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Volumn 3, Issue 11, 2017, Pages 797-808

Migrating into the Tumor: a Roadmap for T Cells

Author keywords

biomarkers; immune cells; immunotherapy; migration; T cells; tumor microenvironment.

Indexed keywords

CHEMOKINE; TUMOR ANTIGEN;

EID: 85032281146     PISSN: 24058033     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trecan.2017.09.006     Document Type: Review
Times cited : (236)

References (102)
  • 1
    • 84863594742 scopus 로고    scopus 로고
    • Cellular constituents of immune escape within the tumor microenvironment
    • Kerkar, S.P., Restifo, N.P., Cellular constituents of immune escape within the tumor microenvironment. Cancer Res. 72 (2012), 3125–3130.
    • (2012) Cancer Res. , vol.72 , pp. 3125-3130
    • Kerkar, S.P.1    Restifo, N.P.2
  • 2
    • 84960422665 scopus 로고    scopus 로고
    • The basis of oncoimmunology
    • Palucka, A.K., Coussens, L.M., The basis of oncoimmunology. Cell 164 (2016), 1233–1247.
    • (2016) Cell , vol.164 , pp. 1233-1247
    • Palucka, A.K.1    Coussens, L.M.2
  • 3
    • 84988976297 scopus 로고    scopus 로고
    • Mechanisms of tumor escape in the context of the T-cell-inflamed and the non-T-cell-inflamed tumor microenvironment
    • Spranger, S., Mechanisms of tumor escape in the context of the T-cell-inflamed and the non-T-cell-inflamed tumor microenvironment. Int. Immunol. 28 (2016), 383–391.
    • (2016) Int. Immunol. , vol.28 , pp. 383-391
    • Spranger, S.1
  • 4
    • 84940372582 scopus 로고    scopus 로고
    • The next hurdle in cancer immunotherapy: overcoming the non-t-cell-inflamed tumor microenvironment
    • Gajewski, T.F., The next hurdle in cancer immunotherapy: overcoming the non-t-cell-inflamed tumor microenvironment. Semin. Oncol. 42 (2015), 663–671.
    • (2015) Semin. Oncol. , vol.42 , pp. 663-671
    • Gajewski, T.F.1
  • 5
    • 84967321420 scopus 로고    scopus 로고
    • The where, the when, and the how of immune monitoring for cancer immunotherapies in the era of checkpoint inhibition
    • Hegde, P.S., et al. The where, the when, and the how of immune monitoring for cancer immunotherapies in the era of checkpoint inhibition. Clin. Cancer Res. 22 (2016), 1865–1874.
    • (2016) Clin. Cancer Res. , vol.22 , pp. 1865-1874
    • Hegde, P.S.1
  • 6
    • 84858800620 scopus 로고    scopus 로고
    • The immune contexture in human tumours: impact on clinical outcome
    • Fridman, W.H., et al. The immune contexture in human tumours: impact on clinical outcome. Nat. Rev. Cancer 12 (2012), 298–306.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 298-306
    • Fridman, W.H.1
  • 7
    • 84862769116 scopus 로고    scopus 로고
    • An immune-active tumor microenvironment favors clinical response to ipilimumab
    • Ji, R.R., et al. An immune-active tumor microenvironment favors clinical response to ipilimumab. Cancer Immunol. Immunother. 61 (2012), 1019–1031.
    • (2012) Cancer Immunol. Immunother. , vol.61 , pp. 1019-1031
    • Ji, R.R.1
  • 8
    • 84920956732 scopus 로고    scopus 로고
    • PD-1 blockade induces responses by inhibiting adaptive immune resistance
    • Tumeh, P.C., et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature 515 (2014), 568–571.
    • (2014) Nature , vol.515 , pp. 568-571
    • Tumeh, P.C.1
  • 9
    • 84976907921 scopus 로고    scopus 로고
    • T-cell landscape in a primary melanoma predicts the survival of patients with metastatic disease after their treatment with dendritic cell vaccines
    • Vasaturo, A., et al. T-cell landscape in a primary melanoma predicts the survival of patients with metastatic disease after their treatment with dendritic cell vaccines. Cancer Res. 76 (2016), 3496–3506.
    • (2016) Cancer Res. , vol.76 , pp. 3496-3506
    • Vasaturo, A.1
  • 10
    • 85009841550 scopus 로고    scopus 로고
    • Homing to solid cancers: a vascular checkpoint in adoptive cell therapy using CAR T-cells
    • Ager, A., et al. Homing to solid cancers: a vascular checkpoint in adoptive cell therapy using CAR T-cells. Biochem. Soc. Trans. 44 (2016), 377–385.
    • (2016) Biochem. Soc. Trans. , vol.44 , pp. 377-385
    • Ager, A.1
  • 11
    • 61349161008 scopus 로고    scopus 로고
    • Migration, maintenance and recall of memory T cells in peripheral tissues
    • Woodland, D.L., Kohlmeier, J.E., Migration, maintenance and recall of memory T cells in peripheral tissues. Nat. Rev. Immunol. 9 (2009), 153–161.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 153-161
    • Woodland, D.L.1    Kohlmeier, J.E.2
  • 12
    • 84944458835 scopus 로고    scopus 로고
    • Local production of the chemokines CCL5 and CXCL10 attracts CD8+ T lymphocytes into esophageal squamous cell carcinoma
    • Liu, J., et al. Local production of the chemokines CCL5 and CXCL10 attracts CD8+ T lymphocytes into esophageal squamous cell carcinoma. Oncotarget 6 (2015), 24978–24989.
    • (2015) Oncotarget , vol.6 , pp. 24978-24989
    • Liu, J.1
  • 13
    • 84978819026 scopus 로고    scopus 로고
    • Functional reprogramming of human prostate cancer to promote local attraction of effector CD8(+) T cells
    • Muthuswamy, R., et al. Functional reprogramming of human prostate cancer to promote local attraction of effector CD8(+) T cells. Prostate 76 (2016), 1095–1105.
    • (2016) Prostate , vol.76 , pp. 1095-1105
    • Muthuswamy, R.1
  • 14
    • 77949780426 scopus 로고    scopus 로고
    • Biomolecular network reconstruction identifies T-cell homing factors associated with survival in colorectal cancer
    • Mlecnik, B., et al. Biomolecular network reconstruction identifies T-cell homing factors associated with survival in colorectal cancer. Gastroenterology 138 (2010), 1429–1440.
    • (2010) Gastroenterology , vol.138 , pp. 1429-1440
    • Mlecnik, B.1
  • 15
    • 78650618910 scopus 로고    scopus 로고
    • Pro-inflammatory chemokine-chemokine receptor interactions within the Ewing sarcoma microenvironment determine CD8(+) T-lymphocyte infiltration and affect tumour progression
    • Berghuis, D., et al. Pro-inflammatory chemokine-chemokine receptor interactions within the Ewing sarcoma microenvironment determine CD8(+) T-lymphocyte infiltration and affect tumour progression. J. Pathol. 223 (2011), 347–357.
    • (2011) J. Pathol. , vol.223 , pp. 347-357
    • Berghuis, D.1
  • 16
    • 67449119127 scopus 로고    scopus 로고
    • IL-7 promotes CXCR3 ligand-dependent T cell antitumor reactivity in lung cancer
    • Andersson, A., et al. IL-7 promotes CXCR3 ligand-dependent T cell antitumor reactivity in lung cancer. J. Immunol. 182 (2009), 6951–6958.
    • (2009) J. Immunol. , vol.182 , pp. 6951-6958
    • Andersson, A.1
  • 17
    • 66149156276 scopus 로고    scopus 로고
    • Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment
    • Harlin, H., et al. Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment. Cancer Res. 69 (2009), 3077–3085.
    • (2009) Cancer Res. , vol.69 , pp. 3077-3085
    • Harlin, H.1
  • 18
    • 84857050018 scopus 로고    scopus 로고
    • Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma
    • Chew, V., et al. Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma. Gut 61 (2012), 427–438.
    • (2012) Gut , vol.61 , pp. 427-438
    • Chew, V.1
  • 19
    • 84932646690 scopus 로고    scopus 로고
    • Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints
    • Mikucki, M.E., et al. Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints. Nat. Commun., 6, 2015, 7458.
    • (2015) Nat. Commun. , vol.6
    • Mikucki, M.E.1
  • 20
    • 84884164413 scopus 로고    scopus 로고
    • CXCR3, a double-edged sword in tumor progression and angiogenesis
    • Billottet, C., et al. CXCR3, a double-edged sword in tumor progression and angiogenesis. Biochim. Biophys. Acta Rev. Cancer 1836 (2013), 287–295.
    • (2013) Biochim. Biophys. Acta Rev. Cancer , vol.1836 , pp. 287-295
    • Billottet, C.1
  • 21
    • 75149141334 scopus 로고    scopus 로고
    • CCL2 blockade augments cancer immunotherapy
    • 2569–2569
    • Fridlender, Z.G., CCL2 blockade augments cancer immunotherapy. Cancer Res., 70, 2010 2569–2569.
    • (2010) Cancer Res. , vol.70
    • Fridlender, Z.G.1
  • 22
    • 84890281217 scopus 로고    scopus 로고
    • Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
    • Feig, C., et al. Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Proc. Natl. Acad. Sci. U. S. A. 110 (2013), 20212–20217.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 20212-20217
    • Feig, C.1
  • 23
    • 84918567280 scopus 로고    scopus 로고
    • Trafficking of T cells into tumors
    • Slaney, C.Y., et al. Trafficking of T cells into tumors. Cancer Res. 74 (2014), 7168–7174.
    • (2014) Cancer Res. , vol.74 , pp. 7168-7174
    • Slaney, C.Y.1
  • 24
    • 84982106672 scopus 로고    scopus 로고
    • Intratumoral interferon-gamma increases chemokine production but fails to increase T cell infiltration of human melanoma metastases
    • Mauldin, I.S., et al. Intratumoral interferon-gamma increases chemokine production but fails to increase T cell infiltration of human melanoma metastases. Cancer Immunol. Immunother. 65 (2016), 1189–1199.
    • (2016) Cancer Immunol. Immunother. , vol.65 , pp. 1189-1199
    • Mauldin, I.S.1
  • 25
    • 84936846631 scopus 로고    scopus 로고
    • TLR2/6 agonists and interferon-gamma induce human melanoma cells to produce CXCL10
    • Mauldin, I.S., et al. TLR2/6 agonists and interferon-gamma induce human melanoma cells to produce CXCL10. Int. J. Cancer 137 (2015), 1386–1396.
    • (2015) Int. J. Cancer , vol.137 , pp. 1386-1396
    • Mauldin, I.S.1
  • 26
    • 80054694464 scopus 로고    scopus 로고
    • Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells
    • Molon, B., et al. Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells. J. Exp. Med. 208 (2011), 1949–1962.
    • (2011) J. Exp. Med. , vol.208 , pp. 1949-1962
    • Molon, B.1
  • 27
    • 84952863049 scopus 로고    scopus 로고
    • Control of CD8 T-cell infiltration into tumors by vasculature and microenvironment
    • Peske, J.D., et al. Control of CD8 T-cell infiltration into tumors by vasculature and microenvironment. Adv. Cancer Res. 128 (2015), 263–307.
    • (2015) Adv. Cancer Res. , vol.128 , pp. 263-307
    • Peske, J.D.1
  • 28
    • 84891094512 scopus 로고    scopus 로고
    • Ways to enhance lymphocyte trafficking into tumors and fitness of tumor infiltrating lymphocytes
    • Bellone, M., Calcinotto, A., Ways to enhance lymphocyte trafficking into tumors and fitness of tumor infiltrating lymphocytes. Front. Oncol., 3, 2013, 231.
    • (2013) Front. Oncol. , vol.3 , pp. 231
    • Bellone, M.1    Calcinotto, A.2
  • 29
    • 84902124970 scopus 로고    scopus 로고
    • Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors
    • Motz, G.T., et al. Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors. Nat. Med. 20 (2014), 607–615.
    • (2014) Nat. Med. , vol.20 , pp. 607-615
    • Motz, G.T.1
  • 30
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • Jain, R.K., Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307 (2005), 58–62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 31
    • 84867902940 scopus 로고    scopus 로고
    • Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy
    • Huang, Y., et al. Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc. Natl. Acad. Sci. U. S. A. 109 (2012), 17561–17566.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 17561-17566
    • Huang, Y.1
  • 32
    • 84964313298 scopus 로고    scopus 로고
    • Bevacizumab plus ipilimumab in patients with metastatic melanoma
    • Hodi, F.S., et al. Bevacizumab plus ipilimumab in patients with metastatic melanoma. Cancer Immunol. Res. 2 (2014), 632–642.
    • (2014) Cancer Immunol. Res. , vol.2 , pp. 632-642
    • Hodi, F.S.1
  • 33
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert, C., et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N. Engl. J. Med. 364 (2011), 2517–2526.
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2517-2526
    • Robert, C.1
  • 34
    • 84994097105 scopus 로고    scopus 로고
    • VEGF neutralization plus CTLA-4 blockade alters soluble and cellular factors associated with enhancing lymphocyte infiltration and humoral recognition in melanoma
    • Wu, X., et al. VEGF neutralization plus CTLA-4 blockade alters soluble and cellular factors associated with enhancing lymphocyte infiltration and humoral recognition in melanoma. Cancer Immunol. Res. 4 (2016), 858–868.
    • (2016) Cancer Immunol. Res. , vol.4 , pp. 858-868
    • Wu, X.1
  • 35
    • 84984870923 scopus 로고    scopus 로고
    • Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma
    • Wallin, J.J., et al. Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma. Nat. Commun., 7, 2016, 12624.
    • (2016) Nat. Commun. , vol.7 , pp. 12624
    • Wallin, J.J.1
  • 36
    • 85015304170 scopus 로고    scopus 로고
    • The potential of combined immunotherapy and antiangiogenesis for the synergistic treatment of advanced NSCLC
    • Manegold, C., et al. The potential of combined immunotherapy and antiangiogenesis for the synergistic treatment of advanced NSCLC. J. Thorac. Oncol. 12 (2017), 194–207.
    • (2017) J. Thorac. Oncol. , vol.12 , pp. 194-207
    • Manegold, C.1
  • 37
    • 84957075682 scopus 로고    scopus 로고
    • Finley, A cancer treatment based on synergy between anti-angiogenic and immune cell therapies
    • Soto-Ortiz, L., Finley, S.D., Finley, A cancer treatment based on synergy between anti-angiogenic and immune cell therapies. J. Theor. Biol. 394 (2016), 197–211.
    • (2016) J. Theor. Biol. , vol.394 , pp. 197-211
    • Soto-Ortiz, L.1    Finley, S.D.2
  • 38
    • 84983489028 scopus 로고    scopus 로고
    • Neutrophils in the tumor microenvironment: trying to heal the wound that cannot heal
    • Singel, K.L., Segal, B.H., Neutrophils in the tumor microenvironment: trying to heal the wound that cannot heal. Immunol. Rev. 273 (2016), 329–343.
    • (2016) Immunol. Rev. , vol.273 , pp. 329-343
    • Singel, K.L.1    Segal, B.H.2
  • 39
    • 84915748819 scopus 로고    scopus 로고
    • Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer
    • Eruslanov, E.B., et al. Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer. J. Clin. Invest. 124 (2014), 5466–5480.
    • (2014) J. Clin. Invest. , vol.124 , pp. 5466-5480
    • Eruslanov, E.B.1
  • 40
    • 84978371387 scopus 로고    scopus 로고
    • Origin and role of a subset of tumor-associated neutrophils with antigen-presenting cell features in early-stage human lung cancer
    • Singhal, S., et al. Origin and role of a subset of tumor-associated neutrophils with antigen-presenting cell features in early-stage human lung cancer. Cancer Cell 30 (2016), 120–135.
    • (2016) Cancer Cell , vol.30 , pp. 120-135
    • Singhal, S.1
  • 42
    • 84929965822 scopus 로고    scopus 로고
    • Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8(+) T cells
    • Carretero, R., et al. Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8(+) T cells. Nat. Immunol. 16 (2015), 609–617.
    • (2015) Nat. Immunol. , vol.16 , pp. 609-617
    • Carretero, R.1
  • 43
    • 85018646512 scopus 로고    scopus 로고
    • Basophils promote tumor rejection via chemotaxis and infiltration of CD8+ T cells
    • Sektioglu, I.M., et al. Basophils promote tumor rejection via chemotaxis and infiltration of CD8+ T cells. Cancer Res. 77 (2017), 291–302.
    • (2017) Cancer Res. , vol.77 , pp. 291-302
    • Sektioglu, I.M.1
  • 44
    • 85016585233 scopus 로고    scopus 로고
    • PD-1/PD-L1 pathway in breast cancer
    • Schutz, F., et al. PD-1/PD-L1 pathway in breast cancer. Oncol. Res. Treat. 40 (2017), 294–297.
    • (2017) Oncol. Res. Treat. , vol.40 , pp. 294-297
    • Schutz, F.1
  • 45
    • 34247532726 scopus 로고    scopus 로고
    • Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer
    • Nomi, T., et al. Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer. Clin. Cancer Res. 13 (2007), 2151–2157.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 2151-2157
    • Nomi, T.1
  • 46
    • 4243096258 scopus 로고    scopus 로고
    • B7-h1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression
    • Konishi, J., et al. B7-h1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression. Clin. Cancer Res. 10 (2004), 5094–5100.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 5094-5100
    • Konishi, J.1
  • 47
    • 84941797037 scopus 로고    scopus 로고
    • Classifying cancers based on T-cell infiltration and PD-L1
    • Teng, M.W.L., et al. Classifying cancers based on T-cell infiltration and PD-L1. Cancer Res. 75 (2015), 2139–2145.
    • (2015) Cancer Res. , vol.75 , pp. 2139-2145
    • Teng, M.W.L.1
  • 48
    • 85008428512 scopus 로고    scopus 로고
    • What does PD-L1 positive or negative mean?
    • Ribas, A., Hu-Lieskovan, S., What does PD-L1 positive or negative mean?. J. Exp. Med. 213 (2016), 2835–2840.
    • (2016) J. Exp. Med. , vol.213 , pp. 2835-2840
    • Ribas, A.1    Hu-Lieskovan, S.2
  • 49
    • 84883863501 scopus 로고    scopus 로고
    • Up-Regulation of PD-L1, IDO, and T-regs in the melanoma tumor microenvironment is driven by CD8(+) T Cells
    • Spranger, S., et al. Up-Regulation of PD-L1, IDO, and T-regs in the melanoma tumor microenvironment is driven by CD8(+) T Cells. Sci. Transl. Med., 5, 2013, 200ra116.
    • (2013) Sci. Transl. Med. , vol.5
    • Spranger, S.1
  • 50
    • 84977161108 scopus 로고    scopus 로고
    • Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment
    • Spranger, S., et al. Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment. J. Immunother. Cancer, 2, 2014, 3.
    • (2014) J. Immunother. Cancer , vol.2 , pp. 3
    • Spranger, S.1
  • 51
    • 84867544962 scopus 로고    scopus 로고
    • PD-1 blockade enhances T-cell migration to tumors by elevating IFN-gamma inducible chemokines
    • Peng, W.Y., et al. PD-1 blockade enhances T-cell migration to tumors by elevating IFN-gamma inducible chemokines. Cancer Res. 72 (2012), 5209–5218.
    • (2012) Cancer Res. , vol.72 , pp. 5209-5218
    • Peng, W.Y.1
  • 52
    • 84962861436 scopus 로고    scopus 로고
    • Immune checkpoint blockade to improve tumor infiltrating lymphocytes for adoptive cell therapy
    • Kodumudi, K.N., et al. Immune checkpoint blockade to improve tumor infiltrating lymphocytes for adoptive cell therapy. PLoS One, 11, 2016, e0153053.
    • (2016) PLoS One , vol.11
    • Kodumudi, K.N.1
  • 53
    • 84935474357 scopus 로고    scopus 로고
    • PD-L1 expression as a predictive biomarker in cancer immunotherapy
    • Patel, S.P., Kurzrock, R., PD-L1 expression as a predictive biomarker in cancer immunotherapy. Mol. Cancer Ther. 14 (2015), 847–856.
    • (2015) Mol. Cancer Ther. , vol.14 , pp. 847-856
    • Patel, S.P.1    Kurzrock, R.2
  • 54
    • 84860852600 scopus 로고    scopus 로고
    • Blocking IDO activity to enhance anti-tumor immunity
    • Munn, D.H., Blocking IDO activity to enhance anti-tumor immunity. Front. Biosci. (Elite Ed.) 4 (2012), 734–745.
    • (2012) Front. Biosci. (Elite Ed.) , vol.4 , pp. 734-745
    • Munn, D.H.1
  • 55
    • 84903816506 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer
    • Prendergast, G.C., et al. Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer. Cancer Immunol. Immunother. 63 (2014), 721–735.
    • (2014) Cancer Immunol. Immunother. , vol.63 , pp. 721-735
    • Prendergast, G.C.1
  • 56
    • 84944045501 scopus 로고    scopus 로고
    • Tumor-expressed IDO recruits and activates MDSCs in a Treg-dependent manner
    • Holmgaard, R.B., et al. Tumor-expressed IDO recruits and activates MDSCs in a Treg-dependent manner. Cell Rep. 13 (2015), 412–424.
    • (2015) Cell Rep. , vol.13 , pp. 412-424
    • Holmgaard, R.B.1
  • 57
    • 85015760957 scopus 로고    scopus 로고
    • First-in-human phase I study of the oral inhibitor of indoleamine 2,3-dioxygenase-1 epacadostat (INCB024360) in patients with advanced solid malignancies
    • Beatty, G.L., et al. First-in-human phase I study of the oral inhibitor of indoleamine 2,3-dioxygenase-1 epacadostat (INCB024360) in patients with advanced solid malignancies. Clin. Cancer Res. 23 (2017), 3269–3276.
    • (2017) Clin. Cancer Res. , vol.23 , pp. 3269-3276
    • Beatty, G.L.1
  • 58
    • 84880664259 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4
    • Holmgaard, R.B., et al. Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4. J. Exp. Med. 210 (2013), 1389–1402.
    • (2013) J. Exp. Med. , vol.210 , pp. 1389-1402
    • Holmgaard, R.B.1
  • 59
    • 84977161108 scopus 로고    scopus 로고
    • Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment
    • Spranger, S., et al. Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment. J. Immunother. Cancer, 2, 2014, 3.
    • (2014) J. Immunother. Cancer , vol.2 , pp. 3
    • Spranger, S.1
  • 60
    • 85021768050 scopus 로고    scopus 로고
    • Dysregulation of TGF beta 1 activity in cancer and its influence on the quality of anti-tumor immunity
    • Hargadon, K.M., Dysregulation of TGF beta 1 activity in cancer and its influence on the quality of anti-tumor immunity. J. Clin. Med., 5, 2016, 76.
    • (2016) J. Clin. Med. , vol.5 , pp. 76
    • Hargadon, K.M.1
  • 61
    • 84879037098 scopus 로고    scopus 로고
    • Targeting TGF-beta signaling in cancer
    • Katz, L.H., et al. Targeting TGF-beta signaling in cancer. Expert Opin. Ther. Targets 17 (2013), 743–760.
    • (2013) Expert Opin. Ther. Targets , vol.17 , pp. 743-760
    • Katz, L.H.1
  • 62
    • 84983096371 scopus 로고    scopus 로고
    • Melanoma-derived factors alter the maturation and activation of differentiated tissue-resident dendritic cells
    • Hargadon, K.M., et al. Melanoma-derived factors alter the maturation and activation of differentiated tissue-resident dendritic cells. Immunol. Cell Biol. 94 (2016), 24–38.
    • (2016) Immunol. Cell Biol. , vol.94 , pp. 24-38
    • Hargadon, K.M.1
  • 63
    • 84941622047 scopus 로고    scopus 로고
    • Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages
    • Ugel, S., et al. Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages. J. Clin. Invest. 125 (2015), 3365–3376.
    • (2015) J. Clin. Invest. , vol.125 , pp. 3365-3376
    • Ugel, S.1
  • 64
    • 84992478733 scopus 로고    scopus 로고
    • L-Arginine modulates T cell metabolism and enhances survival and anti-tumor activity
    • Geiger, R., et al. L-Arginine modulates T cell metabolism and enhances survival and anti-tumor activity. Cell 167 (2016), 829–842.
    • (2016) Cell , vol.167 , pp. 829-842
    • Geiger, R.1
  • 65
    • 84971504949 scopus 로고    scopus 로고
    • L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo
    • Cao, Y., et al. L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo. BMC Cancer, 16, 2016, 343.
    • (2016) BMC Cancer , vol.16 , pp. 343
    • Cao, Y.1
  • 66
    • 79960918412 scopus 로고    scopus 로고
    • Emerging Tim-3 functions in antimicrobial and tumor immunity
    • Sakuishi, K., et al. Emerging Tim-3 functions in antimicrobial and tumor immunity. Trends Immunol. 32 (2011), 345–349.
    • (2011) Trends Immunol. , vol.32 , pp. 345-349
    • Sakuishi, K.1
  • 67
    • 84891053440 scopus 로고    scopus 로고
    • The tumor microenvironment and strategies to improve drug distribution
    • Saggar, J.K., et al. The tumor microenvironment and strategies to improve drug distribution. Front. Oncol., 3, 2013, 154.
    • (2013) Front. Oncol. , vol.3 , pp. 154
    • Saggar, J.K.1
  • 68
    • 84976300398 scopus 로고    scopus 로고
    • Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer
    • Chouaib, S., et al. Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer. Oncogene 36 (2017), 439–445.
    • (2017) Oncogene , vol.36 , pp. 439-445
    • Chouaib, S.1
  • 69
    • 79960393113 scopus 로고    scopus 로고
    • Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
    • Facciabene, A., et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature 475 (2011), 226–230.
    • (2011) Nature , vol.475 , pp. 226-230
    • Facciabene, A.1
  • 70
    • 84911958406 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in regulation of immune responses in tumour microenvironment
    • Kumar, V., Gabrilovich, D.I., Hypoxia-inducible factors in regulation of immune responses in tumour microenvironment. Immunology 143 (2014), 512–519.
    • (2014) Immunology , vol.143 , pp. 512-519
    • Kumar, V.1    Gabrilovich, D.I.2
  • 71
    • 84907979458 scopus 로고    scopus 로고
    • The IL-2 cytokine family in cancer immunotherapy
    • Sim, G.C., Radvanyi, L., The IL-2 cytokine family in cancer immunotherapy. Cytokine Growth Factor Rev. 25 (2014), 377–390.
    • (2014) Cytokine Growth Factor Rev. , vol.25 , pp. 377-390
    • Sim, G.C.1    Radvanyi, L.2
  • 72
    • 84966309581 scopus 로고    scopus 로고
    • The “cancer immunogram”
    • Blank, C.U., et al. The “cancer immunogram”. Science 352 (2016), 658–660.
    • (2016) Science , vol.352 , pp. 658-660
    • Blank, C.U.1
  • 73
    • 85019239740 scopus 로고    scopus 로고
    • Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy
    • Gnjatic, S., et al. Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy. J. Immunother. Cancer, 5, 2017, 44.
    • (2017) J. Immunother. Cancer , vol.5 , pp. 44
    • Gnjatic, S.1
  • 74
    • 84940573674 scopus 로고    scopus 로고
    • Recent developments in multiplexing techniques for immunohistochemistry
    • Dixon, A.R., et al. Recent developments in multiplexing techniques for immunohistochemistry. Expert Rev. Mol. Diagn. 15 (2015), 1171–1186.
    • (2015) Expert Rev. Mol. Diagn. , vol.15 , pp. 1171-1186
    • Dixon, A.R.1
  • 75
    • 85028829596 scopus 로고    scopus 로고
    • Oncolytic virotherapy promotes intratumoral T cell infiltration and improves anti-PD-1 immunotherapy
    • Ribas, A., et al. Oncolytic virotherapy promotes intratumoral T cell infiltration and improves anti-PD-1 immunotherapy. Cell 170 (2017), 1109–1119.
    • (2017) Cell , vol.170 , pp. 1109-1119
    • Ribas, A.1
  • 76
    • 85028938821 scopus 로고    scopus 로고
    • Local delivery of OncoVEXmGM-CSF generates systemic antitumor immune responses enhanced by cytotoxic T-lymphocyte-associated protein blockade
    • Published online July 13, 2017
    • Moesta, A.K., et al. Local delivery of OncoVEXmGM-CSF generates systemic antitumor immune responses enhanced by cytotoxic T-lymphocyte-associated protein blockade. Clin. Cancer Res., 2017, 10.1158/1078-0432.CCR-17-0681 Published online July 13, 2017.
    • (2017) Clin. Cancer Res.
    • Moesta, A.K.1
  • 77
    • 85023757545 scopus 로고    scopus 로고
    • Elimination of large tumors in mice by mRNA-encoded bispecific antibodies
    • Stadler, C.R., et al. Elimination of large tumors in mice by mRNA-encoded bispecific antibodies. Nat. Med. 23 (2017), 815–817.
    • (2017) Nat. Med. , vol.23 , pp. 815-817
    • Stadler, C.R.1
  • 78
    • 84975154579 scopus 로고    scopus 로고
    • Effector, memory, and dysfunctional CD8(+) T cell fates in the antitumor immune response
    • Reiser, J., Banerjee, A., Effector, memory, and dysfunctional CD8(+) T cell fates in the antitumor immune response. J. Immunol. Res., 2016, 2016, 8941260.
    • (2016) J. Immunol. Res. , vol.2016
    • Reiser, J.1    Banerjee, A.2
  • 79
    • 84858785703 scopus 로고    scopus 로고
    • Coordinated regulation of myeloid cells by tumours
    • Gabrilovich, D.I., et al. Coordinated regulation of myeloid cells by tumours. Nat. Rev. Immunol. 12 (2012), 253–268.
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 253-268
    • Gabrilovich, D.I.1
  • 80
    • 84936953099 scopus 로고    scopus 로고
    • Melanoma-intrinsic [bgr]-catenin signalling prevents anti-tumour immunity
    • Spranger, S., et al. Melanoma-intrinsic [bgr]-catenin signalling prevents anti-tumour immunity. Nature 523 (2015), 231–235.
    • (2015) Nature , vol.523 , pp. 231-235
    • Spranger, S.1
  • 81
    • 79953208248 scopus 로고    scopus 로고
    • STAT3 signaling: anticancer strategies and challenges
    • Johnston, P.A., Grandis, J.R., STAT3 signaling: anticancer strategies and challenges. Mol. Interv. 11 (2011), 18–26.
    • (2011) Mol. Interv. , vol.11 , pp. 18-26
    • Johnston, P.A.1    Grandis, J.R.2
  • 82
    • 84891824280 scopus 로고    scopus 로고
    • STAT3 activation: A key factor in tumor immunoescape
    • Rebe, C., et al. STAT3 activation: A key factor in tumor immunoescape. JAKSTAT, 2, 2013, e23010.
    • (2013) JAKSTAT , vol.2
    • Rebe, C.1
  • 83
    • 84887461855 scopus 로고    scopus 로고
    • Downregulation of Stat3 in melanoma: reprogramming the immune microenvironment as an anticancer therapeutic strategy
    • Emeagi, P.U., et al. Downregulation of Stat3 in melanoma: reprogramming the immune microenvironment as an anticancer therapeutic strategy. Gene Ther. 20 (2013), 1085–1092.
    • (2013) Gene Ther. , vol.20 , pp. 1085-1092
    • Emeagi, P.U.1
  • 84
    • 84862570245 scopus 로고    scopus 로고
    • Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis
    • Ihara, S., et al. Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis. Cancer Res. 72 (2012), 2990–2999.
    • (2012) Cancer Res. , vol.72 , pp. 2990-2999
    • Ihara, S.1
  • 85
    • 84962033748 scopus 로고    scopus 로고
    • STAT3 in CD8+ T cells inhibits their tumor accumulation by downregulating CXCR3/CXCL10 Axis
    • Yue, C., et al. STAT3 in CD8+ T cells inhibits their tumor accumulation by downregulating CXCR3/CXCL10 Axis. Cancer Immunol. Res. 3 (2015), 864–870.
    • (2015) Cancer Immunol. Res. , vol.3 , pp. 864-870
    • Yue, C.1
  • 86
    • 84946912433 scopus 로고    scopus 로고
    • Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy
    • Peng, D., et al. Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy. Nature 527 (2015), 249–253.
    • (2015) Nature , vol.527 , pp. 249-253
    • Peng, D.1
  • 87
    • 84958981871 scopus 로고    scopus 로고
    • PRC2 epigenetically silences Th1-type chemokines to suppress effector T-cell trafficking in colon cancer
    • Nagarsheth, N., et al. PRC2 epigenetically silences Th1-type chemokines to suppress effector T-cell trafficking in colon cancer. Cancer Res. 76 (2016), 275–282.
    • (2016) Cancer Res. , vol.76 , pp. 275-282
    • Nagarsheth, N.1
  • 88
    • 77952231121 scopus 로고    scopus 로고
    • Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21
    • Shields, J.D., et al. Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21. Science 328 (2010), 749–752.
    • (2010) Science , vol.328 , pp. 749-752
    • Shields, J.D.1
  • 89
    • 84947863720 scopus 로고    scopus 로고
    • Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma
    • Finkin, S., et al. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat. Immunol. 16 (2015), 1235–1244.
    • (2015) Nat. Immunol. , vol.16 , pp. 1235-1244
    • Finkin, S.1
  • 90
    • 2442606191 scopus 로고    scopus 로고
    • Lymphocyte trafficking across high endothelial venules: dogmas and enigmas
    • Miyasaka, M., Tanaka, T., Lymphocyte trafficking across high endothelial venules: dogmas and enigmas. Nat. Rev. Immunol. 4 (2004), 360–370.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 360-370
    • Miyasaka, M.1    Tanaka, T.2
  • 91
    • 84887827961 scopus 로고    scopus 로고
    • The density and type of MECA-79-positive high endothelial venules correlate with lymphocytic infiltration and tumour regression in primary cutaneous melanoma
    • Avram, G., et al. The density and type of MECA-79-positive high endothelial venules correlate with lymphocytic infiltration and tumour regression in primary cutaneous melanoma. Histopathology 63 (2013), 852–861.
    • (2013) Histopathology , vol.63 , pp. 852-861
    • Avram, G.1
  • 92
    • 80052236068 scopus 로고    scopus 로고
    • Human solid tumors contain high endothelial venules: association with T- and B-lymphocyte infiltration and favorable prognosis in breast cancer
    • Martinet, L., et al. Human solid tumors contain high endothelial venules: association with T- and B-lymphocyte infiltration and favorable prognosis in breast cancer. Cancer Res. 71 (2011), 5678–5687.
    • (2011) Cancer Res. , vol.71 , pp. 5678-5687
    • Martinet, L.1
  • 93
    • 84865129252 scopus 로고    scopus 로고
    • Neogenesis of lymphoid structures and antibody responses occur in human melanoma metastases
    • Cipponi, A., et al. Neogenesis of lymphoid structures and antibody responses occur in human melanoma metastases. Cancer Res. 72 (2012), 3997–4007.
    • (2012) Cancer Res. , vol.72 , pp. 3997-4007
    • Cipponi, A.1
  • 94
    • 84929379918 scopus 로고    scopus 로고
    • Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity
    • Peske, J.D., et al. Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity. Nat. Commun., 6, 2015, 7114.
    • (2015) Nat. Commun. , vol.6
    • Peske, J.D.1
  • 95
    • 84941628879 scopus 로고    scopus 로고
    • Regulatory T cells in tumor-associated tertiary lymphoid structures suppress anti-tumor T cell responses
    • Joshi, N.S., et al. Regulatory T cells in tumor-associated tertiary lymphoid structures suppress anti-tumor T cell responses. Immunity 43 (2015), 579–590.
    • (2015) Immunity , vol.43 , pp. 579-590
    • Joshi, N.S.1
  • 96
    • 60549092550 scopus 로고    scopus 로고
    • Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice
    • Grabner, R., et al. Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice. J. Exp. Med. 206 (2009), 233–248.
    • (2009) J. Exp. Med. , vol.206 , pp. 233-248
    • Grabner, R.1
  • 97
    • 17644400505 scopus 로고    scopus 로고
    • Network communications: lymphotoxins, LIGHT, and TNF
    • Ware, C.F., Network communications: lymphotoxins, LIGHT, and TNF. Annu. Rev. Immunol. 23 (2005), 787–819.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 787-819
    • Ware, C.F.1
  • 98
    • 84962921798 scopus 로고    scopus 로고
    • Facilitating T cell infiltration in tumor microenvironment overcomes resistance to PD-L1 blockade
    • Tang, H., et al. Facilitating T cell infiltration in tumor microenvironment overcomes resistance to PD-L1 blockade. Cancer Cell 29 (2016), 285–296.
    • (2016) Cancer Cell , vol.29 , pp. 285-296
    • Tang, H.1
  • 99
    • 84997171419 scopus 로고    scopus 로고
    • Multiplexed tissue biomarker imaging
    • Stack, E.C., et al. Multiplexed tissue biomarker imaging. J. Immunother. Cancer, 4, 2016, 9.
    • (2016) J. Immunother. Cancer , vol.4 , pp. 9
    • Stack, E.C.1
  • 100
    • 84974782296 scopus 로고    scopus 로고
    • Multispectral imaging of T and B Cells in murine spleen and tumor
    • Feng, Z., et al. Multispectral imaging of T and B Cells in murine spleen and tumor. J. Immunol. 196 (2016), 3943–3950.
    • (2016) J. Immunol. , vol.196 , pp. 3943-3950
    • Feng, Z.1
  • 101
    • 84925186719 scopus 로고    scopus 로고
    • Multiplexed immunohistochemistry, imaging, and quantitation: a review, with an assessment of Tyramide signal amplification, multispectral imaging and multiplex analysis
    • Stack, E.C., et al. Multiplexed immunohistochemistry, imaging, and quantitation: a review, with an assessment of Tyramide signal amplification, multispectral imaging and multiplex analysis. Methods 70 (2014), 46–58.
    • (2014) Methods , vol.70 , pp. 46-58
    • Stack, E.C.1
  • 102
    • 84998704798 scopus 로고    scopus 로고
    • Multispectral imaging of formalin-fixed tissue predicts ability to generate tumor-infiltrating lymphocytes from melanoma
    • Feng, Z., et al. Multispectral imaging of formalin-fixed tissue predicts ability to generate tumor-infiltrating lymphocytes from melanoma. J. Immunother. Cancer, 3, 2015, 47.
    • (2015) J. Immunother. Cancer , vol.3 , pp. 47
    • Feng, Z.1


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