Erratum: Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses (Cell (2015) 162(5) (974–986) (S009286741500848X) (10.1016/j.cell.2015.07.011));Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

Cell

Volumn 162, Issue 5, 2015, Pages 974-986

  Chiappinelli, Katherine B ^a   Strissel, Pamela L ^b   Desrichard, Alexis ^c   Li, Huili ^a   Henke, Christine ^b   Akman, Benjamin ^a   Hein, Alexander ^b   Rote, Neal S ^d   Cope, Leslie M ^a   Snyder, Alexandra ^c   Makarov, Vladimir ^c   Buhu, Sadna ^c   Slamon, Dennis J ^e   Wolchok, Jedd D ^c   Pardoll, Drew M ^a   Beckmann, Matthias W ^b   Zahnow, Cynthia A ^a   Mergoub, Taha ^c   Chan, Timothy A ^c   Baylin, Stephen B ^a   Strick, Reiner ^b   more..

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; BETA INTERFERON; BETA INTERFERON RECEPTOR; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; DNA METHYLTRANSFERASE; DOUBLE STRANDED RNA; INTERFERON; MAVS PROTEIN; MITOCHONDRIAL PROTEIN; RNA BINDING PROTEIN; TOLL LIKE RECEPTOR 3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER IMMUNOTHERAPY; CONTROLLED STUDY; CYTOKINE RESPONSE; DNA METHYLATION; DRUG EFFICACY; DRUG POTENTIATION; ENDOGENOUS RETROVIRUS; EPIGENETICS; FEMALE; GENE OVEREXPRESSION; GENE SILENCING; GENETIC CORRELATION; GENOME ANALYSIS; HOST RESISTANCE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; LOW DRUG DOSE; MELANOMA; MOUSE; MULTIPLE CANCER; MULTIPLE CYCLE TREATMENT; NONHUMAN; ONCOLYTIC VIROTHERAPY; OVARY CANCER; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; UPREGULATION; VIRUS GENE; VIRUS IMMUNITY; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DRUG EFFECTS; GENETICS; IMMUNOLOGY; IMMUNOTHERAPY; LUNG NEOPLASMS; METABOLISM; OVARIAN NEOPLASMS; TUMOR CELL LINE;

ANIMALS; AZACITIDINE; CELL LINE, TUMOR; DNA METHYLATION; DNA MODIFICATION METHYLASES; ENDOGENOUS RETROVIRUSES; FEMALE; HUMANS; IMMUNOTHERAPY; INTERFERON TYPE I; LUNG NEOPLASMS; MELANOMA; MICE; MICE, INBRED C57BL; OVARIAN NEOPLASMS; RNA, DOUBLE-STRANDED;

EID: 84940381273     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.03.036     Document Type: Erratum

References (90)

1. M.S. Anglesio, K.C. Wiegand, N. Melnyk, C. Chow, C. Salamanca, L.M. Prentice, J. Senz, W. Yang, M.A. Spillman, D.R. Cochrane, and et al. Type-specific cell line models for type-specific ovarian cancer research PLoS ONE 8 2013 e72162
2. N. Bannert, and R. Kurth Retroelements and the human genome: new perspectives on an old relation Proc. Natl. Acad. Sci. USA 101 Suppl 2 2004 14572 14579
3. S.B. Baylin, and P.A. Jones A decade of exploring the cancer epigenome - biological and translational implications Nat. Rev. Cancer 11 2011 726 734
4. L. Bénit, A. Calteau, and T. Heidmann Characterization of the low-copy HERV-Fc family: evidence for recent integrations in primates of elements with coding envelope genes Virology 312 2003 159 168
5. R. Berger, R. Rotem-Yehudar, G. Slama, S. Landes, A. Kneller, M. Leiba, M. Koren-Michowitz, A. Shimoni, and A. Nagler Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies Clin. Cancer Res. 14 2008 3044 3051
6. J.J. Bernard, C. Cowing-Zitron, T. Nakatsuji, B. Muehleisen, J. Muto, A.W. Borkowski, L. Martinez, E.L. Greidinger, B.D. Yu, and R.L. Gallo Ultraviolet radiation damages self noncoding RNA and is detected by TLR3 Nat. Med. 18 2012 1286 1290
7. T.H. Bestor, and B. Tycko Creation of genomic methylation patterns Nat. Genet. 12 1996 363 367
8. S. Blaise, N. de Parseval, and T. Heidmann Functional characterization of two newly identified Human Endogenous Retrovirus coding envelope genes Retrovirology 2 2005 19
9. J.L. Blond, F. Besème, L. Duret, O. Bouton, F. Bedin, H. Perron, B. Mandrand, and F. Mallet Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family J. Virol. 73 1999 1175 1185
10. Brahmer, J. (2015). Phase II Anti-PD1 Epigenetic Priming Study in NSCLC (NA-00084192). https://clinicaltrials.gov/ct2/show/NCT01928576.
11. J.R. Brahmer, C.G. Drake, I. Wollner, J.D. Powderly, J. Picus, W.H. Sharfman, E. Stankevich, A. Pons, T.M. Salay, T.L. McMiller, and et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates J. Clin. Oncol. 28 2010 3167 3175
12. J.R. Brahmer, S.S. Tykodi, L.Q. Chow, W.J. Hwu, S.L. Topalian, P. Hwu, C.G. Drake, L.H. Camacho, J. Kauh, K. Odunsi, and et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer N. Engl. J. Med. 366 2012 2455 2465
13. J. Chen, M. Sun, W.J. Kent, X. Huang, H. Xie, W. Wang, G. Zhou, R.Z. Shi, and J.D. Rowley Over 20% of human transcripts might form sense-antisense pairs Nucleic Acids Res. 32 2004 4812 4820
14. K.B. Chiappinelli, B.C. Haynes, M.R. Brent, and P.J. Goodfellow Reduced DICER1 elicits an interferon response in endometrial cancer cells Mol. Cancer Res. 10 2012 316 325
15. L.J. Cooper, J. Krishnamurthy, B. Rabinovich, T. Mi, K. Switzer, S. Olivares, S. Maiti, J.B. Plummer, H. Singh, P. Kumaresan, and et al. Genetic engineering of T cells to target HERV-K, an ancient retrovirus on melanoma Clin. Cancer Res. 21 2015 3241 3251
16. N. de Parseval, V. Lazar, J.F. Casella, L. Benit, and T. Heidmann Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins J. Virol. 77 2003 10414 10422
17. S. Ding, and M.D. Robek Peroxisomal MAVS activates IRF1-mediated IFN-λ production Nat. Immunol. 15 2014 700 701
18. S. Ding, W. Khoury-Hanold, A. Iwasaki, and M.D. Robek Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth PLoS Biol. 12 2014 e1001758
19. S. Domcke, R. Sinha, D.A. Levine, C. Sander, and N. Schultz Evaluating cell lines as tumour models by comparison of genomic profiles Nat. Commun. 4 2013 2126
20. C.G. Drake, E. Jaffee, and D.M. Pardoll Mechanisms of immune evasion by tumors Adv. Immunol. 90 2006 51 81
21. M.F. Egan, R.E. Straub, T.E. Goldberg, I. Yakub, J.H. Callicott, A.R. Hariri, V.S. Mattay, A. Bertolino, T.M. Hyde, C. Shannon-Weickert, and et al. Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia Proc. Natl. Acad. Sci. USA 101 2004 12604 12609
22. M.A. Faghihi, F. Modarresi, A.M. Khalil, D.E. Wood, B.G. Sahagan, T.E. Morgan, C.E. Finch, G. St Laurent 3rd, P.J. Kenny, and C. Wahlestedt Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase Nat. Med. 14 2008 723 730
23. J. Gimenez, C. Montgiraud, J.P. Pichon, B. Bonnaud, M. Arsac, K. Ruel, O. Bouton, and F. Mallet Custom human endogenous retroviruses dedicated microarray identifies self-induced HERV-W family elements reactivated in testicular cancer upon methylation control Nucleic Acids Res. 38 2010 2229 2246
24. E.J. Grow, R.A. Flynn, S.L. Chavez, N.L. Bayless, M. Wossidlo, D.J. Wesche, L. Martin, C.B. Ware, C.A. Blish, H.Y. Chang, and et al. Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells Nature 522 2015 221 225
25. J. Guan, R. Gupta, and F.V. Filipp Cancer systems biology of TCGA SKCM: efficient detection of genomic drivers in melanoma Sci. Rep. 5 2015 7857
26. C. Henke, P.L. Strissel, M.-T. Schubert, M. Mitchell, C.C. Stolt, F. Faschingbauer, M.W. Beckmann, and R. Strick Selective expression of sense and antisense transcripts of the sushi-ichi-related retrotransposon - derived family during mouse placentogenesis Retrovirology 12 2015 9
27. J.G. Herman, J.R. Graff, S. Myöhänen, B.D. Nelkin, and S.B. Baylin Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands Proc. Natl. Acad. Sci. USA 93 1996 9821 9826
28. F.S. Hodi, S.J. O'Day, D.F. McDermott, R.W. Weber, J.A. Sosman, J.B. Haanen, R. Gonzalez, C. Robert, D. Schadendorf, J.C. Hassel, and et al. Improved survival with ipilimumab in patients with metastatic melanoma N. Engl. J. Med. 363 2010 711 723
29. T. Hurst, and G. Magiorkinis Activation of the innate immune response by endogenous retroviruses J. Gen. Virol. 96 2014 1207 1218
30. L.B. Ivashkiv, and L.T. Donlin Regulation of type I interferon responses Nat. Rev. Immunol. 14 2014 36 49
31. J.P. Issa Optimizing therapy with methylation inhibitors in myelodysplastic syndromes: dose, duration, and patient selection Nat. Clin. Pract. Oncol. 2 Suppl 1 2005 S24 S29
32. S.R. James, C.D. Cedeno, A. Sharma, W. Zhang, J.L. Mohler, K. Odunsi, E.M. Wilson, and A.R. Karpf DNA methylation and nucleosome occupancy regulate the cancer germline antigen gene MAGEA11 Epigenetics 8 2013 849 863
33. R.A. Juergens, J. Wrangle, F.P. Vendetti, S.C. Murphy, M. Zhao, B. Coleman, R. Sebree, K. Rodgers, C.M. Hooker, N. Franco, and et al. Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer Cancer Discov. 1 2011 598 607
34. E. Kaminskas, A. Farrell, S. Abraham, A. Baird, L.S. Hsieh, S.L. Lee, J.K. Leighton, H. Patel, A. Rahman, R. Sridhara, et al. FDA Approval summary: azacitidine for treatment of myelodysplastic syndrome subtypes Clin. Cancer Res. 11 2005 3604 3608
35. K. Karikó, M. Buckstein, H. Ni, and D. Weissman Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA Immunity 23 2005 165 175
36. A.R. Karpf, P.W. Peterson, J.T. Rawlins, B.K. Dalley, Q. Yang, H. Albertsen, and D.A. Jones Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator of transcription 1, 2, and 3 genes in colon tumor cells Proc. Natl. Acad. Sci. USA 96 1999 14007 14012
37. A.R. Karpf, A.W. Lasek, T.O. Ririe, A.N. Hanks, D. Grossman, and D.A. Jones Limited gene activation in tumor and normal epithelial cells treated with the DNA methyltransferase inhibitor 5-aza-2′-deoxycytidine Mol. Pharmacol. 65 2004 18 27
38. A.R. Karpf, S. Bai, S.R. James, J.L. Mohler, and E.M. Wilson Increased expression of androgen receptor coregulator MAGE-11 in prostate cancer by DNA hypomethylation and cyclic AMP Mol. Cancer Res. 7 2009 523 535
39. O.I. Kulaeva, S. Draghici, L. Tang, J.M. Kraniak, S.J. Land, and M.A. Tainsky Epigenetic silencing of multiple interferon pathway genes after cellular immortalization Oncogene 22 2003 4118 4127
40. J.M. Larsen, I.J. Christensen, H.J. Nielsen, U. Hansen, B. Bjerregaard, J.F. Talts, and L.I. Larsson Syncytin immunoreactivity in colorectal cancer: potential prognostic impact Cancer Lett. 280 2009 44 49
41. M.J. Laska, K.K. Nissen, and B.A. Nexø (Some) cellular mechanisms influencing the transcription of human endogenous retrovirus, HERV-Fc1 PLoS ONE 8 2013 e53895
42. D.T. Le, J.N. Uram, H. Wang, B.R. Bartlett, H. Kemberling, A.D. Eyring, A.D. Skora, B.S. Luber, N.S. Azad, D. Laheru, and et al. PD-1 blockade in tumors with mismatch-repair deficiency N. Engl. J. Med. 372 2015 2509 2520
43. D.R. Leach, M.F. Krummel, and J.P. Allison Enhancement of antitumor immunity by CTLA-4 blockade Science 271 1996 1734 1736
44. K.I. Leonova, L. Brodsky, B. Lipchick, M. Pal, L. Novototskaya, A.A. Chenchik, G.C. Sen, E.A. Komarova, and A.V. Gudkov p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs Proc. Natl. Acad. Sci. USA 110 2013 E89 E98
45. H. Li, K.B. Chiappinelli, A.A. Guzzetta, H. Easwaran, R.W. Yen, R. Vatapalli, M.J. Topper, J. Luo, R.M. Connolly, N.S. Azad, and et al. Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers Oncotarget 5 2014 587 598
46. R. Löwer, J. Löwer, C. Tondera-Koch, and R. Kurth A general method for the identification of transcribed retrovirus sequences (R-U5 PCR) reveals the expression of the human endogenous retrovirus loci HERV-H and HERV-K in teratocarcinoma cells Virology 192 1993 501 511
47. I.A. Maksakova, D.L. Mager, and D. Reiss Keeping active endogenous retroviral-like elements in check: the epigenetic perspective Cell. Mol. Life Sci. 65 2008 3329 3347
48. A.K. Mankan, T. Schmidt, D. Chauhan, M. Goldeck, K. Höning, M. Gaidt, A.V. Kubarenko, L. Andreeva, K.P. Hopfner, and V. Hornung Cytosolic RNA:DNA hybrids activate the cGAS-STING axis EMBO J. 33 2014 2937 2946
49. D. Matei, F. Fang, C. Shen, J. Schilder, A. Arnold, Y. Zeng, W.A. Berry, T. Huang, and K.P. Nephew Epigenetic resensitization to platinum in ovarian cancer Cancer Res. 72 2012 2197 2205
50. M. Matousková, J. Blazková, P. Pajer, A. Pavlícek, and J. Hejnar CpG methylation suppresses transcriptional activity of human syncytin-1 in non-placental tissues Exp. Cell Res. 312 2006 1011 1020
51. S. Mi, X. Lee, X. Li, G.M. Veldman, H. Finnerty, L. Racie, E. LaVallie, X.Y. Tang, P. Edouard, S. Howes, and et al. Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis Nature 403 2000 785 789
52. H.M. O'Hagan, W. Wang, S. Sen, C. Destefano Shields, S.S. Lee, Y.W. Zhang, E.G. Clements, Y. Cai, L. Van Neste, H. Easwaran, and et al. Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands Cancer Cell 20 2011 606 619
53. K. Odunsi, J. Matsuzaki, S.R. James, P. Mhawech-Fauceglia, T. Tsuji, A. Miller, W. Zhang, S.N. Akers, E.A. Griffiths, A. Miliotto, and et al. Epigenetic potentiation of NY-ESO-1 vaccine therapy in human ovarian cancer Cancer Immunol. Res. 2 2014 37 49
54. D.M. Pardoll The blockade of immune checkpoints in cancer immunotherapy Nat. Rev. Cancer 12 2012 252 264
55. L.C. Platanias Mechanisms of type-I- and type-II-interferon-mediated signalling Nat. Rev. Immunol. 5 2005 375 386
56. N.A. Rizvi, M.D. Hellmann, A. Snyder, P. Kvistborg, V. Makarov, J.J. Havel, W. Lee, J. Yuan, P. Wong, T.S. Ho, and et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer Science 348 2015 124 128
57. M.D. Robek, B.S. Boyd, and F.V. Chisari Lambda interferon inhibits hepatitis B and C virus replication J. Virol. 79 2005 3851 3854
58. N.S. Rote, S. Chakrabarti, and B.P. Stetzer The role of human endogenous retroviruses in trophoblast differentiation and placental development Placenta 25 2004 673 683
59. M. Ruebner, P.L. Strissel, A.B. Ekici, E. Stiegler, U. Dammer, T.W. Goecke, F. Faschingbauer, F.B. Fahlbusch, M.W. Beckmann, and R. Strick Reduced syncytin-1 expression levels in placental syndromes correlates with epigenetic hypermethylation of the ERVW-1 promoter region PLoS ONE 8 2013 e56145
60. K. Rycaj, J.B. Plummer, B. Yin, M. Li, J. Garza, L.G. Radvanyi, L.M. Ramondetta, K. Lin, G.L. Johanning, D.G. Tang, and et al. Cytotoxicity of human endogenous retrovirus K-specific T cells toward autologous ovarian cancer cells Clin. Cancer Res. 21 2015 471 483
61. F.A. Santoni, J. Guerra, and J. Luban HERV-H RNA is abundant in human embryonic stem cells and a precise marker for pluripotency Retrovirology 9 2012 111
62. M. Schaefer, S. Hagemann, K. Hanna, and F. Lyko Azacytidine inhibits RNA methylation at DNMT2 target sites in human cancer cell lines Cancer Res. 69 2009 8127 8132
63. R.D. Schreiber, L.J. Old, and M.J. Smyth Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion Science 331 2011 1565 1570
64. A. Sistigu, T. Yamazaki, E. Vacchelli, K. Chaba, D.P. Enot, J. Adam, I. Vitale, A. Goubar, E.E. Baracco, C. Remédios, and et al. Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy Nat. Med. 20 2014 1301 1309
65. A. Snyder, V. Makarov, T. Merghoub, J. Yuan, J.M. Zaretsky, A. Desrichard, L.A. Walsh, M.A. Postow, P. Wong, T.S. Ho, and et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma N. Engl. J. Med. 371 2014 2189 2199
66. S. Stengel, U. Fiebig, R. Kurth, and J. Denner Regulation of human endogenous retrovirus-K expression in melanomas by CpG methylation Genes Chromosomes Cancer 49 2010 401 411
67. S.A. Stewart, D.M. Dykxhoorn, D. Palliser, H. Mizuno, E.Y. Yu, D.S. An, D.M. Sabatini, I.S. Chen, W.C. Hahn, P.A. Sharp, and et al. Lentivirus-delivered stable gene silencing by RNAi in primary cells RNA 9 2003 493 501
68. C. Stresemann, B. Brueckner, T. Musch, H. Stopper, and F. Lyko Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines Cancer Res. 66 2006 2794 2800
69. R. Strick, S. Ackermann, M. Langbein, J. Swiatek, S.W. Schubert, S. Hashemolhosseini, T. Koscheck, P.A. Fasching, R.L. Schild, M.W. Beckmann, and P.L. Strissel Proliferation and cell-cell fusion of endometrial carcinoma are induced by the human endogenous retroviral Syncytin-1 and regulated by TGF-beta J. Mol. Med. 85 2007 23 38
70. P.L. Strissel, M. Ruebner, F. Thiel, D. Wachter, A.B. Ekici, F. Wolf, F. Thieme, K. Ruprecht, M.W. Beckmann, and R. Strick Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: emergence of new molecular targets Oncotarget 3 2012 1204 1219
71. W.Y. Su, J.T. Li, Y. Cui, J. Hong, W. Du, Y.C. Wang, Y.W. Lin, H. Xiong, J.L. Wang, X. Kong, and et al. Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric cancer Cell Res. 22 2012 1374 1389
72. L. Sun, J. Wu, F. Du, X. Chen, and Z.J. Chen Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway Science 339 2013 786 791
73. V. Tarallo, Y. Hirano, B.D. Gelfand, S. Dridi, N. Kerur, Y. Kim, W.G. Cho, H. Kaneko, B.J. Fowler, S. Bogdanovich, and et al. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88 Cell 149 2012 847 859
74. S.L. Topalian, F.S. Hodi, J.R. Brahmer, S.N. Gettinger, D.C. Smith, D.F. McDermott, J.D. Powderly, R.D. Carvajal, J.A. Sosman, M.B. Atkins, and et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer N. Engl. J. Med. 366 2012 2443 2454
75. S.L. Topalian, C.G. Drake, and D.M. Pardoll Immune checkpoint blockade: a common denominator approach to cancer therapy Cancer Cell 27 2015 450 461
76. M. Tristem Identification and characterization of novel human endogenous retrovirus families by phylogenetic screening of the human genome mapping project database J. Virol. 74 2000 3715 3730
77. H.C. Tsai, H. Li, L. Van Neste, Y. Cai, C. Robert, F.V. Rassool, J.J. Shin, K.M. Harbom, R. Beaty, E. Pappou, and et al. Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells Cancer Cell 21 2012 430 446
78. G. Turner, M. Barbulescu, M. Su, M.I. Jensen-Seaman, K.K. Kidd, and J. Lenz Insertional polymorphisms of full-length endogenous retroviruses in humans Curr. Biol. 11 2001 1531 1535
79. R.G. Verhaak, P. Tamayo, J.Y. Yang, D. Hubbard, H. Zhang, C.J. Creighton, S. Fereday, M. Lawrence, S.L. Carter, C.H. Mermel, and et al. Prognostically relevant gene signatures of high-grade serous ovarian carcinoma J. Clin. Invest. 123 2013 517 525
80. P. Villesen, L. Aagaard, C. Wiuf, and F.S. Pedersen Identification of endogenous retroviral reading frames in the human genome Retrovirology 1 2004 32
81. C.P. Walsh, J.R. Chaillet, and T.H. Bestor Transcription of IAP endogenous retroviruses is constrained by cytosine methylation Nat. Genet. 20 1998 116 117
82. F. Wang-Johanning, A.R. Frost, G.L. Johanning, M.B. Khazaeli, A.F. LoBuglio, D.R. Shaw, and T.V. Strong Expression of human endogenous retrovirus k envelope transcripts in human breast cancer Clin. Cancer Res. 7 2001 1553 1560
83. F. Wang-Johanning, A.R. Frost, B. Jian, L. Epp, D.W. Lu, and G.L. Johanning Quantitation of HERV-K env gene expression and splicing in human breast cancer Oncogene 22 2003 1528 1535
84. F. Wang-Johanning, J. Liu, K. Rycaj, M. Huang, K. Tsai, D.G. Rosen, D.T. Chen, D.W. Lu, K.F. Barnhart, and G.L. Johanning Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer Int. J. Cancer 120 2007 81 90
85. F. Wang-Johanning, K. Rycaj, J.B. Plummer, M. Li, B. Yin, K. Frerich, J.G. Garza, J. Shen, K. Lin, P. Yan, and et al. Immunotherapeutic potential of anti-human endogenous retrovirus-K envelope protein antibodies in targeting breast tumors J. Natl. Cancer Inst. 104 2012 189 210
86. J.S. Weber, S.P. D'Angelo, D. Minor, F.S. Hodi, R. Gutzmer, B. Neyns, C. Hoeller, N.I. Khushalani, W.H. Miller Jr., C.D. Lao, and et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial Lancet Oncol. 16 2015 375 384
87. M.D. Wilkerson, and D.N. Hayes ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking Bioinformatics 26 2010 1572 1573
88. J. Wrangle, W. Wang, A. Koch, H. Easwaran, H.P. Mohammad, F. Vendetti, W. Vancriekinge, T. Demeyer, Z. Du, P. Parsana, and et al. Alterations of immune response of non-small cell lung cancer with azacytidine Oncotarget 4 2013 2067 2079
89. Z. Xiong, and P.W. Laird COBRA: a sensitive and quantitative DNA methylation assay Nucleic Acids Res. 25 1997 2532 2534
90. D. Zamarin, R.B. Holmgaard, S.K. Subudhi, J.S. Park, M. Mansour, P. Palese, T. Merghoub, J.D. Wolchok, and J.P. Allison Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy Sci. Transl. Med. 6 2014 226ra32