T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition

Science

Volumn 355, Issue 6332, 2017, Pages 1428-1433

  Hui, Enfu ^a,d   Cheung, Jeanne ^b   Zhu, Jing ^b   Su, Xiaolei ^a   Taylor, Marcus J ^a   Wallweber, Heidi A ^b   Sasmal, Dibyendu K ^c   Huang, Jun ^c   Kim, Jeong M ^b   Mellman, Ira ^b   Vale, Ronald D ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b GENENTECH INC   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d SECTION OF CELL AND DEVELOPMENTAL BIOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; APC PROTEIN; CD28 ANTIGEN; CD3 ANTIGEN; GLUTAMATE DECARBOXYLASE; INDUCIBLE T CELL COSTIMULATOR; INTERLEUKIN 2; LAT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 1 INHIBITOR; PROPROTEIN CONVERTASE 9; PROTEIN; PROTEIN INHIBITOR; PROTEIN KINASE LCK; PROTEIN KINASE ZAP 70; PROTEIN SH2; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; SLP76 PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; CD274 PROTEIN, HUMAN; PROGRAMMED DEATH 1 RECEPTOR;

BIOCHEMISTRY; CANCER; CELLS AND CELL COMPONENTS; ENZYME; ENZYME ACTIVITY; INHIBITION; LIGAND; PROTEIN;

ANTIGEN PRESENTING CELL; ARTICLE; CELL MEMBRANE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG TARGETING; EFFECTOR CELL; ENZYME ACTIVITY; ENZYME CONFORMATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LYMPHOCYTE FUNCTION; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; GENETICS; IMMUNOLOGY; IMMUNOTHERAPY; JURKAT CELL LINE; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; NEOPLASMS; PHOSPHORYLATION;

ANIMALS; ANTIGENS, CD274; ANTIGENS, CD28; HUMANS; IMMUNOTHERAPY; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; NEOPLASMS; PHOSPHORYLATION; PROGRAMMED CELL DEATH 1 RECEPTOR; T-LYMPHOCYTES;

EID: 85015665428     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf1292     Document Type: Article

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