Type, density, and location of immune cells within human colorectal tumors predict clinical outcome

Science

Volumn 313, Issue 5795, 2006, Pages 1960-1964

  Galon, Jérôme ^a,b,c   Costes, Anne ^a,b,c   Sanchez Cabo, Fatima ^d   Kirilovsky, Amos ^a,b,c   Mlecnik, Bernhard ^d   Lagorce Pagès, Christine ^e   Tosolini, Marie ^a,b,c   Camus, Matthieu ^a,b,c   Berger, Anne ^e   Wind, Philippe ^e   Zinzindohoué, Franck ^f   Bruneval, Patrick ^f   Cugnenc, Paul Henri ^f   Trajanoski, Zlatko ^d   Fridman, Wolf Herman ^a,f   Pagès, Franck ^a,f  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^e AVICENNE HOSPITAL   (France)

^f HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOLOGY; INFILTRATION; PATHOLOGY; PATIENT MONITORING; TUMORS;

HISTOPATHOLOGICAL METHODS; IMMUNE CELLS; IMMUNE RESPONSE; IMMUNOHISTOCHEMICAL STAINING; PROGNOSTIC TOOL;

CELLS;

CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; CD3 ANTIGEN; CD45RO ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; GRANULYSIN; GRANZYME B; INTERFERON REGULATORY FACTOR 1; MATRILYSIN; SURVIVIN; T BOX TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; VASCULOTROPIN;

CANCER; DISEASE CONTROL; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNE RESPONSE; SURVIVAL; TUMOR;

ARTICLE; CANCER GROWTH; CANCER RECURRENCE; CANCER SURVIVAL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL TYPE; COLORECTAL TUMOR; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IMMUNOSURVEILLANCE; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MEMORY T LYMPHOCYTE; OVERALL SURVIVAL; PRIORITY JOURNAL; TH1 CELL; TUMOR ASSOCIATED LEUKOCYTE;

ANTIGENS, CD3; ANTIGENS, CD45; CD8-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; FEMALE; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGIC MEMORY; LYMPHATIC METASTASIS; LYMPHOCYTE COUNT; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; PROGNOSIS; SURVIVAL ANALYSIS; T-LYMPHOCYTE SUBSETS; TH1 CELLS;

EID: 33749319703     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1129139     Document Type: Article

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