-
1
-
-
84928062583
-
Immune checkpoint blockade: A common denominator approach to cancer therapy
-
Topalian SL, Drake CG, Pardoll DM. Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell. 2015;27(4):450-461.
-
(2015)
Cancer Cell
, vol.27
, Issue.4
, pp. 450-461
-
-
Topalian, S.L.1
Drake, C.G.2
Pardoll, D.M.3
-
2
-
-
85016548232
-
Elements of cancer immunity and the cancer-immune set point
-
Chen DS, Mellman I. Elements of cancer immunity and the cancer-immune set point. Nature. 2017;541(7637):321-330.
-
(2017)
Nature
, vol.541
, Issue.7637
, pp. 321-330
-
-
Chen, D.S.1
Mellman, I.2
-
3
-
-
84952317720
-
Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease
-
Cao X. Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease. Nat Rev Immunol. 2016;16(1):35-50.
-
(2016)
Nat Rev Immunol
, vol.16
, Issue.1
, pp. 35-50
-
-
Cao, X.1
-
4
-
-
84919346965
-
Complexity of danger: The diverse nature of damage-associated molecular patterns
-
Schaefer L. Complexity of danger: the diverse nature of damage-associated molecular patterns. J Biol Chem. 2014;289(51):35237-35245.
-
(2014)
J Biol Chem
, vol.289
, Issue.51
, pp. 35237-35245
-
-
Schaefer, L.1
-
5
-
-
66449088641
-
Pathogen recognition and inflammatory signaling in innate immune defenses
-
Mogensen TH. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev. 2009;22(2):240-273.
-
(2009)
Clin Microbiol Rev
, vol.22
, Issue.2
, pp. 240-273
-
-
Mogensen, T.H.1
-
6
-
-
78649526394
-
Sterile inflammation: Sensing and reacting to damage
-
Chen GY, Nuñez G. Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol. 2010;10(12):826-837.
-
(2010)
Nat Rev Immunol
, vol.10
, Issue.12
, pp. 826-837
-
-
Chen, G.Y.1
Nuñez, G.2
-
7
-
-
37849014248
-
Toll-like receptors and immune regulation: Implications for cancer therapy
-
Wang RF, Miyahara Y, Wang HY. Toll-like receptors and immune regulation: implications for cancer therapy. Oncogene. 2008;27(2):181-189.
-
(2008)
Oncogene
, vol.27
, Issue.2
, pp. 181-189
-
-
Wang, R.F.1
Miyahara, Y.2
Wang, H.Y.3
-
8
-
-
80051501538
-
Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them
-
Varki A. Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them. Glycobiology. 2011;21(9):1121-1124.
-
(2011)
Glycobiology
, vol.21
, Issue.9
, pp. 1121-1124
-
-
Varki, A.1
-
9
-
-
84899552000
-
Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates
-
Padler-Karavani V, et al. Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates. FASEB J. 2014;28(3):1280-1293.
-
(2014)
FASEB J
, vol.28
, Issue.3
, pp. 1280-1293
-
-
Padler-Karavani, V.1
-
10
-
-
33947602811
-
Siglecs and their roles in the immune system
-
Crocker PR, Paulson JC, Varki A. Siglecs and their roles in the immune system. Nat Rev Immunol. 2007;7(4):255-266.
-
(2007)
Nat Rev Immunol
, vol.7
, Issue.4
, pp. 255-266
-
-
Crocker, P.R.1
Paulson, J.C.2
Varki, A.3
-
11
-
-
84921786419
-
Siglec-mediated regulation of immune cell function in disease
-
Macauley MS, Crocker PR, Paulson JC. Siglec-mediated regulation of immune cell function in disease. Nat Rev Immunol. 2014;14(10):653-666.
-
(2014)
Nat Rev Immunol
, vol.14
, Issue.10
, pp. 653-666
-
-
Macauley, M.S.1
Crocker, P.R.2
Paulson, J.C.3
-
12
-
-
84960454276
-
Sialic acids in cancer biology and immunity
-
Pearce OM, Läubli H. Sialic acids in cancer biology and immunity. Glycobiology. 2016;26(2):111-128.
-
(2016)
Glycobiology
, vol.26
, Issue.2
, pp. 111-128
-
-
Pearce, O.M.1
Läubli, H.2
-
13
-
-
84905511325
-
CD22 and Siglec-G regulate inhibition of B-cell signaling by sialic acid ligand binding and control B-cell tolerance
-
Nitschke L. CD22 and Siglec-G regulate inhibition of B-cell signaling by sialic acid ligand binding and control B-cell tolerance. Glycobiology. 2014;24(9):807-817.
-
(2014)
Glycobiology
, vol.24
, Issue.9
, pp. 807-817
-
-
Nitschke, L.1
-
14
-
-
84905503889
-
The interplay between Siglecs and sialylated pathogens
-
Chang YC, Nizet V. The interplay between Siglecs and sialylated pathogens. Glycobiology. 2014;24(9):818-825.
-
(2014)
Glycobiology
, vol.24
, Issue.9
, pp. 818-825
-
-
Chang, Y.C.1
Nizet, V.2
-
15
-
-
84893722807
-
Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo
-
Chang YC, et al. Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo. PLoS Pathog. 2014;10(1):e1003846.
-
(2014)
PLoS Pathog
, vol.10
, Issue.1
, pp. e1003846
-
-
Chang, Y.C.1
-
16
-
-
68149179246
-
Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5
-
Carlin AF, et al. Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. J Exp Med. 2009;206(8):1691-1699.
-
(2009)
J Exp Med
, vol.206
, Issue.8
, pp. 1691-1699
-
-
Carlin, A.F.1
-
17
-
-
65349133663
-
Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response
-
Carlin AF, Uchiyama S, Chang YC, Lewis AL, Nizet V, Varki A. Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood. 2009;113(14):3333-3336.
-
(2009)
Blood
, vol.113
, Issue.14
, pp. 3333-3336
-
-
Carlin, A.F.1
Uchiyama, S.2
Chang, Y.C.3
Lewis, A.L.4
Nizet, V.5
Varki, A.6
-
18
-
-
85010508365
-
Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen
-
Schwarz F, et al. Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen. EMBO J. 2017;36(6):751-760.
-
(2017)
EMBO J
, vol.36
, Issue.6
, pp. 751-760
-
-
Schwarz, F.1
-
19
-
-
84978881204
-
Structural basis for sulfationdependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8
-
Pröpster JM, Yang F, Rabbani S, Ernst B, Allain FH, Schubert M. Structural basis for sulfationdependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8. Proc Natl Acad Sci U S A. 2016;113(29):E4170-E4179.
-
(2016)
Proc Natl Acad Sci U S A
, vol.113
, Issue.29
, pp. E4170-E4179
-
-
Pröpster, J.M.1
Yang, F.2
Rabbani, S.3
Ernst, B.4
Allain, F.H.5
Schubert, M.6
-
20
-
-
85021757123
-
Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties
-
Yu H, et al. Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties. Glycobiology. 2017;27(7):657-668.
-
(2017)
Glycobiology
, vol.27
, Issue.7
, pp. 657-668
-
-
Yu, H.1
-
21
-
-
84907588573
-
Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer
-
Läubli H, et al. Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer. Proc Natl Acad Sci U S A. 2014;111(39):14211-14216.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, Issue.39
, pp. 14211-14216
-
-
Läubli, H.1
-
22
-
-
84897566999
-
Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance
-
Jandus C, et al. Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance. J Clin Invest. 2014;124(4):1810-1820.
-
(2014)
J Clin Invest
, vol.124
, Issue.4
, pp. 1810-1820
-
-
Jandus, C.1
-
23
-
-
84890937257
-
Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion
-
Hudak JE, Canham SM, Bertozzi CR. Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion. Nat Chem Biol. 2014;10(1):69-75.
-
(2014)
Nat Chem Biol
, vol.10
, Issue.1
, pp. 69-75
-
-
Hudak, J.E.1
Canham, S.M.2
Bertozzi, C.R.3
-
24
-
-
84912101312
-
Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs
-
Läubli H, et al. Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs. J Biol Chem. 2014;289(48):33481-33491.
-
(2014)
J Biol Chem
, vol.289
, Issue.48
, pp. 33481-33491
-
-
Läubli, H.1
-
25
-
-
84991736614
-
The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9
-
Beatson R, et al. The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9. Nat Immunol. 2016;17(11):1273-1281.
-
(2016)
Nat Immunol
, vol.17
, Issue.11
, pp. 1273-1281
-
-
Beatson, R.1
-
26
-
-
85042610128
-
The tumour glyco-code as a novel immune checkpoint for immunotherapy
-
RodrÍguez E, Schetters STT, van Kooyk Y. The tumour glyco-code as a novel immune checkpoint for immunotherapy. Nat Rev Immunol. 2018;18(3):204-211.
-
(2018)
Nat Rev Immunol
, vol.18
, Issue.3
, pp. 204-211
-
-
Rodriguez, E.1
Schetters, S.T.T.2
Van Kooyk, Y.3
-
27
-
-
84937837169
-
Molecular and cellular insights into T cell exhaustion
-
Wherry EJ, Kurachi M. Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol. 2015;15(8):486-499.
-
(2015)
Nat Rev Immunol
, vol.15
, Issue.8
, pp. 486-499
-
-
Wherry, E.J.1
Kurachi, M.2
-
28
-
-
84873989765
-
Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells
-
Soto PC, Karris MY, Spina CA, Richman DD, Varki A. Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells. J Mol Med. 2013;91(2):261-270.
-
(2013)
J Mol Med
, vol.91
, Issue.2
, pp. 261-270
-
-
Soto, P.C.1
Karris, M.Y.2
Spina, C.A.3
Richman, D.D.4
Varki, A.5
-
29
-
-
33646734488
-
Loss of Siglec expression on T lymphocytes during human evolution
-
Nguyen DH, Hurtado-Ziola N, Gagneux P, Varki A. Loss of Siglec expression on T lymphocytes during human evolution. Proc Natl Acad Sci U S A. 2006;103(20):7765-7770.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.20
, pp. 7765-7770
-
-
Nguyen, D.H.1
Hurtado-Ziola, N.2
Gagneux, P.3
Varki, A.4
-
30
-
-
84860234082
-
CD33-related siglecs as potential modulators of inflammatory responses
-
Crocker PR, McMillan SJ, Richards HE. CD33-related siglecs as potential modulators of inflammatory responses. Ann N Y Acad Sci. 2012;1253:102-111.
-
(2012)
Ann N y Acad Sci
, vol.1253
, pp. 102-111
-
-
Crocker, P.R.1
McMillan, S.J.2
Richards, H.E.3
-
31
-
-
85019673982
-
Chromatin states define tumour-specific T cell dysfunction and reprogramming
-
Philip M, et al. Chromatin states define tumour-specific T cell dysfunction and reprogramming. Nature. 2017;545(7655):452-456.
-
(2017)
Nature
, vol.545
, Issue.7655
, pp. 452-456
-
-
Philip, M.1
-
32
-
-
84920031180
-
In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates
-
Wang C, et al. In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates. Cancer Immunol Res. 2014;2(9):846-856.
-
(2014)
Cancer Immunol Res
, vol.2
, Issue.9
, pp. 846-856
-
-
Wang, C.1
-
33
-
-
85006001617
-
Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency
-
Ishii T, et al. Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency. Respirology. 2017;22(4):684-690.
-
(2017)
Respirology
, vol.22
, Issue.4
, pp. 684-690
-
-
Ishii, T.1
-
34
-
-
84903585835
-
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer
-
Wang Y, et al. Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Nat Genet. 2014;46(7):736-741.
-
(2014)
Nat Genet
, vol.46
, Issue.7
, pp. 736-741
-
-
Wang, Y.1
-
35
-
-
5644239563
-
Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9
-
Ikehara Y, Ikehara SK, Paulson JC. Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9. J Biol Chem. 2004;279(41):43117-43125.
-
(2004)
J Biol Chem
, vol.279
, Issue.41
, pp. 43117-43125
-
-
Ikehara, Y.1
Ikehara, S.K.2
Paulson, J.C.3
-
36
-
-
84879365270
-
T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10
-
Bandala-Sanchez E, et al. T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10. Nat Immunol. 2013;14(7):741-748.
-
(2013)
Nat Immunol
, vol.14
, Issue.7
, pp. 741-748
-
-
Bandala-Sanchez, E.1
-
37
-
-
85061109941
-
Siglec-G represses DAMP-mediated effects on T cells
-
Toubai T, et al. Siglec-G represses DAMP-mediated effects on T cells. JCI Insight. 2017;2(14):e92293.
-
(2017)
JCI Insight
, vol.2
, Issue.14
, pp. e92293
-
-
Toubai, T.1
-
38
-
-
85019744578
-
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
-
Gordon SR, et al. PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity. Nature. 2017;545(7655):495-499.
-
(2017)
Nature
, vol.545
, Issue.7655
, pp. 495-499
-
-
Gordon, S.R.1
-
39
-
-
85028667219
-
Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers
-
Liu Y, et al. Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers. Oncogene. 2017;36(44):6143-6153.
-
(2017)
Oncogene
, vol.36
, Issue.44
, pp. 6143-6153
-
-
Liu, Y.1
-
40
-
-
84899748384
-
PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors
-
Gros A, et al. PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors. J Clin Invest. 2014;124(5):2246-2259.
-
(2014)
J Clin Invest
, vol.124
, Issue.5
, pp. 2246-2259
-
-
Gros, A.1
-
41
-
-
84962129035
-
Progression of lung cancer is associated with increased dysfunction of T cells defined by coexpression of multiple inhibitory receptors
-
Thommen DS, et al. Progression of lung cancer is associated with increased dysfunction of T cells defined by coexpression of multiple inhibitory receptors. Cancer Immunol Res. 2015;3(12):1344-1355.
-
(2015)
Cancer Immunol Res
, vol.3
, Issue.12
, pp. 1344-1355
-
-
Thommen, D.S.1
-
42
-
-
84892146573
-
Inhibitory receptor expression depends more dominantly on differentiation and activation than "exhaustion" of human CD8 T cells
-
Legat A, Speiser DE, Pircher H, Zehn D, Fuertes Marraco SA. Inhibitory receptor expression depends more dominantly on differentiation and activation than "exhaustion" of human CD8 T cells. Front Immunol. 2013;4:455.
-
(2013)
Front Immunol
, vol.4
, pp. 455
-
-
Legat, A.1
Speiser, D.E.2
Pircher, H.3
Zehn, D.4
Fuertes Marraco, S.A.5
-
43
-
-
84982144414
-
Regulatory circuits of T cell function in cancer
-
Speiser DE, Ho PC, Verdeil G. Regulatory circuits of T cell function in cancer. Nat Rev Immunol. 2016;16(10):599-611.
-
(2016)
Nat Rev Immunol
, vol.16
, Issue.10
, pp. 599-611
-
-
Speiser, D.E.1
Ho, P.C.2
Verdeil, G.3
-
44
-
-
84858766894
-
Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer
-
Rabinovich GA, Croci DO. Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer. Immunity. 2012;36(3):322-335.
-
(2012)
Immunity
, vol.36
, Issue.3
, pp. 322-335
-
-
Rabinovich, G.A.1
Croci, D.O.2
-
45
-
-
84960406089
-
Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells
-
Perdicchio M, et al. Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells. Oncotarget. 2016;7(8):8771-8782.
-
(2016)
Oncotarget
, vol.7
, Issue.8
, pp. 8771-8782
-
-
Perdicchio, M.1
-
46
-
-
78650663362
-
Sialylation of 3-methylcholanthrene-induced fibrosarcoma determines antitumor immune responses during immunoediting
-
Cohen M, et al. Sialylation of 3-methylcholanthrene-induced fibrosarcoma determines antitumor immune responses during immunoediting. J Immunol. 2010;185(10):5869-5878.
-
(2010)
J Immunol
, vol.185
, Issue.10
, pp. 5869-5878
-
-
Cohen, M.1
-
47
-
-
84928774156
-
The future of immune checkpoint therapy
-
Sharma P, Allison JP. The future of immune checkpoint therapy. Science. 2015;348(6230):56-61.
-
(2015)
Science
, vol.348
, Issue.6230
, pp. 56-61
-
-
Sharma, P.1
Allison, J.P.2
-
48
-
-
84927130807
-
Immune checkpoint targeting in cancer therapy: Toward combination strategies with curative potential
-
Sharma P, Allison JP. Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell. 2015;161(2):205-214.
-
(2015)
Cell
, vol.161
, Issue.2
, pp. 205-214
-
-
Sharma, P.1
Allison, J.P.2
-
49
-
-
84937846973
-
Evolving synergistic combinations of targeted immunotherapies to combat cancer
-
Melero I, Berman DM, Aznar MA, Korman AJ, Pérez Gracia JL, Haanen J. Evolving synergistic combinations of targeted immunotherapies to combat cancer. Nat Rev Cancer. 2015;15(8):457-472.
-
(2015)
Nat Rev Cancer
, vol.15
, Issue.8
, pp. 457-472
-
-
Melero, I.1
Berman, D.M.2
Aznar, M.A.3
Korman, A.J.4
Gracia, P.J.L.5
Haanen, J.6
|