Tgfß, a potent regulator of tumor microenvironment and host immune response, implication for therapy

Current Molecular Medicine

Volumn 10, Issue 4, 2010, Pages 374-380

  Yang, L ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Antagonism; Bone marrow; Breast tumor; Inflammation; Metastasis; Myeloid cells; Tgf ; Tumor microenvironment

Indexed keywords

ANGIOPOIETIN RECEPTOR; BIOLOGICAL MARKER; CALGRANULIN A; CALGRANULIN B; CD11B ANTIGEN; CD34 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR4; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 21; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1D11; SMAD PROTEIN; SMAD4 PROTEIN; STROMAL CELL DERIVED FACTOR 1; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 1; CARCINOGEN; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CANCER GROWTH; CANCER IMMUNOTHERAPY; CANCER MODEL; CD8+ T LYMPHOCYTE; CYTOTOXIC T LYMPHOCYTE; FIBROBLAST; HOST; HUMAN; IMMUNE RESPONSE; INFLAMMATION; INFLAMMATORY CELL; INFLAMMATORY INFILTRATE; METASTASIS; MICROENVIRONMENT; NATURAL KILLER CELL; NONHUMAN; PATIENT SELECTION; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; TUMOR CELL; TUMOR IMMUNITY; ANIMAL; BIOLOGICAL MODEL; DRUG ANTAGONISM; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; METABOLISM; MOUSE; NEOPLASM; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

ANIMALS; CARCINOGENS; HUMANS; IMMUNE TOLERANCE; INFLAMMATION; MICE; MODELS, BIOLOGICAL; NEOPLASM METASTASIS; NEOPLASMS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEINS;

EID: 77953507082     PISSN: 15665240     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652410791317039     Document Type: Article

References (66)

1. Bierie, B. and Moses, H.L. (2006) Nat. Rev. Cancer, 6, 506-520.
2. Levy, L. and Hill, C.S. (2006) Cytokine Growth Factor Rev., 17, 41-58.
3. Ijichi, H., Chytil, A., Gorska, A.E., Aakre, M.E., Fujitani, Y., Fujitani, S., Wright, C.V. and Moses, H.L. (2006) Genes Dev., 20, 3147-3160.
4. Munoz, N.M., Upton, M., Rojas, A., Washington, M.K., Lin, L., Chytil, A., Sozmen, E.G., Madison, B.B., Pozzi, A., Moon, R.T., Moses, H.L. and Grady, W.M. (2006) Cancer Res., 66, 9837-9844.
5. Forrester, E., Chytil, A., Bierie, B., Aakre, M., Gorska, A.E., Sharif-Afshar, A.R., Muller, W.J. and Moses, H.L. (2005) Cancer Res., 65, 2296-2302.
6. Guasch, G., Schober, M., Pasolli, H.A., Conn, E.B., Polak, L. and Fuchs, E. (2007) Cancer Cell, 12, 313-327.
7. Bruna, A., Darken, R.S., Rojo, F., Ocana, A., Penuelas, S., Arias, A., Paris, R., Tortosa, A., Mora, J., Baselga, J. and Seoane, J. (2007) Cancer Cell, 11, 147-160.
8. Watanabe, T., Wu, T.T., Catalano, P.J., Ueki, T., Satriano, R., Haller, D.G., Benson, 3rd, A.B. and Hamilton, S.R. (2001) N. Engl. J. Med., 344, 1196-1206.
9. Arteaga, C.L. (2006) Curr. Opin. Genet. Dev., 16, 30-37.
10. Mundy, G.R. (2002) Nat. Rev. Cancer, 2, 584-593.
11. Guise, T.A. and Chirgwin, J.M. (2003) Clin. Orthop. Relat. Res., S32-38.
12. Cicek, M., and Oursler, M.J. (2006) Cancer Metastasis Rev., 25, 635-644.
13. Bristow, R.G. and Hill, R.P. (2008) Nat. Rev. Cancer., 8, 180-192.
14. Du, R., Lu, K.V., Petritsch, C., Liu, P., Ganss, R., Passegue, E., Song, H., Vandenberg, S., Johnson, R.S., Werb, Z. and Bergers, G. (2008) Cancer Cell, 13, 206-220.
15. Balkwill, F., and Coussens, L.M. (2004) Nature, 431, 405-406.
16. Coussens, L.M. and Werb, Z. (2002) Nature, 420, 860-867.
17. Yang, L., Debusk, L.M., Fukuda, K., Fingleton, B., GreenJarvis, B., Shyr, Y., Matrisian, L.M., Carbone, D.P. and Lin, P.C. (2004) Cancer Cell, 6, 409-421.
18. Yang, L., Huang, J., Ren, X., Gorska, A.E., Chytil, A., Aakre, M., Carbone, D.P., Matrisian, L.M., Richmond, A., Lin, P.C. and Moses, H.L. (2008) Cancer Cell, 13, 23-35.
19. Scortegagna, M., Cataisson, C., Martin, R.J., Hicklin, D.J., Schreiber, R.D., Yuspa, S.H. and Arbeit, J.M. (2008) Blood, 111, 3343-3354.
20. Orimo, A. and Weinberg, R.A. (2006) Cell Cycle, 5, 1597-1601.
21. Orimo, A., Gupta, P.B., Sgroi, D.C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V.J., Richardson, A.L. and Weinberg, R.A. (2005) Cell, 121, 335-348.
22. Direkze, N.C., Hodivala-Dilke, K., Jeffery, R., Hunt, T., Poulsom, R., Oukrif, D., Alison, M.R. and Wright, N.A. (2004) Cancer Res., 64, 8492-8495.
23. Mishra, P.J., Glod, J.W. and Banerjee, D. (2009) Cancer Res., 69, 1255-1258.
24. Karnoub, A.E., Dash, A.B., Vo, A.P., Sullivan, A., Brooks, M.W., Bell, G.W., Richardson, A.L., Polyak, K., Tubo, R. and Weinberg, R.A. (2007) Nature, 449, 557-563.
25. Lyden, D., Young, A.Z., Zagzag, D., Yan, W., Gerald, W., O'Reilly, R., Bader, B.L., Hynes, R.O., Zhuang, Y., Manova, K. and Benezra, R. (1999) Nature, 401, 670-677.
26. Lyden, D., Hattori, K., Dias, S., Costa, C., Blaikie, P., Butros, L., Chadburn, A., Heissig, B., Marks, W., Witte, L., Wu, Y., Hicklin, D., Zhu, Z., Hackett, N.R., Crystal, R.G., Moore, M.A., Hajjar, K.A., Manova, K., Benezra, R. and Rafii, S. (2001) Nat. Med., 7, 1194-1201.
27. Rafii, S., Lyden, D., Benezra, R., Hattori, K. and Heissig, B. (2002) Nat. Rev. Cancer, 2, 826-835.
28. Nolan, D.J., Ciarrocchi, A., Mellick, A.S., Jaggi, J.S., Bambino, K., Gupta, S., Heikamp, E., McDevitt, M.R., Scheinberg, D.A., Benezra, R. and Mittal, V. (2007) Genes Dev., 21, 1546-1558.
29. Gothert, J.R., Gustin, S.E., van Eekelen, J.A., Schmidt, U., Hall, M.A., Jane, S.M., Green, A.R., Gottgens, B., Izon, D.J. and Begley, C.G. (2004) Blood, 104, 1769-1777.
30. Shinde Patil, V.R., Friedrich, E.B., Wolley, A.E., Gerszten, R.E., Allport, J.R. and Weissleder, R. (2005) Neoplasia, 7, 234-240.
31. Purhonen, S., Palm, J., Rossi, D., Kaskenpaa, N., Rajantie, I., Yla-Herttuala, S., Alitalo, K., Weissman, I.L. and Salven, P. (2008) Proc. Natl. Acad. Sci. USA, 105, 6620-6625.
32. Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G. and Isner, J.M. (1997) Science, 275, 964-967.
33. Takahashi, T., Kalka, C., Masuda, H., Chen, D., Silver, M., Kearney, M., Magner, M., Isner, J.M. and Asahara, T. (1999) Nat. Med., 5, 434-438.
34. Rafii, S., and Lyden, D. (2003) Nat. Med., 9, 702-712.
35. Monteleone, G., Mann, J., Monteleone, I., Vavassori, P., Bremner, R., Fantini, M., Del Vecchio Blanco, G., Tersigni, R., Alessandroni, L., Mann, D., Pallone, F. and MacDonald, T.T. (2004) J. Biol. Chem., 279, 3925-3932.
36. Maggio-Price, L., Treuting, P., Zeng, W., Tsang, M., Bielefeldt-Ohmann, H. and Iritani, B.M. (2006) Cancer Res., 66, 828-838.
37. Engle, S.J., Ormsby, I., Pawlowski, S., Boivin, G.P., Croft, J., Balish, E. and Doetschman, T. (2002) Cancer Res., 62, 6362-6366.
38. Luo, J.L., Tan, W., Ricono, J.M., Korchynskyi, O., Zhang, M., Gonias, S.L., Cheresh, D.A. and Karin, M. (2007) Nature, 446, 690-694.
39. Lu, T., Tian, L., Han, Y., Vogelbaum, M. and Stark, G.R. (2007) Proc. Natl. Acad. Sci. USA, 104, 4365-4370.
40. Bhowmick, N.A., Chytil, A., Plieth, D., Gorska, A.E., Dumont, N., Shappell, S., Washington, M.K., Neilson, E.G. and Moses, H.L. (2004) Science, 303, 848-851.
41. Kim, B.G., Li, C., Qiao, W., Mamura, M., Kasprzak, B., Anver, M., Wolfraim, L., Hong, S., Mushinski, E., Potter, M., Kim, S.J., Fu, X.Y., Deng, C. and Letterio, J.J. (2006) Nature, 441, 1015-1019.
42. Kitamura, T., Kometani, K., Hashida, H., Matsunaga, A., Miyoshi, H., Hosogi, H., Aoki, M., Oshima, M., Hattori, M., Takabayashi, A., Minato, N. and Taketo, M.M. (2007) Nat. Genet., 39, 467-475.
43. Lu, S.L., Herrington, H., Reh, D., Weber, S., Bornstein, S., Wang, D., Li, A.G., Tang, C.F., Siddiqui, Y., Nord, J., Andersen, P., Corless, C.L. and Wang, X.J. (2006) Genes Dev., 20, 1331-1342.
44. Lu, S.L., Reh, D., Li, A.G., Woods, J., Corless, C.L., KuleszMartin, M. and Wang, X.J. (2004) Cancer Res., 64, 4405-4410.
45. Hiratsuka, S., Watanabe, A., Aburatani, H. and Maru, Y. (2006) Nat. Cell Biol., 8, 1369-1375.
46. Padua, D., Zhang, X.H., Wang, Q., Nadal, C., Gerald, W.L., Gomis, R.R. and Massague, J. (2008) Cell, 133, 66-77.
47. Wahl, S.M., Wen, J. and Moutsopoulos, N. (2006) Immunol. Rev., 213, 213-227.
48. Trapani, J.A. (2005) Cancer Cell, 8, 349-350.
49. Terabe, M., Matsui, S., Park, J.M., Mamura, M., Noben Trauth, N., Donaldson, D.D., Chen, W., Wahl, S.M., Ledbetter, S., Pratt, B., Letterio, J.J., Paul, W.E. and Berzofsky, J.A. (2003) J. Exp. Med., 198, 1741-1752.
50. Nam, J.S., Terabe, M., Kang, M.J., Chae, H., Voong, N., Yang, Y.A., Laurence, A., Michalowska, A., Mamura, M., Lonning, S., Berzofsky, J.A. and Wakefield, L.M. (2008) Cancer Res., 68, 3915-3923.
51. Korn, T., Bettelli, E., Gao, W., Awasthi, A., Jager, A., Strom, T.B., Oukka, M. and Kuchroo, V.K. (2007) Nature, 448, 484-487.
52. Ghiringhelli, F., Menard, C., Terme, M., Flament, C., Taieb, J., Chaput, N., Puig, P.E., Novault, S., Escudier, B., Vivier, E., Lecesne, A., Robert, C., Blay, J.Y., Bernard, J., Caillat Zucman, S., Freitas, A., Tursz, T., Wagner-Ballon, O., Capron, C., Vainchencker, W., Martin, F. and Zitvogel, L. (2005) J. Exp. Med., 202, 1075-1085.
53. Nam, J.S., Terabe, M., Mamura, M., Kang, M.J., Chae, H., Stuelten, C., Kohn, E., Tang, B., Sabzevari, H., Anver, M.R., Lawrence, S., Danielpour, D., Lonning, S., Berzofsky, J.A. and Wakefield, L.M. (2008) Cancer Res., 68, 3835-3843.
54. Adorno, M., Cordenonsi, M., Montagner, M., Dupont, S., Wong, C., Hann, B., Solari, A., Bobisse, S., Rondina, M.B., Guzzardo, V., Parenti, A.R., Rosato, A., Bicciato, S., Balmain, A. and Piccolo, S. (2009) Cell, 137, 87-98.
55. Dupont, S., Mamidi, A., Cordenonsi, M., Montagner, M., Zacchigna, L., Adorno, M., Martello, G., Stinchfield, M.J., Soligo, S., Morsut, L., Inui, M., Moro, S., Modena, N., Argenton, F., Newfeld, S.J. and Piccolo, S. (2009) Cell, 136, 123-135.
56. Liu, I.M., Schilling, S.H., Knouse, K.A., Choy, L., Derynck, R. and Wang, X.F. (2009) EMBO J., 28, 88-98.
57. Almand, B., Resser, J.R., Lindman, B., Nadaf, S., Clark, J.I., Kwon, E.D., Carbone, D.P. and Gabrilovich, D.I. (2000) Clin. Cancer Res., 6, 1755-1766.
58. Serafini, P., Borrello, I. and Bronte, V. (2006) Semin. Cancer Biol., 16, 53-65.
59. Marx, J. (2008) Science, 319, 154-156.
60. Gabrilovich, D.I. and Nagaraj, S. (2009) Nat. Rev. Immunol., 9, 162-174.
61. Movahedi, K., Guilliams, M., Van den Bossche, J., Van den Bergh, R., Gysemans, C., Beschin, A., De Baetselier, P. and Van Ginderachter, J.A. (2008) Blood, 111, 4233-4244.
62. Nagaraj, S., Gupta, K., Pisarev, V., Kinarsky, L., Sherman, S., Kang, L., Herber, D.L., Schneck, J. and Gabrilovich, D.I. (2007) Nat. Med., 13, 828-835.
63. Shojaei, F., Wu, X., Malik, A.K., Zhong, C., Baldwin, M.E., Schanz, S., Fuh, G., Gerber, H.P. and Ferrara, N. (2007) Nat. Biotechnol., 25, 911-920.
64. Budhu, A., Forgues, M., Ye, Q.H., Jia, H.L., He, P., Zanetti, K.A., Kammula, U.S., Chen, Y., Qin, L.X., Tang, Z.Y. and Wang, X.W. (2006) Cancer Cell, 10, 99-111.
65. Galon, J., Costes, A., Sanchez-Cabo, F., Kirilovsky, A., Mlecnik, B., Lagorce-Pages, C., Tosolini, M., Camus, M., Berger, A., Wind, P., Zinzindohoue, F., Bruneval, P., Cugnenc, P.H., Trajanoski, Z., Fridman, W.H. and Pages, F. (2006) Science, 313, 1960-1964.
66. Biswas, S., Guix, M., Rinehart, C., Dugger, T.C., Chytil, A., Moses, H.L., Freeman, M.L. and Arteaga, C.L. (2007) J. Clin. Invest., 117, 1305-1313.