Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy

Science

Volumn 355, Issue 6322, 2017, Pages

  Davoli, Teresa ^a   Uno, Hajime ^b   Wooten, Eric C ^a   Elledge, Stephen J ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CTLA4 PROTEIN, HUMAN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; TRANSCRIPTOME; TUMOR MARKER;

BIOMARKER; CANCER; CELLS AND CELL COMPONENTS; IMMUNE RESPONSE; IMMUNITY; TOXICITY; TUMOR;

ANEUPLOIDY; ARTICLE; CANCER CELL; CANCER IMMUNOTHERAPY; CANCER SURVIVAL; CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; COPY NUMBER VARIATION; HUMAN; METASTATIC MELANOMA; MUTATION RATE; PRIORITY JOURNAL; SOMATIC COPY NUMBER ALTERATION; SOMATIC MUTATION; TUMOR ANEUPLOIDY; TUMOR ESCAPE; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; CELL CYCLE; CELL PROLIFERATION; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; GENETICS; IMMUNOLOGY; IMMUNOTHERAPY; MORTALITY; NEOPLASMS; POINT MUTATION; PROGNOSIS; TUMOR ASSOCIATED LEUKOCYTE;

BIOMARKERS, TUMOR; CELL CYCLE; CELL PROLIFERATION; CTLA-4 ANTIGEN; CYTOTOXICITY, IMMUNOLOGIC; DNA COPY NUMBER VARIATIONS; HUMANS; IMMUNOTHERAPY; LYMPHOCYTES, TUMOR-INFILTRATING; MODELS, BIOLOGICAL; NEOPLASMS; POINT MUTATION; PROGNOSIS; T-LYMPHOCYTES, CYTOTOXIC; TRANSCRIPTOME; TUMOR ESCAPE;

EID: 85010652953     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf8399     Document Type: Article

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