The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis

Science Translational Medicine

Volumn 8, Issue 327, 2016, Pages

  Mlecnik, Bernhard ^a,b,c   Bindea, Gabriela ^a,b,c   Kirilovsky, Amos ^a,b,c   Angell, Helen K ^a,b,c,d   Obenauf, Anna C ^e   Tosolini, Marie ^a,b,c   Church, Sarah E ^a,b,c   Maby, Pauline ^a,b,c   Vasaturo, Angela ^a,b,c   Angelova, Mihaela ^a,b,c   Fredriksen, Tessa ^a,b,c   Mauger, Stéphanie ^a,b,c   Waldner, Maximilian ^f   Berger, Anne ^g   Speicher, Michael R ^e   Pagès, Franck ^a,b,c,g   Valge Archer, Viia ^h   Galon, Jérôme ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d ASTRAZENECA   (United Kingdom)

^e MEDICAL UNIVERSITY OF GRAZ   (Austria)

^f UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^g HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^h MEDIMMUNE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; B RAF KINASE; CD74 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CXCL9 CHEMOKINE; EPIDERMAL GROWTH FACTOR RECEPTOR; GELATINASE B; HLA DR ANTIGEN; INTERFERON REGULATORY FACTOR 1; JANUS KINASE 2; K RAS PROTEIN; PROTEIN P53; RANTES; SMAD2 PROTEIN; TRANSCRIPTION FACTOR SOX17;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; BLOOD VESSEL DENSITY; BLOOD VESSEL PARAMETERS; BRAF GENE; CCL5 GENE; CD74 GENE; CHROMOSOMAL INSTABILITY; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; CSF1 GENE; CXCL9 GENE; CXCR4 GENE; DISTANT METASTASIS; EGFR GENE; FBXW7 GENE; FEMALE; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; GENETIC ASSOCIATION; GENOMIC INSTABILITY; GNLY GENE; GZMA GENE; HLA DMA GENE; HLA DMB GENE; HLA DPA1 GENE; HLA DPB1 GENE; HLA DRA GENE; HLA DRB6 GENE; HUMAN; HUMAN TISSUE; IMMUNOCYTOTOXICITY; IMMUNOSCORE; IRF1 GENE; JAK2 GENE; LYMPHATIC VESSEL DENSITY; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; METASTASIS; METASTASIS POTENTIAL; MMP9 GENE; MOUSE; NEXT GENERATION SEQUENCING; NKG7 GENE; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; PTP4A3 GENE; PTPRC GENE; SMAD2 GENE; SOX17 GENE; SRC GENE; T LYMPHOCYTE; TP53 GENE; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT; TUMOR SUPPRESSOR GENE; TUMOR VASCULARIZATION; UPREGULATION; VEGFA GENE; BLOOD VESSEL; CELL COUNT; CELL DEATH; COLORECTAL TUMOR; DISEASE COURSE; GENE EXPRESSION REGULATION; GENETICS; HUMAN GENOME; IMMUNOLOGY; LYMPHATIC SYSTEM; LYMPHOCYTE; METABOLISM; MUTATION; PATHOLOGY;

BLOOD VESSELS; CELL COUNT; CELL DEATH; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME, HUMAN; HUMANS; LYMPHATIC SYSTEM; LYMPHOCYTES; MUTATION; NEOPLASM METASTASIS; TUMOR MICROENVIRONMENT;

EID: 84959422566     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aad6352     Document Type: Article

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