메뉴 건너뛰기




Volumn 128, Issue 11, 2018, Pages 4912-4923

Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells

(22)  Stanczak, Michal A a   Siddiqui, Shoib S b   Trefny, Marcel P a   Thommen, Daniela S a   Boligan, Kayluz Frias c   Von Gunten, Stephan c   Tzankov, Alexandar d   Tietze, Lothar e   Lardinois, Didier a   Heinzelmann Schwarz, Viola a   Von Bergwelt Baildon, Michael f   Zhang, Wu g   Lenz, Heinz Josef g   Han, Younghun h   Amos, Christopher I h   Syedbasha, Mohammedyaseen a   Egli, Adrian a   Stenner, Frank a   Speiser, Daniel E i   Varki, Ajit b   more..


Author keywords

[No Author keywords available]

Indexed keywords

PROGRAMMED DEATH 1 RECEPTOR; SIALIC ACID BINDING IMMUNOGLOBULIN LIKE LECTIN; SIALOGLYCOPROTEIN; SIGLEC 9; UNCLASSIFIED DRUG; LEUKOCYTE ANTIGEN; SIGLEC9 PROTEIN, HUMAN; TUMOR PROTEIN;

EID: 85054764324     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI120612     Document Type: Article
Times cited : (209)

References (49)
  • 1
    • 84928062583 scopus 로고    scopus 로고
    • Immune checkpoint blockade: A common denominator approach to cancer therapy
    • Topalian SL, Drake CG, Pardoll DM. Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell. 2015;27(4):450-461.
    • (2015) Cancer Cell , vol.27 , Issue.4 , pp. 450-461
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 2
    • 85016548232 scopus 로고    scopus 로고
    • Elements of cancer immunity and the cancer-immune set point
    • Chen DS, Mellman I. Elements of cancer immunity and the cancer-immune set point. Nature. 2017;541(7637):321-330.
    • (2017) Nature , vol.541 , Issue.7637 , pp. 321-330
    • Chen, D.S.1    Mellman, I.2
  • 3
    • 84952317720 scopus 로고    scopus 로고
    • Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease
    • Cao X. Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease. Nat Rev Immunol. 2016;16(1):35-50.
    • (2016) Nat Rev Immunol , vol.16 , Issue.1 , pp. 35-50
    • Cao, X.1
  • 4
    • 84919346965 scopus 로고    scopus 로고
    • Complexity of danger: The diverse nature of damage-associated molecular patterns
    • Schaefer L. Complexity of danger: the diverse nature of damage-associated molecular patterns. J Biol Chem. 2014;289(51):35237-35245.
    • (2014) J Biol Chem , vol.289 , Issue.51 , pp. 35237-35245
    • Schaefer, L.1
  • 5
    • 66449088641 scopus 로고    scopus 로고
    • Pathogen recognition and inflammatory signaling in innate immune defenses
    • Mogensen TH. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev. 2009;22(2):240-273.
    • (2009) Clin Microbiol Rev , vol.22 , Issue.2 , pp. 240-273
    • Mogensen, T.H.1
  • 6
    • 78649526394 scopus 로고    scopus 로고
    • Sterile inflammation: Sensing and reacting to damage
    • Chen GY, Nuñez G. Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol. 2010;10(12):826-837.
    • (2010) Nat Rev Immunol , vol.10 , Issue.12 , pp. 826-837
    • Chen, G.Y.1    Nuñez, G.2
  • 7
    • 37849014248 scopus 로고    scopus 로고
    • Toll-like receptors and immune regulation: Implications for cancer therapy
    • Wang RF, Miyahara Y, Wang HY. Toll-like receptors and immune regulation: implications for cancer therapy. Oncogene. 2008;27(2):181-189.
    • (2008) Oncogene , vol.27 , Issue.2 , pp. 181-189
    • Wang, R.F.1    Miyahara, Y.2    Wang, H.Y.3
  • 8
    • 80051501538 scopus 로고    scopus 로고
    • Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them
    • Varki A. Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them. Glycobiology. 2011;21(9):1121-1124.
    • (2011) Glycobiology , vol.21 , Issue.9 , pp. 1121-1124
    • Varki, A.1
  • 9
    • 84899552000 scopus 로고    scopus 로고
    • Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates
    • Padler-Karavani V, et al. Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates. FASEB J. 2014;28(3):1280-1293.
    • (2014) FASEB J , vol.28 , Issue.3 , pp. 1280-1293
    • Padler-Karavani, V.1
  • 10
    • 33947602811 scopus 로고    scopus 로고
    • Siglecs and their roles in the immune system
    • Crocker PR, Paulson JC, Varki A. Siglecs and their roles in the immune system. Nat Rev Immunol. 2007;7(4):255-266.
    • (2007) Nat Rev Immunol , vol.7 , Issue.4 , pp. 255-266
    • Crocker, P.R.1    Paulson, J.C.2    Varki, A.3
  • 11
    • 84921786419 scopus 로고    scopus 로고
    • Siglec-mediated regulation of immune cell function in disease
    • Macauley MS, Crocker PR, Paulson JC. Siglec-mediated regulation of immune cell function in disease. Nat Rev Immunol. 2014;14(10):653-666.
    • (2014) Nat Rev Immunol , vol.14 , Issue.10 , pp. 653-666
    • Macauley, M.S.1    Crocker, P.R.2    Paulson, J.C.3
  • 12
    • 84960454276 scopus 로고    scopus 로고
    • Sialic acids in cancer biology and immunity
    • Pearce OM, Läubli H. Sialic acids in cancer biology and immunity. Glycobiology. 2016;26(2):111-128.
    • (2016) Glycobiology , vol.26 , Issue.2 , pp. 111-128
    • Pearce, O.M.1    Läubli, H.2
  • 13
    • 84905511325 scopus 로고    scopus 로고
    • CD22 and Siglec-G regulate inhibition of B-cell signaling by sialic acid ligand binding and control B-cell tolerance
    • Nitschke L. CD22 and Siglec-G regulate inhibition of B-cell signaling by sialic acid ligand binding and control B-cell tolerance. Glycobiology. 2014;24(9):807-817.
    • (2014) Glycobiology , vol.24 , Issue.9 , pp. 807-817
    • Nitschke, L.1
  • 14
    • 84905503889 scopus 로고    scopus 로고
    • The interplay between Siglecs and sialylated pathogens
    • Chang YC, Nizet V. The interplay between Siglecs and sialylated pathogens. Glycobiology. 2014;24(9):818-825.
    • (2014) Glycobiology , vol.24 , Issue.9 , pp. 818-825
    • Chang, Y.C.1    Nizet, V.2
  • 15
    • 84893722807 scopus 로고    scopus 로고
    • Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo
    • Chang YC, et al. Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo. PLoS Pathog. 2014;10(1):e1003846.
    • (2014) PLoS Pathog , vol.10 , Issue.1 , pp. e1003846
    • Chang, Y.C.1
  • 16
    • 68149179246 scopus 로고    scopus 로고
    • Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5
    • Carlin AF, et al. Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. J Exp Med. 2009;206(8):1691-1699.
    • (2009) J Exp Med , vol.206 , Issue.8 , pp. 1691-1699
    • Carlin, A.F.1
  • 17
    • 65349133663 scopus 로고    scopus 로고
    • Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response
    • Carlin AF, Uchiyama S, Chang YC, Lewis AL, Nizet V, Varki A. Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood. 2009;113(14):3333-3336.
    • (2009) Blood , vol.113 , Issue.14 , pp. 3333-3336
    • Carlin, A.F.1    Uchiyama, S.2    Chang, Y.C.3    Lewis, A.L.4    Nizet, V.5    Varki, A.6
  • 18
    • 85010508365 scopus 로고    scopus 로고
    • Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen
    • Schwarz F, et al. Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen. EMBO J. 2017;36(6):751-760.
    • (2017) EMBO J , vol.36 , Issue.6 , pp. 751-760
    • Schwarz, F.1
  • 19
    • 84978881204 scopus 로고    scopus 로고
    • Structural basis for sulfationdependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8
    • Pröpster JM, Yang F, Rabbani S, Ernst B, Allain FH, Schubert M. Structural basis for sulfationdependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8. Proc Natl Acad Sci U S A. 2016;113(29):E4170-E4179.
    • (2016) Proc Natl Acad Sci U S A , vol.113 , Issue.29 , pp. E4170-E4179
    • Pröpster, J.M.1    Yang, F.2    Rabbani, S.3    Ernst, B.4    Allain, F.H.5    Schubert, M.6
  • 20
    • 85021757123 scopus 로고    scopus 로고
    • Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties
    • Yu H, et al. Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties. Glycobiology. 2017;27(7):657-668.
    • (2017) Glycobiology , vol.27 , Issue.7 , pp. 657-668
    • Yu, H.1
  • 21
    • 84907588573 scopus 로고    scopus 로고
    • Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer
    • Läubli H, et al. Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer. Proc Natl Acad Sci U S A. 2014;111(39):14211-14216.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.39 , pp. 14211-14216
    • Läubli, H.1
  • 22
    • 84897566999 scopus 로고    scopus 로고
    • Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance
    • Jandus C, et al. Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance. J Clin Invest. 2014;124(4):1810-1820.
    • (2014) J Clin Invest , vol.124 , Issue.4 , pp. 1810-1820
    • Jandus, C.1
  • 23
    • 84890937257 scopus 로고    scopus 로고
    • Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion
    • Hudak JE, Canham SM, Bertozzi CR. Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion. Nat Chem Biol. 2014;10(1):69-75.
    • (2014) Nat Chem Biol , vol.10 , Issue.1 , pp. 69-75
    • Hudak, J.E.1    Canham, S.M.2    Bertozzi, C.R.3
  • 24
    • 84912101312 scopus 로고    scopus 로고
    • Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs
    • Läubli H, et al. Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs. J Biol Chem. 2014;289(48):33481-33491.
    • (2014) J Biol Chem , vol.289 , Issue.48 , pp. 33481-33491
    • Läubli, H.1
  • 25
    • 84991736614 scopus 로고    scopus 로고
    • The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9
    • Beatson R, et al. The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9. Nat Immunol. 2016;17(11):1273-1281.
    • (2016) Nat Immunol , vol.17 , Issue.11 , pp. 1273-1281
    • Beatson, R.1
  • 26
    • 85042610128 scopus 로고    scopus 로고
    • The tumour glyco-code as a novel immune checkpoint for immunotherapy
    • RodrÍguez E, Schetters STT, van Kooyk Y. The tumour glyco-code as a novel immune checkpoint for immunotherapy. Nat Rev Immunol. 2018;18(3):204-211.
    • (2018) Nat Rev Immunol , vol.18 , Issue.3 , pp. 204-211
    • Rodriguez, E.1    Schetters, S.T.T.2    Van Kooyk, Y.3
  • 27
    • 84937837169 scopus 로고    scopus 로고
    • Molecular and cellular insights into T cell exhaustion
    • Wherry EJ, Kurachi M. Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol. 2015;15(8):486-499.
    • (2015) Nat Rev Immunol , vol.15 , Issue.8 , pp. 486-499
    • Wherry, E.J.1    Kurachi, M.2
  • 28
    • 84873989765 scopus 로고    scopus 로고
    • Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells
    • Soto PC, Karris MY, Spina CA, Richman DD, Varki A. Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells. J Mol Med. 2013;91(2):261-270.
    • (2013) J Mol Med , vol.91 , Issue.2 , pp. 261-270
    • Soto, P.C.1    Karris, M.Y.2    Spina, C.A.3    Richman, D.D.4    Varki, A.5
  • 30
    • 84860234082 scopus 로고    scopus 로고
    • CD33-related siglecs as potential modulators of inflammatory responses
    • Crocker PR, McMillan SJ, Richards HE. CD33-related siglecs as potential modulators of inflammatory responses. Ann N Y Acad Sci. 2012;1253:102-111.
    • (2012) Ann N y Acad Sci , vol.1253 , pp. 102-111
    • Crocker, P.R.1    McMillan, S.J.2    Richards, H.E.3
  • 31
    • 85019673982 scopus 로고    scopus 로고
    • Chromatin states define tumour-specific T cell dysfunction and reprogramming
    • Philip M, et al. Chromatin states define tumour-specific T cell dysfunction and reprogramming. Nature. 2017;545(7655):452-456.
    • (2017) Nature , vol.545 , Issue.7655 , pp. 452-456
    • Philip, M.1
  • 32
    • 84920031180 scopus 로고    scopus 로고
    • In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates
    • Wang C, et al. In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates. Cancer Immunol Res. 2014;2(9):846-856.
    • (2014) Cancer Immunol Res , vol.2 , Issue.9 , pp. 846-856
    • Wang, C.1
  • 33
    • 85006001617 scopus 로고    scopus 로고
    • Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency
    • Ishii T, et al. Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency. Respirology. 2017;22(4):684-690.
    • (2017) Respirology , vol.22 , Issue.4 , pp. 684-690
    • Ishii, T.1
  • 34
    • 84903585835 scopus 로고    scopus 로고
    • Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer
    • Wang Y, et al. Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Nat Genet. 2014;46(7):736-741.
    • (2014) Nat Genet , vol.46 , Issue.7 , pp. 736-741
    • Wang, Y.1
  • 35
    • 5644239563 scopus 로고    scopus 로고
    • Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9
    • Ikehara Y, Ikehara SK, Paulson JC. Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9. J Biol Chem. 2004;279(41):43117-43125.
    • (2004) J Biol Chem , vol.279 , Issue.41 , pp. 43117-43125
    • Ikehara, Y.1    Ikehara, S.K.2    Paulson, J.C.3
  • 36
    • 84879365270 scopus 로고    scopus 로고
    • T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10
    • Bandala-Sanchez E, et al. T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10. Nat Immunol. 2013;14(7):741-748.
    • (2013) Nat Immunol , vol.14 , Issue.7 , pp. 741-748
    • Bandala-Sanchez, E.1
  • 37
    • 85061109941 scopus 로고    scopus 로고
    • Siglec-G represses DAMP-mediated effects on T cells
    • Toubai T, et al. Siglec-G represses DAMP-mediated effects on T cells. JCI Insight. 2017;2(14):e92293.
    • (2017) JCI Insight , vol.2 , Issue.14 , pp. e92293
    • Toubai, T.1
  • 38
    • 85019744578 scopus 로고    scopus 로고
    • PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
    • Gordon SR, et al. PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity. Nature. 2017;545(7655):495-499.
    • (2017) Nature , vol.545 , Issue.7655 , pp. 495-499
    • Gordon, S.R.1
  • 39
    • 85028667219 scopus 로고    scopus 로고
    • Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers
    • Liu Y, et al. Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers. Oncogene. 2017;36(44):6143-6153.
    • (2017) Oncogene , vol.36 , Issue.44 , pp. 6143-6153
    • Liu, Y.1
  • 40
    • 84899748384 scopus 로고    scopus 로고
    • PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors
    • Gros A, et al. PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors. J Clin Invest. 2014;124(5):2246-2259.
    • (2014) J Clin Invest , vol.124 , Issue.5 , pp. 2246-2259
    • Gros, A.1
  • 41
    • 84962129035 scopus 로고    scopus 로고
    • Progression of lung cancer is associated with increased dysfunction of T cells defined by coexpression of multiple inhibitory receptors
    • Thommen DS, et al. Progression of lung cancer is associated with increased dysfunction of T cells defined by coexpression of multiple inhibitory receptors. Cancer Immunol Res. 2015;3(12):1344-1355.
    • (2015) Cancer Immunol Res , vol.3 , Issue.12 , pp. 1344-1355
    • Thommen, D.S.1
  • 42
    • 84892146573 scopus 로고    scopus 로고
    • Inhibitory receptor expression depends more dominantly on differentiation and activation than "exhaustion" of human CD8 T cells
    • Legat A, Speiser DE, Pircher H, Zehn D, Fuertes Marraco SA. Inhibitory receptor expression depends more dominantly on differentiation and activation than "exhaustion" of human CD8 T cells. Front Immunol. 2013;4:455.
    • (2013) Front Immunol , vol.4 , pp. 455
    • Legat, A.1    Speiser, D.E.2    Pircher, H.3    Zehn, D.4    Fuertes Marraco, S.A.5
  • 43
    • 84982144414 scopus 로고    scopus 로고
    • Regulatory circuits of T cell function in cancer
    • Speiser DE, Ho PC, Verdeil G. Regulatory circuits of T cell function in cancer. Nat Rev Immunol. 2016;16(10):599-611.
    • (2016) Nat Rev Immunol , vol.16 , Issue.10 , pp. 599-611
    • Speiser, D.E.1    Ho, P.C.2    Verdeil, G.3
  • 44
    • 84858766894 scopus 로고    scopus 로고
    • Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer
    • Rabinovich GA, Croci DO. Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer. Immunity. 2012;36(3):322-335.
    • (2012) Immunity , vol.36 , Issue.3 , pp. 322-335
    • Rabinovich, G.A.1    Croci, D.O.2
  • 45
    • 84960406089 scopus 로고    scopus 로고
    • Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells
    • Perdicchio M, et al. Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells. Oncotarget. 2016;7(8):8771-8782.
    • (2016) Oncotarget , vol.7 , Issue.8 , pp. 8771-8782
    • Perdicchio, M.1
  • 46
    • 78650663362 scopus 로고    scopus 로고
    • Sialylation of 3-methylcholanthrene-induced fibrosarcoma determines antitumor immune responses during immunoediting
    • Cohen M, et al. Sialylation of 3-methylcholanthrene-induced fibrosarcoma determines antitumor immune responses during immunoediting. J Immunol. 2010;185(10):5869-5878.
    • (2010) J Immunol , vol.185 , Issue.10 , pp. 5869-5878
    • Cohen, M.1
  • 47
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • Sharma P, Allison JP. The future of immune checkpoint therapy. Science. 2015;348(6230):56-61.
    • (2015) Science , vol.348 , Issue.6230 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2
  • 48
    • 84927130807 scopus 로고    scopus 로고
    • Immune checkpoint targeting in cancer therapy: Toward combination strategies with curative potential
    • Sharma P, Allison JP. Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell. 2015;161(2):205-214.
    • (2015) Cell , vol.161 , Issue.2 , pp. 205-214
    • Sharma, P.1    Allison, J.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.