메뉴 건너뛰기




Volumn 14, Issue 9, 2015, Pages 642-662

Oncolytic viruses: A new class of immunotherapy drugs

Author keywords

[No Author keywords available]

Indexed keywords

AGLATIMAGENE BESADENOVEC; CAVATAK; CG 0070; COLO AD1; DNA 2401; DOUBLE STRANDED DNA; DOUBLE STRANDED RNA; G 207; GANCICLOVIR; GL ONC1; H 101; HF 10; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERFERON REGULATORY FACTOR 9; LONTUCIREV; ONCOLYTIC ADENOVIRUS; ONCOLYTIC VIRUS; ONCOS 102; ORIENX 010; PELAREOREP; PEXASTIMOGENE DEVACIREPVEC; SEPREHVIR; SINGLE STRANDED DNA; SINGLE STRANDED RNA; SVV 001; TALIMOGENE LAHERPAREPVEC; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; UNCLASSIFIED DRUG; UNINDEXED DRUG; VCN 01; IMMUNOLOGIC FACTOR;

EID: 84940824279     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd4663     Document Type: Review
Times cited : (1094)

References (180)
  • 1
    • 1642430137 scopus 로고
    • The destructive effect of the virus of Russian Far East encephalitis on the transplantable mouse sarcoma 180
    • Moore, A. E. The destructive effect of the virus of Russian Far East encephalitis on the transplantable mouse sarcoma 180. Cancer 2, 525-534 (1949).
    • (1949) Cancer , vol.2 , pp. 525-534
    • Moore, A.E.1
  • 2
    • 27644562215 scopus 로고
    • Effect of inoculation of the viruses of influenza A and herpes simplex on the growth of transplantable tumors in mice
    • Moore, A. E. Effect of inoculation of the viruses of influenza A and herpes simplex on the growth of transplantable tumors in mice. Cancer 2, 516-524 (1949).
    • (1949) Cancer , vol.2 , pp. 516-524
    • Moore, A.E.1
  • 3
    • 84933586864 scopus 로고    scopus 로고
    • Talimogene laherparepvec improves durable response rate in patients with advanced melanoma
    • Andtbacka, R. H. et al. Talimogene laherparepvec improves durable response rate in patients with advanced melanoma. J. Clin. Oncol. http://dx.doi.org/10.1200/JCO.2014.58.3377 (2015).
    • (2015) J. Clin. Oncol.
    • Andtbacka, R.H.1
  • 4
    • 84885410330 scopus 로고    scopus 로고
    • A strategy to estimate unknown viral diversity in mammals
    • Anthony, S. J. et al. A strategy to estimate unknown viral diversity in mammals. mBio 4, e00598-e00513 (2013).
    • (2013) MBio , vol.4 , pp. e00598-e00513
    • Anthony, S.J.1
  • 5
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 6
    • 0025864440 scopus 로고
    • Experimental therapy of human glioma by means of a genetically engineered virus mutant
    • Martuza, R. L., Malick, A., Markert, J. M., Ruffner, K. L. & Coen, D. M. Experimental therapy of human glioma by means of a genetically engineered virus mutant. Science 252, 854-856 (1991).
    • (1991) Science , vol.252 , pp. 854-856
    • Martuza, R.L.1    Malick, A.2    Markert, J.M.3    Ruffner, K.L.4    Coen, D.M.5
  • 7
    • 33644852717 scopus 로고    scopus 로고
    • China approves world's first oncolytic virus therapy for cancer treatment
    • Garber, K. China approves world's first oncolytic virus therapy for cancer treatment. J. Natl Cancer Inst. 98, 298-300 (2006).
    • (2006) J. Natl Cancer Inst. , vol.98 , pp. 298-300
    • Garber, K.1
  • 8
    • 67650675099 scopus 로고    scopus 로고
    • Pharmacologic and chemical adjuvants in tumor virotherapy
    • Alvarez-Breckenridge, C., Kaur, B. & Chiocca, E. A. Pharmacologic and chemical adjuvants in tumor virotherapy. Chem. Rev. 109, 3125-3140 (2009).
    • (2009) Chem. Rev. , vol.109 , pp. 3125-3140
    • Alvarez-Breckenridge, C.1    Kaur, B.2    Chiocca, E.A.3
  • 9
    • 84875215479 scopus 로고    scopus 로고
    • Effective treatment of an orthotopic xenograft model of human glioblastoma using an EGFR-retargeted oncolytic herpes simplex virus
    • Uchida, H. et al. Effective treatment of an orthotopic xenograft model of human glioblastoma using an EGFR-retargeted oncolytic herpes simplex virus. Mol. Ther. 21, 561-569 (2013).
    • (2013) Mol. Ther. , vol.21 , pp. 561-569
    • Uchida, H.1
  • 10
    • 0025298202 scopus 로고
    • Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon
    • Meurs, E. et al. Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. Cell 62, 379-390 (1990).
    • (1990) Cell , vol.62 , pp. 379-390
    • Meurs, E.1
  • 11
    • 58749102026 scopus 로고    scopus 로고
    • Protein kinase R reveals an evolutionary model for defeating viral mimicry
    • Elde, N. C., Child, S. J., Geballe, A. P. & Malik, H. S. Protein kinase R reveals an evolutionary model for defeating viral mimicry. Nature 457, 485-489 (2009).
    • (2009) Nature , vol.457 , pp. 485-489
    • Elde, N.C.1    Child, S.J.2    Geballe, A.P.3    Malik, H.S.4
  • 12
    • 2342641580 scopus 로고    scopus 로고
    • Targets and mechanisms for the regulation of translation in malignant transformation
    • Clemens, M. J. Targets and mechanisms for the regulation of translation in malignant transformation. Oncogene 23, 3180-3188 (2004).
    • (2004) Oncogene , vol.23 , pp. 3180-3188
    • Clemens, M.J.1
  • 13
    • 84897476768 scopus 로고    scopus 로고
    • Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy
    • Zamarin, D. et al. Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy. Sci. Transl Med. 6, 226ra32 (2014).
    • (2014) Sci. Transl Med. , vol.6 , pp. 226ra32
    • Zamarin, D.1
  • 14
    • 0022616253 scopus 로고
    • Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy
    • Karre, K., Ljunggren, H. G., Piontek, G. & Kiessling, R. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. Nature 319, 675-678 (1986).
    • (1986) Nature , vol.319 , pp. 675-678
    • Karre, K.1    Ljunggren, H.G.2    Piontek, G.3    Kiessling, R.4
  • 15
    • 0022317963 scopus 로고
    • Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism
    • Ljunggren, H. G. & Karre, K. Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism. J. Exp. Med. 162, 1745-1759 (1985).
    • (1985) J. Exp. Med. , vol.162 , pp. 1745-1759
    • Ljunggren, H.G.1    Karre, K.2
  • 16
    • 0032814773 scopus 로고    scopus 로고
    • Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses
    • Ikeda, K. et al. Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses. Nat. Med. 5, 881-887 (1999).
    • (1999) Nat. Med. , vol.5 , pp. 881-887
    • Ikeda, K.1
  • 17
    • 0036199737 scopus 로고    scopus 로고
    • The complement response against an oncolytic virus is species-specific in its activation pathways
    • Wakimoto, H. et al. The complement response against an oncolytic virus is species-specific in its activation pathways. Mol. Ther. 5, 275-282 (2002).
    • (2002) Mol. Ther. , vol.5 , pp. 275-282
    • Wakimoto, H.1
  • 18
    • 84870909657 scopus 로고    scopus 로고
    • NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors
    • Alvarez-Breckenridge, C. A. et al. NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors. Nat. Med. 18, 1827-1834 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 1827-1834
    • Alvarez-Breckenridge, C.A.1
  • 19
    • 84857692141 scopus 로고    scopus 로고
    • Differential macrophage programming in the tumor microenvironment
    • Ruffell, B., Affara, N. I. & Coussens, L. M. Differential macrophage programming in the tumor microenvironment. Trends Immunol. 33, 119-126 (2012).
    • (2012) Trends Immunol. , vol.33 , pp. 119-126
    • Ruffell, B.1    Affara, N.I.2    Coussens, L.M.3
  • 20
    • 84884556145 scopus 로고    scopus 로고
    • History of myeloid-derived suppressor cells
    • Talmadge, J. E. & Gabrilovich, D. I. History of myeloid-derived suppressor cells. Nat. Rev. Cancer 13, 739-752 (2013).
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 739-752
    • Talmadge, J.E.1    Gabrilovich, D.I.2
  • 21
    • 84886698315 scopus 로고    scopus 로고
    • Innate and adaptive immune cells in the tumor microenvironment
    • Gajewski, T. F., Schreiber, H. & Fu, Y. X. Innate and adaptive immune cells in the tumor microenvironment. Nat. Immunol. 14, 1014-1022 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 1014-1022
    • Gajewski, T.F.1    Schreiber, H.2    Fu, Y.X.3
  • 22
    • 68249158537 scopus 로고    scopus 로고
    • Virus binding to a plasma membrane receptor triggers interleukin-1 α-mediated proinflammatory macrophage response in vivo
    • Di Paolo, N. C. et al. Virus binding to a plasma membrane receptor triggers interleukin-1 α-mediated proinflammatory macrophage response in vivo. Immunity 31, 110-121 (2009).
    • (2009) Immunity , vol.31 , pp. 110-121
    • Di Paolo, N.C.1
  • 23
    • 70450200778 scopus 로고    scopus 로고
    • The case of oncolytic viruses versus the immune system: Waiting on the judgment of Solomon
    • Prestwich, R. J. et al. The case of oncolytic viruses versus the immune system: waiting on the judgment of Solomon. Hum. Gene Ther. 20, 1119-1132 (2009).
    • (2009) Hum. Gene Ther. , vol.20 , pp. 1119-1132
    • Prestwich, R.J.1
  • 24
    • 77955176474 scopus 로고    scopus 로고
    • Potentiating cancer immunotherapy using an oncolytic virus
    • Bridle, B. W. et al. Potentiating cancer immunotherapy using an oncolytic virus. Mol. Ther. 18, 1430-1439 (2010).
    • (2010) Mol. Ther. , vol.18 , pp. 1430-1439
    • Bridle, B.W.1
  • 25
    • 84878074018 scopus 로고    scopus 로고
    • Antiviral and antitumor T-cell immunity in patients treated with GM-CSF-coding oncolytic adenovirus
    • Kanerva, A. et al. Antiviral and antitumor T-cell immunity in patients treated with GM-CSF-coding oncolytic adenovirus. Clin. Cancer Res. 19, 2734-2744 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 2734-2744
    • Kanerva, A.1
  • 26
    • 77954107953 scopus 로고    scopus 로고
    • Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells
    • Carlsten, M. et al. Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells. J. Immunol. 183, 4921-4930 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 4921-4930
    • Carlsten, M.1
  • 27
    • 84918828514 scopus 로고    scopus 로고
    • Genetic basis for clinical response to CTLA-4 blockade in melanoma
    • Snyder, A. et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N. Engl. J. Med. 371, 2189-2199 (2014).
    • (2014) N. Engl. J. Med. , vol.371 , pp. 2189-2199
    • Snyder, A.1
  • 29
    • 84904694379 scopus 로고    scopus 로고
    • Chemotherapy and oncolytic virotherapy: Advanced tactics in the war against cancer
    • Nguyen, A., Ho, L. & Wan, Y. Chemotherapy and oncolytic virotherapy: advanced tactics in the war against cancer. Front. Oncol. 4, 145 (2014).
    • (2014) Front. Oncol. , vol.4 , pp. 145
    • Nguyen, A.1    Ho, L.2    Wan, Y.3
  • 30
    • 36348930079 scopus 로고    scopus 로고
    • Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus
    • Mok, W., Boucher, Y. & Jain, R. K. Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus. Cancer Res. 67, 10664-10668 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 10664-10668
    • Mok, W.1    Boucher, Y.2    Jain, R.K.3
  • 31
    • 20744442757 scopus 로고    scopus 로고
    • Effect of hypoxia on Ad5 infection, transgene expression and replication
    • Shen, B. H. & Hermiston, T. W. Effect of hypoxia on Ad5 infection, transgene expression and replication. Gene Ther. 12, 902-910 (2005).
    • (2005) Gene Ther. , vol.12 , pp. 902-910
    • Shen, B.H.1    Hermiston, T.W.2
  • 32
    • 79951821209 scopus 로고    scopus 로고
    • Phase i clinical study of Seneca Valley Virus (SVV-001), a replication-competent picornavirus, in advanced solid tumors with neuroendocrine features
    • Rudin, C. M. et al. Phase I clinical study of Seneca Valley Virus (SVV-001), a replication-competent picornavirus, in advanced solid tumors with neuroendocrine features. Clin. Cancer Res. 17, 888-895 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 888-895
    • Rudin, C.M.1
  • 33
    • 84858608281 scopus 로고    scopus 로고
    • Phase I/IIa study of intratumoral/ intracerebral or intravenous/intracerebral administration of Parvovirus H-1 (ParvOryx) in patients with progressive primary or recurrent glioblastoma multiforme: ParvOryx01 protocol
    • Geletneky, K. et al. Phase I/IIa study of intratumoral/ intracerebral or intravenous/intracerebral administration of Parvovirus H-1 (ParvOryx) in patients with progressive primary or recurrent glioblastoma multiforme: ParvOryx01 protocol. BMC Cancer 12, 99 (2012).
    • (2012) BMC Cancer , vol.12 , pp. 99
    • Geletneky, K.1
  • 34
    • 7044228126 scopus 로고    scopus 로고
    • A phase i open-label, dose-escalation, multi-institutional trial of injection with an E1B-attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting
    • Chiocca, E. A. et al. A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting. Mol. Ther. 10, 958-966 (2004).
    • (2004) Mol. Ther. , vol.10 , pp. 958-966
    • Chiocca, E.A.1
  • 35
    • 19244362665 scopus 로고    scopus 로고
    • Treatment of advanced CNS malignancies with the recombinant adenovirus H5.010RSVTK: A phase i trial
    • Eck, S. L. et al. Treatment of advanced CNS malignancies with the recombinant adenovirus H5.010RSVTK: a phase I trial. Hum. Gene Ther. 7, 1465-1482 (1996).
    • (1996) Hum. Gene Ther. , vol.7 , pp. 1465-1482
    • Eck, S.L.1
  • 36
    • 0034610723 scopus 로고    scopus 로고
    • A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo
    • Fueyo, J. et al. A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo. Oncogene 19, 2-12 (2000).
    • (2000) Oncogene , vol.19 , pp. 2-12
    • Fueyo, J.1
  • 37
    • 0033782862 scopus 로고    scopus 로고
    • An adenovirus E1A mutant that demonstrates potent and selective systemic antitumoral efficacy
    • Heise, C. et al. An adenovirus E1A mutant that demonstrates potent and selective systemic antitumoral efficacy. Nat. Med. 6, 1134-1139 (2000).
    • (2000) Nat. Med. , vol.6 , pp. 1134-1139
    • Heise, C.1
  • 38
    • 66849134484 scopus 로고    scopus 로고
    • Tumor associated stromal cells play a critical role on the outcome of the oncolytic efficacy of conditionally replicative adenoviruses
    • Lopez, M. V. et al. Tumor associated stromal cells play a critical role on the outcome of the oncolytic efficacy of conditionally replicative adenoviruses. PLoS ONE 4, e5119 (2009).
    • (2009) PLoS ONE , vol.4 , pp. e5119
    • Lopez, M.V.1
  • 39
    • 84858016896 scopus 로고    scopus 로고
    • Oncolytic Newcastle disease virus for cancer therapy: Old challenges and new directions
    • Zamarin, D. & Palese, P. Oncolytic Newcastle disease virus for cancer therapy: old challenges and new directions. Future Microbiol. 7, 347-367 (2012).
    • (2012) Future Microbiol. , vol.7 , pp. 347-367
    • Zamarin, D.1    Palese, P.2
  • 40
    • 27644479547 scopus 로고    scopus 로고
    • Enhanced nectin-1 expression and herpes oncolytic sensitivity in highly migratory and invasive carcinoma
    • Yu, Z. et al. Enhanced nectin-1 expression and herpes oncolytic sensitivity in highly migratory and invasive carcinoma. Clin. Cancer Res. 11, 4889-4897 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 4889-4897
    • Yu, Z.1
  • 41
    • 0027426010 scopus 로고
    • The human CD46 molecule is a receptor for measles virus (Edmonston strain)
    • Dorig, R. E., Marcil, A., Chopra, A. & Richardson, C. D. The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell 75, 295-305 (1993).
    • (1993) Cell , vol.75 , pp. 295-305
    • Dorig, R.E.1    Marcil, A.2    Chopra, A.3    Richardson, C.D.4
  • 42
    • 3142745262 scopus 로고    scopus 로고
    • High CD46 receptor density determines preferential killing of tumor cells by oncolytic measles virus
    • Anderson, B. D., Nakamura, T., Russell, S. J. & Peng, K. W. High CD46 receptor density determines preferential killing of tumor cells by oncolytic measles virus. Cancer Res. 64, 4919-4926 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 4919-4926
    • Anderson, B.D.1    Nakamura, T.2    Russell, S.J.3    Peng, K.W.4
  • 43
    • 84907921198 scopus 로고    scopus 로고
    • ICAM-1 as a molecular target for triple negative breast cancer
    • Guo, P. et al. ICAM-1 as a molecular target for triple negative breast cancer. Proc. Natl Acad. Sci. USA 111, 14710-14715 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 14710-14715
    • Guo, P.1
  • 44
    • 33947538023 scopus 로고    scopus 로고
    • Oncolytic Coxsackievirus A21 as a novel therapy for multiple myeloma
    • Au, G. G., Lincz, L. F., Enno, A. & Shafren, D. R. Oncolytic Coxsackievirus A21 as a novel therapy for multiple myeloma. Br. J. Haematol. 137, 133-141 (2007).
    • (2007) Br. J. Haematol. , vol.137 , pp. 133-141
    • Au, G.G.1    Lincz, L.F.2    Enno, A.3    Shafren, D.R.4
  • 45
    • 1642453768 scopus 로고    scopus 로고
    • Systemic therapy of malignant human melanoma tumors by a common cold-producing enterovirus, coxsackievirus a21
    • Shafren, D. R. et al. Systemic therapy of malignant human melanoma tumors by a common cold-producing enterovirus, coxsackievirus a21. Clin. Cancer Res. 10, 53-60 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 53-60
    • Shafren, D.R.1
  • 47
    • 84867523350 scopus 로고    scopus 로고
    • 67 kDa laminin receptor: Structure, function and role in cancer and infection
    • Rea, V. E. et al. 67 kDa laminin receptor: structure, function and role in cancer and infection. Infez Med. 20 (Suppl. 2), 8-12 (2012).
    • (2012) Infez Med. , vol.20 , pp. 8-12
    • Rea, V.E.1
  • 48
    • 0035050302 scopus 로고    scopus 로고
    • Coxsackievirus-adenovirus receptor expression in ovarian cancer cell lines is associated with increased adenovirus transduction efficiency and transgene expression
    • You, Z. et al. Coxsackievirus-adenovirus receptor expression in ovarian cancer cell lines is associated with increased adenovirus transduction efficiency and transgene expression. Cancer Gene Ther. 8, 168-175 (2001).
    • (2001) Cancer Gene Ther. , vol.8 , pp. 168-175
    • You, Z.1
  • 49
    • 0031003548 scopus 로고    scopus 로고
    • vβ3 integrin is less frequent in ovarian epithelial tumors of low malignant potential in contrast to ovarian carcinomas
    • vβ3 integrin is less frequent in ovarian epithelial tumors of low malignant potential in contrast to ovarian carcinomas. Hum. Pathol. 28, 443-449 (1997).
    • (1997) Hum. Pathol. , vol.28 , pp. 443-449
    • Liapis, H.1    Adler, L.M.2    Wick, M.R.3    Rader, J.S.4
  • 50
    • 16244394824 scopus 로고    scopus 로고
    • Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection
    • Morizono, K. et al. Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection. Nat. Med. 11, 346-352 (2005).
    • (2005) Nat. Med. , vol.11 , pp. 346-352
    • Morizono, K.1
  • 51
    • 0035121424 scopus 로고    scopus 로고
    • Single-chain antibody displayed on a recombinant measles virus confers entry through the tumor-associated carcinoembryonic antigen
    • Hammond, A. L. et al. Single-chain antibody displayed on a recombinant measles virus confers entry through the tumor-associated carcinoembryonic antigen. J. Virol. 75, 2087-2096 (2001).
    • (2001) J. Virol. , vol.75 , pp. 2087-2096
    • Hammond, A.L.1
  • 52
    • 79958119977 scopus 로고    scopus 로고
    • Oncolytic specificity of Newcastle disease virus is mediated by selectivity for apoptosis-resistant cells
    • Mansour, M., Palese, P. & Zamarin, D. Oncolytic specificity of Newcastle disease virus is mediated by selectivity for apoptosis-resistant cells. J. Virol. 85, 6015-6023 (2011).
    • (2011) J. Virol. , vol.85 , pp. 6015-6023
    • Mansour, M.1    Palese, P.2    Zamarin, D.3
  • 53
    • 0032526693 scopus 로고    scopus 로고
    • The molecular basis of viral oncolysis: Usurpation of the Ras signaling pathway by reovirus
    • Strong, J. E., Coffey, M. C., Tang, D., Sabinin, P. & Lee, P. W. The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus. EMBO J. 17, 3351-3362 (1998).
    • (1998) EMBO J. , vol.17 , pp. 3351-3362
    • Strong, J.E.1    Coffey, M.C.2    Tang, D.3    Sabinin, P.4    Lee, P.W.5
  • 54
    • 84859443203 scopus 로고    scopus 로고
    • The oncolytic poxvirus JX-594 selectively replicates in and destroys cancer cells driven by genetic pathways commonly activated in cancers
    • Parato, K. A. et al. The oncolytic poxvirus JX-594 selectively replicates in and destroys cancer cells driven by genetic pathways commonly activated in cancers. Mol. Ther. 20, 749-758 (2012).
    • (2012) Mol. Ther. , vol.20 , pp. 749-758
    • Parato, K.A.1
  • 55
    • 0034910459 scopus 로고    scopus 로고
    • Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1
    • Farassati, F., Yang, A. D. & Lee, P. W. Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1. Nat. Cell Biol. 3, 745-750 (2001).
    • (2001) Nat. Cell Biol. , vol.3 , pp. 745-750
    • Farassati, F.1    Yang, A.D.2    Lee, P.W.3
  • 56
    • 84901366532 scopus 로고    scopus 로고
    • Permissiveness of human cancer cells to oncolytic bovine herpesvirus 1 is mediated in part by KRAS activity
    • Cuddington, B. P. & Mossman, K. L. Permissiveness of human cancer cells to oncolytic bovine herpesvirus 1 is mediated in part by KRAS activity. J. Virol. 88, 6885-6895 (2014).
    • (2014) J. Virol. , vol.88 , pp. 6885-6895
    • Cuddington, B.P.1    Mossman, K.L.2
  • 57
    • 0024433216 scopus 로고
    • Mechanism of interferon action. Activation of the human P1/eIF-2 α protein kinase by individual reovirus s-class mRNAs: S1 mRNA is a potent activator relative to s4 mRNA
    • Bischoff, J. R. & Samuel, C. E. Mechanism of interferon action. Activation of the human P1/eIF-2 α protein kinase by individual reovirus s-class mRNAs: s1 mRNA is a potent activator relative to s4 mRNA. Virology 172, 106-115 (1989).
    • (1989) Virology , vol.172 , pp. 106-115
    • Bischoff, J.R.1    Samuel, C.E.2
  • 58
    • 67649421085 scopus 로고    scopus 로고
    • Expression of RIG-I, IRF3, IFN-β and IRF7 determines resistance or susceptibility of cells to infection by Newcastle Disease Virus
    • Wilden, H., Fournier, P., Zawatzky, R. & Schirrmacher, V. Expression of RIG-I, IRF3, IFN-β and IRF7 determines resistance or susceptibility of cells to infection by Newcastle Disease Virus. Int. J. Oncol. 34, 971-982 (2009).
    • (2009) Int. J. Oncol. , vol.34 , pp. 971-982
    • Wilden, H.1    Fournier, P.2    Zawatzky, R.3    Schirrmacher, V.4
  • 59
    • 0041848214 scopus 로고    scopus 로고
    • Getting oncolytic virus therapies off the ground
    • Bell, J. C., Lichty, B. & Stojdl, D. Getting oncolytic virus therapies off the ground. Cancer Cell 4, 7-11 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 7-11
    • Bell, J.C.1    Lichty, B.2    Stojdl, D.3
  • 61
    • 0033929057 scopus 로고    scopus 로고
    • Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus
    • Stojdl, D. F. et al. Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus. Nat. Med. 6, 821-825 (2000).
    • (2000) Nat. Med. , vol.6 , pp. 821-825
    • Stojdl, D.F.1
  • 62
    • 0041662272 scopus 로고    scopus 로고
    • Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence
    • Takaoka, A. et al. Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence. Nature 424, 516-523 (2003).
    • (2003) Nature , vol.424 , pp. 516-523
    • Takaoka, A.1
  • 63
    • 0035887153 scopus 로고    scopus 로고
    • A phase i trial of CV706, a replication-competent, PSA selective oncolytic adenovirus, for the treatment of locally recurrent prostate cancer following radiation therapy
    • DeWeese, T. L. et al. A phase I trial of CV706, a replication-competent, PSA selective oncolytic adenovirus, for the treatment of locally recurrent prostate cancer following radiation therapy. Cancer Res. 61, 7464-7472 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 7464-7472
    • DeWeese, T.L.1
  • 64
    • 66149098502 scopus 로고    scopus 로고
    • A Phase i study of KH901, a conditionally replicating granulocyte-macrophage colony-stimulating factor: Armed oncolytic adenovirus for the treatment of head and neck cancers
    • Chang, J. et al. A Phase I study of KH901, a conditionally replicating granulocyte-macrophage colony-stimulating factor: armed oncolytic adenovirus for the treatment of head and neck cancers. Cancer Biol. Ther. 8, 676-682 (2009).
    • (2009) Cancer Biol. Ther. , vol.8 , pp. 676-682
    • Chang, J.1
  • 65
    • 31544478298 scopus 로고    scopus 로고
    • CG0070, a conditionally replicating granulocyte macrophage colony-stimulating factor - Armed oncolytic adenovirus for the treatment of bladder cancer
    • Ramesh, N. et al. CG0070, a conditionally replicating granulocyte macrophage colony-stimulating factor - armed oncolytic adenovirus for the treatment of bladder cancer. Clin. Cancer Res. 12, 305-313 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , pp. 305-313
    • Ramesh, N.1
  • 66
    • 0028136903 scopus 로고
    • Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter
    • Neuman, E., Flemington, E. K., Sellers, W. R. & Kaelin, W. G. Jr. Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter. Mol. Cell. Biol. 14, 6607-6615 (1994).
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6607-6615
    • Neuman, E.1    Flemington, E.K.2    Sellers, W.R.3    Kaelin, Jr.W.G.4
  • 67
    • 34547092699 scopus 로고    scopus 로고
    • Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4
    • Post, D. E. et al. Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4. Cancer Res. 67, 6872-6881 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 6872-6881
    • Post, D.E.1
  • 68
    • 79957889064 scopus 로고    scopus 로고
    • MicroRNA-sensitive oncolytic measles viruses for cancer-specific vector tropism
    • Leber, M. F. et al. MicroRNA-sensitive oncolytic measles viruses for cancer-specific vector tropism. Mol. Ther. 19, 1097-1106 (2011).
    • (2011) Mol. Ther. , vol.19 , pp. 1097-1106
    • Leber, M.F.1
  • 69
    • 28844468988 scopus 로고    scopus 로고
    • Phase I/II trial of intravenous NDV-HUJ oncolytic virus in recurrent glioblastoma multiforme
    • Freeman, A. I. et al. Phase I/II trial of intravenous NDV-HUJ oncolytic virus in recurrent glioblastoma multiforme. Mol. Ther. 13, 221-228 (2006).
    • (2006) Mol. Ther. , vol.13 , pp. 221-228
    • Freeman, A.I.1
  • 70
    • 0030807896 scopus 로고    scopus 로고
    • The herpes simplex virus virulence factor ICP34.5 and the cellular protein MyD116 complex with proliferating cell nuclear antigen through the 63-amino-acid domain conserved in ICP34.5 MyD116 and GADD34
    • Brown, S. M., MacLean, A. R., McKie, E. A. & Harland, J. The herpes simplex virus virulence factor ICP34.5 and the cellular protein MyD116 complex with proliferating cell nuclear antigen through the 63-amino-acid domain conserved in ICP34.5, MyD116, and GADD34. J. Virol. 71, 9442-9449 (1997).
    • (1997) J. Virol. , vol.71 , pp. 9442-9449
    • Brown, S.M.1    MacLean, A.R.2    McKie, E.A.3    Harland, J.4
  • 71
    • 0042530129 scopus 로고    scopus 로고
    • The herpes simplex virus (HSV) protein ICP34.5 is a virion component that forms a DNA-binding complex with proliferating cell nuclear antigen and HSV replication proteins
    • Harland, J., Dunn, P., Cameron, E., Conner, J. & Brown, S. M. The herpes simplex virus (HSV) protein ICP34.5 is a virion component that forms a DNA-binding complex with proliferating cell nuclear antigen and HSV replication proteins. J. Neurovirol 9, 477-488 (2003).
    • (2003) J. Neurovirol , vol.9 , pp. 477-488
    • Harland, J.1    Dunn, P.2    Cameron, E.3    Conner, J.4    Brown, S.M.5
  • 72
    • 33947715151 scopus 로고    scopus 로고
    • HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein
    • Orvedahl, A. et al. HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host Microbe 1, 23-35 (2007).
    • (2007) Cell Host Microbe , vol.1 , pp. 23-35
    • Orvedahl, A.1
  • 73
    • 84907454058 scopus 로고    scopus 로고
    • Herpes simplex virus 2 ICP34.5 confers neurovirulence by regulating the type i interferon response
    • Davis, K. L., Korom, M. & Morrison, L. A. Herpes simplex virus 2 ICP34.5 confers neurovirulence by regulating the type I interferon response. Virology 468-470, 330-339 (2014).
    • (2014) Virology , vol.468-470 , pp. 330-339
    • Davis, K.L.1    Korom, M.2    Morrison, L.A.3
  • 74
    • 0037295403 scopus 로고    scopus 로고
    • ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties
    • Liu, B. L. et al. ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties. Gene Ther. 10, 292-303 (2003).
    • (2003) Gene Ther. , vol.10 , pp. 292-303
    • Liu, B.L.1
  • 75
    • 0031008583 scopus 로고    scopus 로고
    • Coxsackievirus A21 binds to decay-accelerating factor but requires intercellular adhesion molecule 1 for cell entry
    • Shafren, D. R., Dorahy, D. J., Ingham, R. A., Burns, G. F. & Barry, R. D. Coxsackievirus A21 binds to decay-accelerating factor but requires intercellular adhesion molecule 1 for cell entry. J. Virol. 71, 4736-4743 (1997).
    • (1997) J. Virol. , vol.71 , pp. 4736-4743
    • Shafren, D.R.1    Dorahy, D.J.2    Ingham, R.A.3    Burns, G.F.4    Barry, R.D.5
  • 76
    • 0029028269 scopus 로고
    • Vaccinia virus B18R gene encodes a type i interferon-binding protein that blocks interferon α transmembrane signaling
    • Colamonici, O. R., Domanski, P., Sweitzer, S. M., Larner, A. & Buller, R. M. Vaccinia virus B18R gene encodes a type I interferon-binding protein that blocks interferon α transmembrane signaling. J. Biol. Chem. 270, 15974-15978 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 15974-15978
    • Colamonici, O.R.1    Domanski, P.2    Sweitzer, S.M.3    Larner, A.4    Buller, R.M.5
  • 77
    • 49649090374 scopus 로고    scopus 로고
    • Pilot study of vaccination with recombinant CEA-MUC-1-TRICOM poxviral-based vaccines in patients with metastatic carcinoma
    • Gulley, J. L. et al. Pilot study of vaccination with recombinant CEA-MUC-1-TRICOM poxviral-based vaccines in patients with metastatic carcinoma. Clin. Cancer Res. 14, 3060-3069 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 3060-3069
    • Gulley, J.L.1
  • 78
    • 38049017526 scopus 로고    scopus 로고
    • Targeting of interferon-β to produce a specific, multi-mechanistic oncolytic vaccinia virus
    • Kirn, D. H., Wang, Y., Le Boeuf, F., Bell, J. & Thorne, S. H. Targeting of interferon-β to produce a specific, multi-mechanistic oncolytic vaccinia virus. PLoS Med. 4, e353 (2007).
    • (2007) PLoS Med. , vol.4 , pp. e353
    • Kirn, D.H.1    Wang, Y.2    Le Boeuf, F.3    Bell, J.4    Thorne, S.H.5
  • 79
    • 0034294865 scopus 로고    scopus 로고
    • Tumor growth inhibition by intratumoral inoculation of defective herpes simplex virus vectors expressing granulocyte-macrophage colony-stimulating factor
    • Toda, M., Martuza, R. L. & Rabkin, S. D. Tumor growth inhibition by intratumoral inoculation of defective herpes simplex virus vectors expressing granulocyte-macrophage colony-stimulating factor. Mol. Ther. 2, 324-329 (2000).
    • (2000) Mol. Ther. , vol.2 , pp. 324-329
    • Toda, M.1    Martuza, R.L.2    Rabkin, S.D.3
  • 80
    • 33845336115 scopus 로고    scopus 로고
    • A phase i study of OncoVEXGM-CSF, a second-generation oncolytic herpes simplex virus expressing granulocyte macrophage colony-stimulating factor
    • Hu, J. C. et al. A phase I study of OncoVEXGM-CSF, a second-generation oncolytic herpes simplex virus expressing granulocyte macrophage colony-stimulating factor. Clin. Cancer Res. 12, 6737-6747 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , pp. 6737-6747
    • Hu, J.C.1
  • 81
    • 84869095632 scopus 로고    scopus 로고
    • A first in human phase 1 study of CG0070, a GM-CSF expressing oncolytic adenovirus, for the treatment of nonmuscle invasive bladder cancer
    • Burke, J. M. et al. A first in human phase 1 study of CG0070, a GM-CSF expressing oncolytic adenovirus, for the treatment of nonmuscle invasive bladder cancer. J. Urol. 188, 2391-2397 (2012).
    • (2012) J. Urol. , vol.188 , pp. 2391-2397
    • Burke, J.M.1
  • 82
    • 0033193127 scopus 로고    scopus 로고
    • Intratumoral recombinant GM-CSF-encoding virus as gene therapy in patients with cutaneous melanoma
    • Mastrangelo, M. J. et al. Intratumoral recombinant GM-CSF-encoding virus as gene therapy in patients with cutaneous melanoma. Cancer Gene Ther. 6, 409-422 (1999).
    • (1999) Cancer Gene Ther. , vol.6 , pp. 409-422
    • Mastrangelo, M.J.1
  • 83
    • 62549085594 scopus 로고    scopus 로고
    • A phase i trial of intratumoral administration of recombinant oncolytic adenovirus overexpressing HSP70 in advanced solid tumor patients
    • Li, J. L. et al. A phase I trial of intratumoral administration of recombinant oncolytic adenovirus overexpressing HSP70 in advanced solid tumor patients. Gene Ther. 16, 376-382 (2009).
    • (2009) Gene Ther. , vol.16 , pp. 376-382
    • Li, J.L.1
  • 84
    • 0031951655 scopus 로고    scopus 로고
    • Herpes simplex virus type 2 ICP47 inhibits human TAP but not mouse TAP
    • Tomazin, R. et al. Herpes simplex virus type 2 ICP47 inhibits human TAP but not mouse TAP. J. Virol. 72, 2560-2563 (1998).
    • (1998) J. Virol. , vol.72 , pp. 2560-2563
    • Tomazin, R.1
  • 85
    • 0030917202 scopus 로고    scopus 로고
    • ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
    • Heise, C. et al. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat. Med. 3, 639-645 (1997).
    • (1997) Nat. Med. , vol.3 , pp. 639-645
    • Heise, C.1
  • 86
    • 0042387798 scopus 로고    scopus 로고
    • Safety of an E1B deleted adenovirus administered intratumorally to patients with cancer
    • in Chinese)
    • Yuan, Z. Y., Zhang, L., Li, S., Qian, X. Z. & Guan, Z. Z. Safety of an E1B deleted adenovirus administered intratumorally to patients with cancer. Ai Zheng 22, 310-313 (in Chinese) (2003).
    • (2003) Ai Zheng , vol.22 , pp. 310-313
    • Yuan, Z.Y.1    Zhang, L.2    Li, S.3    Qian, X.Z.4    Guan, Z.Z.5
  • 87
    • 0034469630 scopus 로고    scopus 로고
    • Inhibition of PKR activation by the proline-rich RNA binding domain of the herpes simplex virus type 1 Us11 protein
    • Poppers, J., Mulvey, M., Khoo, D. & Mohr, I. Inhibition of PKR activation by the proline-rich RNA binding domain of the herpes simplex virus type 1 Us11 protein. J. Virol. 74, 11215-11221 (2000).
    • (2000) J. Virol. , vol.74 , pp. 11215-11221
    • Poppers, J.1    Mulvey, M.2    Khoo, D.3    Mohr, I.4
  • 88
    • 34247170947 scopus 로고    scopus 로고
    • Cytosolic activation of cathepsins mediates parvovirus H-1-induced killing of cisplatin and TRAIL-resistant glioma cells
    • Di Piazza, M. et al. Cytosolic activation of cathepsins mediates parvovirus H-1-induced killing of cisplatin and TRAIL-resistant glioma cells. J. Virol. 81, 4186-4198 (2007).
    • (2007) J. Virol. , vol.81 , pp. 4186-4198
    • Di Piazza, M.1
  • 89
    • 78650312207 scopus 로고    scopus 로고
    • Immune cells participate in the oncosuppressive activity of parvovirus H-1PV and are activated as a result of their abortive infection with this agent
    • Grekova, S. et al. Immune cells participate in the oncosuppressive activity of parvovirus H-1PV and are activated as a result of their abortive infection with this agent. Cancer Biol. Ther. 10, 1280-1289 (2010).
    • (2010) Cancer Biol. Ther. , vol.10 , pp. 1280-1289
    • Grekova, S.1
  • 90
    • 50849129909 scopus 로고    scopus 로고
    • Vesicular egress of non-enveloped lytic parvoviruses depends on gelsolin functioning
    • Bar, S., Daeffler, L., Rommelaere, J. & Nuesch, J. P. Vesicular egress of non-enveloped lytic parvoviruses depends on gelsolin functioning. PLoS Pathog. 4, e1000126 (2008).
    • (2008) PLoS Pathog. , vol.4 , pp. e1000126
    • Bar, S.1    Daeffler, L.2    Rommelaere, J.3    Nuesch, J.P.4
  • 91
    • 2342453303 scopus 로고    scopus 로고
    • A tumor-targeted and conditionally replicating oncolytic adenovirus vector expressing TRAIL for treatment of liver metastases
    • Sova, P. et al. A tumor-targeted and conditionally replicating oncolytic adenovirus vector expressing TRAIL for treatment of liver metastases. Mol. Ther. 9, 496-509 (2004).
    • (2004) Mol. Ther. , vol.9 , pp. 496-509
    • Sova, P.1
  • 92
    • 84924965590 scopus 로고    scopus 로고
    • Immunological effects of a tumor necrosis factor α-armed oncolytic adenovirus
    • Hirvinen, M. et al. Immunological effects of a tumor necrosis factor α-armed oncolytic adenovirus. Hum. Gene Ther. 26, 134-144 (2015).
    • (2015) Hum. Gene Ther. , vol.26 , pp. 134-144
    • Hirvinen, M.1
  • 93
    • 0032503659 scopus 로고    scopus 로고
    • A novel three-pronged approach to kill cancer cells selectively: Concomitant viral, double suicide gene, and radiotherapy
    • Freytag, S. O., Rogulski, K. R., Paielli, D. L., Gilbert, J. D. & Kim, J. H. A novel three-pronged approach to kill cancer cells selectively: concomitant viral, double suicide gene, and radiotherapy. Hum. Gene Ther. 9, 1323-1333 (1998).
    • (1998) Hum. Gene Ther. , vol.9 , pp. 1323-1333
    • Freytag, S.O.1    Rogulski, K.R.2    Paielli, D.L.3    Gilbert, J.D.4    Kim, J.H.5
  • 94
    • 0036733759 scopus 로고    scopus 로고
    • Phase i study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer
    • Freytag, S. O. et al. Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer. Cancer Res. 62, 4968-4976 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 4968-4976
    • Freytag, S.O.1
  • 95
    • 53649094575 scopus 로고    scopus 로고
    • Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus
    • Foloppe, J. et al. Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus. Gene Ther. 15, 1361-1371 (2008).
    • (2008) Gene Ther. , vol.15 , pp. 1361-1371
    • Foloppe, J.1
  • 96
    • 0037429003 scopus 로고    scopus 로고
    • Phase i dose escalation clinical trial of adenovirus vector carrying osteocalcin promoter-driven herpes simplex virus thymidine kinase in localized and metastatic hormone-refractory prostate cancer
    • Kubo, H. et al. Phase I dose escalation clinical trial of adenovirus vector carrying osteocalcin promoter-driven herpes simplex virus thymidine kinase in localized and metastatic hormone-refractory prostate cancer. Hum. Gene Ther. 14, 227-241 (2003).
    • (2003) Hum. Gene Ther. , vol.14 , pp. 227-241
    • Kubo, H.1
  • 97
    • 0030908735 scopus 로고    scopus 로고
    • A phase i study of recombinant adenovirus vector-mediated intraperitoneal delivery of herpes simplex virus thymidine kinase (HSV-TK) gene and intravenous ganciclovir for previously treated ovarian and extraovarian cancer patients
    • Alvarez, R. D. & Curiel, D. T. A phase I study of recombinant adenovirus vector-mediated intraperitoneal delivery of herpes simplex virus thymidine kinase (HSV-TK) gene and intravenous ganciclovir for previously treated ovarian and extraovarian cancer patients. Hum. Gene Ther. 8, 597-613 (1997).
    • (1997) Hum. Gene Ther. , vol.8 , pp. 597-613
    • Alvarez, R.D.1    Curiel, D.T.2
  • 98
    • 0344200002 scopus 로고    scopus 로고
    • Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies
    • Aghi, M., Chou, T. C., Suling, K., Breakefield, X. O. & Chiocca, E. A. Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies. Cancer Res. 59, 3861-3865 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 3861-3865
    • Aghi, M.1    Chou, T.C.2    Suling, K.3    Breakefield, X.O.4    Chiocca, E.A.5
  • 99
    • 0028034286 scopus 로고
    • Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene
    • Boviatsis, E. J. et al. Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene. Cancer Res. 54, 5745-5751 (1994).
    • (1994) Cancer Res. , vol.54 , pp. 5745-5751
    • Boviatsis, E.J.1
  • 100
    • 10744227813 scopus 로고    scopus 로고
    • Phase i study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate cancer
    • Freytag, S. O. et al. Phase I study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate cancer. Cancer Res. 63, 7497-7506 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 7497-7506
    • Freytag, S.O.1
  • 101
    • 0034086730 scopus 로고    scopus 로고
    • Tumor-specific, replication-competent adenovirus vectors overexpressing the adenovirus death protein
    • Doronin, K. et al. Tumor-specific, replication-competent adenovirus vectors overexpressing the adenovirus death protein. J. Virol. 74, 6147-6155 (2000).
    • (2000) J. Virol. , vol.74 , pp. 6147-6155
    • Doronin, K.1
  • 102
    • 45449114994 scopus 로고    scopus 로고
    • Reprogrammed viruses as cancer therapeutics: Targeted, armed and shielded
    • Cattaneo, R., Miest, T., Shashkova, E. V. & Barry, M. A. Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded. Nat. Rev. Microbiol. 6, 529-540 (2008).
    • (2008) Nat. Rev. Microbiol. , vol.6 , pp. 529-540
    • Cattaneo, R.1    Miest, T.2    Shashkova, E.V.3    Barry, M.A.4
  • 103
    • 84875541589 scopus 로고    scopus 로고
    • PEGylation of vesicular stomatitis virus extends virus persistence in blood circulation of passively immunized mice
    • Tesfay, M. Z. et al. PEGylation of vesicular stomatitis virus extends virus persistence in blood circulation of passively immunized mice. J. Virol. 87, 3752-3759 (2013).
    • (2013) J. Virol. , vol.87 , pp. 3752-3759
    • Tesfay, M.Z.1
  • 104
    • 0033587174 scopus 로고    scopus 로고
    • PEGylation of adenovirus with retention of infectivity and protection from neutralizing antibody in vitro and in vivo
    • O'Riordan, C. R. et al. PEGylation of adenovirus with retention of infectivity and protection from neutralizing antibody in vitro and in vivo. Hum. Gene Ther. 10, 1349-1358 (1999).
    • (1999) Hum. Gene Ther. , vol.10 , pp. 1349-1358
    • O'Riordan, C.R.1
  • 105
    • 38649135439 scopus 로고    scopus 로고
    • Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor
    • Morrison, J. et al. Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor. Mol. Ther. 16, 244-251 (2008).
    • (2008) Mol. Ther. , vol.16 , pp. 244-251
    • Morrison, J.1
  • 106
    • 73149102956 scopus 로고    scopus 로고
    • Mesenchymal stem cell carriers protect oncolytic measles viruses from antibody neutralization in an orthotopic ovarian cancer therapy model
    • Mader, E. K. et al. Mesenchymal stem cell carriers protect oncolytic measles viruses from antibody neutralization in an orthotopic ovarian cancer therapy model. Clin. Cancer Res. 15, 7246-7255 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 7246-7255
    • Mader, E.K.1
  • 107
    • 70349853051 scopus 로고    scopus 로고
    • Cell carriers for oncolytic viruses: Fed Ex for cancer therapy
    • Willmon, C. et al. Cell carriers for oncolytic viruses: Fed Ex for cancer therapy. Mol. Ther. 17, 1667-1676 (2009).
    • (2009) Mol. Ther. , vol.17 , pp. 1667-1676
    • Willmon, C.1
  • 108
    • 0033996236 scopus 로고    scopus 로고
    • + cytotoxic T lymphocytes
    • + cytotoxic T lymphocytes. J. Virol. 74, 4465-4473 (2000).
    • (2000) J. Virol. , vol.74 , pp. 4465-4473
    • Berger, C.1
  • 109
    • 33748088164 scopus 로고    scopus 로고
    • Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses
    • Fulci, G. et al. Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses. Proc. Natl Acad. Sci. USA 103, 12873-12878 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 12873-12878
    • Fulci, G.1
  • 110
    • 0033677510 scopus 로고    scopus 로고
    • A blood-tumor barrier limits gene transfer to experimental liver cancer: The effect of vasoactive compounds
    • Bilbao, R. et al. A blood-tumor barrier limits gene transfer to experimental liver cancer: the effect of vasoactive compounds. Gene Ther. 7, 1824-1832 (2000).
    • (2000) Gene Ther. , vol.7 , pp. 1824-1832
    • Bilbao, R.1
  • 111
    • 77955301396 scopus 로고    scopus 로고
    • Hyperthermia potentiates oncolytic herpes viral killing of pancreatic cancer through a heat shock protein pathway
    • Eisenberg, D. P. et al. Hyperthermia potentiates oncolytic herpes viral killing of pancreatic cancer through a heat shock protein pathway. Surgery 148, 325-334 (2010).
    • (2010) Surgery , vol.148 , pp. 325-334
    • Eisenberg, D.P.1
  • 112
    • 78149466754 scopus 로고    scopus 로고
    • Low-dose paclitaxel synergizes with oncolytic adenoviruses via mitotic slippage and apoptosis in ovarian cancer
    • Ingemarsdotter, C. K. et al. Low-dose paclitaxel synergizes with oncolytic adenoviruses via mitotic slippage and apoptosis in ovarian cancer. Oncogene 29, 6051-6063 (2010).
    • (2010) Oncogene , vol.29 , pp. 6051-6063
    • Ingemarsdotter, C.K.1
  • 113
    • 84867719746 scopus 로고    scopus 로고
    • Combination of the tumor angiogenesis inhibitor bevacizumab and intratumoral oncolytic herpes virus injections as a treatment strategy for human gastric cancers
    • Deguchi, T. et al. Combination of the tumor angiogenesis inhibitor bevacizumab and intratumoral oncolytic herpes virus injections as a treatment strategy for human gastric cancers. Hepatogastroenterology 59, 1844-1850 (2012).
    • (2012) Hepatogastroenterology , vol.59 , pp. 1844-1850
    • Deguchi, T.1
  • 114
    • 33645066093 scopus 로고    scopus 로고
    • Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector
    • McKee, T. D. et al. Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector. Cancer Res. 66, 2509-2513 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 2509-2513
    • McKee, T.D.1
  • 115
    • 52449091656 scopus 로고    scopus 로고
    • Intratumoral coadministration of hyaluronidase enzyme and oncolytic adenoviruses enhances virus potency in metastatic tumor models
    • Ganesh, S., Gonzalez-Edick, M., Gibbons, D., Van Roey, M. & Jooss, K. Intratumoral coadministration of hyaluronidase enzyme and oncolytic adenoviruses enhances virus potency in metastatic tumor models. Clin. Cancer Res. 14, 3933-3941 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 3933-3941
    • Ganesh, S.1    Gonzalez-Edick, M.2    Gibbons, D.3    Van Roey, M.4    Jooss, K.5
  • 116
    • 77955403005 scopus 로고    scopus 로고
    • Hyaluronidase expression by an oncolytic adenovirus enhances its intratumoral spread and suppresses tumor growth
    • Guedan, S. et al. Hyaluronidase expression by an oncolytic adenovirus enhances its intratumoral spread and suppresses tumor growth. Mol. Ther. 18, 1275-1283 (2010).
    • (2010) Mol. Ther. , vol.18 , pp. 1275-1283
    • Guedan, S.1
  • 117
    • 2342637176 scopus 로고    scopus 로고
    • Syncytia induction enhances the oncolytic potential of vesicular stomatitis virus in virotherapy for cancer
    • Ebert, O. et al. Syncytia induction enhances the oncolytic potential of vesicular stomatitis virus in virotherapy for cancer. Cancer Res. 64, 3265-3270 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 3265-3270
    • Ebert, O.1
  • 118
    • 13644257013 scopus 로고    scopus 로고
    • Gene therapy for malignant glioma using Sindbis vectors expressing a fusogenic membrane glycoprotein
    • Zhang, J., Frolov, I. & Russell, S. J. Gene therapy for malignant glioma using Sindbis vectors expressing a fusogenic membrane glycoprotein. J. Gene Med. 6, 1082-1091 (2004).
    • (2004) J. Gene Med. , vol.6 , pp. 1082-1091
    • Zhang, J.1    Frolov, I.2    Russell, S.J.3
  • 119
    • 33747871572 scopus 로고    scopus 로고
    • Oncolytic efficacy and enhanced safety of measles virus activated by tumor-secreted matrix metalloproteinases
    • Springfeld, C. et al. Oncolytic efficacy and enhanced safety of measles virus activated by tumor-secreted matrix metalloproteinases. Cancer Res. 66, 7694-7700 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 7694-7700
    • Springfeld, C.1
  • 120
    • 0031017382 scopus 로고    scopus 로고
    • 134.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1α to dephosphorylate the α subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase
    • 134.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1α to dephosphorylate the α subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase. Proc. Natl Acad. Sci. USA 94, 843-848 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 843-848
    • He, B.1    Gross, M.2    Roizman, B.3
  • 121
    • 77149141965 scopus 로고    scopus 로고
    • Local and distant immunity induced by intralesional vaccination with an oncolytic herpes virus encoding GM-CSF in patients with stage IIIc and IV melanoma
    • Kaufman, H. L. et al. Local and distant immunity induced by intralesional vaccination with an oncolytic herpes virus encoding GM-CSF in patients with stage IIIc and IV melanoma. Ann. Surg. Oncol. 17, 718-730 (2010).
    • (2010) Ann. Surg. Oncol. , vol.17 , pp. 718-730
    • Kaufman, H.L.1
  • 122
    • 77957253429 scopus 로고    scopus 로고
    • OPTIM trial: A Phase III trial of an oncolytic herpes virus encoding GM-CSF for unresectable stage III or IV melanoma
    • Kaufman, H. L. & Bines, S. D. OPTIM trial: a Phase III trial of an oncolytic herpes virus encoding GM-CSF for unresectable stage III or IV melanoma. Future Oncol. 6, 941-949 (2010).
    • (2010) Future Oncol. , vol.6 , pp. 941-949
    • Kaufman, H.L.1    Bines, S.D.2
  • 123
    • 84936821506 scopus 로고    scopus 로고
    • Survival, safety, and response patterns in a phase 1b multicenter trial of talimogene laherparepvec (T-VEC) and ipilimumab (ipi) in previously untreated, unresected stage IIIB-IV melanoma
    • Puzanov, I. et al. Survival, safety, and response patterns in a phase 1b multicenter trial of talimogene laherparepvec (T-VEC) and ipilimumab (ipi) in previously untreated, unresected stage IIIB-IV melanoma. J. Clin. Oncol. 33, S9063 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. S9063
    • Puzanov, I.1
  • 124
    • 0344188096 scopus 로고    scopus 로고
    • An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
    • Bischoff, J. R. et al. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science 274, 373-376 (1996).
    • (1996) Science , vol.274 , pp. 373-376
    • Bischoff, J.R.1
  • 125
    • 0026639932 scopus 로고
    • The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins
    • Rao, L. et al. The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc. Natl Acad. Sci. USA 89, 7742-7746 (1992).
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 7742-7746
    • Rao, L.1
  • 126
    • 77049281450 scopus 로고
    • Studies on the use of viruses in the treatment of carcinoma of the cervix
    • Huebner, R. J., Rowe, W. P., Schatten, W. E., Smith, R. R. & Thomas, L. B. Studies on the use of viruses in the treatment of carcinoma of the cervix. Cancer 9, 1211-1218 (1956).
    • (1956) Cancer , vol.9 , pp. 1211-1218
    • Huebner, R.J.1    Rowe, W.P.2    Schatten, W.E.3    Smith, R.R.4    Thomas, L.B.5
  • 128
    • 84882452568 scopus 로고    scopus 로고
    • A phase i clinical trial of Ad5/3-A24, a novel serotype-chimeric, infectivity-enhanced, conditionally-replicative adenovirus (CRAd), in patients with recurrent ovarian cancer
    • Kim, K. H. et al. A phase I clinical trial of Ad5/3-A24, a novel serotype-chimeric, infectivity-enhanced, conditionally-replicative adenovirus (CRAd), in patients with recurrent ovarian cancer. Gynecol. Oncol. 130, 518-524 (2013).
    • (2013) Gynecol. Oncol. , vol.130 , pp. 518-524
    • Kim, K.H.1
  • 129
    • 0031775399 scopus 로고    scopus 로고
    • An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism
    • Dmitriev, I. et al. An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism. J. Virol. 72, 9706-9713 (1998).
    • (1998) J. Virol. , vol.72 , pp. 9706-9713
    • Dmitriev, I.1
  • 130
    • 0033755728 scopus 로고    scopus 로고
    • Dependence of adenovirus infectivity on length of the fiber shaft domain
    • Shayakhmetov, D. M. & Lieber, A. Dependence of adenovirus infectivity on length of the fiber shaft domain. J. Virol. 74, 10274-10286 (2000).
    • (2000) J. Virol. , vol.74 , pp. 10274-10286
    • Shayakhmetov, D.M.1    Lieber, A.2
  • 131
    • 84886785850 scopus 로고    scopus 로고
    • Enhanced antitumor efficacy of fiber-modified, midkine promoter-regulated oncolytic adenovirus in human malignant mesothelioma
    • Takagi-Kimura, M. et al. Enhanced antitumor efficacy of fiber-modified, midkine promoter-regulated oncolytic adenovirus in human malignant mesothelioma. Cancer Sci. 104, 1433-1439 (2013).
    • (2013) Cancer Sci. , vol.104 , pp. 1433-1439
    • Takagi-Kimura, M.1
  • 132
    • 84908156485 scopus 로고    scopus 로고
    • Clinical utility of recombinant adenoviral human p53 gene therapy: Current perspectives
    • Chen, G. X. et al. Clinical utility of recombinant adenoviral human p53 gene therapy: current perspectives. OncoTargets Ther. 7, 1901-1909 (2014).
    • (2014) OncoTargets Ther. , vol.7 , pp. 1901-1909
    • Chen, G.X.1
  • 133
    • 28744437659 scopus 로고    scopus 로고
    • Phase III randomized clinical trial of intratumoral injection of E1B gene-deleted adenovirus (H101) combined with cisplatin-based chemotherapy in treating squamous cell cancer of head and neck or esophagus
    • (in Chinese)
    • Xia, Z. J. et al. Phase III randomized clinical trial of intratumoral injection of E1B gene-deleted adenovirus (H101) combined with cisplatin-based chemotherapy in treating squamous cell cancer of head and neck or esophagus. Ai Zheng 23, 1666-1670 (in Chinese) (2004).
    • (2004) Ai Zheng , vol.23 , pp. 1666-1670
    • Xia, Z.J.1
  • 134
    • 2442624472 scopus 로고    scopus 로고
    • Cellular and humoral immunity against vaccinia virus infection of mice
    • Xu, R., Johnson, A. J., Liggitt, D. & Bevan, M. J. Cellular and humoral immunity against vaccinia virus infection of mice. J. Immunol. 172, 6265-6271 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 6265-6271
    • Xu, R.1    Johnson, A.J.2    Liggitt, D.3    Bevan, M.J.4
  • 135
    • 33749474618 scopus 로고    scopus 로고
    • Human T-cell responses to vaccinia virus envelope proteins
    • Tang, J. et al. Human T-cell responses to vaccinia virus envelope proteins. J. Virol. 80, 10010-10020 (2006).
    • (2006) J. Virol. , vol.80 , pp. 10010-10020
    • Tang, J.1
  • 136
    • 33746916507 scopus 로고    scopus 로고
    • Systemic armed oncolytic and immunologic therapy for cancer with JX-594, a targeted poxvirus expressing GM-CSF
    • Kim, J. H. et al. Systemic armed oncolytic and immunologic therapy for cancer with JX-594, a targeted poxvirus expressing GM-CSF. Mol. Ther 14, 361-370 (2006).
    • (2006) Mol. Ther , vol.14 , pp. 361-370
    • Kim, J.H.1
  • 137
    • 0033852076 scopus 로고    scopus 로고
    • Recombinant vaccinia virus encoding human MUC1 and IL2 as immunotherapy in patients with breast cancer
    • Scholl, S. M. et al. Recombinant vaccinia virus encoding human MUC1 and IL2 as immunotherapy in patients with breast cancer. J. Immunother. 23, 570-580 (2000).
    • (2000) J. Immunother. , vol.23 , pp. 570-580
    • Scholl, S.M.1
  • 138
    • 0030578211 scopus 로고    scopus 로고
    • Phase i study of recombinant CEA vaccinia virus vaccine with post vaccination CEA peptide challenge
    • Cole, D. J. et al. Phase I study of recombinant CEA vaccinia virus vaccine with post vaccination CEA peptide challenge. Hum. Gene Ther. 7, 1381-1394 (1996).
    • (1996) Hum. Gene Ther. , vol.7 , pp. 1381-1394
    • Cole, D.J.1
  • 139
    • 22144457398 scopus 로고    scopus 로고
    • Targeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma
    • Kaufman, H. L. et al. Targeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma. J. Clin. Invest. 115, 1903-1912 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 1903-1912
    • Kaufman, H.L.1
  • 140
    • 33144480152 scopus 로고    scopus 로고
    • Local delivery of vaccinia virus expressing multiple costimulatory molecules for the treatment of established tumors
    • Kaufman, H. L. et al. Local delivery of vaccinia virus expressing multiple costimulatory molecules for the treatment of established tumors. Hum. Gene Ther 17, 239-244 (2006).
    • (2006) Hum. Gene Ther , vol.17 , pp. 239-244
    • Kaufman, H.L.1
  • 141
    • 84940721633 scopus 로고    scopus 로고
    • Phase Ib trial of biweekly intravenous Pexa-Vec (JX-594), an oncolytic and immuno thera-peutic vaccinia virus in colorectal cancer
    • Park, S. H. et al. Phase Ib trial of biweekly intravenous Pexa-Vec (JX-594), an oncolytic and immuno thera-peutic vaccinia virus in colorectal cancer. Mol. Ther http://dx.doi.org/10.1038/mt.2015.109 (2015).
    • (2015) Mol. Ther
    • Park, S.H.1
  • 142
    • 84875225339 scopus 로고    scopus 로고
    • Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer
    • Heo, J. et al. Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer. Nat. Med. 19, 329-336 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 329-336
    • Heo, J.1
  • 143
    • 84861112821 scopus 로고    scopus 로고
    • Coxsackievirus B3 is an oncolytic virus with immunostimulatory properties that is active against lung adenocarcinoma
    • Miyamoto, S. et al. Coxsackievirus B3 is an oncolytic virus with immunostimulatory properties that is active against lung adenocarcinoma. Cancer Res. 72, 2609-2621 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 2609-2621
    • Miyamoto, S.1
  • 144
    • 84940880232 scopus 로고    scopus 로고
    • Final data from CALM: A phase II study of Coxsackievirus A21 (CVA21) oncolytic virus immunotherapy in patients with advanced melanoma
    • Andtbacka, R. H. I.et al. Final data from CALM: A phase II study of Coxsackievirus A21 (CVA21) oncolytic virus immunotherapy in patients with advanced melanoma. J. Clin. Oncol. 33, S9030 (2015).
    • (2015) J. Clin. Oncol. , vol.33 , pp. S9030
    • Andtbacka, R.H.I.1
  • 145
    • 77950482295 scopus 로고    scopus 로고
    • Type i interferon-sensitive recombinant newcastle disease virus for oncolytic virotherapy
    • Elankumaran, S. et al. Type I interferon-sensitive recombinant newcastle disease virus for oncolytic virotherapy. J. Virol. 84, 3835-3844 (2010).
    • (2010) J. Virol. , vol.84 , pp. 3835-3844
    • Elankumaran, S.1
  • 146
    • 0020363377 scopus 로고
    • Interferon production in mouse spleen cells and mouse fibroblasts (L cells) stimulated by various strains of Newcastle disease virus
    • Ito, Y, Nagai, Y. & Maeno, K. Interferon production in mouse spleen cells and mouse fibroblasts (L cells) stimulated by various strains of Newcastle disease virus. J. Gen. Virol. 62, 349-352 (1982).
    • (1982) J. Gen. Virol. , vol.62 , pp. 349-352
    • Ito, Y.1    Nagai, Y.2    Maeno, K.3
  • 147
    • 0036654058 scopus 로고    scopus 로고
    • Human tumor cell infection by Newcastle Disease Virus leads to upregulation of HLA and cell adhesion molecules and to induction of interferons, chemokines and finally apoptosis
    • Washburn, B. & Schirrmacher, V. Human tumor cell infection by Newcastle Disease Virus leads to upregulation of HLA and cell adhesion molecules and to induction of interferons, chemokines and finally apoptosis. Int. J. Oncol. 21, 85-93 (2002).
    • (2002) Int. J. Oncol. , vol.21 , pp. 85-93
    • Washburn, B.1    Schirrmacher, V.2
  • 149
    • 39049178459 scopus 로고    scopus 로고
    • In vivo efficacy of systemic tumor targeting of a viral RNA vector with oncolytic properties using a bispecific adapter protein
    • Bian, H., Wilden, H., Fournier, P., Peeters, B. & Schirrmacher, V In vivo efficacy of systemic tumor targeting of a viral RNA vector with oncolytic properties using a bispecific adapter protein. Int. J. Oncol. 29, 1359-1369 (2006).
    • (2006) Int. J. Oncol. , vol.29 , pp. 1359-1369
    • Bian, H.1    Wilden, H.2    Fournier, P.3    Peeters, B.4    Schirrmacher, V.5
  • 150
    • 36348967103 scopus 로고    scopus 로고
    • Recombinant Newcastle disease virus (NDV) with inserted gene coding for GM-CSF as a new vector for cancer immunogene therapy
    • Janke, M. et al. Recombinant Newcastle disease virus (NDV) with inserted gene coding for GM-CSF as a new vector for cancer immunogene therapy. Gene Ther. 14, 1639-1649 (2007).
    • (2007) Gene Ther. , vol.14 , pp. 1639-1649
    • Janke, M.1
  • 151
    • 38449106720 scopus 로고    scopus 로고
    • Host mediated anti-tumor effect of oncolytic Newcastle disease virus after locoregional application
    • Apostolidis, L., Schirrmacher, V. & Fournier, P. Host mediated anti-tumor effect of oncolytic Newcastle disease virus after locoregional application. Int. J. Oncol. 31, 1009-1019 (2007).
    • (2007) Int. J. Oncol. , vol.31 , pp. 1009-1019
    • Apostolidis, L.1    Schirrmacher, V.2    Fournier, P.3
  • 152
    • 0036569510 scopus 로고    scopus 로고
    • Phase i trial of intravenous administration of PV701, an oncolytic virus, in patients with advanced solid cancers
    • Pecora, A. L. et al. Phase I trial of intravenous administration of PV701, an oncolytic virus, in patients with advanced solid cancers. J. Clin. Oncol. 20, 2251-2266 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 2251-2266
    • Pecora, A.L.1
  • 153
    • 0021992342 scopus 로고
    • The prevalence of antibodies to reovirus type 3 in adults with idiopathic cholestatic liver disease
    • Minuk, G. Y., Paul, R. W. & Lee, P. W. The prevalence of antibodies to reovirus type 3 in adults with idiopathic cholestatic liver disease. J. Med. Virol. 16, 55-60 (1985).
    • (1985) J. Med. Virol. , vol.16 , pp. 55-60
    • Minuk, G.Y.1    Paul, R.W.2    Lee, P.W.3
  • 154
    • 0023267665 scopus 로고
    • Reovirus type 3 infection in patients with primary biliary cirrhosis and primary sclerosing cholangitis
    • Minuk, G. Y. et al. Reovirus type 3 infection in patients with primary biliary cirrhosis and primary sclerosing cholangitis. J. Hepatol. 5, 8-13 (1987).
    • (1987) J. Hepatol. , vol.5 , pp. 8-13
    • Minuk, G.Y.1
  • 155
    • 0015218266 scopus 로고
    • Regression of Burkitt's lymphoma in association with measles infection
    • Bluming, A. Z. & Ziegler, J. L. Regression of Burkitt's lymphoma in association with measles infection. Lancet 2, 105-106 (1971).
    • (1971) Lancet , vol.2 , pp. 105-106
    • Bluming, A.Z.1    Ziegler, J.L.2
  • 156
    • 0015228409 scopus 로고
    • Possible effect of measles on leukaemia
    • Pasquinucci, G. Possible effect of measles on leukaemia. Lancet 1, 136 (1971).
    • (1971) Lancet , vol.1 , pp. 136
    • Pasquinucci, G.1
  • 158
    • 4344646381 scopus 로고    scopus 로고
    • Poliovirus receptor CD155-targeted oncolysis of glioma
    • Merrill, M. K. et al. Poliovirus receptor CD155-targeted oncolysis of glioma. Neuro Oncol. 6, 208-217 (2004).
    • (2004) Neuro Oncol. , vol.6 , pp. 208-217
    • Merrill, M.K.1
  • 160
    • 33645229489 scopus 로고    scopus 로고
    • Cell-type-specific repression of internal ribosome entry site activity by double-stranded RNA-binding protein 76
    • Merrill, M. K., Dobrikova, E. Y. & Gromeier, M. Cell-type-specific repression of internal ribosome entry site activity by double-stranded RNA-binding protein 76. J. Virol. 80, 3147-3156 (2006).
    • (2006) J. Virol. , vol.80 , pp. 3147-3156
    • Merrill, M.K.1    Dobrikova, E.Y.2    Gromeier, M.3
  • 161
    • 33745778659 scopus 로고    scopus 로고
    • The double-stranded RNA binding protein 76:NF45 heterodimer inhibits translation initiation at the rhinovirus type 2 internal ribosome entry site
    • Merrill, M. K. & Gromeier, M. The double-stranded RNA binding protein 76:NF45 heterodimer inhibits translation initiation at the rhinovirus type 2 internal ribosome entry site. J. Virol. 80, 6936-6942 (2006).
    • (2006) J. Virol. , vol.80 , pp. 6936-6942
    • Merrill, M.K.1    Gromeier, M.2
  • 162
    • 84861562252 scopus 로고    scopus 로고
    • Replicating retroviral vectors for oncolytic virotherapy of experimental hepatocellular carcinoma
    • Lu, Y. C. et al. Replicating retroviral vectors for oncolytic virotherapy of experimental hepatocellular carcinoma. Oncol. Rep. 28, 21-26 (2012).
    • (2012) Oncol. Rep. , vol.28 , pp. 21-26
    • Lu, Y.C.1
  • 163
    • 77954916754 scopus 로고    scopus 로고
    • Assessing oncologic benefit in clinical trials of immunotherapy agents
    • Hales, R. K. et al. Assessing oncologic benefit in clinical trials of immunotherapy agents. Ann. Oncol. 21, 1944-1951 (2010).
    • (2010) Ann. Oncol. , vol.21 , pp. 1944-1951
    • Hales, R.K.1
  • 164
    • 33745161873 scopus 로고    scopus 로고
    • A phase i trial of intravenous CG7870, a replication-selective, prostate-specific antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer
    • Small, E. J. et al. A phase I trial of intravenous CG7870, a replication-selective, prostate-specific antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer. Mol. Ther. 14, 107-117 (2006).
    • (2006) Mol. Ther. , vol.14 , pp. 107-117
    • Small, E.J.1
  • 165
    • 33646389525 scopus 로고    scopus 로고
    • A phase 1 clinical study of intravenous administration of PV701, an oncolytic virus, using two-step desensitization
    • Laurie, S. A. et al. A phase 1 clinical study of intravenous administration of PV701, an oncolytic virus, using two-step desensitization. Clin. Cancer Res. 12, 2555-2562 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , pp. 2555-2562
    • Laurie, S.A.1
  • 166
    • 84865077277 scopus 로고    scopus 로고
    • Imaging characteristics, tissue distribution, and spread of a novel oncolytic vaccinia virus carrying the human sodium iodide symporter
    • Haddad, D. et al. Imaging characteristics, tissue distribution, and spread of a novel oncolytic vaccinia virus carrying the human sodium iodide symporter. PLoS ONE 7, e41647 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e41647
    • Haddad, D.1
  • 167
    • 33645663329 scopus 로고    scopus 로고
    • Dual therapy of ovarian cancer using measles viruses expressing carcinoembryonic antigen and sodium iodide symporter
    • Hasegawa, K. et al. Dual therapy of ovarian cancer using measles viruses expressing carcinoembryonic antigen and sodium iodide symporter. Clin. Cancer Res. 12, 1868-1875 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , pp. 1868-1875
    • Hasegawa, K.1
  • 168
    • 1442356959 scopus 로고    scopus 로고
    • Image-guided radiovirotherapy for multiple myeloma using a recombinant measles virus expressing the thyroidal sodium iodide symporter
    • Dingli, D. et al. Image-guided radiovirotherapy for multiple myeloma using a recombinant measles virus expressing the thyroidal sodium iodide symporter. Blood 103, 1641-1646 (2004).
    • (2004) Blood , vol.103 , pp. 1641-1646
    • Dingli, D.1
  • 169
    • 34547354102 scopus 로고    scopus 로고
    • Multitracer positron emission tomographic imaging of exogenous gene expression mediated by a universal herpes simplex virus 1 amplicon vector
    • Kummer, C. et al. Multitracer positron emission tomographic imaging of exogenous gene expression mediated by a universal herpes simplex virus 1 amplicon vector. Mol. Imag. 6, 181-192 (2007).
    • (2007) Mol. Imag. , vol.6 , pp. 181-192
    • Kummer, C.1
  • 170
    • 9544242826 scopus 로고    scopus 로고
    • Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: A potential method for monitoring clinical gene therapy
    • Tjuvajev, J. G. et al. Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy. Cancer Res. 56, 4087-4095 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 4087-4095
    • Tjuvajev, J.G.1
  • 171
    • 84880782388 scopus 로고    scopus 로고
    • Managing unexpected events in the manufacturing of biologic medicines
    • Grampp, G. & Ramanan, S. Managing unexpected events in the manufacturing of biologic medicines. BioDrugs 27, 305-316 (2013).
    • (2013) BioDrugs , vol.27 , pp. 305-316
    • Grampp, G.1    Ramanan, S.2
  • 172
    • 84902684527 scopus 로고    scopus 로고
    • Safety assurance for biologics manufactured in mammalian cell cultures: A multitiered strategy
    • Chen, D. Safety assurance for biologics manufactured in mammalian cell cultures: a multitiered strategy. Adv. Biochem. Eng. Biotechnol. 139, 167-183 (2014).
    • (2014) Adv. Biochem. Eng. Biotechnol. , vol.139 , pp. 167-183
    • Chen, D.1
  • 173
    • 79958811141 scopus 로고    scopus 로고
    • A new roadmap for biopharmaceutical drug product development: Integrating development, validation, and quality by design
    • Martin-Moe, S. et al. A new roadmap for biopharmaceutical drug product development: Integrating development, validation, and quality by design. J. Pharm. Sci. 100, 3031-3043 (2011).
    • (2011) J. Pharm. Sci. , vol.100 , pp. 3031-3043
    • Martin-Moe, S.1
  • 174
    • 79551708505 scopus 로고    scopus 로고
    • A phase i study of the combination of intravenous reovirus type 3 Dearing and gemcitabine in patients with advanced cancer
    • Lolkema, M. P. et al. A phase I study of the combination of intravenous reovirus type 3 Dearing and gemcitabine in patients with advanced cancer. Clin. Cancer Res. 17, 581-588 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 581-588
    • Lolkema, M.P.1
  • 175
    • 8844274068 scopus 로고    scopus 로고
    • HSV1716 injection into the brain adjacent to tumour following surgical resection of high-grade glioma: Safety data and long-term survival
    • Harrow, S. et al. HSV1716 injection into the brain adjacent to tumour following surgical resection of high-grade glioma: safety data and long-term survival. Gene Ther. 11, 1648-1658 (2004).
    • (2004) Gene Ther. , vol.11 , pp. 1648-1658
    • Harrow, S.1
  • 176
    • 0033135221 scopus 로고    scopus 로고
    • In situ gene therapy for adenocarcinoma of the prostate: A phase i clinical trial
    • Herman, J. R. et al. In situ gene therapy for adenocarcinoma of the prostate: a phase I clinical trial. Hum. Gene Ther. 10, 1239-1249 (1999).
    • (1999) Hum. Gene Ther. , vol.10 , pp. 1239-1249
    • Herman, J.R.1
  • 177
    • 0035501397 scopus 로고    scopus 로고
    • Phase I/II trial evaluating combined radiotherapy and in situ gene therapy with or without hormonal therapy in the treatment of prostate cancer - A preliminary report
    • Teh, B. S. et al. Phase I/II trial evaluating combined radiotherapy and in situ gene therapy with or without hormonal therapy in the treatment of prostate cancer - a preliminary report. Int. J. Radiat. Oncol. Biol. Phys. 51, 605-613 (2001).
    • (2001) Int. J. Radiat. Oncol. Biol. Phys. , vol.51 , pp. 605-613
    • Teh, B.S.1
  • 178
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
    • Herbst, R. S. et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 515, 563-567 (2014).
    • (2014) Nature , vol.515 , pp. 563-567
    • Herbst, R.S.1
  • 179
    • 84940826256 scopus 로고    scopus 로고
    • Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression
    • Bellucci, R. et al. Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression. Oncoimmunology 4, e1008824 (2015).
    • (2015) Oncoimmunology , vol.4 , pp. e1008824
    • Bellucci, R.1
  • 180
    • 79952767536 scopus 로고    scopus 로고
    • IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity
    • Terawaki, S. et al. IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity. J. Immunol. 186, 2772-2779 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 2772-2779
    • Terawaki, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.