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Volumn 5, Issue 1, 2017, Pages

Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy

Author keywords

Cancer therapy; Clinical trial; CSF1; CSF1R; Dt GCT; PVNS; Tumor associated macrophage

Indexed keywords

ARRAY 382; ATEZOLIZUMAB; BEVACIZUMAB; BLZ 945; CABIRALIZUMAB; CARBOPLATIN; COLONY STIMULATING FACTOR RECEPTOR; CYCLOPHOSPHAMIDE; DURVALUMAB; EMACTUZUMAB; ERIBULIN; GEMCITABINE; IMMUNOMODULATING AGENT; JNJ 40346527; LY 3022855; MCS 110; NIVOLUMAB; PACLITAXEL; PEXIDARTINIB; PLX 108 01; PLX 3397; RAPAMYCIN; TEMOZOLOMIDE; TICILIMUMAB; UNCLASSIFIED DRUG; VEMURAFENIB; ANTINEOPLASTIC AGENT; CSF1R PROTEIN, HUMAN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; IMMUNOLOGICAL ANTINEOPLASTIC AGENT;

EID: 85024385914     PISSN: None     EISSN: 20511426     Source Type: Journal    
DOI: 10.1186/s40425-017-0257-y     Document Type: Review
Times cited : (736)

References (76)
  • 1
    • 33751551172 scopus 로고    scopus 로고
    • Dual role of macrophages in tumor growth and angiogenesis
    • Lamagna C, Aurrand-Lions M, Imhof BA. Dual role of macrophages in tumor growth and angiogenesis. J Leukoc Biol. 2006;80:705-13.
    • (2006) J Leukoc Biol , vol.80 , pp. 705-713
    • Lamagna, C.1    Aurrand-Lions, M.2    Imhof, B.A.3
  • 2
    • 84873743410 scopus 로고    scopus 로고
    • M1 and M2 Macrophages: Oracles of Health and Disease
    • Mills CD. M1 and M2 Macrophages: Oracles of Health and Disease. Crit Rev Immunol. 2012;32:463-88.
    • (2012) Crit Rev Immunol , vol.32 , pp. 463-488
    • Mills, C.D.1
  • 3
    • 84904406680 scopus 로고    scopus 로고
    • Tumor-associated macrophages: from mechanisms to therapy
    • Noy R, Pollard JW. Tumor-associated macrophages: from mechanisms to therapy. Immunity. 2014;41:49-61.
    • (2014) Immunity , vol.41 , pp. 49-61
    • Noy, R.1    Pollard, J.W.2
  • 4
    • 84926523845 scopus 로고    scopus 로고
    • Macrophages and cancer: from mechanisms to therapeutic implications
    • Ostuni R, Kratochvill F, Murray PJ, Natoli G. Macrophages and cancer: from mechanisms to therapeutic implications. Trends Immunol. 2015;36:229-39.
    • (2015) Trends Immunol , vol.36 , pp. 229-239
    • Ostuni, R.1    Kratochvill, F.2    Murray, P.J.3    Natoli, G.4
  • 8
    • 85009752477 scopus 로고    scopus 로고
    • Role of the colony-stimulating factor (CSF)/CSF-1 receptor axis in cancer
    • Achkova D, Maher J. Role of the colony-stimulating factor (CSF)/CSF-1 receptor axis in cancer. Biochem Soc Trans. 2016;44:333-41.
    • (2016) Biochem Soc Trans , vol.44 , pp. 333-341
    • Achkova, D.1    Maher, J.2
  • 9
    • 84871694284 scopus 로고    scopus 로고
    • Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature
    • Zhang QW, Liu L, Gong CY, Shi HS, Zeng YH, Wang XZ, Zhao YW, Wei YQ. Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature. PLoS One. 2012;7:e50946.
    • (2012) PLoS One , vol.7
    • Zhang, Q.W.1    Liu, L.2    Gong, C.Y.3    Shi, H.S.4    Zeng, Y.H.5    Wang, X.Z.6    Zhao, Y.W.7    Wei, Y.Q.8
  • 10
    • 84975743991 scopus 로고    scopus 로고
    • Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumors
    • Holmgaard RB, Zamarin D, Lesokhin A, Merghoub T, Wolchok JD. Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumors. EBioMedicine. 2016;6:50-8.
    • (2016) EBioMedicine , vol.6 , pp. 50-58
    • Holmgaard, R.B.1    Zamarin, D.2    Lesokhin, A.3    Merghoub, T.4    Wolchok, J.D.5
  • 12
    • 84938090300 scopus 로고    scopus 로고
    • CSF1R inhibition with emactuzumab in locally advanced diffuse-type tenosynovial giant cell tumours of the soft tissue: a dose-escalation and dose-expansion phase 1 study
    • Cassier PA, Italiano A, Gomez-Roca CA, Le Tourneau C, Toulmonde M, Cannarile MA, Ries C, Brillouet A, Muller C, Jegg AM, et al. CSF1R inhibition with emactuzumab in locally advanced diffuse-type tenosynovial giant cell tumours of the soft tissue: a dose-escalation and dose-expansion phase 1 study. Lancet Oncol. 2015;16:949-56.
    • (2015) Lancet Oncol , vol.16 , pp. 949-956
    • Cassier, P.A.1    Italiano, A.2    Gomez-Roca, C.A.3    Tourneau, C.4    Toulmonde, M.5    Cannarile, M.A.6    Ries, C.7    Brillouet, A.8    Muller, C.9    Jegg, A.M.10
  • 14
    • 84966552295 scopus 로고    scopus 로고
    • Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study
    • Butowski N, Colman H, De Groot JF, Omuro AM, Nayak L, Wen PY, Cloughesy TF, Marimuthu A, Haidar S, Perry A, et al. Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study. Neuro Oncol. 2016;18:557-64.
    • (2016) Neuro Oncol , vol.18 , pp. 557-564
    • Butowski, N.1    Colman, H.2    Groot, J.F.3    Omuro, A.M.4    Nayak, L.5    Wen, P.Y.6    Cloughesy, T.F.7    Marimuthu, A.8    Haidar, S.9    Perry, A.10
  • 20
    • 41549158178 scopus 로고    scopus 로고
    • Complete response to imatinib in relapsing pigmented villonodular synovitis/tenosynovial giant cell tumor (PVNS/TGCT)
    • Blay JY, El Sayadi H, Thiesse P, Garret J, Ray-Coquard I. Complete response to imatinib in relapsing pigmented villonodular synovitis/tenosynovial giant cell tumor (PVNS/TGCT). Ann Oncol. 2008;19:821-2.
    • (2008) Ann Oncol , vol.19 , pp. 821-822
    • Blay, J.Y.1    Sayadi, H.2    Thiesse, P.3    Garret, J.4    Ray-Coquard, I.5
  • 21
    • 85058243249 scopus 로고    scopus 로고
    • MCS110, an anti-CSF-1 antibody, for the treatment of pigmented villonodular synovitis (PVNS)
    • Cheng EY ea: MCS110, an anti-CSF-1 antibody, for the treatment of pigmented villonodular synovitis (PVNS). In ISOLS/MSTS 2015 Annual Meeting, Abstract #11105, 2015.
    • In ISOLS/MSTS 2015 Annual Meetin , pp. 2015
    • Cheng, E.Y.1
  • 27
    • 84938063225 scopus 로고    scopus 로고
    • A Phase 1 Study of FPA008, an Anti-Colony Stimulating Factor 1 Receptor (anti-CSF1R) Antibody in Healthy Volunteers and Subjects with Rheumatoid Arthritis (RA): Preliminary Results
    • Hambleton J, Zhou L, Rogers S, van Marle S, van Iersel T, Zanghi J, Masteller E, Baker K, Wong B. A Phase 1 Study of FPA008, an Anti-Colony Stimulating Factor 1 Receptor (anti-CSF1R) Antibody in Healthy Volunteers and Subjects with Rheumatoid Arthritis (RA): Preliminary Results. Arthritis Rheum. 2014;66:S657.
    • (2014) Arthritis Rheum , vol.66 , pp. S657
    • Hambleton, J.1    Zhou, L.2    Rogers, S.3    Marle, S.4    Iersel, T.5    Zanghi, J.6    Masteller, E.7    Baker, K.8    Wong, B.9
  • 28
    • 77958005537 scopus 로고    scopus 로고
    • Safety, Pharmacokinetics, And Pharmacodynamics Of PD-0360324, AHuman Monoclonal Antibody To Monocyte/Macrophage Colony Stimulating Factor, In Healthy Volunteers [abstract]
    • Sadis S, Mukherjee A, Olson S, Dokmanovich M, Maher R, Cai C-H, Le V. Safety, Pharmacokinetics, And Pharmacodynamics Of PD-0360324, AHuman Monoclonal Antibody To Monocyte/Macrophage Colony Stimulating Factor, In Healthy Volunteers [abstract]. Arthritis Rheum. 2009;60 Suppl 10:408.
    • (2009) Arthritis Rheum , vol.60 , pp. 408
    • Sadis, S.1    Mukherjee, A.2    Olson, S.3    Dokmanovich, M.4    Maher, R.5    Cai, C.-H.6    Le, V.7
  • 31
    • 84943302777 scopus 로고    scopus 로고
    • Results from a Phase IIA Parallel Group Study of JNJ-40346527, an Oral CSF-1R Inhibitor, in Patients with Active Rheumatoid Arthritis despite Disease-modifying Antirheumatic Drug Therapy
    • Genovese MC, Hsia E, Belkowski SM, Chien C, Masterson T, Thurmond RL, Manthey CL, Yan XY, Ge TT, Franks C, Greenspan A. Results from a Phase IIA Parallel Group Study of JNJ-40346527, an Oral CSF-1R Inhibitor, in Patients with Active Rheumatoid Arthritis despite Disease-modifying Antirheumatic Drug Therapy. J Rheumatol. 2015;42:1752-60.
    • (2015) J Rheumatol , vol.42 , pp. 1752-1760
    • Genovese, M.C.1    Hsia, E.2    Belkowski, S.M.3    Chien, C.4    Masterson, T.5    Thurmond, R.L.6    Manthey, C.L.7    Yan, X.Y.8    Ge, T.T.9    Franks, C.10    Greenspan, A.11
  • 33
    • 85024396445 scopus 로고    scopus 로고
    • ENLIVEN Phase 3 Study of Pexidartinib in Tenosynovial Giant Cell Tumor (TGCT) Will Continue to Completion Following Enrollment Discontinuation [media release]
    • Tokyo: Daiichi Sankyo Company Ltd; 21 October 2016
    • ENLIVEN Phase 3 Study of Pexidartinib in Tenosynovial Giant Cell Tumor (TGCT) Will Continue to Completion Following Enrollment Discontinuation [media release]. Tokyo: Daiichi Sankyo Company Ltd; 21 October 2016. [ http://www.daiichisankyo.com/media_investors/media_relations/press_releases/detail/006538.html ]
  • 34
    • 84879896214 scopus 로고    scopus 로고
    • Hepatotoxicity of tyrosine kinase inhibitors: clinical and regulatory perspectives
    • Shah RR, Morganroth J, Shah DR. Hepatotoxicity of tyrosine kinase inhibitors: clinical and regulatory perspectives. Drug Saf. 2013;36:491-503.
    • (2013) Drug Saf , vol.36 , pp. 491-503
    • Shah, R.R.1    Morganroth, J.2    Shah, D.R.3
  • 39
    • 84950117835 scopus 로고    scopus 로고
    • Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial
    • Herbst RS, Baas P, Kim DW, Felip E, Perez-Gracia JL, Han JY, Molina J, Kim JH, Arvis CD, Ahn MJ, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet. 2016;387:1540-50.
    • (2016) Lancet , vol.387 , pp. 1540-1550
    • Herbst, R.S.1    Baas, P.2    Kim, D.W.3    Felip, E.4    Perez-Gracia, J.L.5    Han, J.Y.6    Molina, J.7    Kim, J.H.8    Arvis, C.D.9    Ahn, M.J.10
  • 42
    • 84959577118 scopus 로고    scopus 로고
    • Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial
    • Rosenberg JE, Hoffman-Censits J, Powles T, van der Heijden MS, Balar AV, Necchi A, Dawson N, O'Donnell PH, Balmanoukian A, Loriot Y, et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet. 2016;387:1909-20.
    • (2016) Lancet , vol.387 , pp. 1909-1920
    • Rosenberg, J.E.1    Hoffman-Censits, J.2    Powles, T.3    Heijden, M.S.4    Balar, A.V.5    Necchi, A.6    Dawson, N.7    O'Donnell, P.H.8    Balmanoukian, A.9    Loriot, Y.10
  • 45
    • 46249090513 scopus 로고    scopus 로고
    • Colony-stimulating factors in inflammation and autoimmunity
    • Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol. 2008;8:533-44.
    • (2008) Nat Rev Immunol , vol.8 , pp. 533-544
    • Hamilton, J.A.1
  • 46
    • 34447631692 scopus 로고    scopus 로고
    • Pulmonary collectins in innate immunity of the lung
    • Kuroki Y, Takahashi M, Nishitani C. Pulmonary collectins in innate immunity of the lung. Cell Microbiol. 2007;9:1871-9.
    • (2007) Cell Microbiol , vol.9 , pp. 1871-1879
    • Kuroki, Y.1    Takahashi, M.2    Nishitani, C.3
  • 48
    • 84908148912 scopus 로고    scopus 로고
    • Induction of the nuclear receptor PPAR-gamma by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages
    • Schneider C, Nobs SP, Kurrer M, Rehrauer H, Thiele C, Kopf M. Induction of the nuclear receptor PPAR-gamma by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages. Nat Immunol. 2014;15:1026-37.
    • (2014) Nat Immunol , vol.15 , pp. 1026-1037
    • Schneider, C.1    Nobs, S.P.2    Kurrer, M.3    Rehrauer, H.4    Thiele, C.5    Kopf, M.6
  • 49
    • 84941358498 scopus 로고    scopus 로고
    • Characterization of M1/M2 Tumour-Associated Macrophages (TAMs) and Th1/Th2 Cytokine Profiles in Patients with NSCLC
    • Almatroodi SA, McDonald CF, Darby IA, Pouniotis DS. Characterization of M1/M2 Tumour-Associated Macrophages (TAMs) and Th1/Th2 Cytokine Profiles in Patients with NSCLC. Cancer Microenviron. 2016;9:1-11.
    • (2016) Cancer Microenviron , vol.9 , pp. 1-11
    • Almatroodi, S.A.1    McDonald, C.F.2    Darby, I.A.3    Pouniotis, D.S.4
  • 52
    • 84951304572 scopus 로고    scopus 로고
    • The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis
    • Amit I, Winter DR, Jung S. The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis. Nat Immunol. 2016;17:18-25.
    • (2016) Nat Immunol , vol.17 , pp. 18-25
    • Amit, I.1    Winter, D.R.2    Jung, S.3
  • 53
    • 84866651672 scopus 로고    scopus 로고
    • Activating mutations in beta-catenin in colon cancer cells alter their interaction with macrophages; the role of snail
    • Kaler P, Augenlicht L, Klampfer L. Activating mutations in beta-catenin in colon cancer cells alter their interaction with macrophages; the role of snail. PLoS One. 2012;7:e45462.
    • (2012) PLoS One , vol.7
    • Kaler, P.1    Augenlicht, L.2    Klampfer, L.3
  • 55
    • 78149462163 scopus 로고    scopus 로고
    • An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation
    • MacDonald KP, Palmer JS, Cronau S, Seppanen E, Olver S, Raffelt NC, Kuns R, Pettit AR, Clouston A, Wainwright B, et al. An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation. Blood. 2010;116:3955-63.
    • (2010) Blood , vol.116 , pp. 3955-3963
    • MacDonald, K.P.1    Palmer, J.S.2    Cronau, S.3    Seppanen, E.4    Olver, S.5    Raffelt, N.C.6    Kuns, R.7    Pettit, A.R.8    Clouston, A.9    Wainwright, B.10
  • 56
    • 84988371169 scopus 로고    scopus 로고
    • Prognostic and Predictive Significance of Stromal Fibroblasts and Macrophages in Colon Cancer
    • Owusu BY, Vaid M, Kaler P, Klampfer L. Prognostic and Predictive Significance of Stromal Fibroblasts and Macrophages in Colon Cancer. Biomark Cancer. 2015;7:29-37.
    • (2015) Biomark Cancer , vol.7 , pp. 29-37
    • Owusu, B.Y.1    Vaid, M.2    Kaler, P.3    Klampfer, L.4
  • 57
    • 81855166109 scopus 로고    scopus 로고
    • Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer
    • Erreni M, Mantovani A, Allavena P. Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer. Cancer Microenviron. 2011;4:141-54.
    • (2011) Cancer Microenviron , vol.4 , pp. 141-154
    • Erreni, M.1    Mantovani, A.2    Allavena, P.3
  • 59
    • 84922367332 scopus 로고    scopus 로고
    • The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy
    • Xiao Y, Freeman GJ. The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy. Cancer Discov. 2015;5:16-8.
    • (2015) Cancer Discov , vol.5 , pp. 16-18
    • Xiao, Y.1    Freeman, G.J.2
  • 62
    • 84874100938 scopus 로고    scopus 로고
    • Cytokines released from activated human macrophages induce epithelial mesenchymal transition markers of cholangiocarcinoma cells
    • Techasen A, Loilome W, Namwat N, Dokduang H, Jongthawin J, Yongvanit P. Cytokines released from activated human macrophages induce epithelial mesenchymal transition markers of cholangiocarcinoma cells. Asian Pac J Cancer Prev. 2012;13(Suppl):115-8.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 115-118
    • Techasen, A.1    Loilome, W.2    Namwat, N.3    Dokduang, H.4    Jongthawin, J.5    Yongvanit, P.6
  • 65
    • 78149435065 scopus 로고    scopus 로고
    • The myeloid cells of the central nervous system parenchyma
    • Ransohoff RM, Cardona AE. The myeloid cells of the central nervous system parenchyma. Nature. 2010;468:253-62.
    • (2010) Nature , vol.468 , pp. 253-262
    • Ransohoff, R.M.1    Cardona, A.E.2
  • 66
    • 80055051144 scopus 로고    scopus 로고
    • Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits
    • Erblich B, Zhu LY, Etgen AM, Dobrenis K, Pollard JW: Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits. Plos One 2011, 6.
    • (2011) Plos One , pp. 6
    • Erblich, B.1    Zhu, L.Y.2    Etgen, A.M.3    Dobrenis, K.4    Pollard, J.W.5
  • 70
    • 33748532939 scopus 로고    scopus 로고
    • The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses
    • Hussain SF, Yang D, Suki D, Aldape K, Grimm E, Heimberger AB. The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. Neuro Oncol. 2006;8:261-79.
    • (2006) Neuro Oncol , vol.8 , pp. 261-279
    • Hussain, S.F.1    Yang, D.2    Suki, D.3    Aldape, K.4    Grimm, E.5    Heimberger, A.B.6
  • 71
    • 50249144131 scopus 로고    scopus 로고
    • Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas
    • Komohara Y, Ohnishi K, Kuratsu J, Takeya M. Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas. J Pathol. 2008;216:15-24.
    • (2008) J Pathol , vol.216 , pp. 15-24
    • Komohara, Y.1    Ohnishi, K.2    Kuratsu, J.3    Takeya, M.4
  • 73
    • 84982152011 scopus 로고    scopus 로고
    • Phase 1/2 study of combination therapy with pexidartinib and sirolimus to target tumor-associated macrophages in malignant peripheral nerve sheath tumors
    • (suppl; abstr TPS11070);
    • Gulam Abbas Manji PP, Shing Mirn Lee, Nanette Matos, Edward Bentlyewski, Brian Andrew Van Tine, Khanh Tu Do, Suzanne George, Gary K. Schwartz: Phase 1/2 study of combination therapy with pexidartinib and sirolimus to target tumor-associated macrophages in malignant peripheral nerve sheath tumors. In J Clin Oncol 34, 2016 (suppl; abstr TPS11070); 2016.
    • (2016) In J Clin Oncol , vol.34 , pp. 2016
    • Gulam Abbas Manji, P.P.1    Lee, S.M.2    Matos, N.3    Bentlyewski, E.4    Van Tine, B.A.5    Do, K.T.6    George, S.7    Schwartz, G.K.8
  • 74
    • 85084273542 scopus 로고    scopus 로고
    • Phase 1/2a study of double immune suppression blockade by combining a CSF1R inhibitor (pexidartinib/PLX3397) with an anti PD-1 antibody (pembrolizumab) to treat advanced melanoma and other solid tumors
    • Hu-Lieskovan S, Patnaik A, Eisenberg P, Sachdev J, Weise A, Kaufman DR, Aromin I, West BL, Tong S, Ribas A. Phase 1/2a study of double immune suppression blockade by combining a CSF1R inhibitor (pexidartinib/PLX3397) with an anti PD-1 antibody (pembrolizumab) to treat advanced melanoma and other solid tumors. Ann Oncol. 2015;26:7-7.
    • (2015) Ann Oncol , vol.26 , pp. 7-7
    • Hu-Lieskovan, S.1    Patnaik, A.2    Eisenberg, P.3    Sachdev, J.4    Weise, A.5    Kaufman, D.R.6    Aromin, I.7    West, B.L.8    Tong, S.9    Ribas, A.10
  • 76
    • 85024405800 scopus 로고    scopus 로고
    • Phase Ia/Ib trial investigating the CSF-1R inhibitor LY3022855 in combination with durvalumab (MEDI4736) or tremelimumab in patients with advanced solid malignancies
    • Bauer T. Phase Ia/Ib trial investigating the CSF-1R inhibitor LY3022855 in combination with durvalumab (MEDI4736) or tremelimumab in patients with advanced solid malignancies. J ImmunoTher Cancer. 2016;4 Suppl 1:P137.
    • (2016) J ImmunoTher Cancer , vol.4 , pp. P137
    • Bauer, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.