Dendritic cells in tumor-associated tertiary lymphoid structures signal a th1 cytotoxic immune contexture and license the positive prognostic value of infiltrating CD8+ t cells

Cancer Research

Volumn 74, Issue 3, 2014, Pages 705-715

  Goc, Jeremy ^a,b,c   Germain, Claire ^a,b,c   Vo Bourgais, Thi Kim Duy ^a,b,c   Lupo, Audrey ^a,b,c,d   Klein, Christophe ^b   Knockaert, Samantha ^a,b,c   De Chaisemartin, Luc ^a,b,c   Ouakrim, Hanane ^a,b,c   Becht, Etienne ^a,b,c   Alifano, Marco ^e   Validire, Pierre ^a,f   Remark, Romain ^a,b,c   Hammond, Scott A ^h   Cremer, Isabelle ^a,b,c   Damotte, Diane ^a,b,c,d   Fridman, Wolf Herman ^a,b,c,g   Sautes Fridman, Catherine ^a,b,c   Dieu Nosjean, Marie Caroline ^a,b,c  

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d Department of Pathology ^*  (United States)

^e LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^f Institut Mutualiste Montsouris   (United States)

^g HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^h MEDIMMUNE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD27 ANTIGEN; CD45RA ANTIGEN; CD45RO ANTIGEN; CD69 ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR7; DENDRITIC CELL LYSOSOME ASSOCIATED MEMBRANE PROTEIN; INTERLEUKIN 12P40; INTERLEUKIN 15; INTERLEUKIN 2; L SELECTIN; RANTES; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CANCER STAGING; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DENSITY; CELL DIFFERENTIATION; CELL MEDIATED CYTOTOXICITY; CHRONIC INFLAMMATION; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; FLOW CYTOMETRY; HELPER CELL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; LUNG TUMOR; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION; RISK FACTOR; SMOKING; T LYMPHOCYTE ACTIVATION; TH1 CELL; TUMOR ASSOCIATED LEUKOCYTE; TUMOR MICROENVIRONMENT; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CLUSTER ANALYSIS; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; FEMALE; GENE EXPRESSION PROFILING; HUMANS; IMMUNOLOGIC MEMORY; LUNG NEOPLASMS; LYMPHOCYTE ACTIVATION; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; RISK FACTORS; T-LYMPHOCYTE SUBSETS; TH1 CELLS; TUMOR MICROENVIRONMENT; YOUNG ADULT;

EID: 84893851804     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-13-1342     Document Type: Article

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