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Volumn 19, Issue 6, 2013, Pages 1340-1346

Molecular pathways: Toll-like receptors in the tumor microenvironment-poor prognosis or new therapeutic opportunity

Author keywords

[No Author keywords available]

Indexed keywords

852 A; AMP 516; ANTINEOPLASTIC AGENT; ARACHIDONIC ACID; BCG VACCINE; BEVACIZUMAB; CANCER VACCINE; CETUXIMAB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; ERLOTINIB; IMIDAZOQUINOLINE DERIVATIVE; IMIQUIMOD; IMO 2055; INDUCIBLE NITRIC OXIDE SYNTHASE; ISS 1018; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PLACEBO; POLYADENYLIC POLYURIDYLIC ACID; RINTATOLIMOD; RITUXIMAB; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; WART VIRUS VACCINE;

EID: 84875189381     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-12-0408     Document Type: Review
Times cited : (119)

References (66)
  • 1
    • 71649086180 scopus 로고    scopus 로고
    • Toll-like receptor signaling in cell proliferation and survival
    • Li X, Jiang S, Tapping RI. Toll-like receptor signaling in cell proliferation and survival. Cytokine 2010;49:1-9.
    • (2010) Cytokine , vol.49 , pp. 1-9
    • Li, X.1    Jiang, S.2    Tapping, R.I.3
  • 2
    • 70350664389 scopus 로고    scopus 로고
    • Cancer cells expressing Toll-like receptors and the tumor microenvironment
    • Sato Y, Goto Y, Narita N, Hoon DS. Cancer cells expressing Toll-like receptors and the tumor microenvironment. Cancer Microenviron 2009;2(Suppl 1):205-14.
    • (2009) Cancer Microenviron , vol.2 , Issue.SUPPL. 1 , pp. 205-214
    • Sato, Y.1    Goto, Y.2    Narita, N.3    Hoon, D.S.4
  • 3
    • 84866953674 scopus 로고    scopus 로고
    • Adaptors in Toll-like receptor signalling and their potential as therapeutic targets
    • Ve T, Gay NJ, Mansell A, Kobe B, Kellie S. Adaptors in Toll-like receptor signalling and their potential as therapeutic targets. Curr Drug Targets 2012;13:1360-74.
    • (2012) Curr Drug Targets , vol.13 , pp. 1360-1374
    • Ve, T.1    Gay, N.J.2    Mansell, A.3    Kobe, B.4    Kellie, S.5
  • 4
    • 80053283856 scopus 로고    scopus 로고
    • Toll-like receptors in inflammation of the central nervous system
    • Kong Y, Le Y. Toll-like receptors in inflammation of the central nervous system. Int Immunopharmacol 2011;11:1407-14.
    • (2011) Int Immunopharmacol , vol.11 , pp. 1407-1414
    • Kong, Y.1    Le, Y.2
  • 5
    • 84855481978 scopus 로고    scopus 로고
    • Toll-like receptors and diabetes: A therapeutic perspective
    • Dasu MR, Ramirez S, Isseroff RR. Toll-like receptors and diabetes: a therapeutic perspective. Clin Sci (Lond) 2012;122:203-14.
    • (2012) Clin Sci (Lond) , vol.122 , pp. 203-214
    • Dasu, M.R.1    Ramirez, S.2    Isseroff, R.R.3
  • 6
    • 20444432334 scopus 로고    scopus 로고
    • Toll-like receptors on tumor cells facilitate evasion of immune surveillance
    • Huang B, Zhao J, Li H, He KL, Chen Y, Chen SH, et al. Toll-like receptors on tumor cells facilitate evasion of immune surveillance. Cancer Res 2005;65:5009-14.
    • (2005) Cancer Res , vol.65 , pp. 5009-5014
    • Huang, B.1    Zhao, J.2    Li, H.3    He, K.L.4    Chen, Y.5    Chen, S.H.6
  • 8
    • 33847190697 scopus 로고    scopus 로고
    • The toxins of William B. Coley and the treatment of bone and soft-tissue sarcomas
    • McCarthy EF. The toxins of William B. Coley and the treatment of bone and soft-tissue sarcomas. Iowa Orthop J 2006;26:154-8.
    • (2006) Iowa Orthop J , vol.26 , pp. 154-158
    • McCarthy, E.F.1
  • 9
    • 34548553295 scopus 로고    scopus 로고
    • Early experience with novel immunomodulators for cancer treatment
    • Thotathil Z, Jameson MB. Early experience with novel immunomodulators for cancer treatment. Expert Opin Investig Drugs 2007;16: 1391-403.
    • (2007) Expert Opin Investig Drugs , vol.16 , pp. 1391-1403
    • Thotathil, Z.1    Jameson, M.B.2
  • 10
    • 77954480383 scopus 로고    scopus 로고
    • Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling
    • Guan Y, Ranoa DR, Jiang S, Mutha SK, Li X, Baudry J, et al. Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling. J Immunol 2010;184:5094-103.
    • (2010) J Immunol , vol.184 , pp. 5094-5103
    • Guan, Y.1    Ranoa, D.R.2    Jiang, S.3    Mutha, S.K.4    Li, X.5    Baudry, J.6
  • 11
    • 20044368019 scopus 로고    scopus 로고
    • Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88
    • Hasan U, Chaffois C, Gaillard C, Saulnier V, Merck E, Tancredi S, et al. Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. J Immunol 2005;174:2942-50.
    • (2005) J Immunol , vol.174 , pp. 2942-2950
    • Hasan, U.1    Chaffois, C.2    Gaillard, C.3    Saulnier, V.4    Merck, E.5    Tancredi, S.6
  • 12
    • 65749104837 scopus 로고    scopus 로고
    • How location governs toll-like receptor signaling
    • Chaturvedi A, Pierce SK. How location governs toll-like receptor signaling. Traffic 2009;10:621-8.
    • (2009) Traffic , vol.10 , pp. 621-628
    • Chaturvedi, A.1    Pierce, S.K.2
  • 13
    • 50649093779 scopus 로고    scopus 로고
    • The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy
    • Smits EL, Ponsaerts P, Berneman ZN, Van Tendeloo VF. The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy. Oncologist 2008;13:859-75.
    • (2008) Oncologist , vol.13 , pp. 859-875
    • Smits, E.L.1    Ponsaerts, P.2    Berneman, Z.N.3    Van Tendeloo, V.F.4
  • 14
    • 42349090335 scopus 로고    scopus 로고
    • Structural basis of toll-like receptor 3 signaling with double-stranded RNA
    • Liu L, Botos I, Wang Y, Leonard JN, Shiloach J, Segal DM, et al. Structural basis of toll-like receptor 3 signaling with double-stranded RNA. Science 2008;320:379-81.
    • (2008) Science , vol.320 , pp. 379-381
    • Liu, L.1    Botos, I.2    Wang, Y.3    Leonard, J.N.4    Shiloach, J.5    Segal, D.M.6
  • 16
    • 0242351615 scopus 로고    scopus 로고
    • Toll-like receptors and their signaling mechanisms
    • Akira S, Sato S. Toll-like receptors and their signaling mechanisms. Scand J Infect Dis 2003;35:555-62.
    • (2003) Scand J Infect Dis , vol.35 , pp. 555-562
    • Akira, S.1    Sato, S.2
  • 17
    • 34247566510 scopus 로고    scopus 로고
    • The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
    • O'Neill LA, Bowie AG. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 2007;7: 353-64.
    • (2007) Nat Rev Immunol , vol.7 , pp. 353-364
    • O'Neill, L.A.1    Bowie, A.G.2
  • 18
    • 5444262511 scopus 로고    scopus 로고
    • Toll-like receptor control of the adaptive immune responses
    • Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004;5:987-95.
    • (2004) Nat Immunol , vol.5 , pp. 987-995
    • Iwasaki, A.1    Medzhitov, R.2
  • 19
    • 84868101247 scopus 로고    scopus 로고
    • Roles of toll-like receptors in cancer: A double-edged sword for defense and offense
    • Basith S, Manavalan B, Yoo TH, Kim SG, Choi S. Roles of toll-like receptors in cancer: a double-edged sword for defense and offense. Arch Pharm Res 2012;35:1297-316.
    • (2012) Arch Pharm Res , vol.35 , pp. 1297-1316
    • Basith, S.1    Manavalan, B.2    Yoo, T.H.3    Kim, S.G.4    Choi, S.5
  • 21
    • 84857363522 scopus 로고    scopus 로고
    • Involvement of TNF-alpha-induced TLR4-NF-kappaB and TLR4-HIF-1alpha feed-forward loops in the regulation of inflammatory responses in glioma
    • Tewari R, Choudhury SR, Ghosh S, Mehta VS, Sen E. Involvement of TNF-alpha-induced TLR4-NF-kappaB and TLR4-HIF-1alpha feed-forward loops in the regulation of inflammatory responses in glioma. J Mol Med (Berl) 2012;90:67-80.
    • (2012) J Mol Med (Berl) , vol.90 , pp. 67-80
    • Tewari, R.1    Choudhury, S.R.2    Ghosh, S.3    Mehta, V.S.4    Sen, E.5
  • 22
    • 78651407343 scopus 로고    scopus 로고
    • Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation
    • Park HD, Lee Y, Oh YK, Jung JG, Park YW, Myung K, et al. Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation. Oncogene 2011;30:201-11.
    • (2011) Oncogene , vol.30 , pp. 201-211
    • Park, H.D.1    Lee, Y.2    Oh, Y.K.3    Jung, J.G.4    Park, Y.W.5    Myung, K.6
  • 23
  • 25
    • 77957196909 scopus 로고    scopus 로고
    • Toll-like receptor (TLR) 7 and TLR8 expression on CD133+ cells in colorectal cancer points to a specific role for inflammation- induced TLRs in tumourigenesis and tumour progression
    • Grimm M, Kim M, Rosenwald A, Heemann U, Germer CT, Waaga-Gasser AM, et al. Toll-like receptor (TLR) 7 and TLR8 expression on CD133+ cells in colorectal cancer points to a specific role for inflammation- induced TLRs in tumourigenesis and tumour progression. Eur J Cancer 2010;46:2849-57.
    • (2010) Eur J Cancer , vol.46 , pp. 2849-2857
    • Grimm, M.1    Kim, M.2    Rosenwald, A.3    Heemann, U.4    Germer, C.T.5    Waaga-Gasser, A.M.6
  • 26
    • 77649272127 scopus 로고    scopus 로고
    • High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer
    • Wang EL, Qian ZR, Nakasono M, Tanahashi T, Yoshimoto K, Bando Y, et al. High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer. Br J Cancer 2010;102:908-15.
    • (2010) Br J Cancer , vol.102 , pp. 908-915
    • Wang, E.L.1    Qian, Z.R.2    Nakasono, M.3    Tanahashi, T.4    Yoshimoto, K.5    Bando, Y.6
  • 27
    • 77954259621 scopus 로고    scopus 로고
    • Expression and significance of TLR4 and HIF-1alpha in pancreatic ductal adenocarcinoma
    • Zhang JJ, Wu HS, Wang L, Tian Y, Zhang JH, Wu HL. Expression and significance of TLR4 and HIF-1alpha in pancreatic ductal adenocarcinoma. World J Gastroenterol 2010;16:2881-8.
    • (2010) World J Gastroenterol , vol.16 , pp. 2881-2888
    • Zhang, J.J.1    Wu, H.S.2    Wang, L.3    Tian, Y.4    Zhang, J.H.5    Wu, H.L.6
  • 28
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak HF. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 1986;315: 1650-9.
    • (1986) N Engl J Med , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 29
    • 0036276919 scopus 로고    scopus 로고
    • Increased apoptosis in infiltrating mononuclear cells of colorectal cancer: A mechanism for tumor escape
    • Chen GG, Lee JF, Chan UP, Xu H, Ip PC, Lau WY. Increased apoptosis in infiltrating mononuclear cells of colorectal cancer: a mechanism for tumor escape. Arch Pathol Lab Med 2002;126:686-91.
    • (2002) Arch Pathol Lab Med , vol.126 , pp. 686-691
    • Chen, G.G.1    Lee, J.F.2    Chan, U.P.3    Xu, H.4    Ip, P.C.5    Lau, W.Y.6
  • 30
    • 70350331297 scopus 로고    scopus 로고
    • Cyclooxygenase 2 modulates killing of cytotoxic T lymphocytes by colon cancer cells
    • Wang Q, Takei Y, Kobayashi O, Osada T, Watanabe S. Cyclooxygenase 2 modulates killing of cytotoxic T lymphocytes by colon cancer cells. J Clin Biochem Nutr 2009;45:163-70.
    • (2009) J Clin Biochem Nutr , vol.45 , pp. 163-170
    • Wang, Q.1    Takei, Y.2    Kobayashi, O.3    Osada, T.4    Watanabe, S.5
  • 31
    • 78049426509 scopus 로고    scopus 로고
    • Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients
    • Glynn SA, Boersma BJ, Dorsey TH, Yi M, Yfantis HG, Ridnour LA, et al. Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients. J Clin Invest 2010;120:3843-54.
    • (2010) J Clin Invest , vol.120 , pp. 3843-3854
    • Glynn, S.A.1    Boersma, B.J.2    Dorsey, T.H.3    Yi, M.4    Yfantis, H.G.5    Ridnour, L.A.6
  • 32
    • 78149418200 scopus 로고    scopus 로고
    • COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer
    • Glynn SA, Prueitt RL, Ridnour LA, Boersma BJ, Dorsey TM, Wink DA, et al. COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer. BMC Cancer 2010;10:626.
    • (2010) BMC Cancer , vol.10 , pp. 626
    • Glynn, S.A.1    Prueitt, R.L.2    Ridnour, L.A.3    Boersma, B.J.4    Dorsey, T.M.5    Wink, D.A.6
  • 33
    • 0037057521 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion
    • Harmey JH, Bucana CD, Lu W, Byrne AM, McDonnell S, Lynch C, et al. Lipopolysaccharide-induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion. Int J Cancer 2002;101:415-22.
    • (2002) Int J Cancer , vol.101 , pp. 415-422
    • Harmey, J.H.1    Bucana, C.D.2    Lu, W.3    Byrne, A.M.4    McDonnell, S.5    Lynch, C.6
  • 34
    • 4944244259 scopus 로고    scopus 로고
    • Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
    • Murdoch C, Giannoudis A, Lewis CE. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 2004;104:2224-34.
    • (2004) Blood , vol.104 , pp. 2224-2234
    • Murdoch, C.1    Giannoudis, A.2    Lewis, C.E.3
  • 36
    • 33947179887 scopus 로고    scopus 로고
    • TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance
    • He W, Liu Q, Wang L, Chen W, Li N, Cao X. TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance. Mol Immunol 2007;44: 2850-9.
    • (2007) Mol Immunol , vol.44 , pp. 2850-2859
    • He, W.1    Liu, Q.2    Wang, L.3    Chen, W.4    Li, N.5    Cao, X.6
  • 38
    • 23744465234 scopus 로고    scopus 로고
    • Significance of inducible nitric oxide synthase expression in benign and malignant breast epithelium: An immunohistochemical study of 151 cases
    • Bulut AS, Erden E, Sak SD, Doruk H, Kursun N, Dincol D. Significance of inducible nitric oxide synthase expression in benign and malignant breast epithelium: an immunohistochemical study of 151 cases. Virchows Arch 2005;447:24-30.
    • (2005) Virchows Arch , vol.447 , pp. 24-30
    • Bulut, A.S.1    Erden, E.2    Sak, S.D.3    Doruk, H.4    Kursun, N.5    Dincol, D.6
  • 39
    • 19944434036 scopus 로고    scopus 로고
    • The role of early expression of inducible nitric oxide synthase in human breast cancer
    • Loibl S, Buck A, Strank C, von Minckwitz G, Roller M, Sinn HP, et al. The role of early expression of inducible nitric oxide synthase in human breast cancer. Eur J Cancer 2005;41:265-71.
    • (2005) Eur J Cancer , vol.41 , pp. 265-271
    • Loibl, S.1    Buck, A.2    Strank, C.3    Von Minckwitz, G.4    Roller, M.5    Sinn, H.P.6
  • 41
    • 84866497973 scopus 로고    scopus 로고
    • S-nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer
    • Switzer CH, Glynn SA, Cheng RY, Ridnour LA, Green JE, Ambs S, et al. S-nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer. Mol Cancer Res 2012; 10:1203-15.
    • (2012) Mol Cancer Res , vol.10 , pp. 1203-1215
    • Switzer, C.H.1    Glynn, S.A.2    Cheng, R.Y.3    Ridnour, L.A.4    Green, J.E.5    Ambs, S.6
  • 42
    • 2942665472 scopus 로고    scopus 로고
    • Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide
    • Thomas DD, Espey MG, Ridnour LA, Hofseth LJ, Mancardi D, Harris CC, et al. Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide. Proc Natl Acad Sci U S A 2004;101:8894-9.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8894-8899
    • Thomas, D.D.1    Espey, M.G.2    Ridnour, L.A.3    Hofseth, L.J.4    Mancardi, D.5    Harris, C.C.6
  • 43
    • 0346995272 scopus 로고    scopus 로고
    • PGE2-mediated upregulation of iNOS in murine breast cancer cells through the activation of EP4 receptors
    • Timoshenko AV, Lala PK, Chakraborty C. PGE2-mediated upregulation of iNOS in murine breast cancer cells through the activation of EP4 receptors. Int J Cancer 2004;108:384-9.
    • (2004) Int J Cancer , vol.108 , pp. 384-389
    • Timoshenko, A.V.1    Lala, P.K.2    Chakraborty, C.3
  • 44
    • 67649208478 scopus 로고    scopus 로고
    • The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer
    • Ehrchen JM, Sunderkotter C, Foell D, Vogl T, Roth J. The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer. J Leukoc Biol 2009;86:557-66.
    • (2009) J Leukoc Biol , vol.86 , pp. 557-566
    • Ehrchen, J.M.1    Sunderkotter, C.2    Foell, D.3    Vogl, T.4    Roth, J.5
  • 45
    • 38349056713 scopus 로고    scopus 로고
    • Hyaluronan fragments induce cytokine and metalloprotease upregulation in human melanoma cells in part by signalling via TLR4
    • Voelcker V, Gebhardt C, Averbeck M, Saalbach A, Wolf V, Weih F, et al. Hyaluronan fragments induce cytokine and metalloprotease upregulation in human melanoma cells in part by signalling via TLR4. Exp Dermatol 2008;17:100-7.
    • (2008) Exp Dermatol , vol.17 , pp. 100-107
    • Voelcker, V.1    Gebhardt, C.2    Averbeck, M.3    Saalbach, A.4    Wolf, V.5    Weih, F.6
  • 46
    • 33751504690 scopus 로고    scopus 로고
    • Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis
    • Hiratsuka S, Watanabe A, Aburatani H, Maru Y. Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat Cell Biol 2006;8:1369-75.
    • (2006) Nat Cell Biol , vol.8 , pp. 1369-1375
    • Hiratsuka, S.1    Watanabe, A.2    Aburatani, H.3    Maru, Y.4
  • 47
    • 53349099219 scopus 로고    scopus 로고
    • Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein
    • Cheng P, Corzo CA, Luetteke N, Yu B, Nagaraj S, Bui MM, et al. Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med 2008;205:2235-49.
    • (2008) J Exp Med , vol.205 , pp. 2235-2249
    • Cheng, P.1    Corzo, C.A.2    Luetteke, N.3    Yu, B.4    Nagaraj, S.5    Bui, M.M.6
  • 48
    • 84855413325 scopus 로고    scopus 로고
    • Monthly intravesical bacillus Calmette-Guerin maintenance therapy for non-muscle-invasive bladder cancer: 10-year experience in a single institute
    • Yoo KH, Lim TJ, Chang SG. Monthly intravesical bacillus Calmette-Guerin maintenance therapy for non-muscle-invasive bladder cancer: 10-year experience in a single institute. Exp Ther Med 2012;3:221-5.
    • (2012) Exp Ther Med , vol.3 , pp. 221-225
    • Yoo, K.H.1    Lim, T.J.2    Chang, S.G.3
  • 49
    • 45849112914 scopus 로고    scopus 로고
    • Role of neutrophils in BCG immunotherapy for bladder cancer
    • Simons MP, O'Donnell MA, Griffith TS. Role of neutrophils in BCG immunotherapy for bladder cancer. Urol Oncol 2008;26:341-5.
    • (2008) Urol Oncol , vol.26 , pp. 341-345
    • Simons, M.P.1    O'Donnell, M.A.2    Griffith, T.S.3
  • 50
    • 2442710545 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand: A novel mechanism for Bacillus Calmette-Guerin-induced antitumor activity
    • Ludwig AT, Moore JM, Luo Y, Chen X, Saltsgaver NA, O'Donnell MA, et al. Tumor necrosis factor-related apoptosis-inducing ligand: a novel mechanism for Bacillus Calmette-Guerin-induced antitumor activity. Cancer Res 2004;64:3386-90.
    • (2004) Cancer Res , vol.64 , pp. 3386-3390
    • Ludwig, A.T.1    Moore, J.M.2    Luo, Y.3    Chen, X.4    Saltsgaver, N.A.5    O'Donnell, M.A.6
  • 51
    • 33847739814 scopus 로고    scopus 로고
    • Identification of the mycobacterial subcomponents involved in the release of tumor necrosis factor-related apoptosis-inducing ligand from human neutrophils
    • Simons MP, Moore JM, Kemp TJ, Griffith TS. Identification of the mycobacterial subcomponents involved in the release of tumor necrosis factor-related apoptosis-inducing ligand from human neutrophils. Infect Immun 2007;75:1265-71.
    • (2007) Infect Immun , vol.75 , pp. 1265-1271
    • Simons, M.P.1    Moore, J.M.2    Kemp, T.J.3    Griffith, T.S.4
  • 52
    • 75149136162 scopus 로고    scopus 로고
    • Bacillus Calmette-Guerin cell wall cytoskeleton enhances colon cancer radiosensitivity through autophagy
    • Yuk JM, Shin DM, Song KS, Lim K, Kim KH, Lee SH, et al. Bacillus Calmette-Guerin cell wall cytoskeleton enhances colon cancer radiosensitivity through autophagy. Autophagy 2010;6:46-60.
    • (2010) Autophagy , vol.6 , pp. 46-60
    • Yuk, J.M.1    Shin, D.M.2    Song, K.S.3    Lim, K.4    Kim, K.H.5    Lee, S.H.6
  • 53
    • 79952212690 scopus 로고    scopus 로고
    • TLR3 as a biomarker for the therapeutic efficacy of double-stranded RNA in breast cancer
    • Salaun B, Zitvogel L, Asselin-Paturel C, Morel Y, Chemin K, Dubois C, et al. TLR3 as a biomarker for the therapeutic efficacy of double-stranded RNA in breast cancer. Cancer Res 2011;71:1607-14.
    • (2011) Cancer Res , vol.71 , pp. 1607-1614
    • Salaun, B.1    Zitvogel, L.2    Asselin-Paturel, C.3    Morel, Y.4    Chemin, K.5    Dubois, C.6
  • 54
    • 67349117313 scopus 로고    scopus 로고
    • Ampligen: A potential toll-like 3 receptor adjuvant for immunotherapy of cancer
    • Jasani B, Navabi H, Adams M. Ampligen: a potential toll-like 3 receptor adjuvant for immunotherapy of cancer. Vaccine 2009;27:3401-4.
    • (2009) Vaccine , vol.27 , pp. 3401-3404
    • Jasani, B.1    Navabi, H.2    Adams, M.3
  • 56
    • 33847646901 scopus 로고    scopus 로고
    • Sequential gene profiling of basal cell carcinomas treated with imiquimod in a placebo-controlled study defines the requirements for tissue rejection
    • Panelli MC, Stashower ME, Slade HB, Smith K, Norwood C, Abati A, et al. Sequential gene profiling of basal cell carcinomas treated with imiquimod in a placebo-controlled study defines the requirements for tissue rejection. Genome Biol 2007;8:R8.
    • (2007) Genome Biol , vol.8
    • Panelli, M.C.1    Stashower, M.E.2    Slade, H.B.3    Smith, K.4    Norwood, C.5    Abati, A.6
  • 58
    • 84868230186 scopus 로고    scopus 로고
    • Combined intralesional bacille Calmette-Guerin (BCG) and topical imiquimod for in-transit melanoma
    • Kidner TB, Morton DL, Lee DJ, Hoban M, Foshag LJ, Turner RR, et al. Combined intralesional bacille Calmette-Guerin (BCG) and topical imiquimod for in-transit melanoma. J Immunother 2012;35: 716-20.
    • (2012) J Immunother , vol.35 , pp. 716-720
    • Kidner, T.B.1    Morton, D.L.2    Lee, D.J.3    Hoban, M.4    Foshag, L.J.5    Turner, R.R.6
  • 59
    • 38949100471 scopus 로고    scopus 로고
    • An exploratory study of systemic administration of the toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma
    • Dummer R, Hauschild A, Becker JC, Grob JJ, Schadendorf D, Tebbs V, et al. An exploratory study of systemic administration of the toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma. Clin Cancer Res 2008;14:856-64.
    • (2008) Clin Cancer Res , vol.14 , pp. 856-864
    • Dummer, R.1    Hauschild, A.2    Becker, J.C.3    Grob, J.J.4    Schadendorf, D.5    Tebbs, V.6
  • 60
    • 37849002321 scopus 로고    scopus 로고
    • Toll-like receptor 9 (TLR9) agonists in the treatment of cancer
    • Krieg AM. Toll-like receptor 9 (TLR9) agonists in the treatment of cancer. Oncogene 2008;27:161-7.
    • (2008) Oncogene , vol.27 , pp. 161-167
    • Krieg, A.M.1
  • 61
    • 48649102652 scopus 로고    scopus 로고
    • Anti-tumor effect of DNA-based vaccination and dSLIM immunomodulatory molecules in mice with Ph+ acute lymphoblastic leukaemia
    • Kochling J, Prada J, Bahrami M, Stripecke R, Seeger K, Henze G, et al. Anti-tumor effect of DNA-based vaccination and dSLIM immunomodulatory molecules in mice with Ph+ acute lymphoblastic leukaemia. Vaccine 2008;26:4669-75.
    • (2008) Vaccine , vol.26 , pp. 4669-4675
    • Kochling, J.1    Prada, J.2    Bahrami, M.3    Stripecke, R.4    Seeger, K.5    Henze, G.6
  • 62
    • 84863213361 scopus 로고    scopus 로고
    • Anticancer TLR agonists on the ropes
    • Guha M. Anticancer TLR agonists on the ropes. Nat Rev Drug Discov 2012;11:503-5.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 503-505
    • Guha, M.1
  • 63
    • 22544433125 scopus 로고    scopus 로고
    • The TLR7 agonist imiquimod enhances the anti-melanoma effects of a recombinant Listeria monocytogenes vaccine
    • Craft N, Bruhn KW, Nguyen BD, Prins R, Lin JW, Liau LM, et al. The TLR7 agonist imiquimod enhances the anti-melanoma effects of a recombinant Listeria monocytogenes vaccine. J Immunol 2005;175: 1983-90.
    • (2005) J Immunol , vol.175 , pp. 1983-1990
    • Craft, N.1    Bruhn, K.W.2    Nguyen, B.D.3    Prins, R.4    Lin, J.W.5    Liau, L.M.6
  • 64
    • 24144494203 scopus 로고    scopus 로고
    • Transcutaneous immunization with cytotoxic T-cell peptide epitopes provides effective antitumor immunity in mice
    • Itoh T, Celis E. Transcutaneous immunization with cytotoxic T-cell peptide epitopes provides effective antitumor immunity in mice. J Immunother 2005;28:430-7.
    • (2005) J Immunother , vol.28 , pp. 430-437
    • Itoh, T.1    Celis, E.2
  • 65
    • 14044265101 scopus 로고    scopus 로고
    • Cutting edge: Priming of CTL by transcutaneous peptide immunization with imiquimod
    • Rechtsteiner G, Warger T, Osterloh P, Schild H, Radsak MP. Cutting edge: priming of CTL by transcutaneous peptide immunization with imiquimod. J Immunol 2005;174:2476-80.
    • (2005) J Immunol , vol.174 , pp. 2476-2480
    • Rechtsteiner, G.1    Warger, T.2    Osterloh, P.3    Schild, H.4    Radsak, M.P.5
  • 66
    • 77954514970 scopus 로고    scopus 로고
    • Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade
    • Lu H, Wagner WM, Gad E, Yang Y, Duan H, Amon LM, et al. Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade. J Immunol 2010;184:5360-7.
    • (2010) J Immunol , vol.184 , pp. 5360-5367
    • Lu, H.1    Wagner, W.M.2    Gad, E.3    Yang, Y.4    Duan, H.5    Amon, L.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.