메뉴 건너뛰기




Volumn 2, Issue 3, 2012, Pages

Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease

Author keywords

[No Author keywords available]

Indexed keywords

AFLIBERCEPT; ANGIOGENIC FACTOR; ANGIOPOIETIN; BETA INTERFERON; BEVACIZUMAB; CEDIRANIB; CYTOKINE; GROWTH FACTOR; INTEGRIN; LAPATINIB; MONOCLONAL ANTIBODY DC101; NITRIC OXIDE SYNTHASE; PLACENTAL GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR B; SEMAPHORIN; SEX HORMONE; THROMBOSPONDIN; TRANSFORMING GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN; ANGIOGENESIS INHIBITOR; ANGIOPOIETIN 2; CYTOTOXIN; VASCULOTROPIN A;

EID: 84886675563     PISSN: None     EISSN: 21571422     Source Type: Journal    
DOI: 10.1101/cshperspect.a006486     Document Type: Article
Times cited : (269)

References (188)
  • 1
    • 0345798150 scopus 로고    scopus 로고
    • Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors
    • Abramsson A, Lindblom P, Betsholtz C. 2003. Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. J Clin Invest 112: 1142-1151.
    • (2003) J Clin Invest , vol.112 , pp. 1142-1151
    • Abramsson, A.1    Lindblom, P.2    Betsholtz, C.3
  • 2
    • 0347994029 scopus 로고    scopus 로고
    • Inhibition of Rho pathways induces radiosensitization and oxygenation in human glioblastoma xenografts
    • Ader I, Delmas C, Bonnet J, Rochaix P, Favre G, Toulas C, Cohen-Jonathan-MoyalE. 2003. Inhibition of Rho pathways induces radiosensitization and oxygenation in human glioblastoma xenografts. Oncogene 22: 8861-8869.
    • (2003) Oncogene , vol.22 , pp. 8861-8869
    • Ader, I.1    Delmas, C.2    Bonnet, J.3    Rochaix, P.4    Favre, G.5    Toulas, C.6    Cohen-Jonathan-Moyal, E.7
  • 3
    • 84959830787 scopus 로고
    • Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants
    • Algire GH, Chalkley HW. 1945. Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants. J Natl Cancer Inst 6: 73-85.
    • (1945) J Natl Cancer Inst , vol.6 , pp. 73-85
    • Algire, G.H.1    Chalkley, H.W.2
  • 5
  • 6
    • 60749096085 scopus 로고    scopus 로고
    • Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system
    • Augustin HG, Koh GY, Thurston G, Alitalo K. 2009. Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat Rev Mol Cell Biol 10: 165-177.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 165-177
    • Augustin, H.G.1    Koh, G.Y.2    Thurston, G.3    Alitalo, K.4
  • 11
    • 79960087069 scopus 로고    scopus 로고
    • MRI assessment of angiogenesis inhibitor Sunitinib's influence on tumor oxygenation to identify an optimal chemoradiotherapeutic window
    • Batra S, Matsumoto S, Hyodo F, Mitchell J, Krishna MC. 2009. MRI assessment of angiogenesis inhibitor Sunitinib's influence on tumor oxygenation to identify an optimal chemoradiotherapeutic window. Int J Radiat Oncol Biol Phys 75: S43.
    • (2009) Int J Radiat Oncol Biol Phys , vol.75
    • Batra, S.1    Matsumoto, S.2    Hyodo, F.3    Mitchell, J.4    Krishna, M.C.5
  • 12
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin LE, Golijanin D, Itin A, Pode D, Keshet E. 1999. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 103: 159-165.
    • (1999) J Clin Invest , vol.103 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 14
    • 52449104467 scopus 로고    scopus 로고
    • Tumor vascular maturation and improved drug delivery induced by methylselenocysteine leads to therapeutic synergy with anticancer drugs
    • Bhattacharya A, Seshadri M, Oven SD, Toth K, Vaughan MM, Rustum YM. 2008. Tumor vascular maturation and improved drug delivery induced by methylselenocysteine leads to therapeutic synergy with anticancer drugs. Clin Cancer Res 14: 3926-3932.
    • (2008) Clin Cancer Res , vol.14 , pp. 3926-3932
    • Bhattacharya, A.1    Seshadri, M.2    Oven, S.D.3    Toth, K.4    Vaughan, M.M.5    Rustum, Y.M.6
  • 15
    • 69549117151 scopus 로고    scopus 로고
    • Inhibition of colon cancer growth by methylselenocysteine-induced angiogenic chemomodulation is influenced by histologic characteristics of the tumor
    • Bhattacharya A, Toth K, Sen A, Seshadri M, Cao S, Durrani FA, Faber E, RepaskyEA, Rustum YM. 2009. Inhibition of colon cancer growth by methylselenocysteine-induced angiogenic chemomodulation is influenced by histologic characteristics of the tumor. Clin Colorectal Cancer 8: 155-162.
    • (2009) Clin Colorectal Cancer , vol.8 , pp. 155-162
    • Bhattacharya, A.1    Toth, K.2    Sen, A.3    Seshadri, M.4    Cao, S.5    Durrani, F.A.6    Faber, E.7    Repasky, E.A.8    Rustum, Y.M.9
  • 17
    • 0242331613 scopus 로고    scopus 로고
    • Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy
    • Bocci G, Francia G, Man S, Lawler J, Kerbel RS. 2003. Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy. Proc Natl Acad Sci 100: 12917-12922.
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 12917-12922
    • Bocci, G.1    Francia, G.2    Man, S.3    Lawler, J.4    Kerbel, R.S.5
  • 18
    • 65649124507 scopus 로고    scopus 로고
    • Bevacizumab in hereditary hemorrhagic telangiectasia
    • Bose P, Holter JL, Selby GB. 2009. Bevacizumab in hereditary hemorrhagic telangiectasia. N Engl J Med 360: 2143-2144.
    • (2009) N Engl J Med , vol.360 , pp. 2143-2144
    • Bose, P.1    Holter, J.L.2    Selby, G.B.3
  • 19
    • 0025334830 scopus 로고
    • Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: Implications for therapy
    • Boucher Y, Baxter LT, Jain RK. 1990. Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: Implications for therapy. Cancer Res 50: 4478-4484.
    • (1990) Cancer Res , vol.50 , pp. 4478-4484
    • Boucher, Y.1    Baxter, L.T.2    Jain, R.K.3
  • 20
    • 0026350937 scopus 로고
    • Interstitial hypertension in superficial metastatic melanomas in humans
    • Boucher Y, Kirkwood JM, Opacic D, Desantis M, Jain RK. 1991. Interstitial hypertension in superficial metastatic melanomas in humans. Cancer Res 51: 6691-6694.
    • (1991) Cancer Res , vol.51 , pp. 6691-6694
    • Boucher, Y.1    Kirkwood, J.M.2    Opacic, D.3    Desantis, M.4    Jain, R.K.5
  • 21
    • 0017581612 scopus 로고
    • Ultrastructure of the capillary loops in the dermal papillae of psoriasis
    • Braverman IM, Yen A. 1977. Ultrastructure of the capillary loops in the dermal papillae of psoriasis. J Invest Dermatol 68: 53-60.
    • (1977) J Invest Dermatol , vol.68 , pp. 53-60
    • Braverman, I.M.1    Yen, A.2
  • 22
    • 70349469696 scopus 로고    scopus 로고
    • Antiangiogenic approaches to age-related macular degeneration today
    • Bressler NM. 2009a. Antiangiogenic approaches to age-related macular degeneration today. Ophthalmology 116: S15-S23.
    • (2009) Ophthalmology , vol.116
    • Bressler, N.M.1
  • 23
    • 70349449737 scopus 로고    scopus 로고
    • Introduction: Understanding the role of angiogenesis and antiangiogenic agents in age-related macular degeneration
    • Bressler SB. 2009b. Introduction: Understanding the role of angiogenesis and antiangiogenic agents in age-related macular degeneration. Ophthalmology 116: S1-S7.
    • (2009) Ophthalmology , vol.116
    • Bressler, S.B.1
  • 26
    • 36248999001 scopus 로고    scopus 로고
    • Blood vessel morphologic changes depicted with MR angiography during treatment of brain metastases: A feasibility study
    • Bullitt E, Lin NU, Smith JK, Zeng D, Winer EP, Carey LA, Lin W, Ewend MG. 2007. Blood vessel morphologic changes depicted with MR angiography during treatment of brain metastases: A feasibility study. Radiology 245: 824-830.
    • (2007) Radiology , vol.245 , pp. 824-830
    • Bullitt, E.1    Lin, N.U.2    Smith, J.K.3    Zeng, D.4    Winer, E.P.5    Carey, L.A.6    Lin, W.7    Ewend, M.G.8
  • 27
    • 79956328903 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical applications of angiogenesis
    • Carmeliet P, Jain RK. 2011. Molecular mechanisms and clinical applications of angiogenesis. Nature 473: 298-307.
    • (2011) Nature , vol.473 , pp. 298-307
    • Carmeliet, P.1    Jain, R.K.2
  • 28
    • 19244379078 scopus 로고    scopus 로고
    • Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
    • Carmeliet P, Moons L, Luttun A, Vincenti V, Compernolle V, De Mol M, Wu Y, Bono F, Devy L, Beck H, et al. 2001. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med 7: 575-583.
    • (2001) Nat Med , vol.7 , pp. 575-583
    • Carmeliet, P.1    Moons, L.2    Luttun, A.3    Vincenti, V.4    Compernolle, V.5    De Mol, M.6    Wu, Y.7    Bono, F.8    Devy, L.9    Beck, H.10
  • 29
    • 0346059697 scopus 로고    scopus 로고
    • Immunohistochemical demonstration of vascular endothelial growth factor in vestibular schwannomas correlates to tumor growth rate
    • Caye-Thomasen P, Baandrup L, Jacobsen GK, Thomsen J, Stangerup SE. 2003. Immunohistochemical demonstration of vascular endothelial growth factor in vestibular schwannomas correlates to tumor growth rate. Laryngoscope 113: 2129-2134.
    • (2003) Laryngoscope , vol.113 , pp. 2129-2134
    • Caye-Thomasen, P.1    Baandrup, L.2    Jacobsen, G.K.3    Thomsen, J.4    Stangerup, S.E.5
  • 31
    • 68349137598 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy
    • Cerniglia GJ, Pore N, Tsai JH, Schultz S, Mick R, Choe R, Xing X, Durduran T, Yodh AG, Evans SM, et al. 2009. Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy. PLoS One 4: e6539.
    • (2009) PLoS One , vol.4
    • Cerniglia, G.J.1    Pore, N.2    Tsai, J.H.3    Schultz, S.4    Mick, R.5    Choe, R.6    Xing, X.7    Durduran, T.8    Yodh, A.G.9    Evans, S.M.10
  • 34
    • 77953988924 scopus 로고    scopus 로고
    • Targeting the tumour vasculature: Insights from physiological angiogenesis
    • Chung AS, Lee J, Ferrara N. 2010. Targeting the tumour vasculature: Insights from physiological angiogenesis. Nat Rev Cancer 10: 505-514.
    • (2010) Nat Rev Cancer , vol.10 , pp. 505-514
    • Chung, A.S.1    Lee, J.2    Ferrara, N.3
  • 37
    • 0030741782 scopus 로고    scopus 로고
    • Localization of endothelial proliferation and microvascular expansion in active plaque psoriasis
    • Creamer D, Allen MH, Sousa A, Poston R, Barker JN. 1997. Localization of endothelial proliferation and microvascular expansion in active plaque psoriasis. Br J Dermatol 136: 859-865.
    • (1997) Br J Dermatol , vol.136 , pp. 859-865
    • Creamer, D.1    Allen, M.H.2    Sousa, A.3    Poston, R.4    Barker, J.N.5
  • 39
    • 77951228314 scopus 로고    scopus 로고
    • The role of hypoxia and acidosis in promoting metastasis and resistance to chemotherapy
    • DeClerck K, Elble RC. 2010. The role of hypoxia and acidosis in promoting metastasis and resistance to chemotherapy. Front Biosci 15: 213-225.
    • (2010) Front Biosci , vol.15 , pp. 213-225
    • DeClerck, K.1    Elble, R.C.2
  • 40
    • 0347364771 scopus 로고    scopus 로고
    • The farnesyltransferase inhibitor R115777 reduces hypoxia and matrix metalloproteinase 2 expression in human glioma xenograft
    • Delmas C, End D, Rochaix P, Favre G, Toulas C, Cohen-Jonathan E. 2003. The farnesyltransferase inhibitor R115777 reduces hypoxia and matrix metalloproteinase 2 expression in human glioma xenograft. Clin Cancer Res 9: 6062-6068.
    • (2003) Clin Cancer Res , vol.9 , pp. 6062-6068
    • Delmas, C.1    End, D.2    Rochaix, P.3    Favre, G.4    Toulas, C.5    Cohen-Jonathan, E.6
  • 41
    • 72949119124 scopus 로고    scopus 로고
    • Integrins in cancer: Biological implications and therapeutic opportunities
    • Desgrosellier JS, Cheresh DA. 2010. Integrins in cancer: Biological implications and therapeutic opportunities. Nat Rev Cancer 10: 9-22.
    • (2010) Nat Rev Cancer , vol.10 , pp. 9-22
    • Desgrosellier, J.S.1    Cheresh, D.A.2
  • 42
    • 33845917049 scopus 로고    scopus 로고
    • Interferon β-mediated vessel stabilization improves delivery and efficacy of systemically administered topotecan in a murine neuroblastoma model
    • Dickson PV, Hagedorn NL, Hamner JB, Fraga CH, Ng CY, Stewart CF, DavidoffAM. 2007a. Interferon β-mediated vessel stabilization improves delivery and efficacy of systemically administered topotecan in a murine neuroblastoma model. J Pediat Surg 42: 160-165.
    • (2007) J Pediat Surg , vol.42 , pp. 160-165
    • Dickson, P.V.1    Hagedorn, N.L.2    Hamner, J.B.3    Fraga, C.H.4    Ng, C.Y.5    Stewart, C.F.6    Davidoff, A.M.7
  • 45
    • 34250660932 scopus 로고    scopus 로고
    • Scheduling of radiation with angiogenesis inhibitors anginex and Avastin improves therapeutic outcome via vessel normalization
    • Dings RP, Loren M, Heun H, McNiel E, Griffioen AW, Mayo KH, Griffin RJ. 2007. Scheduling of radiation with angiogenesis inhibitors anginex and Avastin improves therapeutic outcome via vessel normalization. Clin Cancer Res 13: 3395-3402.
    • (2007) Clin Cancer Res , vol.13 , pp. 3395-3402
    • Dings, R.P.1    Loren, M.2    Heun, H.3    McNiel, E.4    Griffioen, A.W.5    Mayo, K.H.6    Griffin, R.J.7
  • 47
    • 65249183165 scopus 로고    scopus 로고
    • PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment
    • di Tomaso E, London N, Fuja D, Logie J, Tyrrell JA, Kamoun W, Munn LL, Jain RK. 2009. PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment. PLoS ONE 4: e5123.
    • (2009) PLoS ONE , vol.4
    • di Tomaso, E.1    London, N.2    Fuja, D.3    Logie, J.4    Tyrrell, J.A.5    Kamoun, W.6    Munn, L.L.7    Jain, R.K.8
  • 50
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak HF. 1986. Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 315: 1650-1659.
    • (1986) N Engl J Med , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 52
    • 47949096436 scopus 로고    scopus 로고
    • Contrast enhanced MRI and intravital fluorescence microscopy indicate improved tumor microcirculation in highly vascularized melanomas on short-term anti-VEGFR treatment [see comment]
    • Eichhorn ME, Strieth S, Luedemann S, Kleespies A, Noth U, Passon A, Brix G, Jauch KW, Bruns CJ, Dellian M. 2008. Contrast enhanced MRI and intravital fluorescence microscopy indicate improved tumor microcirculation in highly vascularized melanomas on short-term anti-VEGFR treatment [see comment]. Cancer Biol Ther 7: 1006-1013.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1006-1013
    • Eichhorn, M.E.1    Strieth, S.2    Luedemann, S.3    Kleespies, A.4    Noth, U.5    Passon, A.6    Brix, G.7    Jauch, K.W.8    Bruns, C.J.9    Dellian, M.10
  • 53
    • 0036959644 scopus 로고    scopus 로고
    • Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration
    • Eyetech Study Group
    • Eyetech Study Group. 2002. Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration. Retina 22: 143-152.
    • (2002) Retina , vol.22 , pp. 143-152
  • 54
    • 73649112748 scopus 로고    scopus 로고
    • Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels
    • Falcon BL, Hashizume H, Koumoutsakos P, Chou J, Bready JV, Coxon A, OlinerJD, McDonald DM. 2009. Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels. Am J Pathol 175: 2159-2170.
    • (2009) Am J Pathol , vol.175 , pp. 2159-2170
    • Falcon, B.L.1    Hashizume, H.2    Koumoutsakos, P.3    Chou, J.4    Bready, J.V.5    Coxon, A.6    Oliner, J.D.7    McDonald, D.M.8
  • 55
    • 27944490875 scopus 로고    scopus 로고
    • VEGF as a therapeutic target in cancer
    • Ferrara N. 2005. VEGF as a therapeutic target in cancer. Oncology 69 (Suppl 3): 11-16.
    • (2005) Oncology , vol.69 , Issue.SUPPL. 3 , pp. 11-16
    • Ferrara, N.1
  • 56
    • 77957764473 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and age-related macular degeneration: From basic science to therapy
    • Ferrara N. 2010. Vascular endothelial growth factor and age-related macular degeneration: From basic science to therapy. Nat Med 16: 1107-1111.
    • (2010) Nat Med , vol.16 , pp. 1107-1111
    • Ferrara, N.1
  • 59
    • 33747837492 scopus 로고    scopus 로고
    • Dramatic improvement in hereditary hemorrhagic telangiectasia after treatment with the vascular endothelial growth factor (VEGF) antagonist bevacizumab
    • Flieger D, Hainke S, Fischbach W. 2006. Dramatic improvement in hereditary hemorrhagic telangiectasia after treatment with the vascular endothelial growth factor (VEGF) antagonist bevacizumab. Ann Hematol 85: 631-632.
    • (2006) Ann Hematol , vol.85 , pp. 631-632
    • Flieger, D.1    Hainke, S.2    Fischbach, W.3
  • 60
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. 1971. Tumor angiogenesis: therapeutic implications. N Engl J Med 285: 1182-1186.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 61
    • 77649195502 scopus 로고    scopus 로고
    • Sorafenib-associated remission of psoriasis in hypernephroma: Case report
    • Fournier C, Tisman G. 2010. Sorafenib-associated remission of psoriasis in hypernephroma: Case report. Dermatol Online J 16: 17.
    • (2010) Dermatol Online J , vol.16 , pp. 17
    • Fournier, C.1    Tisman, G.2
  • 63
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • Giantonio BJ, Catalano PJ, Meropol NJ, O'Dwyer PJ, Mitchell EP, Alberts SR, Schwartz MA, Benson AB 3rd. 2007. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 25: 1539-1544.
    • (2007) J Clin Oncol , vol.25 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3    O'Dwyer, P.J.4    Mitchell, E.P.5    Alberts, S.R.6    Schwartz, M.A.7    Benson III, A.B.8
  • 69
    • 0029943319 scopus 로고    scopus 로고
    • Tumor angiogenesis is accompanied by a decreased inflammatory response of tumor-associated endothelium
    • Griffioen AW, Damen CA, Blijham GH, Groenewegen G. 1996. Tumor angiogenesis is accompanied by a decreased inflammatory response of tumor-associated endothelium. Blood 88: 667-673.
    • (1996) Blood , vol.88 , pp. 667-673
    • Griffioen, A.W.1    Damen, C.A.2    Blijham, G.H.3    Groenewegen, G.4
  • 70
    • 84886680508 scopus 로고
    • Vascular normalization
    • In, (ed. Gautherie M, Albert E). A. R. Liss, New York
    • Gullino PM. 1982. Vascular normalization. In Biomedical thermology (ed. Gautherie M, Albert E). A. R. Liss, New York.
    • (1982) Biomedical thermology
    • Gullino, P.M.1
  • 71
    • 33645738314 scopus 로고    scopus 로고
    • Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis
    • Hagendoorn J, Tong R, Fukumura D, Lin Q, Lobo J, Padera TP, Xu L, Kucherlapati R, Jain RK. 2006. Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis. Cancer Res 66: 3360-3364.
    • (2006) Cancer Res , vol.66 , pp. 3360-3364
    • Hagendoorn, J.1    Tong, R.2    Fukumura, D.3    Lin, Q.4    Lobo, J.5    Padera, T.P.6    Xu, L.7    Kucherlapati, R.8    Jain, R.K.9
  • 73
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. 2000. The hallmarks of cancer. Cell 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 74
    • 0034662621 scopus 로고    scopus 로고
    • Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy
    • Hansen-Algenstaedt N, Stoll BR, Padera TP, Dolmans DE, Hicklin DJ, FukumuraD, Jain RK. 2000. Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy. Cancer Res 60: 4556-4560.
    • (2000) Cancer Res , vol.60 , pp. 4556-4560
    • Hansen-Algenstaedt, N.1    Stoll, B.R.2    Padera, T.P.3    Dolmans, D.E.4    Hicklin, D.J.5    Fukumura, D.6    Jain, R.K.7
  • 77
    • 77954035012 scopus 로고    scopus 로고
    • Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): A double-blind, randomised, phase 3 trial
    • Herbst RS, Sun Y, Eberhardt WE, Germonpre P, Saijo N, Zhou C, Wang J, Li L, Kabbinavar F, Ichinose Y, et al. 2010. Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): A double-blind, randomised, phase 3 trial. Lancet Oncol 11: 619-626.
    • (2010) Lancet Oncol , vol.11 , pp. 619-626
    • Herbst, R.S.1    Sun, Y.2    Eberhardt, W.E.3    Germonpre, P.4    Saijo, N.5    Zhou, C.6    Wang, J.7    Li, L.8    Kabbinavar, F.9    Ichinose, Y.10
  • 79
    • 0037109023 scopus 로고    scopus 로고
    • Combined therapy of local and metastatic 4T1 breast tumor in mice using SU6668, an inhibitor of angiogenic receptor tyrosine kinases, and the immunostimulator B7. 2-IgG fusion protein
    • Huang X, Wong MK, Yi H, Watkins S, Laird AD, Wolf SF, Gorelik E. 2002. Combined therapy of local and metastatic 4T1 breast tumor in mice using SU6668, an inhibitor of angiogenic receptor tyrosine kinases, and the immunostimulator B7. 2-IgG fusion protein. Cancer Res 62: 5727-5735.
    • (2002) Cancer Res , vol.62 , pp. 5727-5735
    • Huang, X.1    Wong, M.K.2    Yi, H.3    Watkins, S.4    Laird, A.D.5    Wolf, S.F.6    Gorelik, E.7
  • 80
    • 77954890371 scopus 로고    scopus 로고
    • Targeting the ANGPT-TIE2 pathway in malignancy
    • Huang H, Bhat A, Woodnutt G, Lappe R. 2010. Targeting the ANGPT-TIE2 pathway in malignancy. Nat Rev Cancer 10: 575-585.
    • (2010) Nat Rev Cancer , vol.10 , pp. 575-585
    • Huang, H.1    Bhat, A.2    Woodnutt, G.3    Lappe, R.4
  • 81
    • 78651417422 scopus 로고    scopus 로고
    • Polarization of tumor-associated macrophages: A novel strategy for vascular normalization and antitumor immunity
    • Huang Y, Snuderl M, Jain RK. 2011. Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity. Cancer Cell 19: 1-2.
    • (2011) Cancer Cell , vol.19 , pp. 1-2
    • Huang, Y.1    Snuderl, M.2    Jain, R.K.3
  • 83
    • 0000912662 scopus 로고
    • Vascularization of the Brown-Pearce rabbit epithelioma transplant as seen in the transparent ear chamber
    • Ide AG, Baker NH, Warren SL. 1939. Vascularization of the Brown-Pearce rabbit epithelioma transplant as seen in the transparent ear chamber. Am J Radiol 42: 891-899.
    • (1939) Am J Radiol , vol.42 , pp. 891-899
    • Ide, A.G.1    Baker, N.H.2    Warren, S.L.3
  • 84
    • 3042548695 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
    • Inai T, Mancuso M, Hashizume H, Baffert F, Haskell A, Baluk P, Hu-Lowe DD, Shalinsky DR, Thurston G, Yancopoulos GD, et al. 2004. Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol 165: 35-52.
    • (2004) Am J Pathol , vol.165 , pp. 35-52
    • Inai, T.1    Mancuso, M.2    Hashizume, H.3    Baffert, F.4    Haskell, A.5    Baluk, P.6    Hu-Lowe, D.D.7    Shalinsky, D.R.8    Thurston, G.9    Yancopoulos, G.D.10
  • 85
    • 0043125643 scopus 로고    scopus 로고
    • VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization
    • Ishida S, Usui T, Yamashiro K, Kaji Y, Amano S, Ogura Y, Hida T, Oguchi Y, Ambati J, Miller JW, et al. 2003. VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization. J Exp Med 198: 483-489.
    • (2003) J Exp Med , vol.198 , pp. 483-489
    • Ishida, S.1    Usui, T.2    Yamashiro, K.3    Kaji, Y.4    Amano, S.5    Ogura, Y.6    Hida, T.7    Oguchi, Y.8    Ambati, J.9    Miller, J.W.10
  • 86
    • 0037149539 scopus 로고    scopus 로고
    • Tumour biology: Herceptin acts as an anti-angiogenic cocktail
    • Izumi Y, Xu L, di Tomaso E, Fukumura D, Jain RK. 2002. Tumour biology: Herceptin acts as an anti-angiogenic cocktail. Nature 416: 279-280.
    • (2002) Nature , vol.416 , pp. 279-280
    • Izumi, Y.1    Xu, L.2    di Tomaso, E.3    Fukumura, D.4    Jain, R.K.5
  • 87
    • 0023909330 scopus 로고
    • Determinants of tumor blood flow: A review
    • Jain RK. 1988. Determinants of tumor blood flow: A review. Cancer Res 48: 2641-2658.
    • (1988) Cancer Res , vol.48 , pp. 2641-2658
    • Jain, R.K.1
  • 88
    • 0024505574 scopus 로고
    • Delivery of novel therapeutic agents in tumors: Physiological barriers and strategies
    • Jain RK. 1989. Delivery of novel therapeutic agents in tumors: Physiological barriers and strategies. J Natl Cancer Inst 81: 570-576.
    • (1989) J Natl Cancer Inst , vol.81 , pp. 570-576
    • Jain, R.K.1
  • 89
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • Jain RK. 2001. Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy. Nat Med 7: 987-989.
    • (2001) Nat Med , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 90
    • 0038376002 scopus 로고    scopus 로고
    • Molecular regulation of vessel maturation
    • Jain RK. 2003. Molecular regulation of vessel maturation. Nat Med 9: 685-693.
    • (2003) Nat Med , vol.9 , pp. 685-693
    • Jain, R.K.1
  • 91
    • 23444460271 scopus 로고    scopus 로고
    • Antiangiogenic therapy for cancer: Current and emerging concepts
    • Jain RK. 2005a. Antiangiogenic therapy for cancer: Current and emerging concepts. Oncology (Williston Park) 19: 7-16.
    • (2005) Oncology (Williston Park) , vol.19 , pp. 7-16
    • Jain, R.K.1
  • 92
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK. 2005b. Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy. Science 307: 58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 93
    • 38749084161 scopus 로고    scopus 로고
    • Taming vessels to treat cancer
    • Jain RK. 2008. Taming vessels to treat cancer. Sci Am 298: 56-63.
    • (2008) Sci Am , vol.298 , pp. 56-63
    • Jain, R.K.1
  • 94
    • 0346727319 scopus 로고    scopus 로고
    • What brings pericytes to tumor vessels?
    • Jain RK, Booth MF. 2003. What brings pericytes to tumor vessels? J Clin Invest 112: 1134-1136.
    • (2003) J Clin Invest , vol.112 , pp. 1134-1136
    • Jain, R.K.1    Booth, M.F.2
  • 95
    • 0032169018 scopus 로고    scopus 로고
    • Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: Role of vascular endothelial growth factor
    • Jain RK, Safabakhsh N, Sckell A, Chen Y, Jiang P, Benjamin L, Yuan F, Keshet E. 1998. Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: Role of vascular endothelial growth factor. Proc Natl Acad Sci 95: 10820-10825.
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 10820-10825
    • Jain, R.K.1    Safabakhsh, N.2    Sckell, A.3    Chen, Y.4    Jiang, P.5    Benjamin, L.6    Yuan, F.7    Keshet, E.8
  • 96
    • 30944446883 scopus 로고    scopus 로고
    • Lessons from phase III clinical trials on anti-VEGF therapy for cancer
    • Jain RK, Duda DG, Clark JW, Loeffler JS. 2006. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 3: 24-40.
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 24-40
    • Jain, R.K.1    Duda, D.G.2    Clark, J.W.3    Loeffler, J.S.4
  • 97
    • 34548267693 scopus 로고    scopus 로고
    • Antiangiogenic therapy for normalization of atherosclerotic plaque vasculature: A potential strategy for plaque stabilization
    • Jain RK, Finn AV, Kolodgie FD, Gold HK, Virmani R. 2007. Antiangiogenic therapy for normalization of atherosclerotic plaque vasculature: A potential strategy for plaque stabilization. Nat Clin Pract Cardiovasc Med 4: 491-502.
    • (2007) Nat Clin Pract Cardiovasc Med , vol.4 , pp. 491-502
    • Jain, R.K.1    Finn, A.V.2    Kolodgie, F.D.3    Gold, H.K.4    Virmani, R.5
  • 99
    • 0032982363 scopus 로고    scopus 로고
    • Local neovascularization and cellular composition within vulnerable regions of atherosclerotic plaques of human carotid arteries
    • Jeziorska M, Woolley DE. 1999. Local neovascularization and cellular composition within vulnerable regions of atherosclerotic plaques of human carotid arteries. J Pathol 188: 189-196.
    • (1999) J Pathol , vol.188 , pp. 189-196
    • Jeziorska, M.1    Woolley, D.E.2
  • 102
  • 106
    • 2942615257 scopus 로고    scopus 로고
    • The anti-angiogenic basis of metronomic chemotherapy
    • Kerbel RS, Kamen BA. 2004. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 4: 423-436.
    • (2004) Nat Rev Cancer , vol.4 , pp. 423-436
    • Kerbel, R.S.1    Kamen, B.A.2
  • 107
    • 33847020465 scopus 로고    scopus 로고
    • SU-011248, a vascular endothelial growth factor receptor-tyrosine kinase inhibitor, controls chronic psoriasis
    • Keshtgarpour M, Dudek AZ. 2007. SU-011248, a vascular endothelial growth factor receptor-tyrosine kinase inhibitor, controls chronic psoriasis. Trans Res 149: 103-106.
    • (2007) Trans Res , vol.149 , pp. 103-106
    • Keshtgarpour, M.1    Dudek, A.Z.2
  • 108
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS, Ferrara N. 1993. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 362: 841-844.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6    Ferrara, N.7
  • 109
    • 77955534812 scopus 로고    scopus 로고
    • Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage
    • Koh YJ, Kim HZ, Hwang SI, Lee JE, Oh N, Jung K, Kim M, Kim KE, Kim H, Lim NK, et al. 2010. Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage. Cancer Cell 18: 171-184.
    • (2010) Cancer Cell , vol.18 , pp. 171-184
    • Koh, Y.J.1    Kim, H.Z.2    Hwang, S.I.3    Lee, J.E.4    Oh, N.5    Jung, K.6    Kim, M.7    Kim, K.E.8    Kim, H.9    Lim, N.K.10
  • 111
    • 0035132923 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts
    • Kozin SV, Boucher Y, Hicklin DJ, Bohlen P, Jain RK, Suit HD. 2001. Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts. Cancer Res 61: 39-44.
    • (2001) Cancer Res , vol.61 , pp. 39-44
    • Kozin, S.V.1    Boucher, Y.2    Hicklin, D.J.3    Bohlen, P.4    Jain, R.K.5    Suit, H.D.6
  • 115
    • 0026089377 scopus 로고
    • Microvascular architecture in a mammary carcinoma: Branching patterns and vessel dimensions
    • Less JR, Skalak TC, Sevick EM, Jain RK. 1991. Microvascular architecture in a mammary carcinoma: Branching patterns and vessel dimensions. Cancer Res 51: 265-273.
    • (1991) Cancer Res , vol.51 , pp. 265-273
    • Less, J.R.1    Skalak, T.C.2    Sevick, E.M.3    Jain, R.K.4
  • 117
    • 0031090132 scopus 로고    scopus 로고
    • Geometric resistance and microvascular network architecture of human colorectal carcinoma
    • Less JR, Posner MC, Skalak TC, Wolmark N, Jain RK. 1997. Geometric resistance and microvascular network architecture of human colorectal carcinoma. Microcirculation 4: 25-33.
    • (1997) Microcirculation , vol.4 , pp. 25-33
    • Less, J.R.1    Posner, M.C.2    Skalak, T.C.3    Wolmark, N.4    Jain, R.K.5
  • 118
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. 1989. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246: 1306-1309.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 119
    • 0026459493 scopus 로고
    • Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice
    • Leunig M, Yuan F, Menger MD, Boucher Y, Goetz AE, Messmer K, Jain RK. 1992. Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. Cancer Res 52: 6553-6560.
    • (1992) Cancer Res , vol.52 , pp. 6553-6560
    • Leunig, M.1    Yuan, F.2    Menger, M.D.3    Boucher, Y.4    Goetz, A.E.5    Messmer, K.6    Jain, R.K.7
  • 120
    • 33845343558 scopus 로고    scopus 로고
    • Vascular endothelial growth factor blockade reduces intratumoral regulatory T cells and enhances the efficacy of a GM-CSF-secreting cancer immunotherapy
    • Li B, Lalani AS, Harding TC, Luan B, Koprivnikar K, Huan Tu G, Prell R, VanRoeyMJ, Simmons AD, et al. 2006. Vascular endothelial growth factor blockade reduces intratumoral regulatory T cells and enhances the efficacy of a GM-CSF-secreting cancer immunotherapy. Clin Cancer Res 12: 6808-6816.
    • (2006) Clin Cancer Res , vol.12 , pp. 6808-6816
    • Li, B.1    Lalani, A.S.2    Harding, T.C.3    Luan, B.4    Koprivnikar, K.5    Huan Tu, G.6    Prell, R.7    VanRoey, M.J.8    Simmons, A.D.9
  • 121
    • 79952728354 scopus 로고    scopus 로고
    • TGF-β blockade controls ascites by preventing abnormalization of lymphatic vessels in an orthotopic human ovarian carcinoma models
    • Liao S, Liu J, Lin P, Jain RK, Xu L. 2011. TGF-β blockade controls ascites by preventing abnormalization of lymphatic vessels in an orthotopic human ovarian carcinoma models. Clin Cancer Res 17: 1415-1424.
    • (2011) Clin Cancer Res , vol.17 , pp. 1415-1424
    • Liao, S.1    Liu, J.2    Lin, P.3    Jain, R.K.4    Xu, L.5
  • 122
    • 54949123005 scopus 로고    scopus 로고
    • Antisense hypoxia-inducible factor 1α gene therapy enhances the therapeutic efficacy of doxorubicin to combat hepatocellular carcinoma
    • Liu F, Wang P, Jiang X, Tan G, Qiao H, Jiang H, Krissansen GW, Sun X. 2008. Antisense hypoxia-inducible factor 1α gene therapy enhances the therapeutic efficacy of doxorubicin to combat hepatocellular carcinoma. Cancer Sci 99: 2055-2061.
    • (2008) Cancer Sci , vol.99 , pp. 2055-2061
    • Liu, F.1    Wang, P.2    Jiang, X.3    Tan, G.4    Qiao, H.5    Jiang, H.6    Krissansen, G.W.7    Sun, X.8
  • 123
    • 77649248823 scopus 로고    scopus 로고
    • The neurofibromatoses. Part 2: NF2 and schwannomatosis
    • Lu-Emerson C, Plotkin SR. 2009. The neurofibromatoses. Part 2: NF2 and schwannomatosis. Rev Neurol Dis 6: E81-E86.
    • (2009) Rev Neurol Dis , vol.6
    • Lu-Emerson, C.1    Plotkin, S.R.2
  • 128
    • 34547662268 scopus 로고    scopus 로고
    • Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content
    • McCarty MF, Somcio RJ, Stoeltzing O, Wey J, Fan F, Liu W, Bucana C, Ellis LM. 2007. Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content. J Clin Invest 117: 2114-2122.
    • (2007) J Clin Invest , vol.117 , pp. 2114-2122
    • McCarty, M.F.1    Somcio, R.J.2    Stoeltzing, O.3    Wey, J.4    Fan, F.5    Liu, W.6    Bucana, C.7    Ellis, L.M.8
  • 132
    • 0033528660 scopus 로고    scopus 로고
    • Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice
    • Moulton KS, Heller E, Konerding MA, Flynn E, Palinski W, Folkman J. 1999. Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Circulation 99: 1726-1732.
    • (1999) Circulation , vol.99 , pp. 1726-1732
    • Moulton, K.S.1    Heller, E.2    Konerding, M.A.3    Flynn, E.4    Palinski, W.5    Folkman, J.6
  • 133
    • 62549151252 scopus 로고    scopus 로고
    • Why are tumour blood vessels abnormal and why is it important to know?
    • Nagy JA, Chang SH, Dvorak AM, Dvorak HF. 2009. Why are tumour blood vessels abnormal and why is it important to know? Br J Cancer 100: 865-869.
    • (2009) Br J Cancer , vol.100 , pp. 865-869
    • Nagy, J.A.1    Chang, S.H.2    Dvorak, A.M.3    Dvorak, H.F.4
  • 134
    • 32944478893 scopus 로고    scopus 로고
    • Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors
    • Nakahara T, Norberg SM, Shalinsky DR, Hu-Lowe DD, McDonald DM. 2006. Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors. Cancer Res 66: 1434-1445.
    • (2006) Cancer Res , vol.66 , pp. 1434-1445
    • Nakahara, T.1    Norberg, S.M.2    Shalinsky, D.R.3    Hu-Lowe, D.D.4    McDonald, D.M.5
  • 135
    • 77953363622 scopus 로고    scopus 로고
    • Improvement of psoriasis during sunitinib therapy for renal cell carcinoma
    • Narayanan S, Callis-Duffin K, Batten J, Agarwal N. 2010. Improvement of psoriasis during sunitinib therapy for renal cell carcinoma. Am J Med Sci 339: 580-581.
    • (2010) Am J Med Sci , vol.339 , pp. 580-581
    • Narayanan, S.1    Callis-Duffin, K.2    Batten, J.3    Agarwal, N.4
  • 137
    • 72949117051 scopus 로고    scopus 로고
    • TSU68, an antiangiogenic receptor tyrosine kinase inhibitor, induces tumor vascular normalization in a human cancer xenograft nude mouse model
    • Ohta M, Kawabata T, Yamamoto M, Tanaka T, Kikuchi H, Hiramatsu Y, Kamiya K, Baba M, Konno H. 2009. TSU68, an antiangiogenic receptor tyrosine kinase inhibitor, induces tumor vascular normalization in a human cancer xenograft nude mouse model. Surg Today 39: 1046-1053.
    • (2009) Surg Today , vol.39 , pp. 1046-1053
    • Ohta, M.1    Kawabata, T.2    Yamamoto, M.3    Tanaka, T.4    Kikuchi, H.5    Hiramatsu, Y.6    Kamiya, K.7    Baba, M.8    Konno, H.9
  • 141
    • 33749472340 scopus 로고    scopus 로고
    • Nelfinavir down-regulates hypoxia-inducible factor 1α and VEGF expression and increases tumor oxygenation: Implications for radiotherapy
    • Pore N, Gupta AK, Cerniglia GJ, Jiang Z, Bernhard EJ, Evans SM, Koch CJ, HahnSM, Maity A. 2006a. Nelfinavir down-regulates hypoxia-inducible factor 1α and VEGF expression and increases tumor oxygenation: implications for radiotherapy. Cancer Res 66: 9252-9259.
    • (2006) Cancer Res , vol.66 , pp. 9252-9259
    • Pore, N.1    Gupta, A.K.2    Cerniglia, G.J.3    Jiang, Z.4    Bernhard, E.J.5    Evans, S.M.6    Koch, C.J.7    Hahn, S.M.8    Maity, A.9
  • 142
    • 33645499486 scopus 로고    scopus 로고
    • EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms
    • Pore N, Jiang Z, Gupta A, Cerniglia G, Kao GD, Maity A. 2006b. EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms. Cancer Res 66: 3197-3204.
    • (2006) Cancer Res , vol.66 , pp. 3197-3204
    • Pore, N.1    Jiang, Z.2    Gupta, A.3    Cerniglia, G.4    Kao, G.D.5    Maity, A.6
  • 145
    • 77954076027 scopus 로고    scopus 로고
    • Ocular angiogenesis: Mechanisms and recent advances in therapy
    • Rajappa M, Saxena P, Kaur J. 2010. Ocular angiogenesis: mechanisms and recent advances in therapy. Adv Clin Chem 50: 103-121.
    • (2010) Adv Clin Chem , vol.50 , pp. 103-121
    • Rajappa, M.1    Saxena, P.2    Kaur, J.3
  • 146
    • 62449124416 scopus 로고    scopus 로고
    • Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil
    • Reck M, von Pawel J, Zatloukal P, Ramlau R, Gorbounova V, Hirsh V, Leighl N, Mezger J, Archer V, Moore N, et al. 2009. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. J Clin Oncol 27: 1227-1234.
    • (2009) J Clin Oncol , vol.27 , pp. 1227-1234
    • Reck, M.1    von Pawel, J.2    Zatloukal, P.3    Ramlau, R.4    Gorbounova, V.5    Hirsh, V.6    Leighl, N.7    Mezger, J.8    Archer, V.9    Moore, N.10
  • 147
    • 0026348691 scopus 로고
    • Interstitial hypertension in carcinoma of uterine cervix in patients: Possible correlation with tumor oxygenation and radiation response
    • Roh HD, Boucher Y, Kalnicki S, Buchsbaum R, Bloomer WD, Jain RK. 1991. Interstitial hypertension in carcinoma of uterine cervix in patients: Possible correlation with tumor oxygenation and radiation response. Cancer Res 51: 6695-6698.
    • (1991) Cancer Res , vol.51 , pp. 6695-6698
    • Roh, H.D.1    Boucher, Y.2    Kalnicki, S.3    Buchsbaum, R.4    Bloomer, W.D.5    Jain, R.K.6
  • 148
  • 150
    • 17144428081 scopus 로고    scopus 로고
    • Inhibition of TGF-β modulates macrophages and vessel maturation in parallel to a lowering of interstitial fluid pressure in experimental carcinoma
    • Salnikov AV, Roswall P, Sundberg C, Gardner H, Heldin NE, Rubin K. 2005. Inhibition of TGF-β modulates macrophages and vessel maturation in parallel to a lowering of interstitial fluid pressure in experimental carcinoma. Lab Invest 85: 512-521.
    • (2005) Lab Invest , vol.85 , pp. 512-521
    • Salnikov, A.V.1    Roswall, P.2    Sundberg, C.3    Gardner, H.4    Heldin, N.E.5    Rubin, K.6
  • 151
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
    • Saltz LB, Clarke S, Diaz-Rubio E, Scheithauer W, Figer A, Wong R, Koski S, Lichinitser M, Yang TS, Rivera F, et al. 2008. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol 26: 2013-2019.
    • (2008) J Clin Oncol , vol.26 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Diaz-Rubio, E.3    Scheithauer, W.4    Figer, A.5    Wong, R.6    Koski, S.7    Lichinitser, M.8    Yang, T.S.9    Rivera, F.10
  • 154
    • 75849142549 scopus 로고    scopus 로고
    • Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis
    • Schonthaler HB, Huggenberger R, Wculek SK, Detmar M, Wagner EF. 2009. Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis. Proc Natl Acad Sci 106: 21264-21269.
    • (2009) Proc Natl Acad Sci , vol.106 , pp. 21264-21269
    • Schonthaler, H.B.1    Huggenberger, R.2    Wculek, S.K.3    Detmar, M.4    Wagner, E.F.5
  • 155
    • 33749256089 scopus 로고    scopus 로고
    • Potentiation of cyclophosphamide chemotherapy using the anti-angiogenic drug thalidomide: Importance of optimal scheduling to exploit the "normalization" window of the tumor vasculature
    • Segers J, Di Fazio V, Ansiaux R, Martinive P, Feron O, Wallemacq P, Gallez B. 2006. Potentiation of cyclophosphamide chemotherapy using the anti-angiogenic drug thalidomide: importance of optimal scheduling to exploit the "normalization" window of the tumor vasculature. Cancer Lett 244: 129-135.
    • (2006) Cancer Lett , vol.244 , pp. 129-135
    • Segers, J.1    Di Fazio, V.2    Ansiaux, R.3    Martinive, P.4    Feron, O.5    Wallemcq, P.6    Gallez, B.7
  • 156
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • Semenza GL. 2010. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29: 625-634.
    • (2010) Oncogene , vol.29 , pp. 625-634
    • Semenza, G.L.1
  • 157
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF. 1983. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219: 983-985.
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 158
    • 77955406159 scopus 로고    scopus 로고
    • Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer
    • Shrimali RK, Yu Z, Theoret MR, Chinnasamy D, Restifo NP, Rosenberg SA. 2010. Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer. Cancer Res 70: 6171-6180.
    • (2010) Cancer Res , vol.70 , pp. 6171-6180
    • Shrimali, R.K.1    Yu, Z.2    Theoret, M.R.3    Chinnasamy, D.4    Restifo, N.P.5    Rosenberg, S.A.6
  • 160
    • 67650463119 scopus 로고    scopus 로고
    • A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients
    • Sorensen AG, Batchelor TT, Zhang WT, Chen PJ, Yeo P, Wang M, Jennings D, Wen PY, Lahdenranta J, Ancukiewicz M, et al. 2009. A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients. Cancer Res 69: 5296-5300.
    • (2009) Cancer Res , vol.69 , pp. 5296-5300
    • Sorensen, A.G.1    Batchelor, T.T.2    Zhang, W.T.3    Chen, P.J.4    Yeo, P.5    Wang, M.6    Jennings, D.7    Wen, P.Y.8    Lahdenranta, J.9    Ancukiewicz, M.10
  • 164
    • 38949178751 scopus 로고    scopus 로고
    • Anti-tumor activity and tumor vessel normalization by the vascular endothelial growth factor receptor tyrosine kinase inhibitor KRN951 in a rat peritoneal disseminated tumor model
    • Taguchi E, Nakamura K, Miura T, Shibuya M, Isoe T. 2008. Anti-tumor activity and tumor vessel normalization by the vascular endothelial growth factor receptor tyrosine kinase inhibitor KRN951 in a rat peritoneal disseminated tumor model. Cancer Sci 99: 623-630.
    • (2008) Cancer Sci , vol.99 , pp. 623-630
    • Taguchi, E.1    Nakamura, K.2    Miura, T.3    Shibuya, M.4    Isoe, T.5
  • 166
    • 0030018743 scopus 로고    scopus 로고
    • A systems approach to cancer therapy (antioncogenics+standard cytotoxics→mechanism(s) of interaction)
    • Teicher BA. 1996. A systems approach to cancer therapy (antioncogenics+standard cytotoxics→mechanism(s) of interaction). Cancer Metastasis Rev 15: 247-272.
    • (1996) Cancer Metastasis Rev , vol.15 , pp. 247-272
    • Teicher, B.A.1
  • 167
    • 0029120875 scopus 로고
    • Antiangiogenic treatment (TNP-470/minocycline) increases tissue levels of anticancer drugs in mice bearing Lewis lung carcinoma
    • Teicher BA, Dupuis NP, Robinson MF, Emi Y, Goff DA. 1995a. Antiangiogenic treatment (TNP-470/minocycline) increases tissue levels of anticancer drugs in mice bearing Lewis lung carcinoma. Oncol Res 7: 237-243.
    • (1995) Oncol Res , vol.7 , pp. 237-243
    • Teicher, B.A.1    Dupuis, N.P.2    Robinson, M.F.3    Emi, Y.4    Goff, D.A.5
  • 171
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. 2004. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res 64: 3731-3736.
    • (2004) Cancer Res , vol.64 , pp. 3731-3736
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3    Winkler, F.4    Hicklin, D.J.5    Jain, R.K.6
  • 175
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B, Kinzler KW. 2004. Cancer genes and the pathways they control. Nat Med 10: 789-799.
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 178
    • 30944452436 scopus 로고    scopus 로고
    • Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: Continued experience of a phase I trial in rectal cancer patients
    • Willett CG, Boucher Y, Duda DG, di Tomaso E, Munn LL, Tong RT, Kozin SV, Petit L, Jain RK, Chung DC, et al. 2005. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: Continued experience of a phase I trial in rectal cancer patients. J Clin Oncol 23: 8136-8139.
    • (2005) J Clin Oncol , vol.23 , pp. 8136-8139
    • Willett, C.G.1    Boucher, Y.2    Duda, D.G.3    di Tomaso, E.4    Munn, L.L.5    Tong, R.T.6    Kozin, S.V.7    Petit, L.8    Jain, R.K.9    Chung, D.C.10
  • 180
    • 19944422751 scopus 로고    scopus 로고
    • Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases [see comment]
    • Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, Xu L, HicklinDJ, Fukumura D, di Tomaso E, et al. 2004. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases [see comment]. Cancer Cell 6: 553-563.
    • (2004) Cancer Cell , vol.6 , pp. 553-563
    • Winkler, F.1    Kozin, S.V.2    Tong, R.T.3    Chae, S.S.4    Booth, M.F.5    Garkavtsev, I.6    Xu, L.7    Hicklin, D.J.8    Fukumura, D.9    di Tomaso, E.10
  • 181
  • 183
    • 56449087509 scopus 로고    scopus 로고
    • Palomid 529, a novel small-molecule drug, is a TORC1/TORC2 inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeability
    • Xue Q, Hopkins B, Perruzzi C, Udayakumar D, Sherris D, Benjamin LE. 2008. Palomid 529, a novel small-molecule drug, is a TORC1/TORC2 inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeability. Cancer Res 68: 9551-9557.
    • (2008) Cancer Res , vol.68 , pp. 9551-9557
    • Xue, Q.1    Hopkins, B.2    Perruzzi, C.3    Udayakumar, D.4    Sherris, D.5    Benjamin, L.E.6
  • 185
    • 0029949160 scopus 로고    scopus 로고
    • Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
    • Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, Jain RK. 1996. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc Natl Acad Sci 93: 14765-14770.
    • (1996) Proc Natl Acad Sci , vol.93 , pp. 14765-14770
    • Yuan, F.1    Chen, Y.2    Dellian, M.3    Safabakhsh, N.4    Ferrara, N.5    Jain, R.K.6
  • 186
    • 67649583236 scopus 로고    scopus 로고
    • Differential effect of sunitinib on the distribution of temozolomide in an orthotopic glioma model
    • Zhou Q, Gallo JM. 2009. Differential effect of sunitinib on the distribution of temozolomide in an orthotopic glioma model. Neuro-Oncology 11: 301-310.
    • (2009) Neuro-Oncology , vol.11 , pp. 301-310
    • Zhou, Q.1    Gallo, J.M.2
  • 187
    • 40949141801 scopus 로고    scopus 로고
    • Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide [erratum appears in Clin Cancer Res, 2008 Aug 15; 14(16): 5308-9]
    • Zhou Q, Guo P, Gallo JM. 2008. Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide [erratum appears in Clin Cancer Res, 2008 Aug 15; 14(16): 5308-9]. Clin Cancer Res 14: 1540-1549.
    • (2008) Clin Cancer Res , vol.14 , pp. 1540-1549
    • Zhou, Q.1    Guo, P.2    Gallo, J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.