization of human CD25+ B cells
-
16556269
-
M.Brisslert, M.Bokarewa, P.Larsson, K.Wing, L.V.Collins, A.Tarkowski. Phenotypic and functional characterization of human CD25+ B cells. Immunology 2006; 117:548-57; PMID:16556269; 10.1111/j.1365-2567.2006.02331.x
-
(2006)
Immunology
, vol.117
, pp. 548-557
-
-
Brisslert, M.1
Bokarewa, M.2
Larsson, P.3
Wing, K.4
Collins, L.V.5
Tarkowski, A.6
-
15
-
-
0031932548
-
Does the IL-2 receptor alpha chain induced on dendritic cells have a biological function?
-
9533452
-
V.Kronin, D.Vremec, K.Shortman. Does the IL-2 receptor alpha chain induced on dendritic cells have a biological function? Int Immunol 1998; 10:237-40; PMID:9533452; 10.1093/intimm/10.2.237
-
(1998)
Int Immunol
, vol.10
, pp. 237-240
-
-
Kronin, V.1
Vremec, D.2
Shortman, K.3
-
16
-
-
77955345138
-
Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells
-
20547866
-
C.Krieg, S.Letourneau, G.Pantaleo, O.Boyman. Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells. Proc Natl Acad Sci U S A 2010; 107:11906-11; PMID:20547866; 10.1073/pnas.1002569107
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 11906-11911
-
-
Krieg, C.1
Letourneau, S.2
Pantaleo, G.3
Boyman, O.4
-
17
-
-
65549136983
-
Mechanisms of foxp3+ T regulatory cell-mediated suppression
-
19464986
-
E.M.Shevach. Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 2009; 30:636-45; PMID:19464986; 10.1016/j.immuni.2009.04.010
-
(2009)
Immunity
, vol.30
, pp. 636-645
-
-
Shevach, E.M.1
-
18
-
-
84907979458
-
The IL-2 cytokine family in cancer immunotherapy
-
25200249
-
G.C.Sim, L.Radvanyi. The IL-2 cytokine family in cancer immunotherapy. Cytokine Growth Factor Rev 2014; 25:377-90; PMID:25200249; 10.1016/j.cytogfr.2014.07.018
-
(2014)
Cytokine Growth Factor Rev
, vol.25
, pp. 377-390
-
-
Sim, G.C.1
Radvanyi, L.2
-
19
-
-
0027232919
-
The hematopoietin receptor superfamily
-
8392875
-
D.Cosman. The hematopoietin receptor superfamily. Cytokine 1993; 5:95-106; PMID:8392875; 10.1016/1043-4666(93)90047-9
-
(1993)
Cytokine
, vol.5
, pp. 95-106
-
-
Cosman, D.1
-
20
-
-
33750219508
-
Both integrated and differential regulation of components of the IL-2/IL-2 receptor system
-
16911870
-
H.P.Kim, J.Imbert, W.J.Leonard. Both integrated and differential regulation of components of the IL-2/IL-2 receptor system. Cytokine Growth Factor Rev 2006; 17:349-66; PMID:16911870; 10.1016/j.cytogfr.2006.07.003
-
(2006)
Cytokine Growth Factor Rev
, vol.17
, pp. 349-366
-
-
Kim, H.P.1
Imbert, J.2
Leonard, W.J.3
-
21
-
-
0033491981
-
Biology of the interleukin-2 receptor
-
9755337
-
B.H.Nelson, D.M.Willerford. Biology of the interleukin-2 receptor. Adv Immunol 1998; 70:1-81; PMID:9755337; 10.1016/S0065-2776(08)60386-7
-
(1998)
Adv Immunol
, vol.70
, pp. 1-81
-
-
Nelson, B.H.1
Willerford, D.M.2
-
22
-
-
0030963355
-
Expression of the IL-2 receptor gamma subunit in resting human CD4 T lymphocytes: mRNA is constitutively transcribed and the protein stored as an intracellular component
-
9138018
-
L.Bani, D.David, J.L.Moreau, A.Cayota, T.Nakarai, J.Ritz, J.Theze. Expression of the IL-2 receptor gamma subunit in resting human CD4 T lymphocytes: mRNA is constitutively transcribed and the protein stored as an intracellular component. Int Immunol 1997; 9:573-80; PMID:9138018; 10.1093/intimm/9.4.573
-
(1997)
Int Immunol
, vol.9
, pp. 573-580
-
-
Bani, L.1
David, D.2
Moreau, J.L.3
Cayota, A.4
Nakarai, T.5
Ritz, J.6
Theze, J.7
-
23
-
-
20344387872
-
The structure of interleukin-2 complexed with its alpha receptor
-
15933202
-
M.Rickert, X.Wang, M.J.Boulanger, N.Goriatcheva, K.C.Garcia. The structure of interleukin-2 complexed with its alpha receptor. Science. 2005; 308:1477-80; PMID:15933202; 10.1126/science.1109745
-
(2005)
Science
, vol.308
, pp. 1477-1480
-
-
Rickert, M.1
Wang, X.2
Boulanger, M.J.3
Goriatcheva, N.4
Garcia, K.C.5
-
24
-
-
0027405991
-
The IL-2 receptor complex: its structure, function, and target genes
-
8476561
-
Y.Minami, T.Kono, T.Miyazaki, T.Taniguchi. The IL-2 receptor complex: its structure, function, and target genes. Annu Rev Immunol 1993; 11:245-68; PMID:8476561; 10.1146/annurev.iy.11.040193.001333
-
(1993)
Annu Rev Immunol
, vol.11
, pp. 245-268
-
-
Minami, Y.1
Kono, T.2
Miyazaki, T.3
Taniguchi, T.4
-
25
-
-
0023907493
-
Interleukin-2: inception, impact, and implications
-
3131876
-
K.A.Smith. Interleukin-2: inception, impact, and implications. Science 1988; 240:1169-76; PMID:3131876; 10.1126/science.3131876
-
(1988)
Science
, vol.240
, pp. 1169-1176
-
-
Smith, K.A.1
-
26
-
-
0031934575
-
Interleukin-2, interleukin-15, and their receptors
-
9505189
-
T.Waldmann, Y.Tagaya, R.Bamford. Interleukin-2, interleukin-15, and their receptors. Int Rev Immunol 1998; 16:205-26; PMID:9505189; 10.3109/08830189809042995
-
(1998)
Int Rev Immunol
, vol.16
, pp. 205-226
-
-
Waldmann, T.1
Tagaya, Y.2
Bamford, R.3
-
27
-
-
0022349817
-
Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer
-
3903508
-
S.A.Rosenberg, M.T.Lotze, L.M.Muul, S.Leitman, A.E.Chang, S.E.Ettinghausen, Y.L.Matory, J.M.Skibber, E.Shiloni, J.T.Vetto et al. Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. N Engl J Med 1985; 313:1485-92; PMID:3903508; 10.1056/NEJM198512053132327
-
(1985)
N Engl J Med
, vol.313
, pp. 1485-1492
-
-
Rosenberg, S.A.1
Lotze, M.T.2
Muul, L.M.3
Leitman, S.4
Chang, A.E.5
Ettinghausen, S.E.6
Matory, Y.L.7
Skibber, J.M.8
Shiloni, E.9
Vetto, J.T.10
-
28
-
-
84902191817
-
IL-2: the first effective immunotherapy for human cancer
-
24907378
-
S.A.Rosenberg. IL-2: the first effective immunotherapy for human cancer. J Immunol 2014; 192:5451-8; PMID:24907378; 10.4049/jimmunol.1490019
-
(2014)
J Immunol
, vol.192
, pp. 5451-5458
-
-
Rosenberg, S.A.1
-
29
-
-
0027462554
-
Randomized phase II trial of high-dose interleukin-2 either alone or in combination with interferon alfa-2b in advanced renal cell carcinoma
-
8478661
-
M.B.Atkins, J.Sparano, R.I.Fisher, G.R.Weiss, K.A.Margolin, K.I.Fink, L.Rubinstein, A.Louie, J.W.Mier, R.Gucalp et al. Randomized phase II trial of high-dose interleukin-2 either alone or in combination with interferon alfa-2b in advanced renal cell carcinoma. J Clin Oncol. 1993; 11:661-70; PMID:8478661; 10.1146/annurev.iy.11.040193.001333
-
(1993)
J Clin Oncol
, vol.11
, pp. 661-670
-
-
Atkins, M.B.1
Sparano, J.2
Fisher, R.I.3
Weiss, G.R.4
Margolin, K.A.5
Fink, K.I.6
Rubinstein, L.7
Louie, A.8
Mier, J.W.9
Gucalp, R.10
-
30
-
-
0036240987
-
A multi-institutional phase II trial of a novel inpatient schedule of continuous interleukin-2 with interferon alpha-2b in advanced renal cell carcinoma: major durable responses in a less highly selected patient population
-
12056712
-
J.I.Clark, T.M.Kuzel, T.M.Lestingi, S.G.Fisher, P.Sorokin, B.Martone, M.Viola, J.A.Sosman. A multi-institutional phase II trial of a novel inpatient schedule of continuous interleukin-2 with interferon alpha-2b in advanced renal cell carcinoma: major durable responses in a less highly selected patient population. Ann Oncol 2002; 13:606-13; PMID:12056712; 10.1093/annonc/mdf105
-
(2002)
Ann Oncol
, vol.13
, pp. 606-613
-
-
Clark, J.I.1
Kuzel, T.M.2
Lestingi, T.M.3
Fisher, S.G.4
Sorokin, P.5
Martone, B.6
Viola, M.7
Sosman, J.A.8
-
31
-
-
17944403024
-
Outpatient subcutaneous interleukin-2 and interferon-alpha for metastatic renal cell cancer: five-year follow-up of the Cytokine Working Group Study
-
9161781
-
J.P.Dutcher, R.I.Fisher, G.Weiss, F.Aronson, K.Margolin, A.Louie, J.Mier, G.Caliendo, J.A.Sosman, J.R.Eckardt et al. Outpatient subcutaneous interleukin-2 and interferon-alpha for metastatic renal cell cancer: five-year follow-up of the Cytokine Working Group Study. Cancer J Sci Am 1997; 3:157-62; PMID:9161781
-
(1997)
Cancer J Sci Am
, vol.3
, pp. 157-162
-
-
Dutcher, J.P.1
Fisher, R.I.2
Weiss, G.3
Aronson, F.4
Margolin, K.5
Louie, A.6
Mier, J.7
Caliendo, G.8
Sosman, J.A.9
Eckardt, J.R.10
-
32
-
-
16644401873
-
Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma
-
15625368
-
D.F.McDermott, M.M.Regan, J.I.Clark, L.E.Flaherty, G.R.Weiss, T.F.Logan, J.M.Kirkwood, M.S.Gordon, J.A.Sosman, M.S.Ernstoff et al. Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J Clin Oncol 2005; 23:133-41; PMID:15625368; 10.1200/JCO.2005.03.206
-
(2005)
J Clin Oncol
, vol.23
, pp. 133-141
-
-
McDermott, D.F.1
Regan, M.M.2
Clark, J.I.3
Flaherty, L.E.4
Weiss, G.R.5
Logan, T.F.6
Kirkwood, J.M.7
Gordon, M.S.8
Sosman, J.A.9
Ernstoff, M.S.10
-
33
-
-
7144227930
-
Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma. Groupe Francais d'Immunotherapie
-
9562581
-
S.Negrier, B.Escudier, C.Lasset, J.Y.Douillard, J.Savary, C.Chevreau, A.Ravaud, A.Mercatello, J.Peny, M.Mousseau et al. Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma. Groupe Francais d'Immunotherapie. N Engl J Med 1998; 338:1272-8; PMID:9562581; 10.1056/NEJM199804303381805
-
(1998)
N Engl J Med
, vol.338
, pp. 1272-1278
-
-
Negrier, S.1
Escudier, B.2
Lasset, C.3
Douillard, J.Y.4
Savary, J.5
Chevreau, C.6
Ravaud, A.7
Mercatello, A.8
Peny, J.9
Mousseau, M.10
-
34
-
-
0042914703
-
Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer
-
12915604
-
J.C.Yang, R.M.Sherry, S.M.Steinberg, S.L.Topalian, D.J.Schwartzentruber, P.Hwu, C.A.Seipp, L.Rogers-Freezer, K.E.Morton, D.E.White et al. Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer. J Clin Oncol 2003; 21:3127-32; PMID:12915604; 10.1200/JCO.2003.02.122
-
(2003)
J Clin Oncol
, vol.21
, pp. 3127-3132
-
-
Yang, J.C.1
Sherry, R.M.2
Steinberg, S.M.3
Topalian, S.L.4
Schwartzentruber, D.J.5
Hwu, P.6
Seipp, C.A.7
Rogers-Freezer, L.8
Morton, K.E.9
White, D.E.10
-
35
-
-
0020047160
-
Lysis of fresh human solid tumors by autologous lymphocytes activated in vitro with lectins
-
7059990
-
A.Mazumder, E.A.Grimm, H.Z.Zhang, S.A.Rosenberg. Lysis of fresh human solid tumors by autologous lymphocytes activated in vitro with lectins. Cancer Res 1982; 42:913-8; PMID:7059990; 10.0008-5472/82/0042-000002.00
-
(1982)
Cancer Res
, vol.42
, pp. 913-918
-
-
Mazumder, A.1
Grimm, E.A.2
Zhang, H.Z.3
Rosenberg, S.A.4
-
36
-
-
0019951384
-
Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes
-
6176669
-
E.A.Grimm, A.Mazumder, H.Z.Zhang, S.A.Rosenberg. Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes. J Exp Med 1982; 155:1823-41; PMID:6176669; 10.1084/jem.155.6.1823
-
(1982)
J Exp Med
, vol.155
, pp. 1823-1841
-
-
Grimm, E.A.1
Mazumder, A.2
Zhang, H.Z.3
Rosenberg, S.A.4
-
37
-
-
0024426529
-
Experience with the use of high-dose interleukin-2 in the treatment of 652 cancer patients
-
discussion 484-5, 2679456
-
S.A.Rosenberg, M.T.Lotze, J.C.Yang, P.M.Aebersold, W.M.Linehan, C.A.Seipp, D.E.White. Experience with the use of high-dose interleukin-2 in the treatment of 652 cancer patients. Ann Surg 1989; 210:474-84; discussion 484-5; PMID:2679456; 10.1097/00000658-198910000-00008
-
(1989)
Ann Surg
, vol.210
, pp. 474-484
-
-
Rosenberg, S.A.1
Lotze, M.T.2
Yang, J.C.3
Aebersold, P.M.4
Linehan, W.M.5
Seipp, C.A.6
White, D.E.7
-
38
-
-
20244366111
-
Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma
-
15800326
-
M.E.Dudley, J.R.Wunderlich, J.C.Yang, R.M.Sherry, S.L.Topalian, N.P.Restifo, R.E.Royal, U.Kammula, D.E.White, S.A.Mavroukakis et al. Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma. J Clin Oncol 2005; 23:2346-57; PMID:15800326; 10.1200/JCO.2005.00.240
-
(2005)
J Clin Oncol
, vol.23
, pp. 2346-2357
-
-
Dudley, M.E.1
Wunderlich, J.R.2
Yang, J.C.3
Sherry, R.M.4
Topalian, S.L.5
Restifo, N.P.6
Royal, R.E.7
Kammula, U.8
White, D.E.9
Mavroukakis, S.A.10
-
39
-
-
55949125601
-
Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens
-
18809613
-
M.E.Dudley, J.C.Yang, R.Sherry, M.S.Hughes, R.Royal, U.Kammula, P.F.Robbins, J.Huang, D.E.Citrin, S.F.Leitman et al. Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens. J Clin Oncol 2008; 26:5233-9; PMID:18809613; 10.1200/JCO.2008.16.5449
-
(2008)
J Clin Oncol
, vol.26
, pp. 5233-5239
-
-
Dudley, M.E.1
Yang, J.C.2
Sherry, R.3
Hughes, M.S.4
Royal, R.5
Kammula, U.6
Robbins, P.F.7
Huang, J.8
Citrin, D.E.9
Leitman, S.F.10
-
40
-
-
84858758766
-
Adoptive immunotherapy for cancer: harnessing the T cell response
-
22437939
-
N.P.Restifo, M.E.Dudley, S.A.Rosenberg. Adoptive immunotherapy for cancer: harnessing the T cell response. Nat Rev Immunol 2012; 12:269-81; PMID:22437939; 10.1038/nri3191
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 269-281
-
-
Restifo, N.P.1
Dudley, M.E.2
Rosenberg, S.A.3
-
41
-
-
41149097574
-
Adoptive cell transfer: a clinical path to effective cancer immunotherapy
-
18354418
-
S.A.Rosenberg, N.P.Restifo, J.C.Yang, R.A.Morgan, M.E.Dudley. Adoptive cell transfer: a clinical path to effective cancer immunotherapy. Nat Rev Cancer 2008; 8:299-308; PMID:18354418; 10.1038/nrc2355
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 299-308
-
-
Rosenberg, S.A.1
Restifo, N.P.2
Yang, J.C.3
Morgan, R.A.4
Dudley, M.E.5
-
42
-
-
73949086540
-
MART-1-specific melanoma tumor-infiltrating lymphocytes maintaining CD28 expression have improved survival and expansion capability following antigenic restimulation in vitro
-
19949105
-
Y.Li, S.Liu, J.Hernandez, L.Vence, P.Hwu, L.Radvanyi. MART-1-specific melanoma tumor-infiltrating lymphocytes maintaining CD28 expression have improved survival and expansion capability following antigenic restimulation in vitro. J Immunol 2010; 184:452-65; PMID:19949105; 10.4049/jimmunol.0901101
-
(2010)
J Immunol
, vol.184
, pp. 452-465
-
-
Li, Y.1
Liu, S.2
Hernandez, J.3
Vence, L.4
Hwu, P.5
Radvanyi, L.6
-
43
-
-
33646252963
-
Cytokine-based therapy and biochemotherapy for advanced melanoma
-
16609058
-
M.B.Atkins. Cytokine-based therapy and biochemotherapy for advanced melanoma. Clin Cancer Res 2006; 12:2353s-8s; PMID:16609058; 10.1158/1078-0432.CCR-05-2503
-
(2006)
Clin Cancer Res
, vol.12
, pp. 2353-2358
-
-
Atkins, M.B.1
-
44
-
-
0342894822
-
Interferon alfa-2a and interleukin-2 with or without cisplatin in metastatic melanoma: a randomized trial of the European Organization for Research and Treatment of Cancer Melanoma Cooperative Group
-
9215828
-
U.Keilholz, S.H.Goey, C.J.Punt, T.M.Proebstle, R.Salzmann, C.Scheibenbogen, D.Schadendorf, D.Lienard, A.Enk, R.Dummer et al. Interferon alfa-2a and interleukin-2 with or without cisplatin in metastatic melanoma: a randomized trial of the European Organization for Research and Treatment of Cancer Melanoma Cooperative Group. J Clin Oncol 1997; 15:2579-88; PMID:9215828; 10.0732-183X/97/1507-00033.00/0
-
(1997)
J Clin Oncol
, vol.15
, pp. 2579-2588
-
-
Keilholz, U.1
Goey, S.H.2
Punt, C.J.3
Proebstle, T.M.4
Salzmann, R.5
Scheibenbogen, C.6
Schadendorf, D.7
Lienard, D.8
Enk, A.9
Dummer, R.10
-
45
-
-
0037089629
-
Sequential biochemotherapy versus chemotherapy for metastatic melanoma: results from a phase III randomized trial
-
11956264
-
O.Eton, S.S.Legha, A.Y.Bedikian, J.J.Lee, A.C.Buzaid, C.Hodges, S.E.Ring, N.E.Papadopoulos, C.Plager, M.J.East et al. Sequential biochemotherapy versus chemotherapy for metastatic melanoma: results from a phase III randomized trial. J Clin Oncol 2002; 20:2045-52; PMID:11956264; 10.1200/JCO.2002.07.044
-
(2002)
J Clin Oncol
, vol.20
, pp. 2045-2052
-
-
Eton, O.1
Legha, S.S.2
Bedikian, A.Y.3
Lee, J.J.4
Buzaid, A.C.5
Hodges, C.6
Ring, S.E.7
Papadopoulos, N.E.8
Plager, C.9
East, M.J.10
-
46
-
-
0032976897
-
Prospective randomized trial of the treatment of patients with metastatic melanoma using chemotherapy with cisplatin, dacarbazine, and tamoxifen alone or in combination with interleukin-2 and interferon alfa-2b
-
10071291
-
S.A.Rosenberg, J.C.Yang, D.J.Schwartzentruber, P.Hwu, F.M.Marincola, S.L.Topalian, C.A.Seipp, J.H.Einhorn, D.E.White, S.M.Steinberg. Prospective randomized trial of the treatment of patients with metastatic melanoma using chemotherapy with cisplatin, dacarbazine, and tamoxifen alone or in combination with interleukin-2 and interferon alfa-2b. J Clin Oncol 1999; 17:968-75; PMID:10071291
-
(1999)
J Clin Oncol
, vol.17
, pp. 968-975
-
-
Rosenberg, S.A.1
Yang, J.C.2
Schwartzentruber, D.J.3
Hwu, P.4
Marincola, F.M.5
Topalian, S.L.6
Seipp, C.A.7
Einhorn, J.H.8
White, D.E.9
Steinberg, S.M.10
-
47
-
-
27244432257
-
Dacarbazine, cisplatin, and interferon-alfa-2b with or without interleukin-2 in metastatic melanoma: a randomized phase III trial (18951) of the European Organisation for Research and Treatment of Cancer Melanoma Group
-
16170182
-
U.Keilholz, C.J.Punt, M.Gore, W.Kruit, P.Patel, D.Lienard, J.Thomas, T.M.Proebstle, A.Schmittel, D.Schadendorf et al. Dacarbazine, cisplatin, and interferon-alfa-2b with or without interleukin-2 in metastatic melanoma: a randomized phase III trial (18951) of the European Organisation for Research and Treatment of Cancer Melanoma Group. J Clin Oncol 2005; 23:6747-55; PMID:16170182; 10.1200/JCO.2005.03.202
-
(2005)
J Clin Oncol
, vol.23
, pp. 6747-6755
-
-
Keilholz, U.1
Punt, C.J.2
Gore, M.3
Kruit, W.4
Patel, P.5
Lienard, D.6
Thomas, J.7
Proebstle, T.M.8
Schmittel, A.9
Schadendorf, D.10
-
48
-
-
0037087755
-
Cisplatin, dacarbazine with or without subcutaneous interleukin-2, and interferon alpha-2b in advanced melanoma outpatients: results from an Italian multicenter phase III randomized clinical trial
-
11896110
-
R.Ridolfi, V.Chiarion-Sileni, M.Guida, A.Romanini, R.Labianca, A.Freschi, G.Lo Re, R.Nortilli, S.Brugnara, P.Vitali et al. Cisplatin, dacarbazine with or without subcutaneous interleukin-2, and interferon alpha-2b in advanced melanoma outpatients: results from an Italian multicenter phase III randomized clinical trial. J Clin Oncol 2002; 20:1600-7; PMID:11896110; 10.1200/JCO.20.6.1600
-
(2002)
J Clin Oncol
, vol.20
, pp. 1600-1607
-
-
Ridolfi, R.1
Chiarion-Sileni, V.2
Guida, M.3
Romanini, A.4
Labianca, R.5
Freschi, A.6
Lo Re, G.7
Nortilli, R.8
Brugnara, S.9
Vitali, P.10
-
49
-
-
33645275176
-
Multicenter phase III randomized trial of polychemotherapy (CVD regimen) versus the same chemotherapy (CT) plus subcutaneous interleukin-2 and interferon-alpha2b in metastatic melanoma
-
16469753
-
E.Bajetta, M.Del Vecchio, P.Nova, A.Fusi, A.Daponte, M.R.Sertoli, P.Queirolo, P.Taveggia, M.G.Bernengo, S.S.Legha et al. Multicenter phase III randomized trial of polychemotherapy (CVD regimen) versus the same chemotherapy (CT) plus subcutaneous interleukin-2 and interferon-alpha2b in metastatic melanoma. Ann Oncol 2006; 17:571-7; PMID:16469753; 10.1093/annonc/mdl007
-
(2006)
Ann Oncol
, vol.17
, pp. 571-577
-
-
Bajetta, E.1
Del Vecchio, M.2
Nova, P.3
Fusi, A.4
Daponte, A.5
Sertoli, M.R.6
Queirolo, P.7
Taveggia, P.8
Bernengo, M.G.9
Legha, S.S.10
-
50
-
-
53949108399
-
Phase III trial comparing concurrent biochemotherapy with cisplatin, vinblastine, dacarbazine, interleukin-2, and interferon alfa-2b with cisplatin, vinblastine, and dacarbazine alone in patients with metastatic malignant melanoma (E3695): a trial coordinated by the Eastern Cooperative Oncology Group
-
19001327
-
M.B.Atkins, J.Hsu, S.Lee, G.I.Cohen, L.E.Flaherty, J.A.Sosman, V.K.Sondak, J.M.Kirkwood, Eastern Cooperative Oncology G. Phase III trial comparing concurrent biochemotherapy with cisplatin, vinblastine, dacarbazine, interleukin-2, and interferon alfa-2b with cisplatin, vinblastine, and dacarbazine alone in patients with metastatic malignant melanoma (E3695): a trial coordinated by the Eastern Cooperative Oncology Group. J Clin Oncol 2008; 26:5748-54; PMID:19001327; 10.1200/JCO.2008.17.5448
-
(2008)
J Clin Oncol
, vol.26
, pp. 5748-5754
-
-
Atkins, M.B.1
Hsu, J.2
Lee, S.3
Cohen, G.I.4
Flaherty, L.E.5
Sosman, J.A.6
Sondak, V.K.7
Kirkwood, J.M.8
-
51
-
-
34648827914
-
Chemoimmunotherapy versus chemotherapy for metastatic malignant melanoma
-
17253556
-
A.D.Sasse, E.C.Sasse, L.G.Clark, L.Ulloa, O.A.Clark. Chemoimmunotherapy versus chemotherapy for metastatic malignant melanoma. Cochrane Database Syst Rev 2007; CD005413; PMID:17253556; 10.1002/14651858.CD005413.pub2
-
(2007)
Cochrane Database Syst Rev
, pp. 5413
-
-
Sasse, A.D.1
Sasse, E.C.2
Clark, L.G.3
Ulloa, L.4
Clark, O.A.5
-
52
-
-
36849061558
-
Chemotherapy compared with biochemotherapy for the treatment of metastatic melanoma: a meta-analysis of 18 trials involving 2,621 patients
-
18048825
-
N.J.Ives, R.L.Stowe, P.Lorigan, K.Wheatley. Chemotherapy compared with biochemotherapy for the treatment of metastatic melanoma: a meta-analysis of 18 trials involving 2,621 patients. J Clin Oncol 2007; 25:5426-34; PMID:18048825; 10.1200/JCO.2007.12.0253
-
(2007)
J Clin Oncol
, vol.25
, pp. 5426-5434
-
-
Ives, N.J.1
Stowe, R.L.2
Lorigan, P.3
Wheatley, K.4
-
53
-
-
84962322411
-
Overcoming Resistance to Targeted Therapies in Cancer
-
26615134
-
K.L.Redmond, A.Papafili, M.Lawler, S.Van Schaeybroeck. Overcoming Resistance to Targeted Therapies in Cancer. Semin Oncol. 2015; 42:896-908; PMID:26615134; 10.1053/j.seminoncol.2015.09.028
-
(2015)
Semin Oncol
, vol.42
, pp. 896-908
-
-
Redmond, K.L.1
Papafili, A.2
Lawler, M.3
Van Schaeybroeck, S.4
-
54
-
-
84928739294
-
AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer
-
25923549
-
P.A.Janne, J.C.Yang, D.W.Kim, D.Planchard, Y.Ohe, S.S.Ramalingam, M.J.Ahn, S.W.Kim, W.C.Su, L.Horn et al. AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer. N Engl J Med 2015; 372:1689-99; PMID:25923549; 10.1056/NEJMoa1411817
-
(2015)
N Engl J Med
, vol.372
, pp. 1689-1699
-
-
Janne, P.A.1
Yang, J.C.2
Kim, D.W.3
Planchard, D.4
Ohe, Y.5
Ramalingam, S.S.6
Ahn, M.J.7
Kim, S.W.8
Su, W.C.9
Horn, L.10
-
55
-
-
84940489292
-
Treatment approaches for EGFR-inhibitor-resistant patients with non-small-cell lung cancer
-
26370354
-
C.S.Tan, D.Gilligan, S.Pacey. Treatment approaches for EGFR-inhibitor-resistant patients with non-small-cell lung cancer. Lancet Oncol 2015; 16:e447-59; PMID:26370354; 10.1016/S1470-2045(15)00246-6
-
(2015)
Lancet Oncol
, vol.16
, pp. 447-459
-
-
Tan, C.S.1
Gilligan, D.2
Pacey, S.3
-
56
-
-
0031923377
-
Analysis of interleukin-2/interleukin-2 receptor system in advanced non-small-cell lung cancer
-
9619711
-
F.De Vita, G.Turitto, M.di Grazia, A.Frattolillo, G.Catalano. Analysis of interleukin-2/interleukin-2 receptor system in advanced non-small-cell lung cancer. Tumori 1998; 84:33-8; PMID:9619711
-
(1998)
Tumori
, vol.84
, pp. 33-38
-
-
De Vita, F.1
Turitto, G.2
di Grazia, M.3
Frattolillo, A.4
Catalano, G.5
-
57
-
-
0031463668
-
Restoration of the immunocompetence by IL-2 activation and TCR-CD3 engagement of the in vivo anergized tumor-specific CTL from lung cancer patients
-
9336742
-
Y.M.Chen, W.K.Yang, J.Whang-Peng, W.Y.Tsai, Y.M.Hung, D.M.Yang, W.C.Lin, R.P.Perng, C.C.Ting. Restoration of the immunocompetence by IL-2 activation and TCR-CD3 engagement of the in vivo anergized tumor-specific CTL from lung cancer patients. J Immunother 1997; 20:354-64; PMID:9336742; 10.1097/00002371-199709000-00004
-
(1997)
J Immunother
, vol.20
, pp. 354-364
-
-
Chen, Y.M.1
Yang, W.K.2
Whang-Peng, J.3
Tsai, W.Y.4
Hung, Y.M.5
Yang, D.M.6
Lin, W.C.7
Perng, R.P.8
Ting, C.C.9
-
58
-
-
84875859979
-
Plasma RANTES, IL-10, and IL-8 levels in non-small-cell lung cancer patients treated with EGFR-TKIs
-
23566546
-
K.Umekawa, T.Kimura, S.Kudoh, T.Suzumura, T.Oka, M.Nagata, S.Mitsuoka, K.Matsuura, T.Nakai, N.Yoshimura et al. Plasma RANTES, IL-10, and IL-8 levels in non-small-cell lung cancer patients treated with EGFR-TKIs. BMC Res Notes 2013; 6:139; PMID:23566546; 10.1186/1756-0500-6-139
-
(2013)
BMC Res Notes
, vol.6
, pp. 139
-
-
Umekawa, K.1
Kimura, T.2
Kudoh, S.3
Suzumura, T.4
Oka, T.5
Nagata, M.6
Mitsuoka, S.7
Matsuura, K.8
Nakai, T.9
Yoshimura, N.10
-
59
-
-
80051974226
-
Off-target serine/threonine kinase 10 inhibition by erlotinib enhances lymphocytic activity leading to severe skin disorders
-
21606217
-
N.Yamamoto, M.Honma, H.Suzuki. Off-target serine/threonine kinase 10 inhibition by erlotinib enhances lymphocytic activity leading to severe skin disorders. Mol Pharmacol 2011; 80:466-75; PMID:21606217; 10.1124/mol.110.070862
-
(2011)
Mol Pharmacol
, vol.80
, pp. 466-475
-
-
Yamamoto, N.1
Honma, M.2
Suzuki, H.3
-
60
-
-
84907677503
-
Gefitinib plus interleukin-2 in advanced non-small cell lung cancer patients previously treated with chemotherapy
-
25271833
-
M.Bersanelli, S.Buti, R.Camisa, M.Brighenti, S.Lazzarelli, G.Mazza, R.Passalacqua. Gefitinib plus interleukin-2 in advanced non-small cell lung cancer patients previously treated with chemotherapy. Cancers (Basel) 2014; 6:2035-48; PMID:25271833; 10.3390/cancers6042035
-
(2014)
Cancers (Basel)
, vol.6
, pp. 2035-2048
-
-
Bersanelli, M.1
Buti, S.2
Camisa, R.3
Brighenti, M.4
Lazzarelli, S.5
Mazza, G.6
Passalacqua, R.7
-
61
-
-
84906099224
-
Retrospective analysis of the safety and efficacy of high-dose interleukin-2 after prior tyrosine kinase inhibitor therapy in patients with advanced renal cell carcinoma
-
25075565
-
E.T.Lam, M.K.Wong, N.Agarwal, B.G.Redman, T.Logan, D.Gao, T.W.Flaig, K.Lewis, J.Poust, P.Monk et al. Retrospective analysis of the safety and efficacy of high-dose interleukin-2 after prior tyrosine kinase inhibitor therapy in patients with advanced renal cell carcinoma. J Immunother 2014; 37:360-5; PMID:25075565; 10.1097/CJI.0000000000000044
-
(2014)
J Immunother
, vol.37
, pp. 360-365
-
-
Lam, E.T.1
Wong, M.K.2
Agarwal, N.3
Redman, B.G.4
Logan, T.5
Gao, D.6
Flaig, T.W.7
Lewis, K.8
Poust, J.9
Monk, P.10
-
62
-
-
0033846635
-
The future of interleukin-2: enhancing therapeutic anticancer vaccines
-
10685664
-
W.W.Overwijk, M.R.Theoret, N.P.Restifo. The future of interleukin-2: enhancing therapeutic anticancer vaccines. Cancer J Sci Am 2000; 6(Suppl 1):S76-80; PMID:10685664
-
(2000)
Cancer J Sci Am
, vol.6
, pp. 76-80
-
-
Overwijk, W.W.1
Theoret, M.R.2
Restifo, N.P.3
-
63
-
-
53049088033
-
Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines
-
18765555
-
F.O.Smith, S.G.Downey, J.A.Klapper, J.C.Yang, R.M.Sherry, R.E.Royal, U.S.Kammula, M.S.Hughes, N.P.Restifo, C.L.Levy et al. Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines. Clin Cancer Res 2008; 14:5610-8; PMID:18765555; 10.1158/1078-0432.CCR-08-0116
-
(2008)
Clin Cancer Res
, vol.14
, pp. 5610-5618
-
-
Smith, F.O.1
Downey, S.G.2
Klapper, J.A.3
Yang, J.C.4
Sherry, R.M.5
Royal, R.E.6
Kammula, U.S.7
Hughes, M.S.8
Restifo, N.P.9
Levy, C.L.10
-
64
-
-
79957831345
-
gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma
-
21631324
-
D.J.Schwartzentruber, D.H.Lawson, J.M.Richards, R.M.Conry, D.M.Miller, J.Treisman, F.Gailani, L.Riley, K.Conlon, B.Pockaj et al. gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma. N Engl J Med. 2011; 364:2119-27; PMID:21631324; 10.1056/NEJMoa1012863
-
(2011)
N Engl J Med
, vol.364
, pp. 2119-2127
-
-
Schwartzentruber, D.J.1
Lawson, D.H.2
Richards, J.M.3
Conry, R.M.4
Miller, D.M.5
Treisman, J.6
Gailani, F.7
Riley, L.8
Conlon, K.9
Pockaj, B.10
-
65
-
-
0023270567
-
A new member of the immunoglobulin superfamily–CTLA-4
-
3496540
-
J.F.Brunet, F.Denizot, M.F.Luciani, M.Roux-Dosseto, M.Suzan, M.G.Mattei, P.Golstein. A new member of the immunoglobulin superfamily–CTLA-4. Nature 1987; 328:267-70; PMID:3496540; 10.1038/328267a0
-
(1987)
Nature
, vol.328
, pp. 267-270
-
-
Brunet, J.F.1
Denizot, F.2
Luciani, M.F.3
Roux-Dosseto, M.4
Suzan, M.5
Mattei, M.G.6
Golstein, P.7
-
66
-
-
84939263638
-
Immune checkpoint blockade opens an avenue of cancer immunotherapy with a potent clinical efficacy
-
25981182
-
K.Adachi, K.Tamada. Immune checkpoint blockade opens an avenue of cancer immunotherapy with a potent clinical efficacy. Cancer Sci 2015; 106:945-50; PMID:25981182; 10.1111/cas.12695
-
(2015)
Cancer Sci
, vol.106
, pp. 945-950
-
-
Adachi, K.1
Tamada, K.2
-
67
-
-
84894499071
-
Immune checkpoint blockade: the hope for immunotherapy as a treatment of lung cancer?
-
24565586
-
J.R.Brahmer. Immune checkpoint blockade: the hope for immunotherapy as a treatment of lung cancer? Semin Oncol 2014; 41:126-32; PMID:24565586; 10.1053/j.seminoncol.2013.12.014
-
(2014)
Semin Oncol
, vol.41
, pp. 126-132
-
-
Brahmer, J.R.1
-
68
-
-
0033517152
-
Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
-
10430624
-
A.van Elsas, A.A.Hurwitz, J.P.Allison. Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J Exp Med 1999; 190:355-66; PMID:10430624; 10.1084/jem.190.3.355
-
(1999)
J Exp Med
, vol.190
, pp. 355-366
-
-
van Elsas, A.1
Hurwitz, A.A.2
Allison, J.P.3
-
69
-
-
0029947568
-
Enhancement of antitumor immunity by CTLA-4 blockade
-
8596936
-
D.R.Leach, M.F.Krummel, J.P.Allison. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996; 271:1734-6; PMID:8596936; 10.1126/science.271.5256.1734
-
(1996)
Science
, vol.271
, pp. 1734-1736
-
-
Leach, D.R.1
Krummel, M.F.2
Allison, J.P.3
-
70
-
-
0034194329
-
Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade
-
10811122
-
A.A.Hurwitz, B.A.Foster, E.D.Kwon, T.Truong, E.M.Choi, N.M.Greenberg, M.B.Burg, J.P.Allison. Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade. Cancer Res 2000; 60:2444-8; PMID:10811122
-
(2000)
Cancer Res
, vol.60
, pp. 2444-2448
-
-
Hurwitz, A.A.1
Foster, B.A.2
Kwon, E.D.3
Truong, T.4
Choi, E.M.5
Greenberg, N.M.6
Burg, M.B.7
Allison, J.P.8
-
71
-
-
27844458057
-
Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study
-
16283570
-
A.V.Maker, G.Q.Phan, P.Attia, J.C.Yang, R.M.Sherry, S.L.Topalian, U.S.Kammula, R.E.Royal, L.R.Haworth, C.Levy et al. Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study. Ann Surg Oncol 2005; 12:1005-16; PMID:16283570; 10.1245/ASO.2005.03.536
-
(2005)
Ann Surg Oncol
, vol.12
, pp. 1005-1016
-
-
Maker, A.V.1
Phan, G.Q.2
Attia, P.3
Yang, J.C.4
Sherry, R.M.5
Topalian, S.L.6
Kammula, U.S.7
Royal, R.E.8
Haworth, L.R.9
Levy, C.10
-
72
-
-
84961290760
-
Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25
-
25582080
-
D.Hannani, M.Vetizou, D.Enot, S.Rusakiewicz, N.Chaput, D.Klatzmann, M.Desbois, N.Jacquelot, N.Vimond, S.Chouaib et al. Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25. Cell Res 2015; 25:208-24; PMID:25582080; 10.1038/cr.2015.3
-
(2015)
Cell Res
, vol.25
, pp. 208-224
-
-
Hannani, D.1
Vetizou, M.2
Enot, D.3
Rusakiewicz, S.4
Chaput, N.5
Klatzmann, D.6
Desbois, M.7
Jacquelot, N.8
Vimond, N.9
Chouaib, S.10
-
73
-
-
33644784733
-
IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients
-
16304057
-
M.Ahmadzadeh, S.A.Rosenberg. IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients. Blood 2006; 107:2409-14; PMID:16304057; 10.1182/blood-2005-06-2399
-
(2006)
Blood
, vol.107
, pp. 2409-2414
-
-
Ahmadzadeh, M.1
Rosenberg, S.A.2
-
74
-
-
77954953523
-
Increase of circulating CD4+CD25highFoxp3+ regulatory T cells in patients with metastatic renal cell carcinoma during treatment with dendritic cell vaccination and low-dose interleukin-2
-
20386464
-
A.Berntsen, M.K.Brimnes, P.thor Straten, I.M.Svane. Increase of circulating CD4+CD25highFoxp3+ regulatory T cells in patients with metastatic renal cell carcinoma during treatment with dendritic cell vaccination and low-dose interleukin-2. J Immunother 2010; 33:425-34; PMID:20386464; 10.1097/CJI.0b013e3181cd870f
-
(2010)
J Immunother
, vol.33
, pp. 425-434
-
-
Berntsen, A.1
Brimnes, M.K.2
thor Straten, P.3
Svane, I.M.4
-
75
-
-
84892920498
-
IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients
-
24292706
-
G.C.Sim, N.Martin-Orozco, L.Jin, Y.Yang, S.Wu, E.Washington, D.Sanders, C.Lacey, Y.Wang, L.Vence, P.Hwu, L.Radvanyi. IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients. J Clin Invest 2014; 124:99-110; PMID:24292706; 10.1172/JCI46266
-
(2014)
J Clin Invest
, vol.124
, pp. 99-110
-
-
Sim, G.C.1
Martin-Orozco, N.2
Jin, L.3
Yang, Y.4
Wu, S.5
Washington, E.6
Sanders, D.7
Lacey, C.8
Wang, Y.9
Vence, L.10
Hwu, P.11
Radvanyi, L.12
-
76
-
-
84862490985
-
Levels of peripheral CD4(+)FoxP3(+) regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer
-
22555974
-
X.Yao, M.Ahmadzadeh, Y.C.Lu, D.J.Liewehr, M.E.Dudley, F.Liu, D.S.Schrump, S.M.Steinberg, S.A.Rosenberg, P.F.Robbins. Levels of peripheral CD4(+)FoxP3(+) regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer. Blood 2012; 119:5688-96; PMID:22555974; 10.1182/blood-2011-10-386482
-
(2012)
Blood
, vol.119
, pp. 5688-5696
-
-
Yao, X.1
Ahmadzadeh, M.2
Lu, Y.C.3
Liewehr, D.J.4
Dudley, M.E.5
Liu, F.6
Schrump, D.S.7
Steinberg, S.M.8
Rosenberg, S.A.9
Robbins, P.F.10
-
77
-
-
0023819395
-
Role of asialo-GM1-positive lymphoid cells in mediating the toxic effects of recombinant IL-2 in mice
-
3259967
-
M.K.Gately, T.D.Anderson, T.J.Hayes. Role of asialo-GM1-positive lymphoid cells in mediating the toxic effects of recombinant IL-2 in mice. J Immunol 1988; 141:189-200; PMID:3259967; 10.0022-l767/88/1411-018902.0
-
(1988)
J Immunol
, vol.141
, pp. 189-200
-
-
Gately, M.K.1
Anderson, T.D.2
Hayes, T.J.3
-
78
-
-
0024490846
-
Toxicity and therapeutic efficacy of high-dose interleukin 2. In vivo infusion of antibody to NK-1.1 attenuates toxicity without compromising efficacy against murine leukemia
-
2783332
-
D.J.Peace, M.A.Cheever. Toxicity and therapeutic efficacy of high-dose interleukin 2. In vivo infusion of antibody to NK-1.1 attenuates toxicity without compromising efficacy against murine leukemia. J Exp Med 1989; 169:161-73; PMID:2783332; 10.1084/jem.169.1.161
-
(1989)
J Exp Med
, vol.169
, pp. 161-173
-
-
Peace, D.J.1
Cheever, M.A.2
-
79
-
-
2942560498
-
NK cells and polymorphonuclear neutrophils are both critical for IL-2-induced pulmonary vascular leak syndrome
-
15187148
-
E.Assier, V.Jullien, J.Lefort, J.L.Moreau, J.P.Di Santo, B.B.Vargaftig, J.R.Lapa e Silva, J.Theze. NK cells and polymorphonuclear neutrophils are both critical for IL-2-induced pulmonary vascular leak syndrome. J Immunol 2004; 172:7661-8; PMID:15187148; 10.4049/jimmunol.172.12.7661
-
(2004)
J Immunol
, vol.172
, pp. 7661-7668
-
-
Assier, E.1
Jullien, V.2
Lefort, J.3
Moreau, J.L.4
Di Santo, J.P.5
Vargaftig, B.B.6
Lapa e Silva, J.R.7
Theze, J.8
-
80
-
-
0023784524
-
A novel method for the detection of necrotic lesions in human cancers
-
3048650
-
A.L.Epstein, F.M.Chen, C.R.Taylor. A novel method for the detection of necrotic lesions in human cancers. Cancer Res 1988; 48:5842-8; PMID:3048650
-
(1988)
Cancer Res
, vol.48
, pp. 5842-5848
-
-
Epstein, A.L.1
Chen, F.M.2
Taylor, C.R.3
-
81
-
-
34247486420
-
Angiopoietin 2 is a potential mediator of high-dose interleukin 2-induced vascular leak
-
17404094
-
D.C.Gallagher, R.S.Bhatt, S.M.Parikh, P.Patel, V.Seery, D.F.McDermott, M.B.Atkins, V.P.Sukhatme. Angiopoietin 2 is a potential mediator of high-dose interleukin 2-induced vascular leak. Clin Cancer Res 2007; 13:2115-20; PMID:17404094; 10.1158/1078-0432.CCR-06-2509
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2115-2120
-
-
Gallagher, D.C.1
Bhatt, R.S.2
Parikh, S.M.3
Patel, P.4
Seery, V.5
McDermott, D.F.6
Atkins, M.B.7
Sukhatme, V.P.8
-
82
-
-
79957922807
-
Endothelial nitric oxide synthase is a key mediator of interleukin-2-induced hypotension and vascular leak syndrome
-
21577143
-
W.E.Samlowski, M.Kondapaneni, S.Tharkar, J.R.McGregor, V.E.Laubach, D.Salvemini. Endothelial nitric oxide synthase is a key mediator of interleukin-2-induced hypotension and vascular leak syndrome. J Immunother 2011; 34:419-27; PMID:21577143; 10.1097/CJI.0b013e31821dcb50
-
(2011)
J Immunother
, vol.34
, pp. 419-427
-
-
Samlowski, W.E.1
Kondapaneni, M.2
Tharkar, S.3
McGregor, J.R.4
Laubach, V.E.5
Salvemini, D.6
-
83
-
-
1442359483
-
Interleukin-2 mutants with enhanced alpha-receptor subunit binding affinity
-
14983090
-
B.M.Rao, A.T.Girvin, T.Ciardelli, D.A.Lauffenburger, K.D.Wittrup. Interleukin-2 mutants with enhanced alpha-receptor subunit binding affinity. Protein Eng 2003; 16:1081-7; PMID:14983090; 10.1093/protein/gzg111
-
(2003)
Protein Eng
, vol.16
, pp. 1081-1087
-
-
Rao, B.M.1
Girvin, A.T.2
Ciardelli, T.3
Lauffenburger, D.A.4
Wittrup, K.D.5
-
84
-
-
4844219871
-
Interleukin 2 (IL-2) variants engineered for increased IL-2 receptor alpha-subunit affinity exhibit increased potency arising from a cell surface ligand reservoir effect
-
15385640
-
B.M.Rao, I.Driver, D.A.Lauffenburger, K.D.Wittrup. Interleukin 2 (IL-2) variants engineered for increased IL-2 receptor alpha-subunit affinity exhibit increased potency arising from a cell surface ligand reservoir effect. Mol Pharmacol 2004; 66:864-9; PMID:15385640; 10.1124/mol.66.4
-
(2004)
Mol Pharmacol
, vol.66
, pp. 864-869
-
-
Rao, B.M.1
Driver, I.2
Lauffenburger, D.A.3
Wittrup, K.D.4
-
85
-
-
0033758065
-
A T-cell-selective interleukin 2 mutein exhibits potent antitumor activity and is well tolerated in vivo
-
11062441
-
A.B.Shanafelt, Y.Lin, M.C.Shanafelt, C.P.Forte, N.Dubois-Stringfellow, C.Carter, J.A.Gibbons, S.L.Cheng, K.A.Delaria, R.Fleischer et al. A T-cell-selective interleukin 2 mutein exhibits potent antitumor activity and is well tolerated in vivo. Nat Biotechnol. 2000; 18:1197-202; PMID:11062441; 10.1038/81199
-
(2000)
Nat Biotechnol
, vol.18
, pp. 1197-1202
-
-
Shanafelt, A.B.1
Lin, Y.2
Shanafelt, M.C.3
Forte, C.P.4
Dubois-Stringfellow, N.5
Carter, C.6
Gibbons, J.A.7
Cheng, S.L.8
Delaria, K.A.9
Fleischer, R.10
-
86
-
-
34250689881
-
Phase I trial of BAY 50–4798, an interleukin-2-specific agonist in advanced melanoma and renal cancer
-
17545537
-
K.Margolin, M.B.Atkins, J.P.Dutcher, M.S.Ernstoff, J.W.Smith, 2nd, J.I.Clark, J.Baar, J.Sosman, J.Weber, C.Lathia et al. Phase I trial of BAY 50–4798, an interleukin-2-specific agonist in advanced melanoma and renal cancer. Clin Cancer Res 2007; 13:3312-9; PMID:17545537; 10.1158/1078-0432.CCR-06-1341
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3312-3319
-
-
Margolin, K.1
Atkins, M.B.2
Dutcher, J.P.3
Ernstoff, M.S.4
Smith, J.W.5
Clark, J.I.6
Baar, J.7
Sosman, J.8
Weber, J.9
Lathia, C.10
-
87
-
-
0027245684
-
Human interleukin 2 analogues that preferentially bind the intermediate-affinity interleukin 2 receptor lead to reduced secondary cytokine secretion: implications for the use of these interleukin 2 analogues in cancer immunotherapy
-
8495422
-
K.M.Heaton, G.Ju, E.A.Grimm. Human interleukin 2 analogues that preferentially bind the intermediate-affinity interleukin 2 receptor lead to reduced secondary cytokine secretion: implications for the use of these interleukin 2 analogues in cancer immunotherapy. Cancer Res 1993; 53:2597-602; PMID:8495422
-
(1993)
Cancer Res
, vol.53
, pp. 2597-2602
-
-
Heaton, K.M.1
Ju, G.2
Grimm, E.A.3
-
88
-
-
0028986560
-
Differential inhibition of lymphokine-activated killing, proliferation, and cytokine secretion by humanized antibodies against the low- and intermediate-affinity interleukin-2 receptors. A novel model for activation of human peripheral blood mononuclear cells by interleukin 2
-
7759316
-
K.M.Heaton, E.A.Grimm. Differential inhibition of lymphokine-activated killing, proliferation, and cytokine secretion by humanized antibodies against the low- and intermediate-affinity interleukin-2 receptors. A novel model for activation of human peripheral blood mononuclear cells by interleukin 2. Hum Immunol 1995; 42:274-80; PMID:7759316; 10.1016/0198-8859(94)00106-Z
-
(1995)
Hum Immunol
, vol.42
, pp. 274-280
-
-
Heaton, K.M.1
Grimm, E.A.2
-
89
-
-
84862776988
-
Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’
-
22446627
-
A.M.Levin, D.L.Bates, A.M.Ring, C.Krieg, J.T.Lin, L.Su, I.Moraga, M.E.Raeber, G.R.Bowman, P.Novick et al. Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’. Nature 2012; 484:529-33; PMID:22446627; 10.1038/nature10975
-
(2012)
Nature
, vol.484
, pp. 529-533
-
-
Levin, A.M.1
Bates, D.L.2
Ring, A.M.3
Krieg, C.4
Lin, J.T.5
Su, L.6
Moraga, I.7
Raeber, M.E.8
Bowman, G.R.9
Novick, P.10
-
90
-
-
33645056478
-
Antibody targeted drugs as cancer therapeutics
-
16424916
-
D.Schrama, R.A.Reisfeld, J.C.Becker. Antibody targeted drugs as cancer therapeutics. Nat Rev Drug Discov 2006; 5:147-59; PMID:16424916; 10.1038/nrd1957
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 147-159
-
-
Schrama, D.1
Reisfeld, R.A.2
Becker, J.C.3
-
91
-
-
84884828581
-
Immunocytokines: a review of molecules in clinical development for cancer therapy
-
23990735
-
T.List, D.Neri. Immunocytokines: a review of molecules in clinical development for cancer therapy. Clin Pharmacol 2013; 5:29-45; PMID:23990735; 10.2147/CPAA.S49231
-
(2013)
Clin Pharmacol
, vol.5
, pp. 29-45
-
-
List, T.1
Neri, D.2
-
92
-
-
0028060152
-
A recombinant antibody-interleukin 2 fusion protein suppresses growth of hepatic human neuroblastoma metastases in severe combined immunodeficiency mice
-
7937818
-
H.Sabzevari, S.D.Gillies, B.M.Mueller, J.D.Pancook, R.A.Reisfeld. A recombinant antibody-interleukin 2 fusion protein suppresses growth of hepatic human neuroblastoma metastases in severe combined immunodeficiency mice. Proc Natl Acad Sci U S A 1994; 91:9626-30; PMID:7937818; 10.1073/pnas.91.20.9626
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 9626-9630
-
-
Sabzevari, H.1
Gillies, S.D.2
Mueller, B.M.3
Pancook, J.D.4
Reisfeld, R.A.5
-
93
-
-
0036493867
-
Enhancement of the antitumor properties of interleukin-2 by its targeted delivery to the tumor blood vessel extracellular matrix
-
11861281
-
B.Carnemolla, L.Borsi, E.Balza, P.Castellani, R.Meazza, A.Berndt, S.Ferrini, H.Kosmehl, D.Neri, L.Zardi. Enhancement of the antitumor properties of interleukin-2 by its targeted delivery to the tumor blood vessel extracellular matrix. Blood 2002; 99:1659-65; PMID:11861281; 10.1182/blood.V99.5.1659
-
(2002)
Blood
, vol.99
, pp. 1659-1665
-
-
Carnemolla, B.1
Borsi, L.2
Balza, E.3
Castellani, P.4
Meazza, R.5
Berndt, A.6
Ferrini, S.7
Kosmehl, H.8
Neri, D.9
Zardi, L.10
-
94
-
-
63849274108
-
Complete eradication of human B-cell lymphoma xenografts using rituximab in combination with the immunocytokine L19-IL2
-
19005180
-
C.Schliemann, A.Palumbo, K.Zuberbuhler, A.Villa, M.Kaspar, E.Trachsel, W.Klapper, H.D.Menssen, D.Neri. Complete eradication of human B-cell lymphoma xenografts using rituximab in combination with the immunocytokine L19-IL2. Blood 2009; 113:2275-83; PMID:19005180; 10.1182/blood-2008-05-160747
-
(2009)
Blood
, vol.113
, pp. 2275-2283
-
-
Schliemann, C.1
Palumbo, A.2
Zuberbuhler, K.3
Villa, A.4
Kaspar, M.5
Trachsel, E.6
Klapper, W.7
Menssen, H.D.8
Neri, D.9
-
95
-
-
51049100187
-
The targeted immunocytokine L19-IL2 efficiently inhibits the growth of orthotopic pancreatic cancer
-
18676770
-
K.`Wagner, P.Schulz, A.Scholz, B.Wiedenmann, A.Menrad. The targeted immunocytokine L19-IL2 efficiently inhibits the growth of orthotopic pancreatic cancer. Clin Cancer Res 2008; 14:4951-60; PMID:18676770; 10.1158/1078-0432.CCR-08-0157
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4951-4960
-
-
K.1
2
Schulz, P.4
Scholz, A.5
Wiedenmann, B.6
Menrad, A.7
-
96
-
-
33645679838
-
A phase I clinical trial of the hu14.18-IL2 (EMD 273063) as a treatment for children with refractory or recurrent neuroblastoma and melanoma: a study of the Children's Oncology Group
-
16551859
-
K.L.Osenga, J.A.Hank, M.R.Albertini, J.Gan, A.G.Sternberg, J.Eickhoff, R.C.Seeger, K.K.Matthay, C.P.Reynolds, C.Twist et al. A phase I clinical trial of the hu14.18-IL2 (EMD 273063) as a treatment for children with refractory or recurrent neuroblastoma and melanoma: a study of the Children's Oncology Group. Clin Cancer Res 2006; 12:1750-9; PMID:16551859; 10.1158/1078-0432.CCR-05-2000
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1750-1759
-
-
Osenga, K.L.1
Hank, J.A.2
Albertini, M.R.3
Gan, J.4
Sternberg, A.G.5
Eickhoff, J.6
Seeger, R.C.7
Matthay, K.K.8
Reynolds, C.P.9
Twist, C.10
-
97
-
-
4344569693
-
Safety, pharmacokinetics, and biological pharmacodynamics of the immunocytokine EMD 273066 (huKS-IL2): results of a phase I trial in patients with prostate cancer
-
15076141
-
Y.J.Ko, G.J.Bubley, R.Weber, C.Redfern, D.P.Gold, L.Finke, A.Kovar, T.Dahl, S.D.Gillies. Safety, pharmacokinetics, and biological pharmacodynamics of the immunocytokine EMD 273066 (huKS-IL2): results of a phase I trial in patients with prostate cancer. J Immunother 2004; 27:232-9; PMID:15076141; 10.1097/00002371-200405000-00008
-
(2004)
J Immunother
, vol.27
, pp. 232-239
-
-
Ko, Y.J.1
Bubley, G.J.2
Weber, R.3
Redfern, C.4
Gold, D.P.5
Finke, L.6
Kovar, A.7
Dahl, T.8
Gillies, S.D.9
-
98
-
-
79955023417
-
Development of an attenuated interleukin-2 fusion protein that can be activated by tumour-expressed proteases
-
21426339
-
J.Puskas, D.Skrombolas, A.Sedlacek, E.Lord, M.Sullivan, J.Frelinger. Development of an attenuated interleukin-2 fusion protein that can be activated by tumour-expressed proteases. Immunology 2011; 133:206-20; PMID:21426339; 10.1111/j.1365-2567.2011.03428.x
-
(2011)
Immunology
, vol.133
, pp. 206-220
-
-
Puskas, J.1
Skrombolas, D.2
Sedlacek, A.3
Lord, E.4
Sullivan, M.5
Frelinger, J.6
-
99
-
-
64149086421
-
IL-1beta and IL-2 convert human Treg into T(H)17 cells
-
19211307
-
F.Deknuydt, G.Bioley, D.Valmori, M.Ayyoub. IL-1beta and IL-2 convert human Treg into T(H)17 cells. Clin Immunol 2009; 131:298-307; PMID:19211307; 10.1016/j.clim.2008.12.008
-
(2009)
Clin Immunol
, vol.131
, pp. 298-307
-
-
Deknuydt, F.1
Bioley, G.2
Valmori, D.3
Ayyoub, M.4
|