Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes

Science

Volumn 359, Issue 6379, 2018, Pages 1037-1042

  Sockolosky, Jonathan T ^a,b   Trotta, Eleonora ^c   Parisi, Giulia ^d   Picton, Lora ^a   Su, Leon L ^a   Le, Alan C ^a   Chhabra, Akanksha ^a   Silveria, Stephanie L ^c   George, Benson M ^a,b,e   King, Indigo C ^f   Tiffany, Matthew R ^a   Jude, Kevin ^a   Sibener, Leah V ^a   Baker, David ^f   Shizuru, Judith A ^a   Ribas, Antoni ^d,g   Bluestone, Jeffrey A ^c,g   Garcia, K Christopher ^a,b,g  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD CANCER INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e STANFORD UNIVERSITY   (United States)

^f UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^g PARKER INSTITUTE FOR CANCER IMMUNOTHERAPY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 2 RECEPTOR BETA; INTERLEUKIN 2 RECEPTOR GAMMA; PROGRAMMED DEATH 1 RECEPTOR; STAT5 PROTEIN; INTERLEUKIN 2 RECEPTOR;

BIOENGINEERING; CANCER; CELL; IMMUNE RESPONSE; PLEIOTROPY; PROTEIN; TOXICITY;

ADOPTIVE IMMUNOTHERAPY; ADOPTIVE TRANSFER; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; BINDING AFFINITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ENGINEERING; CELL EXPANSION; CELL FUNCTION; CELL SURVIVAL; CELL TRANSFER; CELLULAR IMMUNITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOKINE PRODUCTION; GENOTYPE; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TUMOR IMMUNITY; ANIMAL; EXPERIMENTAL MELANOMA; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; NEOPLASM; PROCEDURES;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL ENGINEERING; HEK293 CELLS; HUMANS; IMMUNOTHERAPY, ADOPTIVE; MELANOMA, EXPERIMENTAL; MICE; NEOPLASMS; RECEPTORS, INTERLEUKIN-2;

EID: 85042829852     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aar3246     Document Type: Article

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